Laurea magistrale ciclo unico 5 anni in Chimica e tecnologia farmaceutiche

Academic program

Print guide
Print
Year Course ID Course Teachers SSD Curriculum Site CFU
1 FA0021 ANALYTICAL CHEMISTRY AND METHODS IN DRUGS ANALYSIS MASSAROTTI Alberto, SORBA Giovanni CHIM/08 All 5
1 F0506 COMPUTER SKILLS SALERNO Thomas INF/01 All 1
1 F0507 ENGLISH L-LIN/12 All 3
1 F0496 GENERAL AND INORGANIC CHEMISTRY GIOVENZANA Giovanni Battista CHIM/03 All 7
1 FA0022 GENERAL MICROBIOLOGY FRACCHIA Letizia BIO/19 All 7
1 F0499 GENERAL PHYSIOLOGY DISTASI Carla, LIM Dmitry BIO/09 All 7
1 F0341 HUMAN ANATOMY BOSETTI Michela BIO/16 All 6
1 F0338 MATHEMATICS AND STATISTICS RINALDI Maurizio MAT/04 All 7
1 FA0023 ORGANIC CHEMISTRY I PANZA Luigi CHIM/06 All 5
1 F0339 PHYSICS ARCIDIACONO Roberta FIS/07 All 5
1 F0501 PLANT AND ANILMAL BIOLOGY MORO Laura BIO/13 All 7
2 FA0025 BIOCHEMISTRY RIZZI Menico BIO/10 All 8
2 FA0099 Biochimica applicata ROSSI Franca BIO/10 All 8
2 FA0028 Chimica, tecnologia e contaminanti degli alimenti ARLORIO Marco CHIM/10 All 7
2 FA0093 Chimica organica II e Chimica degli eterocicli PANZA Luigi, APPENDINO Giovanni Battista CHIM/06 All 9
2 FA0026 DRUG ANALYSIS I ALLEGRONE Gianna CHIM/08 All 6
2 F0417 PATHOLOGY (MEDICAL TERMINOLOGY) SICA Antonio, PORTA Chiara MED/04 All 8
2 F0428 PHARMACOGNOSY AND PHYTOTHERAPY LOMBARDI Grazia BIO/14 All 6
2 F0592 STATISTIC WITH R RINALDI Maurizio MAT/04 All 2
3 F0424 ADVANCED ORGANIC CHEMISTRY AND PROCESS DEVELOPMENT APPENDINO Giovanni Battista CHIM/06 All 10
3 FA0056 ADVANCED SYNTHETIC METHODS PANZA Luigi CHIM/06 All 2
3 FA0030 Analisi dei farmaci II GROSA Giorgio All 8
3 FA0034 Biochimica applicata ROSSI Franca BIO/10 All 6
3 FA0031 Biologia molecolare con laboratorio ROSSI Franca All 6
3 FA0028 Chimica, tecnologia e contaminanti degli alimenti ARLORIO Marco CHIM/10 All 7
3 FA0029 Chimica farmaceutica e progettazione del farmaco I TRON Gian Cesare CHIM/08 All 12
3 F0507 ENGLISH L-LIN/12 All 2
3 F0592 STATISTIC WITH R RINALDI Maurizio MAT/04 All 2
3 FA0032 Tecnologia e Legislazione Farmaceutiche I PATTARINO Franco CHIM/09 All 10
4 FA0056 ADVANCED SYNTHETIC METHODS PANZA Luigi CHIM/06 All 2
4 FA0040 Aspetti tecnologici e normativi dei prodotti medicinali e Economia e regolazione del farmaco PATTARINO Franco, JOMMI Claudio CHIM/09, SECS-P/07 All 15
4 FA0046 Biologia strutturale + Farmacologia preclinica e clinica GENAZZANI Armando, GARAVAGLIA Silvia, ORSETTI Marco Riccardo Lilio BIO/10, BIO/14 All 15
4 FA0043 Biotecnologie alimentari + Analisi e controllo di qualità dei prodotti alimentari ARLORIO Marco, COISSON Jean Daniel CHIM/10 All 15
4 FA0035 Chimica farmaceutica e progettazione del farmaco II SORBA Giovanni, TRON Gian Cesare CHIM/08 All 11
4 FA0037 Farmacologia sperimentale e farmacoterapia GRILLI Mariagrazia BIO/14 All 15
4 FA0036 Metodologie avanzate in analisi chimica-tossicologica ALLEGRONE Gianna CHIM/08 All 5
4 FA0063 PHARMACEUTICAL POLICY AND LEGISLATION DE ROSA Mauro BIO/14 All 3
4 FA0038 Rilascio e direzionamento di sostanze bioattive PATTARINO Franco CHIM/09 All 5
4 F0504 SPECTROSCOPIC METHODS IN ORGANIC CHEMISTRY AND LABORATORY OF SYNTHETIC MEDICINAL CHEMISTRY PANZA Luigi, MINASSI Alberto, PIRALI Tracey CHIM/06, CHIM/08 All 15
4 F0592 STATISTIC WITH R RINALDI Maurizio MAT/04 All 2
4 FA0033 Tecnologia e Legislazione Farmaceutiche II GIOVANNELLI Lorella CHIM/09 All 10
4 FA0039 Tossicologia e laboratorio di farmacologia TERRAZZINO Salvatore BIO/14 All 6
5 FA0056 ADVANCED SYNTHETIC METHODS PANZA Luigi CHIM/06 All 2
5 F0421 FINAL EXAM PROFIN_S All 30
5 F0068 INTERNSHIP NN All 30
5 FA0063 PHARMACEUTICAL POLICY AND LEGISLATION DE ROSA Mauro BIO/14 All 3
5 F0592 STATISTIC WITH R RINALDI Maurizio MAT/04 All 2
Print
CourseANALYTICAL CHEMISTRY AND METHODS IN DRUGS ANALYSIS
Course IDFA0021
Academic Year2016/2017
Year of rule2016/2017
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderMASSAROTTI Alberto
TeachersSORBA Giovanni, MASSAROTTI Alberto
CFU5
Teaching duration (hours)40
Individual study time 85
SSDCHIM/08 - Pharmaceutical chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Sites and/or partitions
Close course details
Print
CourseCOMPUTER SKILLS
Course IDF0506
Academic Year2016/2017
Year of rule2016/2017
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderSALERNO Thomas
TeachersSALERNO Thomas
CFU1
Individual study time 13
SSDINF/01 - Informatics
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryF - Stage e altre attività formative
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageItalian
AbstractStructure of the exam. Introduction to the course. What is a computer. Hardware: Internal components of a computer motherboard , CPU , memory ( RAM and hard disk) Hardware: Interfaces and Peripherals . Capacitive screens and resistive screens . Input and output devices Software: operating systems and application programs . The PC and file management. Computer viruses: what they are and how to treat them . ( 2h ) Software : word processing ( 2h ) Software : spreadsheet, and presentation tools ( 2h ) Internet , Web , identity and reputation ( 2h ) Online transactions and security ( 2h ) Latest analysis and IT innovations ( 2h )
Reference textsAll the reference material is posted on the DIR website
Teaching targetsThe aim of the course is to provide information and methodologies to beginners for the use of PC and useful software packages to produce reports and theses .
PrerequisitesNone
Didattics MethodsLectures are given in a standard classroom , slides and videos are available for download
Grading rulesComputer test with multiple choice questions . The assessment gives rise to pass/no pass evaluation .
Full argumentsStructure of the exam. Introduction to the course. What is a computer. Hardware: Internal components of a computer motherboard , CPU , memory ( RAM and hard disk) Hardware: Interfaces and Peripherals . capacitive screens and resistive screens . input and output devices Software: operating systems and application programs . The PC and file management. Computer viruses: what they are and how to treat them . ( 2h ) Software : word processing ( 2h ) Software : spreadsheet, and presentation tools ( 2h ) Internet , Web , identity and reputation ( 2h ) Online transactions and security ( 2h ) Latest analysis and IT innovations ( 2h )
Close course details
Print
CourseENGLISH
Course IDF0507
Academic Year2016/2017
Year of rule2016/2017
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
CFU3
Individual study time 75
SSDL-LIN/12 - Language and translation - English
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryE - Prova finale e lingua straniera
Year1
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Print
CourseGENERAL AND INORGANIC CHEMISTRY
Course IDF0496
Academic Year2016/2017
Year of rule2016/2017
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderGIOVENZANA Giovanni Battista
TeachersGIOVENZANA Giovanni Battista
CFU7
Teaching duration (hours)40
Individual study time 111
SSDCHIM/03 - General and inorganic chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe matter: elementary particles, atoms, molecules and ions. Chemical formulas. Atomic structure and the periodic system of elements. Chemical bonds. Molecular structure. Valence, oxidation state, coordination number. Chemical reactions: classification and balancing. Thermodynamics, chemical equilibrium, equilibrium constant. Principles of kinetics. States of matter, phase transitions. Solutions: concentration, solubility. Aqueous solutions, pH, acids, bases, salts, buffers. Stoichiometry and solution equilibria. Electrochemistry. Principles of inorganic nomenclature. Chemistry of the elements. Radiochemistry and applications in medicine.
Reference textsM.S. Silberberg. Chimica La Natura molecolare della materia e delle sue trasformazioni. McGraw Hill. ISBN 9788838667459. J.C. Kotz, P.M. Treichel, G. C. Weaver. Chimica. EdiSes ISBN 9788879597777.
Teaching targetsAim of the course is the knowledge of the basic concepts of general and inorganic chemistry required to tackle the following topics of the degree course. Knowledge of the structure and properties of chemicals is required as is the ability to communicate the corresponding information using a suitable and dedicated terminology. The student should be able to predict and calculate the behavior of chemical species, retrieving the necessary data and processing it properly, paying particular attention to aspects of special biological significance.
PrerequisitesNone
Didattics MethodsClassroom lessons (slides, movies and blackboard exercises). The course material (pdf/ppt files of slides) will be made available to the students in the online platform.
Grading rulesThe final exam of General and Inorganic Chemistry will be organized in three sections: i) general concepts; ii) prediction and calculation of thermodynamic, kinetic, equilibrium properties, iii) chemistry of the elements and their applications. Points i) and iii) will require answering to specific questions, while point ii) will require the resolution of physico-chemical problems. The student must reach at least a 6/10 grade simultaneously in each section to pass the exam. The final grade will be represented by the weighted average of the grades of the three sections.
Full argumentsThe matter: elementary particles, atoms, molecules and ions. Atomic models, quantum numbers, orbitals, electronic configuration and the periodic system of elements. Elements and compounds, chemical formulas, atomic weight, molecular weight, formula weight. Isotopes. Covalent bond, ionic bond, hydrogen bond, metallic bond, intermolecular interactions. Molecular structure: geometry, hybridization, molecular orbitals, resoncance, Lewis structures. VSEPR theory. Valence, oxidation state, coordination number. Principles of inorganic chemistry nomenclature. States of matter, definitions and properties, phase transitions. Gas laws. Chemical reactions: classification and balancing. Basics of chemical metrics. Redox reactions, definition, balancing methods, reduction potential, basics of electrochemistry, electrolysis, batteries. Principles of thermodynamics and application to chemical reactions. Enthalpy, entropy and free energy. Chemical equilibria. Equilibrium constant, influence of the temperature, Le Châtelier principle. Principles of kinetics, reaction rate, reaction order. Solutions: definition, concentration, solubility. Water self-ionisation, pH. Acids, bases, salts, buffers, coordination complexes. Stoichiometry and application to solution equilibria. Chemistry of the elements: natural abundance and sources, properties, industrial applications and biological relevance. Principles of radiochemistry and nuclear reactions, applications to medicine.
Close course details
Print
CourseGENERAL MICROBIOLOGY
Course IDFA0022
Academic Year2016/2017
Year of rule2016/2017
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderFRACCHIA Letizia
TeachersFRACCHIA Letizia
CFU7
Teaching duration (hours)56
Individual study time 119
SSDBIO/19 - General microbiology
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year1
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
Abstract- Structure and function of the prokaryotic cell - Features of microbial metabolism - Kinetic of microbial growth - Nutritional requirements of bacteria - Environmental effects on microbial growth - Cultivation of bacteria in the laboratory - Control of microbial growth - Duplication and expression of the prokaryotic genome - Horizontal gene transfer - Virus: structure and replication cycle of bacterial and animal viruses - Human-microorganism interaction: colonization and virulence factors - Non-specific and specific host defence mechanisms - The artificial active immunization - Antimicrobial drugs: mechanisms of action and resistance
Reference texts-Dehò- Galli - Biologia dei Microrganismi – Seconda Edizione 2014 Casa Editrice Ambrosiana – Distribuzione esclusiva Zanichelli -Brock- Biologia dei Microrganismi (Volume 1 Microbiologia generale + Volume 3 Microbiologia Biomedica), 2012 Casa Editrice Ambrosiana -Nicola Carlone – Microbiologia farmaceutica. Seconda Edizione Casa Editrice EdiSES
Teaching targetsThe course aims to provide students with basic knowledge of the microbial world from the point of view of cellular, metabolic and genetic organization, of the peculiarities of these aspects and the similarities with other living beings. The course will also give students the basic knowledge about the interactions between microorganism and host, the pathogenic activity of microorganisms in general and of some important pathogens in particular, and about the host non-specific and specific defense mechanisms. The structure and replication mechanisms of the principal bacterial viruses (bacteriophages) and animal viruses will be also studied. Finally, the course aims to give students an adequate knowledge of the mechanisms of action of the major antibacterial drugs. The course will also provide insights on the handling of microorganisms (isolation, propagation in culture, selective and differential media, conservation and sterility concept), the control of their growth (sterilization methods, treatment with disinfecting agents) and their identification
PrerequisitesBasic knowledge of the structure and of the principal functions of the eukaryotic and prokaryotic cell
Didattics MethodsLectures with slides show. Some topics will be deepened with videos in English and Italian.
Other informationsThe slides of the lectures and additional material are available on the website “Didattica in Rete”: https://www.dir.uniupo.it/
Grading rulesWritten exam with open questions. In itinere tests are also provided: in February in itinere test with multiple choice questions related to the first part of the course, in July test with open questions related to the second part of the course. The final score derives from the arithmetic mean of the scores of the two tests.
Full arguments- Structure and function of the bacterial cell Structural morphology and size of the bacterial cell The cell membrane: structure, function; transport systems The cell wall of Gram-positive and Gram-negative bacteria Gram staining - Microbial locomotion Flagella, gliding motility, chemotaxis, phototaxis and others - The surface structures and intracellular inclusions Fimbriae, pili, capsules, reserve materials, cytoplasmic inclusions, gas vesicles Endospores -The microbial metabolism: Glycolysis Respiration and electron transport chain The proton motive force The aerobic and anaerobic respiration Main types of fermentation The citric acid cycle The anabolism: the biosynthesis of key monomers Biosynthesis of peptidoglycan -The structure of DNA and DNA replication - Nutritional types of bacteria - Environmental effects on microbial growth Temperature, pH, oxygen. - Cultivation of microorganisms in the laboratory Sterilization and disinfection Complex, selective and/or differential culture media; autoclave sterilization The aseptic technique (isolation of pure culture) Identification of a bacterial strain by biochemical methods - Microbial growth The binary fission The growth cycle of a bacterial population (the growth curve) Continuous-culture: the chemostat system Direct evaluation of microbial growth: viable-cell count The indirect methods (turbidity measurement) Evaluation of the microbial biomass, chemical analysis of a cell component. - The microbial biofilms Growth and biological functions - Principles of molecular biology of microorganisms Synthesis and processing of RNA, protein synthesis - Genetic of microorganisms Transformation Generalized and specialized transduction Plasmids Conjugation Hfr conjugation and chromosomal transfer -Control of microbial growth Sterilization and disinfection: chemical and physical methods for the control of microbial growth - Principles of virology Viruses and virions General properties of viruses (viral structure and classification) Bacteriophages: virulent phages (phage T4), temperate phages (lambda phage) The animal viruses: retroviruses, DNA viruses, RNA (+) and RNA (-) viruses Growth and quantification of bacterial and animal viruses - Interactions host-microorganism Positive and egative interactions between microorganisms and human Virulence factors and bacterial toxins (exotoxins and endotoxins) - Nonspecific host defenses - Specific host defenses The immune response Antigens, T cells and cellular immunity Antibodies and immunity Humoral and cell-mediated immunity - The artificial active immunization Vaccines - Artificial passive immunization (outline) Immune sera, immunoglobulins - Antimicrobial drugs The spectrum of antimicrobial activity Mechanisms of action of antimicrobial drugs Overview of the most common antimicrobial drugs Mechanisms of resistance to antimicrobial drugs
Course borrowed fromFARMACIA (1506) - FA0004 Microbiologia generale
Close course details
Print
CourseGENERAL PHYSIOLOGY
Course IDF0499
Academic Year2016/2017
Year of rule2016/2017
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderDISTASI Carla
TeachersDISTASI Carla, LIM Dmitry
CFU7
Teaching duration (hours)56
Individual study time 119
SSDBIO/09 - Physiology
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year1
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Sites and/or partitions
Close course details
Print
CourseHUMAN ANATOMY
Course IDF0341
Academic Year2016/2017
Year of rule2016/2017
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderBOSETTI Michela
TeachersBOSETTI Michela
CFU6
Teaching duration (hours)48
Individual study time 102
SSDBIO/16 - Human anatomy
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractGeneral Embryology, the early stages of development. Microscopic anatomy of the bones, muscles and joints. Functional anatomy of the circulatory system: the movement in 'adult and fetus, external and internal configuration of the heart, the main vessels of the trunk, and limbs cephalic end, the concept of circulatory and lymphatic lymphoid organs, with particular reference to lymph nodes and spleen. Gross anatomy and microscopic functional central nervous system (spinal cord, brain stem, diencephalon, telencephalon and cerebellum) and peripheral (general of the large nerve plexus and the cranial nerves), the meninges and cerebrospinal fluid, the main streets of motility and sensitivity; generality of the sympathetic nervous system. Functional anatomy and microanatomy of the visceral apparates (digestive system, respiratory system, urogenital system) with particular reference to the functional units of liver, kidney, lung. Functional anatomy and microanatomy of the endocrine system with particular reference to hypothalamus and pituitary, adrenal, thyroid, gonads, pancreas. The skin.
Reference texts- Anatomia Umana di McKinley PICCIN ed. - Anatomia di Seeley SORBONA ed. - Anatomia Umana di Pasqualino-Panattoni UTET - Principi di Anatomia Umana di Tortora e Nielsen Casa Editrice Ambrosiana - Anatomia Umana di Saladin PICCIN ed. - Anatomia Umana di Castano et al. Edi-ermes
Teaching targetsKnowledge of the morphology of the human body. Macroscopic, topographic, microscopic and functional human anatomy. Ability to apply their knowledge to describe with autonomy and comunication skills organs and apparatus from a macroscopic and topographic point of view. Ability to apply the microscopic knowledge to understand and describe functional anatomy.
PrerequisitesNO
Didattics MethodsLessons in the classroom with the support of images, video and plastic (skeleton and organs)
Grading rulesOral examination on three different topics. Evaluation of the acquired knowledges and of the ability to use them with comunicative skills and medical terms to describe the asked anatomical structure. The evaluation of the familiarity with microscopic structures will demonstrate functional knowledge of the anatomical structure examined. Together with the description of an anatomical structure it will be tested the ability of the student to connect various topics as a result of a depth and not only a mnemonic study.
Full arguments- GENERAL ANATOMY: General and systematic knowledge of the anatomy, topography and terminology of location and movement, full hollow organs, anatomical position. - MICROSCOPIC ANATOMY: epithelial tissues, connective tissues with particular attention to blood. Emo-limphopoietic organs. - OSTEOARTHROMIOLOGY: general anatomy of the bones, muscles and joints. - CENTRAL AND PERIPHERAL NERVOUS SYSTEM: generality of macroscopic and microscopic anatomy of the central nervous system and peripheral sympathetic nervous system, the cavities of the central nervous system, the cerebrospinal fluid, the blood-brain barrier, the meninges. Spinal cord, brainstem, cranial nerves and their nuclei, forebrain, the main motor and sensory pathways. - CARDIOVASCULAR SYSTEM: generality of systematic anatomy of the cardiovascular system, the circulation in the adult configuration inside and outside of the heart, major vessels of the trunk, cephalic end and the arts. The fetal circulation. - DIGESTIVE SYSTEM: general systematic anatomy of the digestive system, especially the stomach, liver, intestines. General information on the peritoneum. - Respiratory system: general anatomy of the respiratory system systematically, with particular reference to the upper airways and lungs, the pleura generality. - UROGENITAL SYSTEM: general anatomy of the uro-genital systematic, with particular reference to the kidney, the nephron and urinary tract stones. Bladder, uterus, fallopian tubes, sperm streets. -OTHER DEVICES AND SYSTEMS: overview of systematic anatomy of the endocrine system with particular reference to: Hypothalamus, pituitary ovary, testis, adrenal, thyroid, pancreas, digestive juxtaglomerular apparatus
Close course details
Print
CourseMATHEMATICS AND STATISTICS
Course IDF0338
Academic Year2016/2017
Year of rule2016/2017
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderRINALDI Maurizio
TeachersRINALDI Maurizio
CFU7
Teaching duration (hours)48
Individual study time 115
SSDMAT/04 - Mathematics education and history of mathematics
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year1
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractFunctions Derivatives Integrals Descriptive Statistics Probability Statistical hyphotesis testing R
Reference textsSergio Invernizzi, Maurizio Rinaldi, Andrea Sgarro, Moduli di Matematica e Statistica, Zanichelli Editore, Bologna 2000

Teaching targets*Knowledge and understanding The course is intended to provide students with the knowledge and the ability to manage the mathematical tools required to understand and follow the other courses of the Degree. More specifically the course aims to provide students with basic methods of differential and integral calculus plus the basic notions of probability and statistics needed to understand mathematical models and to undertake statistical analysis of experimental results. *Applying knowledge and understanding Students are expected to be able use the acquired skills even in a multidisciplinary context and they should be able to resort to mathematics and statistics even in situations external to the course. *Making judgements. At the end of the course students are expected to apply learned methods even in different situations and that they have acquired the tools needed to extend their knowledge by themselves. * Communication skills At the end of the course students are expected to be able to express the learned concepts in a clear way. * Learning skills. During the course students should learn how to study by choosing their personal path and should become able to choose the appropriate resources, possibly online.
PrerequisitesThe student should have the basic knowledge of the subject that can be acquired in a normal high school. In particular: arithmetic operations, powers, Cartesian plane, the line equations, parabola and circumference, angles, measured in degrees and radians, circular functions, fundamental formulas of plane and solid geometry. In case of failure in the test of basic knowledge the student should follow the course on basic mathematics and pass the final test.
Didattics MethodsLectures are given either in the classroom or in the computer lab.
Other informationsReference material and further details are provided on the DIR website. https://www.dir.uniupo.it/course/view.php?id=218 Enrolment key is provided during the lectures.
Grading rulesOngoing Quizzes and online Final Examination (possibly splitted in two parts). The ongoing quizzes are assigned periodically at the end of a given subject. The Final focuses on all the course matters. Final evaluation gives a weight of 30% to the ongoing quizzes and 70% to the Final. Ongoing quizzes could be replaced by an oral examination.
Full argumentsCredit 1 [Functions] Mathematical concept of functions. Domain and codomain (target), Image. Exponential and power functions. Function composition. Invertible function and inverse function. Inverse circular functions. Logarithms. Credit 2 [Derivatives] Meaning of Derivative Geometric meaning of the derivative. Graphic computation of the derivative through repeated zooms. Approximation of the derivative at a point via Newton quotient. Three point rule. Derivative for tabulated functions. Derivative function. Differentiation rules Derivative of the sum, of the product, of the composite function, of the reciprocal and of the quotient. Derivative of the inverse function. Application of the derivatives Increasing and decreasing functions, Minima and maxima of functions. Computation of maxima and minima with the help of the derivative, Second derivative and study of concavity-convexity of a graph. Credit 3 [Area and Integrals] Numerical Integration Definite integral for positive functions over finite intervals, Computation. Numerical integration with the rectangle methods and trapezoid method. Stochastic integration with the Montecarlo methods. Exact integration The Fundamental Theorem of Calculus. Indefinite integral and antiderivatives. Computation of antiderivatives. Area between two curves. Extensions of the Integral Integrals for non positive functions. Inversions of integration endpoints. Credit 4 [Statistical Data] Introduction Experimental data and simulated data. How to simulate a fair dice. Single Variable Statistical Units. Samples, populations, variables. Single variable statistics. Data presentations: sorting, absolute frequencies, relative frequencies. Conti- nuous and discrete variables. Bar charts, histograms and box-plot. Properties of the Summation symbol. Statistical parameter, Measures of centrality (mean, median) and measures of dispersion (extensions, quartiles, sample variance and sample standard deviation). Statistical Indices for repeated data. Credit 5 [Double variables statistics Probability.] Double variables Two variables representations. Scatter plot. Covariance, Linear regression (linear regression over X and over Y). Application of linear regression. Power and exponential laws. Variable transformations to reduce to a linear relationship. Credit 6 [Probabilities] Frequentist definition of probability. Complete systems of events. Union and intersection of events. Bayes rule. Probability computations using Bayes rule. Random variables and probabilities densities for discrete and continuous variables. Expected values and standard deviation of a population. Computation of Expected values and variance. Normal variables. Com- putation of the probability P{a < X < b} for a normal variable. Standard variables. Credit 7 [Statistical Tests] Estimations of statistical parameters Reliability criterions. Confidence level and reliability. Point estimates and interval estimates. Interval estimate of the mean of a normal population. Statistical tests Student’s t-test with with one sample and two samples (paired data, equal variance data). Welch test. chi square-test.
Close course details
Print
CourseORGANIC CHEMISTRY I
Course IDFA0023
Academic Year2016/2017
Year of rule2016/2017
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderPANZA Luigi
TeachersPANZA Luigi
CFU5
Teaching duration (hours)40
Individual study time 85
SSDCHIM/06 - Organic chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year1
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractStructure and properties of organic compounds Functional groups, physical properties and nomenclature Isomerism, conformational analysis, introduction to stereochemistry Stereochemistry Alkanes Alkenes Alkynes Alkyl halides
Reference textsP. H. Bruice, Chimica organica, Edises N. E. Shore, P. Vollhardt, Chimica organica, Zanichelli W.H. Brown, C.S. Foote, Chimica organica, Edises J. McMurry, Chimica organica, Piccin
Teaching targetsProvide students with the structural basis of organic chemistry, the basic concepts of systematic nomenclature, the ability to manage configurational and conformational analysis of organic compounds, the acidity and basicity concepts in organic chemistry, the ability to use the resonance structures and deliver the basic concepts on the reactivity of saturated and unsaturated hydrocarbons and haloalkanes
PrerequisitesKnowledge of the chemical bond, the Lewis structures and concepts of acidity and basicity. Knowledge of the main inorganic acids, bases and salts
Didattics MethodsLectures with multimedia support and exercises. In particular, the use of concepts in facing specific problems will be shown in order to provide a problem-solving ability.
Grading rulesWritten test for admission to the oral examination, usually consisting of 5 questions with problems on nomenclature, stereochemistry, acidity, resonance, Lewis structures and simple guided synthesis. Oral exam with a proposal of reactivity problems, to be discussed including mechanistic aspects.
Full argumentsStructure and properties of organic compounds: General introduction to the chemical bond. Ionic, covalent, and polar covalent chemical bond: properties and geometry. Modern theories of chemical bond. Lewis structures and formal charges. Resonance structure formulas. Aromaticity. Summary Exercises Functional groups, physical properties and nomenclature: representation of organic molecules. Functional groups; influence of functional groups on the physical properties; acidity and basicity. Intermolecular interactions. Nomenclature of organic compounds. Summary exercises. Isomers, conformation analysis and introduction to stereochemistry: isomerism: definition and classification. Conformational analysis of non-cyclic compounds. Conformational analysis of cyclic compounds. Biological relevance conformational analysis. Configurational analysis: alkenes. Chirality. Kinetics and thermodynamics of chemical processes. Summary exercises. Stereochemistry: Chirality and stereogenicity. Configurational descriptors. Configurational analysis: diastereoisomerism and enantiomerism. Biological importance of chirality. Resolution of mixtures of diastereoisomers and mixtures of enantiomers. Summary exercises. Alkanes: Reactivity: combustion and heats of formation, reactivity and selectivity of halogenation; homolytic bond dissociation energies; Hammond postulate. Alkenes: Preparation, stability and reactivity. Formation, stability and reactivity of carbocations; elimination reactions; dehydration, dehydrohalogenation, dehalogenation. Mechanisms E2, E1, (E1cb: outline). Kinetics, stereochemistry, stereoselectivity and stereospecificity concepts, orientation, reactivity. Hydrogenation. Electrophilic addition reactions to the double bond. Addition of halogens: formation of halohydrins and haloethers. Hydration. Addition of hydracids. Epoxidation. Addition of ozone and ozonolysis. Hydroboration-oxidation. Osmilation and reaction with permanganate. Dienes, and polyenes. The isoprenic rule. Reactivity of conjugated dienes: kinetic and thermodynamic control of a reaction. Diels-Alder reaction. Outline on the polymerization reaction. Alkynes: preparation and reactivity. Acidity and use of organometallic derivatives. Addition reactions (compared with alkenes). Alkyl halides: preparation and reactivity. Aliphatic nucleophilic substitution. SN1 and SN2 mechanisms, kinetics and stereochemistry. Outline of dipolar aprotic solvents.
Close course details
Print
CoursePHYSICS
Course IDF0339
Academic Year2016/2017
Year of rule2016/2017
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderARCIDIACONO Roberta
TeachersARCIDIACONO Roberta
CFU5
Teaching duration (hours)24
Individual study time 77
SSDFIS/07 - Applied physics
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year1
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe course covers the following topics: Introduction on Physics observables and some reminders on Mathematics. Mechanics: Kinematics, Dynamics of the point (outline of complex systems), Statics Electricity and Magnetism Waves, Optics, Acustic Fluidostatics, Fluidodynamics Radioactivity Radiation-matter interaction.
Reference textsGiancoli, “Fisica. Principi e applicazioni” CEA Ragozzino “Principi di Fisica” EdiSES Scannicchio, “Fisica Biomedica” EdiSES J.W. Kane, M.M. Sternheim, Fisica biomedica , Edizioni Mediche Scientifiche Internazionali
Teaching targetsThe objective is to provide the students with a solid knowledge of the main concepts of General Physics, with some outline given to modern physics. These concepts are fundamental for the deep understanding of many of the phenomena in chemistry and in the involved instrumentations. The student will be able to analyze and resolve physics problems of medium/easy level. The student will have to communicate in an effective and appropriate way his knowledge.
PrerequisitesNone
Didattics MethodsThe course is offered in the traditional way, with lectures and collective exercises. Slides, and occasionally videos and multimedia applications are used to assist the lectures. Many hours are devoted to problem solving. Several homeworks are proposed to the students in order to encourage their participation.
Grading rulesMidterm written test. Final written examination, with exercizes and theory. Final oral examination optional.
Full argumentsIntroduction on Physics observables and some reminders on Mathematics. Goniometric functions. Vectors algebra. Measurement significant figures. Fundamental and derived observables. Measurements units and SI System. Units conversion. Physics laws. Mechanics Reference frames. Velocity, acceleration. Motion (linear, accelerated, circular). Freely falling object. Newton's laws. Mass, force. Friction. Work and energy.Conservative and nonconservative forces. Mechanical energy and its conservation. Power. Linear momentum and its conservation. Elastic and inelastic collisions. Center of Mass. Rotational Motion: angular acceleration, torque and rotational inertia. Angular momentum and its conservation. Rigid objects motion. Static equilibrium. Simple harmonic motion. Elasticity. Dumped and forced oscillations: resonance. Electricity and magnetism Electric charge, Coulomb law, electric field and Gauss's law. Electric potential. Definition of electronvolt. Electric dipole and its characteristics. Dipole in a uniform electric field. Conductors and insulators. Capacitor and its properties. Capacitors in series and in parallel. Electric current. Resistance and resistivity. Ohm laws. Resistors in series and in parallel. Electric power. Joule effect. DC and AC simple electric circuits. Magnetic field. Lorentz force. Mass spectrograph.. Magnetic force on a wire with current. Magnetic fields induced by currents: straight wire, spire, solenoid. Magnetic dipole and its characteristics. Magnetic field flux. Faraday-Neumann-Lenz law. Electromagnetic waves. The frequency spectrum and the visible light. Photoelectric effect. Corpuscolar nature of light. Photon. X ray generation. X-ray tube. Waves,optics, acustic Characteristics of wave motion. Wave speed in a medium. Reflection and transmission. Interference. Standing waves. Refraction and diffraction. Sound characteristics. Intensity of sound: decibel. Sources of sound. Doppler effect. Doppler flow meter. The ray model of light and its behaviour.Young's experiment. Single slit diffraction. X rays and diffraction. Fluids Pressure, density. Pascal's principle. Hydrostatic pressure. Atmospheric pressure. Stevino's law. Archimedes' principle. Fluids in motion: equation of continuity. Bernoulli's law. Viscosity. Poiseuille's equation. Hydrodinamic resistance. Stokes' law. Sedimentation velovity. Radioactivity Outline on atomic structure. Nucleus properties: dimensions, mass, binding energy. Stability curve. Alfa, beta and gamma decays. Radioactive decay law. Mean lifetime and half life; activity. Radiation-matter interaction. Outline on charged particle, photons and neutrons interaction with matter. Biologic effects. Dose.
Close course details
Print
CoursePLANT AND ANILMAL BIOLOGY
Course IDF0501
Academic Year2016/2017
Year of rule2016/2017
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderMORO Laura
TeachersMORO Laura
CFU7
Teaching duration (hours)56
Individual study time 119
SSDBIO/13 - Experimental biology
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year1
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractBasic properties and components of living organisms (proteins, lipids, carbohydrates and nucleic acids) DNA organization, replication and repair Principles of transcription and translation of the genetic information Cell structure and functions Cell communication Animal and plant cell comparison
Reference textsBiologia molecolare della cellula, Alberts, Zanichelli L’essenziale di Biologia molecolare della cellula, Alberts, Zanichelli Biologia cellulare e molecolare, Karp, Edises Il mondo della cellula, Becker, Edises Biologia Vegetale, Longo, UTET Biologia vegetale, Pupillo, Zanichelli Biologia delle piante, Raven, Zanichelli
Teaching targetsTo provide students with basic knowledge of structural organization of eukaryotic cells of animals and plants, on cellular processes and intercellular relationships. Provide also basic knowledge on the mechanisms of transmission and expression of genetic information.
PrerequisitesNone
Didattics MethodsClassroom lectures will be held during October to January and March to May
Grading rulesWritten-exam, consists of 15-20 short or multiple choice answer concerning the items listed in the program. Each correct response results in a positive score, from 0.5 to 2, and omitted items result in no mark (exams are held in February, June / July and September with at least two calls per session).
Full arguments• Biological macromolecules: nucleic acids DNA and RNA, amino acids and proteins, lipids and carbohydrates. • DNA: the double helix structure. Levels of organization of DNA inside the cell: nuclear chromatin and chromosome structure. DNA replication. Mechanisms of control of the fidelity of copying the genetic message. Mutations: importance in the pathology and evolution. • Molecular definition of gene. • The transcription and maturation of RNAs. • The lac operon as a paradigmatic example of gene regulation in prokaryotes. • The modulation of gene expression in eukaryotes. • The genetic code and its characteristics. • The protein synthesis. • Plasma membrane: organization of the phospholipid bilayer, proteins and sugars. • The mechanisms of transport of small molecules: permeability of the bilayer, channel proteins and carrier proteins, active and passive transport. • Rough endoplasmic reticulum and Golgi apparatus: membrane and secreted protein synthesis, signal sequences, glycosylation and maturation of proteins in the Golgi. Exocytosis and endocytosis. • Smooth endoplasmic reticulum. Lysosomes and peroxisomes . • Mitochondria. • General principles of cell communication. Properties of receptors and intracellular generation of messages. The extracellular matrix: glucosamminoglycans, proteoglycans, structural proteins and adhesive proteins. • The cytoskeleton: actin and myosin microfilaments, intermediate filaments and microtubules The phases of the cell cycle and mitosis. The cell cycle control. Comparison of plant and animal organisms. • General features of plant cells: size, shape, organization, wall, plastids, vacuole. • Wall: wall formation, chemical composition of the wall, primary and secondary wall cell wall modifications. Importance of the wall in the control of osmotic pressure (see also the vacuole). • Plastids: plastids in the meristematic cell, differentiation, forms and interconversion between the plastids, hypothesis on the origin of plastids. The plastids in the adult cell: chloroplasts, leucoplasts, chromoplasts. • Vacuole: the vacuole in the meristematic cell, differentiation, the vacuole in the adult cell. Importance of the vacuole in the control of osmotic pressure. Solid and liquid includes of the vacuole. • Growth and development of plant cells. Characteristics of the meristematic cell and of adult cell. • The plant tissues. • Photosynthesis: dark phase and light phase. • Plant hormones: auxin, cytokinins, gibberellins, ethylene and abscisic acid. • Responses of plants to external stimuli, light and temperature
Close course details
Print
CourseBIOCHEMISTRY
Course IDFA0025
Academic Year2016/2017
Year of rule2015/2016
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderRIZZI Menico
TeachersRIZZI Menico
CFU8
Teaching duration (hours)64
Individual study time 136
SSDBIO/10 - Biochemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian with slides in English
Abstract- Proteins - Lipids - Carbohydrates - Enzymes - Basic thermodynamic concepts in metabolism - Carbohydrates metabolism - Biological oxidation - Lipids metabolism - Amino-acids metabolism - Nucleic acids - DNA replication - DNA transcription - Protein synthesis - Protein targeting - Protein degradation
Reference texts- Donald Voet, Judith G. Voet Charlotte W. Pratt FONDAMENTI DI BIOCHIMICA Terza edizione Italiana 2013, Zanichelli Editore ISBN 9788808175441 - David L. Nelson, Michael M. Cox I PRINCIPI DI BIOCHIMICA DI LEHNINGER 2006, Zanichelli Editore ISBN 978-8808-19774-0 - Thomas M: Devlin BIOCHIMICA con aspetti clinico-farmaceutici 2013, EdiSES srl ISBN: 978 8879 597 807
Teaching targetsThe Course aims at providing the necessary knowledge to understand: (1) the structure, the function and the structure-function relationship of biological macro-molecules and (2) the metabolic pathways. The core of the course consists of the in depth description and analysis, in different contexts, of the major metabolic pathways to develop the capacity to see the metabolism as a highly integrated network with a particular attention to the regulatory and energetic aspects. Moreover, the detailed description of the mechanism sustaining protein functions, provides an atomic view of a specific biochemical event as a requisite to understand the molecular/atomic bases of diseases for their pharmacological treatment. Overall, the course aims to develop in the student both a specific knowledge of the chemistry behind biochemical events, essential in the process of drug design, and the capacity to frame the effect of a pharmacological intervention on a specific target, at the level of the whole cell/organ/organism. This to allow understanding the complex process of drug discovery, with critical thinking. Attention is also dedicated to nomenclature and “biochemistry language”, to develop the essential communication skills required to efficiently operates in the highly multidisciplinary field of drug development
PrerequisitesThe knowledge of the basic principles of general biology, phisycal-chemistry, inorganic and organic chemistry is essential. It is therefore highly recommended that the student has passed the exams of General Biology and Inorganic Chemistry and have attended the Course of Organic Chemistry , before taking the course of Biochemistry.
Didattics MethodsEx-cathedra lectures. During the Course, after a specific topic has been covered in the lectures, a discussion with the students is conducted to allow both the teacher and the students to assess the extend to which the different concepts (and not specific information) have been understood and received always trying to stimulate and develop a critical thinking attitude.
Other informationsNA
Grading rulesWritten and oral exams. The written exam is based on four open questions spanning the whole program with two questions specifically addressing the central metabolism. Metabolites chemical formula, enzymatic reactions and regulation of metabolic pathways are invariably requested. Only the students that pass the written exam (i.e. that received a mark equal or higher than 18/30) can proceed to the oral part during which, starting from the questions asked in the written exam, the capacity of the student to link different topics with critical thinking in both pathological and/or physiological states, will be assessed together with the communication skills.
Full arguments- Proteins: amino-acids: structure, properties, function. The peptide bonds. Structural organization of proteins: amino-acid sequence, secondary structures; overall structure: fold type; quaternary structure. The process of protein folding. Chaperonines. Oxygen transport. Myoglobin and Hemoglobin: structure and function; allostery and allosteric factors; hemoglobin variants; the theory of co-operativity: sequential model and concerted model - Lipids: structure, properties and functions - Carbohydrates: structure, properties and functions; glycoproteins - Enzymes: classification; coenzymes; Theory of catalysis; Enzyme kinetics; mechanisms of irreversible and reversible enzyme inhibition; regulation of enzyme activity; examples of enzyme catalysis (serine proteinases). -Basic thermodynamic concept in metabolism: phospho-compounds; ATP and the reaction of phosphorylation. Redox equilibrium in the biological systems: NAD(P) and FAD - Carbohydrates metabolism: Glycolysis. Fermentation. Glycogen degradation. Gluconeogenesis. Pyruvate oxidation and the citric cycle. - Biological oxidation: the respiratory chain: electron transport and oxidative phosphorylation. FoF1 ATP synthase. - Lipids metabolism: lipids transport and activation; fatty acids transport into mitochondria; the process of beta-oxidation: odd chain, saturated and unsaturated fatty acids. Ketone bodies. Fatty acids biosynthesis. - Amino-acids metabolism. Oxidation of amino-acids and the urea cycle. - Nucleic acids: structure and function of DNA and RNA - DNA replication: the DNA replication machinery in prokaryotes and eukaryotes and major differences - DNA transcription: synthesis of mRNA; RNA polymerase: structure and enzyme mechanism; post-trancriptional modifications; regulation of transcription - Protein synthesis: the genetic code; the process of translation: tRNA; aminoacyl-tRNA synthetases; ribosome structure and catalysis; initiation-elongation-termination processes in protein synthesis; ribosome inhibition; post-translational modifications. - Protein targeting: membrane, mitochondrial and nuclear targeting. - Protein degradation: ubiquitin and the process of ubiquitination; proteasome: structure and catalytic mechanism.
Close course details
Print
CourseBiochimica applicata
Course IDFA0099
Academic Year2016/2017
Year of rule2015/2016
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderROSSI Franca
TeachersROSSI Franca
CFU8
Teaching duration (hours)64
Individual study time 136
SSDBIO/10 - Biochemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractPurification of proteins and macromolecular complexes Biochemical analysis of proteins and macromolecular complexes Functional analysis of proteins and macromolecular complexes Expression of recombinant proteins
Reference textsStoppini, M e Bellotti, V “Biochimica Applicata” Ed. EdiSES ISBN 9788879597135 Bonaccorsi di Patti, MC, et al. “Metodologie Biochimiche” Ed. CEA ISBN 978-8808-18329-3 Selected Reviews
Teaching targetsThe "Applied Biochemistry” course describes the theoretical and practical aspects, and the overall impact of Biochemistry in a wide range of Research fields, ranging from health and life sciences, to bio-analytical disciplines. The course aims to provide a solid technical background in Biochemistry, also by illustrating the most advanced methods used in the production, purification, manipulation, biochemical characterization and functional analysis of biological macromolecules. By assigning each Student with individual tasks, and by stimulating an independent and critical thinking, the Students are expected to develop the capability to rationally approach a complex biochemistry problem.
PrerequisitesAn adequate knowledge of biochemistry is required.
Didattics MethodsLectures and Seminars
Other informationsSome lessons will be held in the computer room to introduce the Students to the use of publicly accessible programs for the analysis and the alignment of DNA and protein sequences. This activity is instrumental to the preparation of a report that will be evaluated concomitantly to the “standard” exam (written test).
Grading rulesWritten exam (exercises and free text) The first exercise will be focused on the steps required to construct a vector for the expression of a given recombinant protein (PCR primers design, restriction analysis, analysis of the expected protein); 10 pt. In the second exercise the Student will be asked either to define the best/fastest way to purify/isolate a protein from a given complex mixture, or to design a strategy for the expression and characterisation of given protein; 10 pt. The open question will concern a technical subject (e.g. “Principles of ion exchange chromatography”) or a broader topic (e.g. “Current methods to investigate macromolecular interactions”);10 pt.
Full arguments-Preparation of biological samples for biochemical analysis. -Working with proteins: general principles. -Techniques of cell lysis. Samples fractionation by centrifugation. -Protein electrophoresis: principles and systems. Electrophoresis in native and denaturing conditions: SDS-PAGE, iso-electrofocusing, 2D electrophoresis. -Techniques for the detection of proteins separated by electrophoresis: total protein staining, specific staining and immuno-staining. -Immunoassays (ELISA), immunofluorescence (IFA) and radio-immunological techniques (RIA). Devices for self-diagnosis based on lateral flow immunoassays. -Liquid Chromatography techniques for proteins purification and analysis: general principles, materials and instrumentation. Applications in detail: ion exchange chromatography, hydrophobic interaction chromatography, affinity chromatography, and size exclusion chromatography. - Determination of the concentration of proteins in a given sample and of the purity of enzyme preparations. -Post-purification processing; protein concentration; dialysis and ultrafiltration. -Functional characterization of enzymes: selected examples. -Purification and analysis of nucleic acids. -Site-directed mutagenesis. -System for recombinant proteins expression: applications, advantages, disadvantages, and selection guide. -Expression of recombinant proteins in Escherichia coli. -The Baculovirus/insect cell system. -Pichia Pastoris as protein expression system in yeast. -Methods to study protein-protein and protein-DNA interactions. - “N”-hybrid systems (in bacteria, yeast and mammalian cells ) -Interaction cloning approaches for the identification of genes encoding potential partners of a protein of interest. - Study of protein-protein and protein-ligand interactions using SPR (surface plasmon resonance). - Study of protein-protein and protein-ligand interactions using ITC (isothermal titration calorimetry). -Analysis of proteomes.
Course borrowed toCHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - FA0034 Biochimica applicata
Close course details
Print
CourseChimica, tecnologia e contaminanti degli alimenti
Course IDFA0028
Academic Year2016/2017
Year of rule2015/2016
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderARLORIO Marco
TeachersARLORIO Marco
CFU7
Teaching duration (hours)56
Individual study time 119
SSDCHIM/10 - Food chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageThe teaching will be delivered in Italian; part of the material used by the teacher will be in English.
Abstract- Chemistry of amino acids, proteins, carbohydrates and lipids: deepening on the peculiarities correlated to the food area - Vitamins, minerals and polyphenols - Definitions: food product, ingredient, processed food, regulatory framework - Food products interest in Pharma area - Chemical composition of foods: (principal and minor compounds) - Bioactive compounds in foods and nutraceutics: examples from plant, animal and fungal foods - Food industry and food technology; food processing; unit processes. - Techniques of sanitization and processing; Mild technologies, microorganisms and food biotechnologies - Bio-proteins from microbial source, fungi and algae - Definition of NOAEL and DGA, toxicological studies and Risk Assessment - Improvement agents (food additives, enzymes, flavouring compounds): classification and case studies - Food contaminants: classification and case studies - Residues in foods: plant protection products, pesticides and veterinary drugs - The food significance in modern nutrition - Biological detoxification mechanisms (overview)
Reference textsSlides used in the course, provided by the Teacher Food Chemistry and composition: *INTRODUZIONE ALLA CHIMICA DEGLI ALIMENTI. Martelli, M. Arlorio:. Edizioni CLU, 1996, Torino *CHIMICA DEGLI ALIMENTI, a cura di A. Martelli, P. Cabras. Piccin Editore, 2003 *P. Cappelli, V. Vannucchi: Chimica degli alimenti, Ed. Zanichelli Toxicology and Food Toxicology: *TOSSICOLOGIA, a cura di C.G. Galli, E. Corsini, M. Marinovich. Piccin Editore, 2003 Regulatory framework: Gazzette Ufficiali Italiana ed Europea (e supplementi) For insight into the topic of food chemistry: *Belitz, Grosch, Schieberle “Food Chemistry”, Ed. Springer (IV Edition) For insight into the topic of Toxicology: Food Toxicology. W. Helferich, C. Winter Editor. CRC Press, Boca Raton Florida, 2001 Food Biotechnology: *C.Gigliotti, R.Verga: Biotecnologie Alimentari, Ed. Piccin Padova.
Teaching targetsThe course aims to provide basic knowledge concerning) i) basic chemical knowledge on molecules and macromolecules in foods, also concerning vitamins, minerals, polyphenols and other minor compounds; ii) the basic knowledge on food technologies for food sanitization, processing, also considering Mild Technologies, biotechnologies and new sustainable approaches; iii) the chemical composition and nutritional value of the food and iv) the knowledge on chemistry and usefulness of the main food additives, processing aids, flavourings and enzymes. Moreover, the course will take into account v) the main contaminants (natural and induced by technology) and residues (veterinary drugs/pesticides) in foods also describing their chemical structures, toxicological aspects and the "food risk" correlated to their presence in diet. Another aim will be to transfer a general basic knowledge on the regulatory framework in food and nutrition area. Particular emphasis will be given to the description of the main bioactive compounds in "functional foods” and ingredients used also for the formulation of dietary supplements and "nutraceuticals", in order to provide the student a broad knowledge in the field. The knowledge gained from the course will be useful to the student in Chemistry and Pharmaceutical Technology to manage the food production and analysis, as well as to formulate ingredients for functional foods, dietetics for particular use (ADAP) and food supplements. Final aim of this course is to give to the student autonomy in evaluation of the quality of foods through the acquired knowledge. Critically applying this knowledge, the student will be able to manage the production and the analysis of foods, improving the capacity to design new ingredients for functional foods, for food dedicated to special medical uses and for the food supplements.
PrerequisitesWe recommend the acquisition of knowledge about the courses of Organic Chemistry and Biochemistry, fundamental for the understanding of the lessons of this course.
Didattics MethodsThe teaching method used provides ex-cathedra lectures given by the teacher, complemented by class discussion of cases study. The discussion of selected case studies is finalized to improve the capacity to critically understand the arguments correlated to the course, permitting to the student to acquire in autonomy the knowledge, object of the course. Specific seminars could be organized in cooperation with external Teachers and experts in the field.
Other informationsConsidering the complexity of the theme as well as the high interest of industry (or regulatory board) towards this field, the teacher will try to discuss deeply the case studies, discussing the most critical sides of the themes in an interactive way with the class. Questions or suggestions by the students will be welcomed, in order to deeply discuss together the case studies. The course takes time to study in addition to the lessons, in order to improve the capacity to manage this field deepening the topics.
Grading rulesThe assessment of the learning is based on the elaboration of a written Test that includes: 1. writing of structural formulas of the compounds considered during the course (the list of the structure to be known can be downloaded from the Department's website) 2. open questions, that relate to topics covered and 3. some multiple choice questions. The first part (structural formulas) will permit the evaluation of the degree of knowledge about the “chemistry” of the foods considered in this course, moreover the drafting of the “open questions” will permit the evaluation of the general knowledge about the field. Finally, the reply to the last two questions (multiple choice) will permit the evaluation of the deepening of the study performed by the student. The overcoming of the first part of the written Test (4 out of 6 formulas must to be exact) will be considered to gain access to parts 2 and 3 of the Test and, therefore, to reach the evaluation of the same. The Test schedule is posted on the Department's website. WARNING: only the off-course / repeaters or enrolled in the fifth year will have access to the "special Tests", planned outside the examination period.
Full argumentsBasic knowledge for food chemistry comprehension Amino acids, carbohydrates, lipids: chemical and nutritional properties. Protein and functional properties; examples of proteins and their use in food and nutraceutics production. Maillard Reactions; Mono- oligo- and polysaccharides useful in food area. Vitamins, minerals, polyphenols, Dietetic Fiber. Minor compounds in foods. Food Chemistry and Technology Food Industry, food technology, food processing. Food sanitization and stabilization, transformation of raw foods/materials, impact of technology on food. Advanced and novel techniques for food/nutraceutics production. Food biotechnology. Microorganism and enzymes in food technology. Bioproteins from microbial source, fungi and algae. Definitions (food, ingredients, processed foods), regulatory framework. Foods meaning in Pharma area. Plant and animal proteins. Soy and derived foods. Fruits, vegetables, pulses. Preservation, Ethylene’s role, modified atmospheres. Non alcoholic beverages, fruit juices, nectars, marmalade and jams. Cereals, proteins and celiac disease. Minor cereals and pseudo-cereals. Flours, semolina, bread and pasta. Bakery products. Starch, HGCS, HMCS, HFCS, Honey. Sucrose. Bioactive compounds from foods: case studies. Wine, chemical composition, alcoholic grade. Special wines. Beer, malt production, minor compound of beer. Nervine foods. Food lipids: classification, rectification, hardening. Oxidation and thermo-oxidation. lipids deterioration. Margarine, olive oil and other oils. Milk: composition and classification. HD milk, concentrated and powdered milk. Butter, Yogurt and fermented milks. Cheese, composition and classification. Meat: classification and composition, minor bioactive compounds. Homogenized and lyophilized meats. Fish and Fish products. Eggs and derived products. Water. Novel ingredients e novel foods; Food supplements (definitions). Food Additives, contaminants and residues Quality and safety of foods, toxicity, Risk assessment (NOAEL; DGA). EU’s regulatory framework. Food colours; sweeteners (bulk or intensive): classification, properties, examples. Other Additives (classification and case studies). Flavourings and Enzymes. Classification of undesired contaminants in foods. Adverse reactions. Antinutritive compounds. Natural toxins (from plant, bacteria, fungi, algae and microalgae, fish). Toxic compounds from essential oils. Microbiological diseases. Food allergens. SO2. Pseudo-allergic reactions, biogenic amines in foods. Food parasites (Anisakis). Technological contaminants: examples. Heavy metals. Residues (pesticides, products for plant protection, veterinary drugs). Environmental contaminants; contaminant from packages. Endocrine disruptors. Detoxifications mechanisms. Web resources.
Course borrowed toCHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - FA0028 Chimica, tecnologia e contaminanti degli alimenti
Close course details
Print
CourseChimica organica II e Chimica degli eterocicli
Course IDFA0093
Academic Year2016/2017
Year of rule2015/2016
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderPANZA Luigi
TeachersPANZA Luigi, APPENDINO Giovanni Battista
CFU9
Teaching duration (hours)72
Individual study time 153
SSDCHIM/06 - Organic chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year2
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractAlcohols and ethers Aldehydes e ketones Aromatic hydrocarbons Carboxylic acids Aliphatic and aromatic amines Aromatic aldehyides Phenols Outline on main sulfur containing compounds Structure, nomenclature and properties of the main penta- and hexacyclic etherocyclic systems Functionalization of electron-rich and electron-poor heterocyclic systems Synthetic entries into the main heterocyclic systems and their products of benzo-condensation
Reference textsP. H. Bruice, Chimica organica, Edises N. E. Shore, P. Vollhardt, Chimica organica, Zanichelli W.H. Brown, C.S. Foote, Chimica organica, Edises J. McMurry, Chimica organica, Piccin Broggini-Zecchi. La Chimica degli Eterocicli. La Scientifica, 2009 (paperback/e-Book) D’Auria et al.. Guida Ragionata allo Svolgimento degli Esercizi di Chimica Organica. Loghia Additional textbook R. Norman, J.M. Coxon, Principi di sintesi organica, Ed. Piccin
Teaching targetsKnowledge of the reactivity of the main functional groups of organic molecules, with emphasis on reaction mechanisms, also with links to biological examples to exemplify the prerequisites to other disciplines. Introduction of the basic concepts of organic synthesis, to prepare the student to the construction of even polyfunctional molecules.Applications of these concepts to the chemistry of heterocycles. Development of a critical ability in facing complex problems.
PrerequisitesKnowledge of the structure and properties of the main functional groups of organic compounds. Ability to manage the resonance formulas and concepts of acidity and basicity in organic chemistry.
Didattics MethodsLectures with multimedia support and exercises. In particular, the use of concepts in facing specific problems will be shown in order to provide a problem-solving ability.
Grading rulesWritten test for admission to the oral examination, usually consisting of a set of questions and problems related to the contents of the course (reaction mechanisms, guided and open-ended questions of synthesis of multifunctional organic compounds, heterocyclic chemistry). Oral examination with discussion of synthetic and mechanistic aspects related to the synthesis of polyfunctional molecules and heterocycles. It will be offered to the students the opportunity to substitute the final written exam by in-course tests.
Full argumentsAlcohols: nomenclature and properties. Preparation and reactivity. Cromium oxidations (Jones, CrO3-pyridine, PDC, PCC) Swern oxidation. Diols. Degradation with periodate and permanganate. Pinacolinic trasposition, mechanism and stereochemistry.Substitutions of the hydroxyl group with halogens. Sulfonates. Lithium, magnesium and copper (mention) organometallic reagents: comparison of reactivity. Ethers: nomenclature and properties. Preparation and reactivity. Aldehydes and ketons: nomenclature and properties. Preparation and carbonyl reactivity. Keto-enol tautomerism. Acyl nucleophilic addition reactions: addition of organometallic compounds, hydrides, HCN, alcohols ammonia derivatives. Bayer-Villiger reaction. Mention to the concept of protecting groups. Acetals as protecting groups. Wittig reaction. Enolate ions. Mechanism of base and acid catalyzed ketones halogenation. Aldol condensation with mention to stereochemical aspects. Aromatic hydrocarbons. Aromaticity. Huckel rule. Omoaromatic and structures of main heterocyclic compounds. Aromatic ions. Electrophilic aromatic substitution: nitration, sulfonation, Halogenation, Friedel-Crafts alkylation and acylation, chloromethylation reaction. Mechanism and substituent effect on reactivity and orientation. Electrophilic substitution on polycyclic aromatic compounds. Nucleophilic aromatic substitution. Mechanisms of addition-elimination and elimination-addition. Carboxylic acids: acyl halides, esters and amides. Nucleophilic acyl substitution reactions. Mechanisms of basic and acid hydrolysis of esters. Hofmann transposition of amides. Hell-Vohlard-Zelinsky. Dicarboxylic acids; alkylation of malonates and acetacetates. Ketoacids and ketoesters; Claisen and Dieckmann condensation acid and basic cleavage and keto-enol tautomerism.. Claisen reaction. Perkin condensation. Oxyacids. Reformatsky reaction. Mannich condensation. -Unsaturated carbonyl compounds: Preparation and reactivity. Michael reaction and Robinson annulation. Mention to aliphatic nitroderivatives. Aliphatic and aromatic amines: basicity and preparations. Reactivity: quaternari ammonium salts and Hofmann degradation, amides and sulfonamides, Hinsberg test, reaction with nitrous acid. Diazonium salts: formation and reactivity. Azo-, azoxi e idrazoderivatives. Aromatic aldehyides: formylation reactions (Gattermann, Gattermann-Koch, Vielsmeier). Phenols: acidity and preparations. Reactivity. Fries transposition. Kolbe and Reimer-Tiemann reaction. Quinones. Mention on main sulfur containing compounds: Thiols, thiophenols, sulfides, sulfoxides, sulfones, sulfenic, sulfynic and sulfonic acids, sulfonyl chlorides and sulfonamides. Structure and properties of the main heterocycles systems (nomenclature, aromaticity, tautomerism, acid-base properties) General synthetic methods for heterocyclic compounds. Survey of the major electron-rich (pyrrole, furan, thiophene, 1,2-azoles, 1,3-azoles and their products of benzo-condensation) and electron-poor systems (pyridine, pyrilium ion and their benzo-condensed products.
Close course details
Print
CourseDRUG ANALYSIS I
Course IDFA0026
Academic Year2016/2017
Year of rule2015/2016
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderALLEGRONE Gianna
TeachersALLEGRONE Gianna
CFU6
Teaching duration (hours)24
Individual study time 90
SSDCHIM/08 - Pharmaceutical chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageitalian language
AbstractSafety in laboratory. Glass works used in laboratory. Qualitative analysis of inorganic substances. Identification of cations and anions of inorganic pharmaceutical substances reported in Farmacopeia. Quantitative analysis. Volumetric analysis. Titrant standard solutions. Chemical reactions of titrations. Titration curves. Indicators. Acid-base titrations. Precipitometric titrations. Redox titrations. Complexometric titrations. Laboratory exercitations on qualitative and quantitative analysis
Reference textsHarris “Quantitative chemical analysis” ISBN 0-7167-70415 Farmacopea Ufficiale della Repubblica Italiana, XII edizione. European Pharmacopoeia, VIII edition
Teaching targetsThe formative path of the first part is learning how to perform qualitative analysis of inorganic drugs following the Italian and European Farmacopeia. The formative path of the second part of this course leads to the ability of understanding and mastering the dosing methods within Italian and European Pharmacopoeias, from the choice of the method to the assessment of operating conditions, from sample preparation and measurement execution to result evaluation.
PrerequisitesThe students need basic knowledge from the courses of General and Inorganic Chemistry and Analytical Chemistry and medicinal analysis
Didattics MethodsLessons and laboratory esercitazions
Grading rulesWritten examination and evaluation of lab activities. Ongoing evaluation before entering laboratories
Full argumentsSafety in laboratory. Glass works used in laboratory. Qualitative analysis of inorganic substances. Identification of cations (ammonium, aluminum, silver, bismuth, calcium, lithium, magnesium, potassium, sodium, zinc) and anions (carbonates, bicarbonates, chlorides, bromides, iodides, phosphates, thiosulfates, sulfates, borates) of inorganic pharmaceutical substances reported in Farmacopeia. Flame test Quantitative analysis. Volumetric analysis. Titrant standard solutions. Chemical reactions of titrations. Indicators. Acid-base titrations Titration curves. Reagents used in acidimetry (HCl, H2SO4, HNO3) and primary standards (Na2CO3 and KHCO3). Reagents used in alkalimetry (KOH, NaOH, Ba (OH)2 and primary standardsd. Drugs quantitative determination by acid-base titration: acetic acid, citric acid, benzoic acid, tartaric acid, ammonia. Exercises on the acid-base titrations Precipitometric titrations. Titration curves. Use of chromatic indicators for the determination of the end point. Mohr, Vohlard, Fajans methods. Drugs quantitative determination by titration precipitometriche: sodium chloride .Exercises on titration precipitometriche. Redox titrations. Titration curves. Redox indicators. Permanganometry: standard KMnO4 solutions, preparation, stability, standardization; Analytical reactions of KMnO4. Iodimetric methods: preparaziome of I2 and standardization solution. Iodometric methods: use of a starch solution as an indicator. Drugs quantitative determination by redox titration: H2O2, Sodium hypochlorite Exercises on redox titrations. Complexometric titrations Titration curves. Titration techniques: direct, return and displacement. Metallochromic indicators. Determination of Ca ++ and Mg ++ in waters. Exercises on complexometric titrations. Laboratory exercitations on qualitative and quantitative analysis
Close course details
Print
CoursePATHOLOGY (MEDICAL TERMINOLOGY)
Course IDF0417
Academic Year2016/2017
Year of rule2015/2016
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderSICA Antonio
TeachersSICA Antonio, PORTA Chiara
CFU8
Teaching duration (hours)64
Individual study time 136
SSDMED/04 - Experimental medicine and pathophysiology
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year2
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractBasic knowledge of the pathogenic mechanisms; cellular pathology, basic knowledge of the innate and adaptive immune system, basic knowledge of oncology, basic knowledge of immunopathology, physiology of the vessels and clotting; mechanisms promoting the metabolic syndrome
Reference textsLe basi patologiche delle malattie, Robbins, Cotran, Piccin editore Patologia Generale; Pontieri-Russo-Frati, Piccin editore Fondamenti di Immunologia ABBAS ABUL K.-LICHTMAN ANDREW H. Piccin editore
Teaching targetsUnderstand the etiologic basis and pathological mechanisms that guide the development of diseases. Acquire full knowledge and understanding of the topics discussed and dissemination skills.
PrerequisitesIt is advisable to have already followed the physiology course
Didattics MethodsTraditional: lectures and seminars
Grading rulesWritten (test with multiple choice questions) and oral (open-ended questions) exam
Full arguments1: Adaptive cell response. Cellular damage and death. Cell and tissue responses to stress conditions. Cell death: necrosis and apoptosis Degenerative processes by macromolecules accumulation 2: Inflammation and innate immunity Biological and physical barriers of innate immunity Innate immune cells: origin and functions Endothelium and leukocyte recruitment Pathogen recognition: structure and signaling of TLR receptors family Mechanisms of pathogens killing: phagocytosis and reactive oxygen species. Soluble mediators of innate immunity: vasoactive ammines and inflammatory cytokines Transcriptional programs of innate immunity and inflammation. The complement system Chronic and polarized inflammation. Granuloma. Tissue repair: Granulation tissues Fibrosis and sclerosis Dendritic cells: link between innate and adaptive immunity. 3: Specific immunity Specific Immunity: Specificity, memory and tolearnce Lymphocyte functions Primary and secondary lymphoid tissues B lymphocytes: differentiation, activation and maturation Antibodies: structure, classes, functions. Immunoglobulin genes: mechanisms of rearrangement, variability, Primary and secondary response T lymphocytes: differentiation, activation and maturation The TCR: structure, signaling transduction, mechanisms of rearrangement and variability The major complex of hystocompatibility: class I and class II (structures and functions) HLA genes: poligenia and polimorphism; MHC restriction and graft rejection Cytiotoxic T lymphocytes Helper T lymphocytes Thymic selection Peripheral and central tolerance 4: Principles of Oncology Definition and classification Biology of tumor growth Tumor angiogenesis and metastasis Neoplastic transformation: chemical and phisical transformation Oncogenic viruses Cancerogenesis as a multistep process Oncogenes: definition and classification; Role in neoplastic transformation Onco-suppressor genes: Role in neoplastic transformation and in tumor growth Apoptotic genes and DNA repair genes: Genetic instability. Gene Methylation Tumor immunology Dendritic cell-based vaccines 5: Immunopatology congenital and acquired immunodeficiency Hypersensibility reactions types I, II; III and IV Autoimmune reactions: antibody- and cell-mediated Tolerance and graft rejection Mucosal immunity and inflammatory bowel diseases (IBD) 6: Phisiology of vessels and coagulation Atherosclerosis: pathogenesis and risk factors atherosclerotic plaques: generation and stabilization Clinical manifestation of atherosclerosis Haemorrhagic diseases Thrombosis: pathogenesis and clinical manifestation Metabolic syndrome
Close course details
Print
CoursePHARMACOGNOSY AND PHYTOTHERAPY
Course IDF0428
Academic Year2016/2017
Year of rule2015/2016
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderLOMBARDI Grazia
TeachersLOMBARDI Grazia
CFU6
Teaching duration (hours)48
Individual study time 102
SSDBIO/14 - Pharmacology
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe Course is composed of one section (5 CFU) of Pharmacognosy and one (1 CFU) of Phytotherapy. It aims to give to the student the scientific basis for a full knowledge and understanding of the main natural drugs, as well as the principal phytotherapic compounds. During the Course, the student will acquire skills on how to apply these scientific knowledge and develop independent judgment, communication skills, and ability to learn. The Course is organized as follows: i) a first small-section of general Pharmacognosy, concerning the study of bioactive compounds derived from natural products found in plants and animals, the main methods for their preparation, preservation, recognition, quality assessment, purity and activity; ii) a second small-section of systematic Pharmacognosy, concerning the study of some natural drugs. The section of Phytotherapy focuses on the general aspects of this discipline, as well as on the therapeutic properties of some medicinal plants.
Reference textsH.P. Rang, M.M. Dale, J.M. Ritter, Farmacologia, Ed. Casa Editrice Elsevier B.G. Katzung, Farmacologia Generale e Clinica, Ed. Piccin R.D. Howland, M. J. Mycek LE BASI DELLA FARMACOLOGIA, Ed. Zanichelli Trease, W.C. Evans, Farmacognosia, Ed. Piccin Dewick P.M., Chimica, Biosintesi e bioattività delle sostanze naturali, Ed. Piccin E. Ragazzi, Farmacognosia minerale, Ed. CEDAM Fabio Firenzuoli, Fitoterapia, Ed. Masson
Teaching targetsThe Course aims to give to the students the principles of Pharmacognosy and Phytotherapy. To achieve this goal a section (5 CFU) of Pharmacognosy, dealing with the basis of natural drug action as well as the specific properties of several natural compounds, and a section (1 CFU) of Phytotherapy, dealing with the general as well as the specific characteristics of some medicinal plants, will be considered.
PrerequisitesWe strongly suggest to pass the Biology, Biochemistry, Physiology, and Pathology exams before studying this Course
Didattics MethodsLectures will be given throughout the October-January and March-June. The students will be constantly stimulated to participate to the lesson with questions and comments in order to ensure the achievement of the goals. Seminars on specific scientific topics will be always organized.
Other informationsThe Professor will receive the students for specific questions every day by appointment.
Grading rulesWritten exams with open questions with multiple choices will be proposed. There will be the possibility of supplementary oral examinations. The questions will be organized to allow students the achievement of goals.
Full argumentsPHARMACOGNOSY (5 CFU) • General principles: drugs in Pharmacognosy. Biogenesis of the main pharmacologically active compounds: synthetic pathways. • Genetic and environmental factors affecting the contents of biologically active compounds. • Cell cultures as methods for studying the main biosynthetic pathways and the sources of biologically active compounds. • Preparation, preservation, recognition, quality determination, purity, and activity of drugs. • Vegetable drugs used in the pathology of: f. The central and peripheral nervous systems: psycostimulants and tonics (cocaine, methylxanthine), hypnotics and sedatives (chrysin, valerianic acid), antidepressives (hyperic), analgesics (morphine) g. The cardiovascular system: cardiotonic (digoxin), vasoconstrictor (ergot alkaloids), antihypertensive (reserpine) agents. h. The respiratory system: cough suppression (codeine), antiasthma (ephedrine) agents. i. The gastrointestinal system: stomatics (azulenes), eupeptics (capsaicin), antispastics (atropine). j. The urogenital system: anti-androgens (Serenoa Repens), antiseptics (arbutin). • Drugs from plants, animals, and minerals: hormones, vitamins, antibiotics, halogens, metals, alkaline metals, metalloids, non-metals PHYTOTHERAPY (1 CFU) • The herbal medicines in human therapy: a. Phytotherapy, general principles, historical outlines b. The chemical compounds of herbal medicines: heterosides, flavonoids, alkaloids, essential oils, tannins, carbohydrates c. The variability of biological active compounds d. The vegetable compounds in therapy and the phytotherapics e. Principles of Galenic • Adverse drug reactions against phytotherapics: f. The essential oils , the embryotoxicity g. The acute toxicity h. The allergic reactions and the photosensitisation i. Drug interactions j. Pharmacovigilance • Clinical Phytotherapy: pediatric, geriatric, and pregnancy uses of phytotherapics • Examples of phytoterapics used in the most common pathologies of the following systems: a. nervous b. respiratory c. cardiovascular d. gastro-enteric e. metabolic f. urogenital g. reumatic h. cutaneous
Close course details
Print
CourseSTATISTIC WITH R
Course IDF0592
Academic Year2016/2017
Year of rule2015/2016
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderRINALDI Maurizio
TeachersRINALDI Maurizio
CFU2
Individual study time 26
SSDMAT/04 - Mathematics education and history of mathematics
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryD - A scelta dallo studente
Year2
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe R software and its use to represent data and for statistical data analysis.
Reference textsReference material is posted on the DIR website
Teaching targets*Knowledge and understanding The course aims to enrich the theoretical knowledge of statistics and probability with appropriate calculation data analysis. Aims of the course is also to display the results. The course in based on the free and open source software R. *Applying knowledge and understanding Students should be able to use the acquired skills even in multidisciplinary context and they should be able to analyse data and generate professional graphical representations. *Making judgements. At the end of the course students are expected to apply R even in different situations and that they have acquired the tools needed to extend their knowledge by themselves. * Communication skills At the end of the course students are expected to be able to express their results both numerically and graphically. * Learning skills. During the course students should learn how to study by choosing their personal path and should become able to choose the appropriate resources.
PrerequisitesThe student should have the basic knowledge of mathematics and statistics
Didattics MethodsPractical lectures are given in the computer lab.
Other informationsReference material and additional informations are posted on the DIR website https://www.dir.uniupo.it/enrol/index.php?id=219
Grading rulesOngoing Quizzes and online Final Examination. Both count toward the final grade in a ratio 3/7.
Full argumentsR software. Elementary operations. Functions and graphs. Import, export in R. Data Structures, packages. Matrices, lists, arrays. The data frame. Working with sata: selecting elements, logical operators. Loops and conditionals. Missing data. Additional graphics packages: ggplot2. Regression line and regression curves. Anova. Pharmacokinetic models. Clustering. Simulations.
Course borrowed fromFARMACIA (1506) - FA0078 Statistica con R
Close course details
Print
CourseADVANCED ORGANIC CHEMISTRY AND PROCESS DEVELOPMENT
Course IDF0424
Academic Year2016/2017
Year of rule2014/2015
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderAPPENDINO Giovanni Battista
TeachersAPPENDINO Giovanni Battista
CFU10
Teaching duration (hours)80
Individual study time 170
SSDCHIM/06 - Organic chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year3
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe course aims at familiarizing students with the basic structural and synthetic aspects of the most important heterocycles and biomolecules of biomedical relevance (peptides and proteins; mono-, oligo-, and polysaccharides; nucleosides and nucleic acids). The chemistry of selected classes of secondary metabolites (isoprenoids, alkaloids, acetogenins, flavonoids) of biological relevance will also be presented as well as a survey of the mechanistic aspects of pericyclic reactions (cycloadditions, electrocyclic reactions, sigmatropic rearrangements) and of reactions mediated by transition metals. The couse also covers some fundamental aspects of applied industrial organic chemistry (polymers and supply chain of their alfa-olefinic precursors), analyzing the basic issues involved in the industrial scale-up of laboratory syntheses. A selection of industrial syntheses of bioactive compounds (Reichstein synthesis of vitamin C, Monsanto synthesis of L-DOPA, BASF synthesis of citral) will be detailed and critically commented. The ultimate objectiveof the course is to provide students an overview of the main applications and problems of the modern organic chemistry applied to pharmaceutical research.
Reference textsClayden, J et al.. Organic Chemistry, Oxford University Press, 2012. Norman, Coxon. Sintesi Organica, Piccin, 1999. Farina, V. Notes from the course of organometallic chemistry, AA 2001-2002. Broggini-Zecchi. La Chimica degli Eterocicli. La Scientifica, 2009 (cartaceo/e- Book).
Teaching targetsThe course aims at giving students a survey of the major applications and criticisms of modern organic chemistry, with emphasis on its interface with biomedical research. The problems and exercises that accompany the course will foster the development of critical thinking in students by making reference to real life issues.
PrerequisitesExam preparatory Organic Chemistry 2
Didattics MethodsFrontal seminars complemented by telematic applications and screen presentations
Grading rulesWritten test and oral discussion, aimed at the evaluation of the knowledge and the critical rielaboration of the topics presented in the seminars
Full argumentsPart A: Heterocyclic chemistry and transition metal chemistry Credit 1: Structure and properties of aromatic heterocyclic compounds 1. Aromaticity 2. Nomenclature of monocyclic systems 3. 11. Nomenclatura of polycyclic systems 4. 12. Tautomerisms 5. 13. Acid-base properties 6. 14. Deprotonation of heterocyclic systems 7. 15. General synthetic strategies 8. 16. Revision and correction of the exercises Credit 2: Penta-atomic heterocyclic systems 1. Pyrrole, furan and thiophene: properties and synthesis 2. Pyrrole, furan and thiophene: reactivity 3. Oxazole, imidazolo and thiazole: properties and synthesis 4. Oxazole, imidazolo and thiazole: reactivity 5. Isooxazole and pyrazole: properties and synthesis. 6. Indole: Properties and synthesis 7. Indole: reactivity 8. Revision and correction of the exercises Credit 3: Hexa-atomic heterocyclic systems 1. Pyridine: properties and synthesis 2. Piridine and pyridine oxide: reactivity 3. Quinoline and isoquinoline: properties and synthesis 4. Pyran and benzopyran: properties 5. Pyran and benzopyra: synthesis 6. General revision and correction of the exercises 7. General revision and correction of the exercises 8. General revision and correction of the exercises Credit 4: Organotransition metal chemistry 1. Structure of transition metal complexes and rule of the 18 electrons 2. General mechanisms of reaction-Hydroformylation 3. Ruthenium complexes: Metathesis 4. Rhodium and nickel complexes 5. Palladiumcomplexes and Heck reaction 6. Coupling reactions 7. Revision and correction of the exercises 8. Revision and correction of the exercises Credit 5: Process development and final revision 1. General principles 1 2. General principles 2 3. The industrial synthesis of indacum 4. Exercises-1 5. Exercises-2 6. Exercises-3 7. Exercises-4 8. Exercises-5 MODULO B: Biomolecules, polymers and pericyclic reactions Credit 1: Carbohydrates 1. Structure and nomenclature. Anomeric equilibria and redox reactions 2. Protection reactions (alkylations, silylation, acetalization) 3. Glycosidation reactions 4. O-, N-, e S-Glycosides. Glucosinolates and cyanogenic glycosides 5. Modified sugars (deoxy- and aminosugars) and synthetic applications 6. Nucleosides 7. Solid-phase synthesis of oligonucleosides 8. Revision and correction of the exercises Credit 2: Aminoacids 1. Structure, classification and detection 2. Acid-base properties 3. Aminoacid synthesis (HVZ; Streker, azlactone) 4. Asymmetric synthesis and homogenous hydrogenation 5. Peptide synthesis. Protection and deprotection strategies 6. Solid phase peptide synthesis (Merrifield and Wang resins) 7. Peptide degradation 8. Revision and correction of the exercises Credit 3: Secondary metabolites and polymers 1. Alkaloids and Mannich reactions 2. Synthetic applications of alkaloids and asymmetric dihydroxylation 3. Isoprenoids and non-classic carbocations 4. Quinones and vitamin K 5. Phenol coupling and Pummerer ketone 6. Addition polymers 7. Condensation polymers 8. Revision and correction of the exercises Credit 4. Pericyclic reactions 1. Generalities and Woodward-Hoffmann rules 2. Ccyloadditions-1 3. Diels-Alder reaction 4. Dipolar cycloadditions 5. Electrocyclic reactions and  lactam Staudinger synthesis 6. Sigmatropic reactions and vitamin D 7. Claisen e Cope rearrangements 8. Revision and correction of the exercises Credit 5: Process development and drug synthesis- Final revision 1. The industrial synthesis of vitamin C (Reichstein) 2. The industrial synthesis of L-DOPA (Monsanto) 3. The industrial synthesis of citral (BASF) 4. Exercises-1 5. Exercises-2 6. Exercises-3 7. Exercises-4 8. Exercises-5
Close course details
Print
CourseADVANCED SYNTHETIC METHODS
Course IDFA0056
Academic Year2016/2017
Year of rule2014/2015
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderPANZA Luigi
TeachersPANZA Luigi
CFU2
Teaching duration (hours)16
Individual study time 34
SSDCHIM/06 - Organic chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryD - A scelta dallo studente
Year3
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractProtecting groups Organoboron compounds Organosilicon compounds Organotin compounds Modern synthetic strategies
Reference textsSlides provided by the teacher with references to chemical literature and to advanced books.
Teaching targetsProvide students with the knowledge of modern synthesis techniques to supplement the curricular preparation. Introduce students to the principles of modern organic synthesis and to their use
PrerequisitesKnowledge of the structure and of the reactivity of the main classes of organic compounds
Didattics MethodsLectures with multimedia support. Discussion of examples of total synthesis and exercises.
Grading rulesOral exam based on the critical analysis of a literature article on the synthesis of complex molecules.
Full argumentsProtecting Groups: Introduction to the use of protecting groups in organic synthesis. Protecting groups for the main functional groups: introduction and removal. Orthogonality of protecting groups. Organoboron compounds: Introduction to the element. Boranes and their use in synthesis: alkyl, alchenyl- and alkinylborani. Preparation and reactivity. Outline of boronic acids and their use in cross coupling reactions. Outline of boron cluster. Organosilicon compounds: Introduction to the element. Silicones. Silyl enol ethers, vinylsilanes, epoxysilanes, allylsilanes and their use in organic synthesis. -Silyl carbanions. Trimethylsilyl cyanide. Trimethylsilyl triflate. Trimethylsilyl iodide. Organotin compounds. Introduction to the element. Stannilethers and acetals. Vinyl and allyl stannanes and their use in organic synthesis. Hydrides of tin. Alkynyl stannanes. Modern synthetic strategies. A brief history of organic synthesis. Retrosynthesis: definitions of concepts of synthons, retrons, disconnections, transformations. Retrosynthetic analysis. Guidelines for the application of the different strategies used in the retrosynthetic analysis: strategies based on structure, functional groups or processes. Examples of total synthesis.
Course borrowed toCHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - FA0056 Metodologie sintentiche avanzate
CHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - FA0056 Metodologie sintentiche avanzate
Close course details
Print
CourseAnalisi dei farmaci II
Course IDFA0030
Academic Year2016/2017
Year of rule2014/2015
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderGROSA Giorgio
CFU8
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year3
PeriodPrimo Semestre
Grading typeFinal grade
Teaching languageItalian
Abstract• General aspects of the pharmaceutical analysis • Drug chemical stability: forced degradation studies and stability studies of drug substance and drug product • Methods of analysis for the identification of drugs: characters, melting point, optical rotation, infrared spectrometry (IR) and TLC. • Methods of analysis for the determination of drugs in drug substance and drug product: UV-Vis spectrophotometry and spectrofluorimetry; theoretical and instrumental aspects; method development. • Chromatographic methods. HPLC: theoretical and instrumental aspects; method development. • Calculation in pharmaceutical analysis. • Laboratory practices: identification of drugs whose monograph are reported in the current European pharmacopoeia; determination of the content of the active pharmaceutical ingredients in drug substance and drug products
Reference texts- European Pharmacopoeia current edition - Analisi Chimico Farmaceutica F. Savelli, O. Bruno, Piccin, Padova - Analisi Farmaceutica, D. G. Watson, EDRA LSWR, Milano - Analisi Farmaceutica Qualitativa” A. Carta, M.G. Mamolo, F. Novelli e S. Piras Edises, Napoli - Analisi Farmaceutica, Metodi di riconoscimento e di separazione. V. Cavrini e V. Andrisano Società Editrice Esculapio, Bologna. - Chimica Analitica Quantitativa. D. C. Harris, Zanichelli.
Teaching targetsThe student, attending the course, acquire the basic knowledge of the problems inherent chemical stability of drugs and analytical techniques used in the stability studies. The laboratory exercises allow the student to apply the analytical methods to real pharmaceutical samples. In addition, the proposed calculation exercises allow the student to calculate and evaluate correctly the results obtained in the laboratory practices.
PrerequisitesCourse teaching is based on the assumption that students have previous knowledge from basal courses in inorganic chemistry and analytical chemistry. Moreover the attendance to the previous course Drug Analysis-1 is mandatory . Special IT knowledge is not a requirement, but all students should know the use of electronic spreadsheet Excel for the statistical evaluation of data.
Didattics MethodsThe theoretical lessons will be held partially by using slides. Calculation exercises are done by solving typical problems in pharmaceutical analysis field. The laboratory activity will be carried out in laboratories equipped with specific reagents and analytical instrumentation (UV- and FTIR spectrophotometers, HPLC apparatus, polarimeter, melting point apparatus etc.), suitable for the drug quality control. Statistical evaluation of analytical data was done in computer laboratory.
Grading rulesThe learning assessment consists of: individual written examination (2 hr) plus the evaluation of the results obtained in laboratory practices. The written part consists of: 10 questions (1.6 points each, with the partial evaluation of the response), two questions (2 points each) and two calculation exercises (up to a maximum of 10 points in total). The first ten questions are related to the theory of the stability of drugs and chromatographic (HPLC and TLC) and spectroscopic techniques (UV-Vis and fluorimetry) and the procedures of the laboratory exercises. The questions (2 points each) and the calculation exercises are related to the calculation and interpretation of the results obtained in the laboratory practices or in real cases from pharmaceutical analysis field.
Full argumentsPharmaceutical analysis: general aspects; main phases of a method of analysis; the role of the matrix and interfering substances in pharmaceutical analysis. Drug chemical stability: main degradation reactions. Forced degradation studies. Long-term and accelerated stability studies of drug substance and drug product: protocol assessment. Assays and analytical controls in the stability studies. Analytical methods in pharmaceutical analysis: UV-VIS spectrophotometry: general aspects, Beer's law, inherent limitations, instrumental and chemical deviations. Method development: selectivity and linearity (calibration curves). Calibration of a UV-Vis spectrophotometer according to the European Pharmacopoeia. Methods based on light emission: fluorescence and phosphorescence. Spectrofluorimetry: general aspects. Beer's law applied to fluorimetry, method development. Polarimetry: General and instrumental aspects of the technique; optical rotation, specific optical rotation. optical purity. Melting point determination: experimental aspects of the technique. Chromatographic methods: HPLC. Instrumental aspects: pumping system, detectors (Uv-vis, FL, ECD). Stationary phases: silica and chemically modified silica. Characterization of chromatographic peaks: evaluation of asymmetry (tailing factor and asymmetry factor), efficiency (number of theoretical plates), separation factor and resolution. Role of pH in the HPLC analysis. Calculations related to the buffer solutions used in mobile phase preparation. Main operating parameters of a HPLC method of analysis. Method development. Pharmaceutical analysis calculations. Resolution of problems regarding the analysis of active ingredients and their formulations. Laboratory practices: Determination of average weight and weight uniformity. Determination of the active ingredient (Fe2+) in a formulation of ferrous gluconate in sachets. Determination of the impurity (Fe3+) in a formulation of ferrous gluconate in sachets. Determination of loss on drying using thermo gravimetric balance. Determination of pH of a pharmaceutical powder when reconstituted in aqueous solution. Determination of percent content of furosemide in a solution for injections. Determination of percent content of troxerutin in drug substance.
Modules
Course ID Course SSD Teachers
Close course details
Print
CourseBiochimica applicata
Course IDFA0034
Academic Year2016/2017
Year of rule2014/2015
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderROSSI Franca
TeachersROSSI Franca
CFU6
Teaching duration (hours)48
Individual study time 102
SSDBIO/10 - Biochemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year3
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractPurification of proteins and macromolecular complexes Biochemical analysis of proteins and macromolecular complexes Functional analysis of proteins and macromolecular complexes Expression of recombinant proteins
Reference textsStoppini, M e Bellotti, V “Biochimica Applicata” Ed. EdiSES ISBN 9788879597135 Bonaccorsi di Patti, MC, et al. “Metodologie Biochimiche” Ed. CEA ISBN 978-8808-18329-3 (Monografie suggerite dal Docente) (Selected Reviews)
Teaching targetsThe “Applied Biochemistry” course describes the theoretical and practical aspects, and the overall impact of Biochemistry in a wide range of Research fields, ranging from health and life sciences, to bio-analytical disciplines. The course aims to provide a solid technical background in Biochemistry, also by illustrating the most advanced methods used in the production, purification, manipulation, biochemical characterization and functional analysis of biological macromolecules. By assigning each Student with individual tasks, and by stimulating an independent and critical thinking, the Students are expected to develop the capability to rationally approach a complex biochemistry problem.
PrerequisitesAn adequate knowledge of biochemistry.
Didattics MethodsLectures/seminars
Other informationsFour lessons will be held in the computer room to introduce the Students to the use of publicly accessible programs for the analysis and the alignment of DNA and protein sequences. This activity is instrumental to the preparation by each Student of a report that will be evaluated concomitantly to the “standard” exam (written test).
Grading rulesWritten exam (exercises and free text)
Full arguments-Preparation of biological samples for biochemical analysis. -Working with proteins: general principles. -Techniques of cell lysis. Samples fractionation by centrifugation. -Protein electrophoresis: principles and systems. Electrophoresis in native and denaturing conditions: SDS-PAGE, iso-electrofocusing, 2D electrophoresis. -Techniques for the detection of proteins separated by electrophoresis: total protein staining, specific staining and immuno-staining. -Immunoassays (ELISA), immunofluorescence (IFA) and radio-immunological techniques (RIA). Devices for self-diagnosis based on lateral flow immunoassays. -Liquid Chromatography techniques for proteins purification and analysis: general principles, materials and instrumentation. Applications in detail: ion exchange chromatography, hydrophobic interaction chromatography, affinity chromatography, and size exclusion chromatography. - Determination of the concentration of proteins in a given sample and of the purity of enzyme preparations. -Post-purification processing; protein concentration; dialysis and ultrafiltration. -Functional characterization of enzymes: selected examples. -Purification and analysis of nucleic acids. -Site-directed mutagenesis. -System for recombinant proteins expression: applications, advantages, disadvantages, and selection guide. -Expression of recombinant proteins in Escherichia coli. -The Baculovirus/insect cell system. -Pichia Pastoris as protein expression system in yeast. -Methods to study protein-protein and protein-DNA interactions. -Interaction cloning approaches for the identification of genes encoding potential partners of a protein of interest. - Study of protein-protein and protein-ligand interactions using SPR (surface plasmon resonance). -Analysis of proteomes.
Course borrowed fromCHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - FA0099 Biochimica applicata
Close course details
Print
CourseBiologia molecolare con laboratorio
Course IDFA0031
Academic Year2016/2017
Year of rule2014/2015
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderROSSI Franca
CFU6
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year3
PeriodPrimo Semestre
Grading typeFinal grade
Teaching languageItalian
AbstractThe timeline of the discoveries and advancements in Molecular Biology Organization, structure and evolution of genes, chromosomes and genomes Replication and maintenance of the genome Transcription and its regulation RNA processing and maturation Translation and its regulation Genomic alterations, epigenetic and post-translational modifications Approaches, techniques and models in Molecular Biology
Reference textsDNA ricombinante, 2nd ed. (3rd US ed.) Zanichelli ISBN 978-88-08-06623-7
Teaching targetsThe “Molecular Biology” course describes, at the molecular level, the main biological phenomena taking place inside the cell, through the in depth study of DNA, RNA, proteins, and other macromolecules involved in genetic information transmission, expression and integration. A special emphasis will be given to the description of molecular techniques currently used in the molecular biology field, as well as of selected well established model systems. Overall, the course aims at boosting the Student’s capability of carry out an integrated analysis of multiple aspects of the biology of the cell, in physiologic and pathologic conditions.
PrerequisitesAn adequate knowledge of the eukaryotic cell biology and protein biochemistry is required.
Didattics MethodsLectures/seminars and “virtual-lab”
Grading rulesWritten test (quiz and free text)
Full arguments-Introduction -The recombinant DNA: restriction endonucleases and modification enzymes; sub-cloning vectors. The polymerase chain reaction (PCR). Construction of gene libraries. DNA Sequencing: the Sanger method and its automation. -The structure of nucleic acids and organization of eukaryotic genomes. -Transposable elements. -DNA replication and its control. -Mutations and DNA repair mechanisms (DR, DSBR, HR and NHEJ). -DNA recombination. -The transcription units. Eukaryotic RNA polymerases. Promoters and transcription factors. Chromatin remodeling and effects on gene transcription rates. -RNA processing: capping, polyadenylation and splicing; biogenesis of rRNA; remodeling of tRNA; RNA editing. -The nucleus-cytoplasm traffic: nuclear localization and export signals; importins and exportins; the RAN cycle. -Protein synthesis: similarities and differences in the synthesis of proteins with petide signal. -Translation control: response elements in untranslated RNA; modulation of initiation factors; RNA degradation. -Post-translational modifications: site-specific proteolysis; phosphorylation; acetylation; glycosylation; lipidation; ubiquitination and sumoylation. -Protein topogenesis, addressing and sorting. -Cell communication and intercellular signal transduction: characteristics and properties; classes of ligands and receptors; second messengers, mediators/effectors. Examples of signal transduction pathways. - Detection methods used in Molecular Biology: radioactive isotopes, colorimetry, chemiluminescence, fluorescence. Labeled DNA probes for the identification of specific sequences of DNA (Southern blot and FISH). - Strategies for the genome sequencing: cloning in high-capacity vectors (cosmids, YAC and BAC). - Generation of monoclonal antibodies: obtaining hybridoma. Antibody Phage Display. - Basic techniques in protein analysis. Study of the sub-cellular localization of proteins. - Flow cytometry: principles and applications. -The model organisms. -Genesis of knock-out mice: positive/negative selection. Analysis of the phenotype. - Artificial cultures of animal cells: basic concepts.
Modules
Course ID Course SSD Teachers
Close course details
Print
CourseChimica, tecnologia e contaminanti degli alimenti
Course IDFA0028
Academic Year2016/2017
Year of rule2014/2015
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderARLORIO Marco
TeachersARLORIO Marco
CFU7
Teaching duration (hours)56
Individual study time 119
SSDCHIM/10 - Food chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year3
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
Abstract- Chemistry of amino acids, proteins, carbohydrates and lipids: food peculiarities - Vitamins, minerals and polyphenols - Definitions: food product, ingredient, processed food, regulatory framework - Food products in Pharma area - Chemical composition of foods: (principal and minor compounds) - Bioactive compounds in foods and nutraceutics: examples from plant, animal and fungal foods - Food industry and food technology; food processing - Techniques of sanitization and processing; Mild technologies, microorganisms and food biotechnologies - Bio-proteins from microbial source, fungi and algae - Definition of NOAEL and DGA, toxicological studies and Risk Assessment - Improvement agents (food additives, enzymes, flavouring compounds): classification and case studies - Food contaminants: classification and case studies - Residues in foods: plant protection products, pesticides and veterinary drugs - The food significance in modern nutrition - Biological detoxification mechanisms (overview)
Reference textsSlides used in the course, provided by the Teacher Food Chemistry and composition: *INTRODUZIONE ALLA CHIMICA DEGLI ALIMENTI. Martelli, M. Arlorio:. Edizioni CLU, 1996, Torino *CHIMICA DEGLI ALIMENTI, a cura di A. Martelli, P. Cabras. Piccin Editore, 2003 *P. Cappelli, V. Vannucchi: Chimica degli alimenti, Ed. Zanichelli Toxicology and Food Toxicology: *TOSSICOLOGIA, a cura di C.G. Galli, E. Corsini, M. Marinovich. Piccin Editore, 2003 Regulatory framework: Gazzette Ufficiali Italiana ed Europea (e supplementi) For insight into the topic of food chemistry: *Belitz, Grosch, Schieberle “Food Chemistry”, Ed. Springer (IV Edition) For insight into the topic of Toxicology: Food Toxicology. W. Helferich, C. Winter Editor. CRC Press, Boca Raton Florida, 2001 Food Biotechnology: *C.Gigliotti, R.Verga: Biotecnologie Alimentari, Ed. Piccin Padova.
Teaching targetsThe course aims to provide basic knowledge concerning) i) basic chemical knowledge on molecules and macromolecules in foods, also concerning vitamins, minerals, polyphenols and other minor compounds; ii) the basic knowledge on food technologies for food sanitization, processing, also considering Mild Technologies, biotechnologies and new sustainable approaches; iii) the chemical composition and nutritional value of the food and iv) the knowledge on chemistry and usefulness of the main food additives, processing aids, flavourings and enzymes. Moreover, the course will take into account v) the main contaminants (natural and induced by technology) and residues (veterinary drugs/pesticides) in foods also describing their chemical structures, toxicological aspects and the "food risk" correlated to their presence in diet. Another aim will be to transfer a general basic knowledge on the regulatory framework in food and nutrition area. Particular emphasis will be given to the description of the main bioactive compounds in "functional foods” and ingredients used also for the formulation of dietary supplements and "nutraceuticals", in order to provide the student a broad knowledge in the field. The knowledge gained from the course will be useful to the student in Chemistry and Pharmaceutical Technology to manage the food production and analysis, as well as to formulate ingredients for functional foods, dietetics for particular use (ADAP) and food supplements.
PrerequisitesWe recommend the acquisition of knowledge about the courses of Organic Chemistry and Biochemistry, fundamental for the understanding of the lessons of this course.
Didattics MethodsThe teaching method used provides ex-cathedra lectures given by the teacher, complemented by class discussion of cases study. Specific seminars could be organized in cooperation with external Teachers and experts in the field.
Grading rulesThe assessment of the learning is based on the elaboration of a written Test that includes: 1. writing of structural formulas of the compounds considered during the course (the list of the structure to be known can be downloaded from the Department's website) 2. open questions, that relate to topics covered and 3. some multiple choice questions. The overcoming of the first part of the written Test (4 out of 6 formulas must to be exact) will be considered to gain access to parts 2 and 3 of the Test and, therefore, to reach the evaluation of the same. The Test schedule is posted on the Department's website. WARNING: only the off-course / repeaters or enrolled in the fifth year will have access to the "special Tests", planned outside the examination period.
Full argumentsBasic knowledge for food chemistry comprehension Amino acids, carbohydrates, lipids: chemical and nutritional properties. Protein and functional properties; examples of proteins and their use in food and nutraceutics production. Maillard Reactions; Mono- oligo- and polysaccharides useful in food area. Vitamins, minerals, polyphenols, Dietetic Fiber. Minor compounds in foods. Food Chemsitry and Technology Food Industry, food technology, food processing. Food sanitization and stabilization, trasformation of raw foods/materials, impact of technology on food. Advanced and novel techniques for food/nutraceutics production. Food biotechnology. Microorganism and enzymes in food technology. Bioproteins from microbial source, fungi and algae. Definitions (food, ingredients, processed foods), regulatory framework. Foods meaning in Pharma area. Plant and animal proteins. Soy and derived foods. Fruits, vegetables, pulses. Preservation, Ethylene’s role, modified atmospheres. Non alcoholic beverages, fruit juices, nectars, marmalade and jams. Cereals, proteins and celiac disease. Minor cereals and pseudo-cereals. Flours, semolina, bread and pasta. Bakery products. Starch, HGCS, HMCS, HFCS, Honey. Sucrose. Bioactive compounds from foods: case studies. Wine, chemical composition, alcoholic grade. Special wines. Beer, malt production, minor compound of beer. Nervine foods. Food lipids: classification, rectification, hardening. Oxidation and thermo-oxidation. lipids deterioration. Margarine, olive oil and other oils. Milk: composition and classification. HD milk, concentrated and powdered milk. Butter, Yogurt and fermented milks. Cheese, composition and classification. Meat: classification and composition, minor bioactive compounds. Homogenised and lyophilised meats. Fish and Fish products. Eggs and derived products. Water. Novel ingredients e novel foods; Food supplements (definitions). Food Additives, contaminants and residues Quality and safety of foods, toxicity, Risk assessment (NOAEL; DGA). EU’s regulatory framework. Food colours; sweeteners (bulk or intensive): classification, properties, examples. Other Additives (classification and case studies). Flavourings and Enzymes. Classification of undesired contaminants in foods. Adverse reactions. Antinutritive compounds. Natural toxins (from plant, bacteria, fungi, algae and microalgae, fish). Toxic compounds from essential oils. Microbiological diseases. Food allergens. SO2. Pseudo-allergic reactions, biogenic amines in foods. Food parasites (Anisakis). Technological contaminants: examples. Heavy metals. Residues (pesticides, products for plant protection, veterinary drugs). Environmental contaminants; contaminant from packages. Endocrine disruptors. Detoxifications mechanisms. Web resources.
Course borrowed fromCHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - FA0028 Chimica, tecnologia e contaminanti degli alimenti
Close course details
Print
CourseChimica farmaceutica e progettazione del farmaco I
Course IDFA0029
Academic Year2016/2017
Year of rule2014/2015
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderTRON Gian Cesare
TeachersTRON Gian Cesare
CFU12
Teaching duration (hours)96
Individual study time 204
SSDCHIM/08 - Pharmaceutical chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year3
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe course is divided into two parts. In the first part, the course will deal with the processes inherent the discovery, optimization and validation of molecules with biological activity. ( Lead discovery , lead optimization , QSAR , molecular modeling , ADMET ) . In the second part different classes of drugs will be studied considering the rationale for their discovery, the mechanism of action, the structure activity relationships, and the therapeutic use . In particular they will be taken into consideration drugs that act on the central and peripheral nervous system, anticoagulants, and antidiabetic drugs.
Reference textsG.L. Patrick An Introduction to medicinal chemistry (III Eds.) Oxford E. Stevens Medicinal Chemistry: The modern drug discovery process, Ed Pearson
Teaching targetsThe goals of the course of Medicinal Chemistry and Drug Design I are, in the first part of the course, to introduce students to the key topics relating to medicinal chemistry and at the same time present and discuss general strategies for the drug design. In the second part, the goal will be to present and discuss several classes of drugs, with the aim of rationalizing their discovery. At the end of the course, the student will have gain the essential stock of knowledge with regard to the drug design and the issues relating to their development. He/she will be also able to read, in a critical manner, scientific articles on medicinal chemistry.
PrerequisitesExam preparatory Organic Chemistry 2
Didattics MethodsTraditional theoretical lessons, compulsory attendance.
Grading rulesOral exam. In particular, six questions will be posed to the student.
Full argumentsDefinition of Medicinal Chemistry, Pharmacodynamics, Pharmacokinetics. The concept of receptor. Receptor theory of Langley and Ehrlich. Definition of pharmacophore. Receptor theory of Fisher. .. Agonists, partial agonists, antagonists. Inverse agonists. Reversible antagonism, irreversible antagonistm, allosteric antagonism. Binding studies and the Scatchard plot. Dose-response curves for agonists. Effectiveness and affinity. Clarke Ariens and Stephenson receptor theories. The spare receptors. Dose-response curves for competitive antagonist. Theory of adaptation induced receptor. Receptor theory of the two-stage model. The enzymes. Acid-basic and nucleophilic catalysis mechanism. Reversible inhibitors, irreversible, allosteric. chemical functional groups useful for irreversible inhibition. Transition state inhibitors (examples). Suicide inhibitors (examples). Michaelis-Menten equation. Lineweaver-Burk equation. Competitive inhibitors, non-competitive, competitive, mixed. How drugs interact with receptors. Thermodynamics of interaction. The enthalpy and entropy contribution. Ionic bond. Hydrogen bond. Intramolecular hydrogen bond. Dipole-dipole interaction. Dipole-dipole induced. Covalent bond. Charge transfer. π -π interactions and π-cation. Halogen bond. Hydrophobic interactions. The chirality in drugs. Types of chirality. Definitions three-point Easson and Steadmann. hypothesis. Pfeiffer rule. eudismica analysis. Use of chirality in pharmaceutical chemistry. Chiral switch. Reverse enzymatic configurational, the case of ibuprofen. When to use a chiral drug. When to use a racemic drug. The problem of thalidomide. Lead discovery. Me-too compounds.. Functional groups to avoid. The problem of promiscuity. The problem of latent hits. Natural products. Amplification of the side effects. Fragment-based ligand design. Lead optimization. Pro-drug. Definition. Accidental Pro-drugs. Pro-drug in two stages, three stages, mutual pro-drug and pro-drug polymer. Pro-drug to improve the stability (examples). Pro-drug to prevent the metabolism of the first passage (example of bambuterol). Pro-drug to increase the duration of action (examples). Pro-drug to increase the solubility (examples). Pro-drug to improve the organoleptic characteristics (examples). Pro-drug to improve absorption (examples). Pro-drug to direct a drug (examples). Pro-drug to direct the drug in the CNS (examples). Pro-drug of alcohols, thiols and acids. Pro-drug for amides, imides and compounds with NH groups. Definition and examples of hard and soft drug. Isosterism and bioisosterism. Isosters of Langmuoir. Isosters of Grimm. Isosters of Erlenmeyer. The bioisostere concept. Classical and nonclassical isosters. Isosteric substitutions: H-D, H-F, F-OH, NH2-OH, OH-SH. The lethal synthesis. Divalent, trivalent and tetravalent isosteric substitutions. Non-classical bioisosteres of aromatic rings, esters, amides, carboxylic acids, phenols, catechols, carbonyls. isosters reversed. Isosterism carbon-silicon. The differences between silicon and carbon. Isosterism C-B and C-Se. Disjunctive approaches. molecular and simplifications on chiral centers.. Conjunctive approaches.. Introduction of cycles (see part on rigid analogues). Benzo-cracking or dissociation of the rings. Restructuring of cyclic systems. Introduction of new functional groups. Tactics. Change the distribution. Increase the metabolic stability. Synthesis of irreversible inhibitors. Functionalization of the aromatic rings. Repositioning of functional groups. Rational. Tactics. Vinilogy. Introduction, examples and rational method. Limits. Molecular doubling (twin-drugs). Rational and examples. The symmetry as a basis in the design of inhibitors of HIV protease. Molecular hybridization. Ideas, limitations. The concept of the balanced hybrid. Examples. Hybrids from the union of pharmacophoric groups of natural origin. The rigid analogues. Ideas, Benefits. Locate the active conformation. The case of acetylcholine, the case of dopamine. Stabilize a high energy conformation. Improve selectivity. Increase the power (the negative entropic effect). metabolic stabilization. Synthesis of partial agonists. Locate receptor subclasses. Examples. Disadvantages. Tactics. "Template" resistant to the hydrophobic collapse. QSAR (QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP) Cholinergic. Adrenergic. Antidepressants. Antiparkinson. General anesthetics. Local anesthetics. Anticoagulants and coagulants. Hypoglycemic. Anxiolytics: Barbiturates
Close course details
Print
CourseENGLISH
Course IDF0507
Academic Year2016/2017
Year of rule2014/2015
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
CFU2
Individual study time 50
SSDL-LIN/12 - Language and translation - English
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryE - Prova finale e lingua straniera
Year3
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Print
CourseSTATISTIC WITH R
Course IDF0592
Academic Year2016/2017
Year of rule2014/2015
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderRINALDI Maurizio
TeachersRINALDI Maurizio
CFU2
Individual study time 26
SSDMAT/04 - Mathematics education and history of mathematics
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryD - A scelta dallo studente
Year3
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe R software and its use to represent data and for statistical data analysis.
Reference textsReference material is posted on the DIR website
Teaching targets*Knowledge and understanding The course aims to enrich the theoretical knowledge of statistics and probability with appropriate calculation data analysis. Aims of the course is also to display the results. The course in based on the free and open source software R. *Applying knowledge and understanding Students should be able to use the acquired skills even in multidisciplinary context and they should be able to analyse data and generate professional graphical representations. *Making judgements. At the end of the course students are expected to apply R even in different situations and that they have acquired the tools needed to extend their knowledge by themselves. * Communication skills At the end of the course students are expected to be able to express their results both numerically and graphically. * Learning skills. During the course students should learn how to study by choosing their personal path and should become able to choose the appropriate resources.
PrerequisitesThe student should have the basic knowledge of mathematics and statistics
Didattics MethodsPractical lectures are given in the computer lab.
Other informationsReference material and additional informations are posted on the DIR website https://www.dir.uniupo.it/enrol/index.php?id=219
Grading rulesOngoing Quizzes and online Final Examination. Both count toward the final grade in a ratio 3/7.
Full argumentsR software. Elementary operations. Functions and graphs. Import, export in R. Data Structures, packages. Matrices, lists, arrays. The data frame. Working with sata: selecting elements, logical operators. Loops and conditionals. Missing data. Additional graphics packages: ggplot2. Regression line and regression curves. Anova. Pharmacokinetic models. Clustering. Simulations.
Course borrowed fromFARMACIA (1506) - FA0078 Statistica con R
Close course details
Print
CourseTecnologia e Legislazione Farmaceutiche I
Course IDFA0032
Academic Year2016/2017
Year of rule2014/2015
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderPATTARINO Franco
TeachersPATTARINO Franco
CFU10
Teaching duration (hours)80
Individual study time 170
SSDCHIM/09 - Pharmaceutical and technological applications of chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year3
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
Abstract•The teaching is aimed to illustrate principles, strategies and technologies used for the development and production of solid and liquid dosage forms employed in the therapeutic field, with a particular focus on the industrial medicines. The structure and the characteristics of the different pharmaceutical forms, the properties of the ingredients and their impact on the product performance, the processes employed by both pharmacists and industrial companies for their production and control will be described.
Reference textsColombo P et al. Principi di tecnologie farmaceutiche. 2° Ed, 2015, Ed. Ambrosiana. Aulton ME, Taylor K.M.G. Tecnologie farmaceutiche, 2015 EDRA LSWR. Minghetti P, Marchetti M. Legislazione farmaceutica. Ed. Ambrosiana. Farmacopea Ufficiale Italiana edizione vigente. Farmacopea Europea edizione vigente. Lachman L, Lieberman H, Kanig J. The theory and practice of industrial pharmacy. Ed. Lea & Febiger, USA. Fabris L, Rigamonti S. La fabbricazione industriale dei medicinali. Ed. Esculapio, Bologna. Manuali Tecnici A.F.I., Ed. OEMF, Milano.
Teaching targetsThe course objectives are: - provide students with knowledge about the characteristics and functions of conventional drug dosage forms and the ability to understand which tools and methodologies are used for their development and manufacturing - develop the students' ability to apply their knowledge for the identification and description of the technological and biopharmaceutical properties of pharmaceutical dosage forms - develop the students' ability to use the specific language of this discipline - develop the critical skills of the students to identify the role played by the pharmaceutical components and to evaluate how they affect the medicinal properties and the activity of the active ingredient - to direct the students to use tools that allow them to update the knowledge in the field of pharmaceutical technology
PrerequisitesThere are no prerequisites, but it is strongly recommended to attend the training only after having passed the examinations of the courses of the first two years
Didattics MethodsThe course will be provided in form of lectures. Occasionally, the students will be asked to answer questions about the treated subjects and to recover supplementary material from AIFA, EMA and FDA websites.
Grading rulesThe examination will be carried out in oral form. To achieve the final vote, the student must demonstrate that he has understood, and he is able to use the fundamental concepts of each topic. The evaluation will be based on the following criteria: 1. knowledge and theoretical understanding and application of the studied subjects; 2. independence of judgment and ability to link the studied arguments; 3. communication skills and appropriateness in the use of technical language; 4. learning ability.
Full arguments• Pharmaceutical dosage forms (PDF): definition of dosage form; principles of biopharmaceutics (drug delivery, absorption, distribution, metabolization and elimination; concept of bioavailability); route of drug administration (oral sublingual, buccal, rectal, transdermal, nasal, pulmonary, parenteral, topical, ophtalmic, vaginal route); concept of preformulation. • Pharmaceutical powders: definition; powder properties: particle shape, particle size, particle size analysis methods (sieve methods, microscope methods, Coulter Counter, sedimentation methods, laser light scattering methods) and particle size distribution, surface area and methods for the determination of the surface area; volume; density; porosity; flowability properties. • Materials employed in pharmaceutical field. Measure, control and regulation of temperature, pressure and flow. Ventilated, controlled climate and clean rooms. • Processes for solid dosage forms: milling, seiving, granulation, desiccation. • Granules: formulation of granules; introduction to granulation, granulation methods (wet granulation and dry granulation) and granulation mechanisms; effervescent granules, coated granules, modified release granules, gastroresistant granules; specific technological assays. • Tablets: definition; characteristics; classification (uncoated tablets, multiplayer tablets, coated tablets, effervescent tablets, chewable tablets, soluble and dispersible tablets, oral disisntegrating tablets, sublingual tablets, gastro-resistant tablets, modified release tablets); excipients for tablets (fillers, binders, lubricants, antiadherents, glidants, disintegrants, colourants, flavours, modified release agents); examples of tablet formulations; specific technological tests; coating of tablets (sugar coating, film coating, press coating). • Capsules: definition; hard gelatin capsules: excipients, shell manufacturing procedure and capsule filling; soft gelatin capsules; specific technological tests. • Manufacturing processes of pharmaceutical dosage forms: powders, tablets, coated tablets, capsules. • Solutions: properties of solutions; surfactants, interfacial tension, HLB; pharmaceutical solutions and excipients; aqueous and non-aqueous solutions; syrups; quality assurance tests; extractive preparations: hydrolates, essences, alcoholates, exctracts, infusions, tinctures, decoctions. • Parenteral dosage forms: classification; requirements; vehicles; packaging; insulin formulations; small volume preparations (SVP) and large volume preparations (LVP); parenteral nutrition; powders for parenteral administration. Sterilization: definition, physical and chemical methods; sterility assurance level. • Ophthalmic dosage forms: definition; eye anatomy and physiology; requirements and specific characteristics of ophthalmic preparations; eye drops; semisolid ophthalmic preparations; ophthalmic inserts; eye-baths; specific technological tests. • Manufacturing processes of liquid not parenteral and parenteral forms. Extemporaneous liquid pharmaceutical forms. Freeze-drying: principles, equipment, control and regulation tools. • Transfer of solids, liquids and gases in the pharmaceutical plant
Close course details
Print
CourseADVANCED SYNTHETIC METHODS
Course IDFA0056
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderPANZA Luigi
TeachersPANZA Luigi
CFU2
Teaching duration (hours)16
Individual study time 34
SSDCHIM/06 - Organic chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryD - A scelta dallo studente
Year4
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractProtecting groups Organoboron compounds Organosilicon compounds Organotin compounds Modern synthetic strategies
Reference textsSlides provided by the teacher with references to chemical literature and to advanced books.
Teaching targetsProvide students with the knowledge of modern synthesis techniques to supplement the curricular preparation. Introduce students to the principles of modern organic synthesis and to their use
PrerequisitesKnowledge of the structure and of the reactivity of the main classes of organic compounds
Didattics MethodsLectures with multimedia support. Discussion of examples of total synthesis and exercises.
Grading rulesOral exam based on the critical analysis of a literature article on the synthesis of complex molecules.
Full argumentsProtecting Groups: Introduction to the use of protecting groups in organic synthesis. Protecting groups for the main functional groups: introduction and removal. Orthogonality of protecting groups. Organoboron compounds: Introduction to the element. Boranes and their use in synthesis: alkyl, alchenyl- and alkinylborani. Preparation and reactivity. Outline of boronic acids and their use in cross coupling reactions. Outline of boron cluster. Organosilicon compounds: Introduction to the element. Silicones. Silyl enol ethers, vinylsilanes, epoxysilanes, allylsilanes and their use in organic synthesis. -Silyl carbanions. Trimethylsilyl cyanide. Trimethylsilyl triflate. Trimethylsilyl iodide. Organotin compounds. Introduction to the element. Stannilethers and acetals. Vinyl and allyl stannanes and their use in organic synthesis. Hydrides of tin. Alkynyl stannanes. Modern synthetic strategies. A brief history of organic synthesis. Retrosynthesis: definitions of concepts of synthons, retrons, disconnections, transformations. Retrosynthetic analysis. Guidelines for the application of the different strategies used in the retrosynthetic analysis: strategies based on structure, functional groups or processes. Examples of total synthesis.
Course borrowed fromCHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - FA0056 Metodologie sintentiche avanzate
Close course details
Print
CourseAspetti tecnologici e normativi dei prodotti medicinali e Economia e regolazione del farmaco
Course IDFA0040
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderPATTARINO Franco
TeachersPATTARINO Franco, JOMMI Claudio
CFU15
Course typeAttività formativa integrata
Course mandatorietyOpzional course
Year4
PeriodAnnuale
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
FA0041 Aspetti tecnologici e normativi dei prodotti medicinali CHIM/09 - Pharmaceutical and technological applications of chemistry PATTARINO Franco
FA0042 Pharmaceutical economics and regulation SECS-P/07 - Business administration and Management JOMMI Claudio
Close course details
Show parent course details
Print
CourseAspetti tecnologici e normativi dei prodotti medicinali
Course IDFA0041
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderPATTARINO Franco
TeachersPATTARINO Franco
CFU8
Teaching duration (hours)64
Individual study time 136
SSDCHIM/09 - Pharmaceutical and technological applications of chemistry
Course typeModulo di sola Frequenza
Course categoryC - Affine o integrativo
Year4
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageItalian
AbstractThe teaching want to give an understanding about the different stages that characterize the life cycle of a product that contain a new therapeutic agent, from the inception to the medicine withdrawal from the market. Besides it has the purpose to describe the rules governing medicinal products in Italy and in the EU and, in particular, the requirements from the regulatory athorities for getting the marketing authorization of the product. The strategies and methodologies implemented by the pharmaceutical companies to satisfy these requirements are detailed.
Teaching targetsThe course objectives are: - provide students with the knowledge of the life cycle of a product, from the stage of discovery of new therapeutic agent for disposal of the medicinal product that contains it, with particular relevance to the strategies employed to achieve a pharmaceutical product success and to comply with requests of the regulators about quality, safety and efficacy of the medicinal - develop the students' ability to apply their knowledge to describe the content of the documentation pertaining the medicinal product and to identify and illustrate the methods used to compose such documentation - develop the students' ability to use the specific language of this very specialized discipline - develop the students' critical thinking skills to address the professional responsibilities of the pharmaceutical technologist. They will be able to assess the implications and results of studies aimed at obtaining the marketing authorization for a medicinal product - directing the student to the use of tools that allow them to update their knowledge in the field of pharmaceutical-technological-applicative disciplines and therefore be able to competently carry out his professional career in the pharmaceutical industry
PrerequisitesThere are no prerequisites, but it is strongly recommended to attend the training only after having attended and/or passed the examinations of the courses of the first three years and in particular those of Medicinal Chemistry, Pharmacology and Pharmaceutical Technology.
Didattics MethodsThe course will be delivered mainly in form of lectures. Some seminars are planned, carried out by experienced people from pharmaceutical industry, which will illustrate the practical application of the exposed theoretical concepts. Occasionally, students will be invited to respond jointly to questions on topics already treated and to recover supplementary educational material on AIFA web sites, EMA and FDA
Grading rulesThe examination will be carried out in oral form. To achieve the final vote, the student must demonstrate that he has understood, and he is able to use the fundamental concepts of each topic. The evaluation will be based on the following criteria: 1. knowledge and theoretical understanding and application of the studied subjects; 2. independence of judgment and ability to link the studied arguments; 3. communication skills and appropriateness in the use of technical language; 4. learning ability.
Full argumentsPharmaceutical product lifecycle Exploratory phase Research phase: preformulation and formulation Development phase: pharmaceutical development, pre-clinical and clinical Trials (Phase I, II and III) Marketing and post-marketing The rules governing the marketing of medicinal products Intellectual property: fundamentals, procedures; pharmaceutical patent Marketing Authorization Manufacturing Authorization Clinical Trial Authorization Procedures, Common Technical Document. The quality in the pharmaceutical industry Quality System: introduction, references, objectives, quality monitoring. Quality Control and Quality Assurance. Quality Risk Management: the risk and the risk management, references, QRM process, techniques, case studies Quality by Design: statistical tools: Design of Experiments Validation procedures and protocols for product and processes.
Close course details
Show parent course details
Print
CoursePharmaceutical economics and regulation
Course IDFA0042
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderJOMMI Claudio
TeachersJOMMI Claudio
CFU7
Teaching duration (hours)56
Individual study time 119
SSDSECS-P/07 - Business administration and Management
Course typeModulo di sola Frequenza
Course categoryC - Affine o integrativo
Year4
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageItalian
AbstractFirst part: pharmaceutical market and its regulation (price & reimbursement: case-studies) Second part: pharmaceutical companies and their organisational structure Third part: economic evaluation of drugs (theory and exercises)
Reference textsPart 1: Pisano G, Science Business, 2006, Harvard Business School Press; Gianfrate F, Il mercato dei farmaci tra salute e business, Franco Angeli Editore, 2014. Part 2: Readings list. Part 3: Mennini FS, Cicchetti A, Fattore G, Russo P. La Valutazione Economica dei Programmi Sanitari. Il Pensiero Scientifico ed. 2011. Terza Edizione.
Teaching targetsThe course aims at (i) making students aware of the regulatory context of the pharmaceutical companies, of innovation processes in the pharmaceutical industry, and on the organisational structure and the main functions of the pharmaceutical companies (ii) and carrying out drugs comparative analysis from an economic perspective. Knowledge and competences will be applied to case studies focused on negotiation of prices and reimbursement and exercises on economic evaluation and budget impact analysis. Students are expected to be more autonomous in managing drugs market access issue and to improce communication skills thanks case-studies discussion and groups projetc.
PrerequisitesNone
Didattics MethodsThe course is organised in traditional lectures, exercises (on economic evaluation and budget impact analysis), case-studies and guest speakers coming from the pharmaceutical industry (on negotiation of drugs prices and reimbursement). Students are also required to work on a groups project. The topic and organisation of groups project are presented during the first classes Students are required to participate fully in class and pull their weight in group work. Group projects will be graded.
Other informationsNone
Grading rulesGrading is based on: • one written exam (80% of the final grade); all topics discussed druing the course will be covered by the final exam, which will include open question (no multiple choice), exercises and the discussion of a case-study • groups project results (20% of the grade).
Full argumentsFirst part: pharmaceutical market and its regulations The Italian health care system: main aspects and relationships with the industry The pharmaceutical market: international and national trends. Aggregate trends and their split per main therapeutic areas, distribution systems, reimbursability status, and patent status. Pharmaceutical market regulation: Pre-Marketing Regulation, Marketing Authorisation, Price and Reimbursement, Managed Market Entry Contracts, Regional and Local Policies (formularies, procurement, distribution systems, actions on prescribing behaviour) Secondo part: pharmaceutical companies and their functions Pharmaceutical companies: organisational structure and main functions Research and Development: phases, economics, relationships among companies (co-research, co-development, licensing, patent negotiation) Market access and Public affairs Marketing and sales Third part: economic evaluation of drugs An introduction to Health Technology Assessment Economic evaluation of drugs: principles, methods, phases Budget impact analysis: differences from the economic evaluation Budget impact analysis and economic evaluation of drugs
Close course details
Print
CourseBiologia strutturale + Farmacologia preclinica e clinica
Course IDFA0046
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderGENAZZANI Armando
TeachersGARAVAGLIA Silvia, ORSETTI Marco Riccardo Lilio, GENAZZANI Armando
CFU15
Course typeAttività formativa integrata
Course mandatorietyOpzional course
Year4
PeriodAnnuale
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
FA0047 Biologia strutturale BIO/10 - Biochemistry GARAVAGLIA Silvia
FA0048 Farmacologia preclinica e clinica BIO/14 - Pharmacology GENAZZANI Armando, ORSETTI Marco Riccardo Lilio
Close course details
Show parent course details
Print
CourseBiologia strutturale
Course IDFA0047
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderGARAVAGLIA Silvia
TeachersGARAVAGLIA Silvia
CFU5
Teaching duration (hours)40
Individual study time 85
SSDBIO/10 - Biochemistry
Course typeModulo di sola Frequenza
Course categoryC - Affine o integrativo
Year4
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal judgment
Course borrowed toFARMACIA (1506) - FA0092 Biologia Strutturale
FARMACIA (1506) - FA0092 Biologia Strutturale
Close course details
Show parent course details
Print
CourseFarmacologia preclinica e clinica
Course IDFA0048
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderGENAZZANI Armando
TeachersORSETTI Marco Riccardo Lilio, GENAZZANI Armando
CFU10
Teaching duration (hours)80
Individual study time 170
SSDBIO/14 - Pharmacology
Course typeModulo di sola Frequenza
Course categoryC - Affine o integrativo
Year4
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageItalian
AbstractEvaluation of preclinical and clinical evidences The mail jobs and responsabilities in the pharmaceutical industry The lifecycle of a drug: from the bench to late commercialization Clinical Development Regulatory requirements Post-marketing Licensing Patents Extensions of use Characteristics of the main animal models used in pre-clinical pharmacology (Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, rodents, primates, rabbit) Laws governing animal use for scientific puroposes Guidelines for animal welfare Radioligand binding to calculate in vitro parameters of novel drugs Experiments on isolates organs Preclinical in vivo experiments: pharmacokinetics (t1/2, Vd, Kel, CL and bioavailability) toxicology teratogenesis evaluation og abuse potential of drugs evaluation of cognitive functions evaluation of anti-epileptic, antidepressive, and antipsychotic drugs evaluation on analgesic and anti-inflammatory drugs
Reference textsEPARs (European Public Assessment Report) from the European Medicines Agency (www.ema.europa.eu) Lecture notes and handouts
Teaching targetsThis course is part of the following set of interlinked courses with a continuum of objectives: - Farmacognosia e Fitoterapia (II year) - Farmacologia e Farmacoterapia (IV year) - Tossicologia e Laboratorio di Farmacologia (IV year) - Opzione farmacologica (pre-clinica e clinica; IV year) In particular, this course will allow: to gain basic elements to enter the pharmaceutical world in the private sector gain basic elements to allow students to create start-up companies Gain basic elements to evaluate drugs or health technologies
PrerequisitesThere are no formal requirements although to gain the most from the course a knowledge of pharmacology is required.
Didattics MethodsTraditional lectures, as well as projects performed by students and commented during lectures
Other informationsn.a.
Grading rulesA written report and a powerpoint presentation will be the basis of the evaluation. The work will be a simulation of the pre-clinical and clinical development of a medicinal product. The pre-clinical module will be evaluated with an oral exam with two questions.
Full argumentsEvaluation of preclinical and clinical evidences The principal jobs and responsabilities in the pharmaceutical industry The lifecycle of a drug: from the bench to late commericalization Clinical Development Regulatory requirements Post-marketing Licensing Patents Extensions of use Characteristics of the main animal models used in pre-clinical pharmacology (Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, rodents, primates, rabbit) Laws governing animal use for scientific puroposes Guidelines for animal welfare Radioligand binding to calculate in vitro parameters of novel drugs Experiments on isolates organs Preclinical in vivo experiments: pharmacokinetics (t1/2, Vd, Kel, CL and bioavailability) toxicology teratogenesis evaluation og abuse potential of drugs evaluation of cognitive functions evaluation of anti-epileptic, antidepressive, and antipsychotic drugs evaluation on analgesic and anti-inflammatory drugs
Close course details
Print
CourseBiotecnologie alimentari + Analisi e controllo di qualità dei prodotti alimentari
Course IDFA0043
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderARLORIO Marco
TeachersARLORIO Marco, COISSON Jean Daniel
CFU15
Teaching duration (hours)72
Individual study time 231
SSDCHIM/10 - Food chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryC - Affine o integrativo
Year4
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageThe teaching will be delivered in Italian; part of the material used by the teacher will be in English (Food Biotechnology part)
AbstractPart I: - Food biotechnology: introduction - Characteristics of microorganisms useful in biotechnology: the cell as “ molecular factory” - Fermentations in food area - Virtuous microorganisms and “microbial starters” - Prebiotic, probiotics and synbiotics - Fermented foods - Industrial microbiology: classificationd of fermentations and characteristics - Bioreactors and downstream processes - Fermentation’s kinetics - Enzymes and cells immobilization - Biomasses, Single Cell Proteins (SCP) - Examples of primary and secondary metabolites: alcohols, sweteners, gums, organic acids, aminoacids, flavorings pigments. - Examples of bio-conversions and bio-remediations (overview) - Enzymes: classification, production and applications. - Recombinant technology in food area: MGMOs e GMOs - Regulatory framework (overview) - Analytical biotechnology: overview - Web resources Part II - Methods of analysis useful for the determinations of parameters present on nutrition labels (proteins, saturated and unsaturated lipids, simple and complex carbohydrates, fiber, minerals). - Official methods of analysis for some foods such as: drinking water, wine, milk, olive oil, flour, pasta. - Instrumental analyses applied to foods, such as electrophoresis and capillary electrophoresis, GCxGC-MS, HPLC-MS, MALDI-TOF, atomic spectroscopy, PCR and Real-time PCR. - Laboratory activities focused on the analysis of drinking water, olive oil, wine, milk candies and chocolate. - Laboratory activities relate to a complex food (cheese), defining its nutritional label, its characterization and evaluating the ripening.
Reference textsSlides used in the course, provided by the Teachers Food Biotechnology “BIOTECNOLOGIE ALIMENTARI”, Gigliotti-Verga; Piccin Editore Industrial microbiology and fermentations CHIMICA DELLE FERMENTAZIONI E MICROBIOLOGIA INDUSTRIALE, Marzona, II Edizione. PICCIN Editore. Applied Biotechnologies: BIOTECNOLOGIE DI BASE, Colin Ratledge, Bjørn Kristiansen; Zanichelli Editore Deep insights in biotechnology: BIOTECNOLOGIA MOLECOLARE, Glick, Pasternak; Zanichelli Editore. Food Analysis: ANALISI DEI PRODOTTI ALIMENTARI, Cabras, Tuberoso, Ed. Piccin, Padova, 2014 Lab. activities: Notes and protocols from the teacher
Teaching targetsThe knowledge gained from the course will be useful to the student in Chemistry and Pharmaceutical Technology to complete the knowledge in “food area” . The first part, related to food biotechnologies, provides the students with the basic knowledge in the field of biotechnology in the food industry (molecular biology bases; virtuous microorganisms and microbial starter, fermentation, bio-production and recovery of bio-products used in food, nutraceutical and pharmaceutical industries; production of flavourings and additives through biotechnology, food enzymes and applications; recombinant biotechnology, GMO and GMO; notes on the regulatory field). In the part related to the Food Analyses the student will acquire the basic knowledge in food analysis, in order to understand the meaning of each analysis and its scope. The laboratory exercises aim to prove students in food analysis and to verify their ability to apply the knowledge related to analysis of simple and complex food matrices. The student must demonstrate the ability to correctly obtain and discuss the analytical data and to use the appropriate method of communication of the results obtained
PrerequisitesDrug Analysis I (Analisi dei Farmaci I) is compulsory in order to access to the lab experiences. We recommend the acquisition of knowledge about the courses of Organic Chemistry, Biochemistry and Food chemistry, technology and contaminants, fundamental for the understanding of the lessons of this course. The basic knowledge in Quantitative Drug Analysis laboratory (Analisi dei Farmaci II) is welcomed.
Didattics MethodsThe teaching method used provides ex-cathedra lectures given by the teachers, complemented by class discussion of cases study. Specific seminars could be organized in cooperation with external Teachers and experts in the field. For the analysis part, in addition to lectures, calculation exercises related to methods of analysis applied in the laboratory will be proposed. With regard to laboratory activities, students will perform the required analyzes, interpreting the supplied protocols, reporting the steps performed in the laboratory notebook, making the calculations in order to express the result in the unit of measure required and filling the analysis reports. Will also be given the means of preparing a comprehensive report on the food analyzed complex.
Other informationsThe course, even if structured in two parts, must to be considered a whole course finalized to complete the knowledge and the skills in "food area" of the chemist expert in pharmaceutical sciences, both considering the analysis of foods (quality and safety assessment) as well as the production of new bioactive ingredients/food by mean of biotechnology methodologies. The lab activities are scheduled in two parts, the first including the analyses of simple foods (wine matrices, milk, oil, water, candy) will take place in January, the second related to the characterization of a complex food (cheese) will take place in March.
Grading rulesFor the Food Biotechnology part, the assessment of the learning is based on an oral Test, focused on the themes developed in this Course. The test is organised in three questions, one question focused on the first part of the Course (microorganisms, fermentation, probiotics); one question on the second part (industrial microbiology and bio-products), and one on the last part (recombinant biotechnologies and recombinant products) For the Food Analysis part the assessment of the learning starts as an evaluation in itinere as written test at the end of theory lessons, mandatory for the laboratory admission, related to all topics described in the preparatory lessons (including lab safety rules). This evaluation consists in a written test with 7 multiple choice questions, 2 calculation exercises and 6 open questions, between these two questions in particular require that the student selects the most suitable analyses in order to solve a specific analytical problem. The evaluation of the in itinere test is part of the final evaluation of the course and, in case of unsatisfactory results, will be integrated with oral questions during the period in the laboratory or at the end of the course as a specific exam. Oral questions are typically 3: one to provide a description of an instrumental analytical method, one to describe an analysis performed in the laboratory with specific focus on safety rules and a question on the selection of methods of analysis. Related to the activities carried out in the laboratory, the evaluation includes the preparation of analysis reports, the correctness of the calculations and completeness of the laboratory notebook. Finally, it will evaluate the presentation skills of analytical data obtained on the complex food in a written report form.
Full argumentsPart I (Food Biotechnology, Prof. Arlorio) History and meaning of food biotechnology. Molecules/macromolecules of biotechnological interest. Features of microorganisms (prokaryotes and eukaryotes), characteristics. Transcription, translation, gene expression and regulation. Cell as "molecular factory." Food fermentations: alcoholic, homo- and hetero-lactic malo-lactic, propionic, acetic, butyric, and isobutyric, citric fermentation. Virtuous and starter microorganisms in food productions. Fungi of food interest (filamentous fungi, yeasts, edible mushrooms). The lactic acid bacteria. Bifidobacteria. Prebiotics, probiotics and synbiotics. Bioactive peptides of milk; prebiotic oligosaccharides. Industrial production of starters cultures and probiotic microorganisms. Bacteriocins: features and classification. Cyanobacteria and microalgae, biomass and pigments production. Fermented foods: microbiological, biochemical, biotechnological and fermentation features (milk/dairy products, alcoholics, fermented vegetables; leavened bakery products, cocoa, coffee and tea, sausages, other fermented foods). Industrial microbiology: classification of fermentations (continuous, discontinuous). Bio-reactors. Fermentation parameters. Kinetics, yields of fermentation. Immobilized enzymes/cells. Application of immobilized systems. Operations Units for recovery, separation and purification of fermented products (downstream processing). Biomass, Single Cell Protein (SCP). Red yeast rice, Pruteen, Quorn. Primary and secondary metabolites obtained by fermentation: alcohols, amino acids, organic acids, neutral polysaccharides, other bioproducts. Production of sweeteners (aspartame, glucose syrup/ maltose/fructose and isomalt). Examples of bio-conversion and bio-remediation in food. Flavourings. Receptors and taste/aroma perception. Examples of flavourings from biotechnology: lactones, terpenes, vanillin. Cyclodextrins production. Pigments: carotenoids productions. Enzymes: meaning and production, classification. Enzymes as markers of food processes. Enzyme applications in food technology (production of glucose syrups; milk delactosation, meat tenderizing, extraction technologies, production of chitosan, clarification and stabilization of juices and alcoholic beverages, accelerated ripening of cheese, enzymatic reduction of acrylamide, other applications). Enzymes from extremophiles microorganisms. Food Biotechnology of the second generation: recombinant DNA. GMMO: r-Chym and r-BGH. Plant biotechnology: GMO foods: Flavr-SavrTM tomato, Bt corn, Soja Round-up Ready, Golden Rice, other GMOs. Food biotechnology in animal area (cloning, salmonids, mammals, other experimental modifications). National and international regulatory framework. Outline on Analytical Biotechnology in food area. Web resources useful in food biotechnology. Part II (Food Analysis and Quality Control, Prof. Coisson) The food analysis and quality control: importance and principal fields. Moisture: oven drying, Marcusson and Karl Fischer methods. Proteins: total nitrogen (Kjeldahl), principles, instruments, safety procedures, correction factors. Extraction, SDS-PAGE and native-PAGE electrophoresis, mono and two-dimensional; isoelectrofocusing. Lipids: extraction in Soxhlet apparatus, Gerber methods for dairy products. Methods for characterization: refractive index, saponification number, iodine number. Quality evaluation: acidity, peroxide number, p-anisidine number. Olive oils: European regulations. Panel test. Spectrophotometric analysis. FAME (Fatty Acid Methyl Esters) and unsaponifiable fraction analyses (sterols, superior alcohols, erythrodiol/uvaol). Milk: density, cryoscopic index, dry matter, acidity, peroxidase and phosphatase tests, soluble not-denatured whey proteins. Cheese analysis. Sugars: reducing sugars (Fehling), sucrose with polarimetric method (Clerget). Refractive index and Brix degrees. Cereals and derived products (flours, bread and pasta): moisture, ashes, gluten, acidity, bleaching contaminants, ascorbic acid. Methods for identification of common wheat and eggs in pasta. Wine: ethanol percentage, dry matter, total, fixed and volatile acidity, proline, polyphenols, NMR and mass spectrometry methods for evaluation of sugars origin. Water: legislation for drinking water and mineral water. Ammoniac (Nessler and phenol-ipochlorite), nitrites (Griess), nitrates, oxidative Kubel number, BOD, COD., hardness, chlorides, chlorine, sulfides, iron and chrome Additives: quantification of benzoic acid in non-alcoholic beverages. Enzymatic analysis: aims, sample preparation, examples of methods and protocols. Total antioxidant activity methods. DNA analysis: PCR and PCR-related techniques (AFLP, RFLP, RAPD, Real time). HPLC applications and previous extraction and purification by SPE; GC-techniques applications, aroma extraction by SPME. Metal analysis: Atomic absorption spectrometry, theory and applications. Practical experiences Analyses of drinking water, wine, milk, olive oil. Benzoic acid quantification in non-alcoholic beverages, sucrose in chocolate and candies. Characterization of a complex food (cheese): moisture, ashes, proteins, lipids (Soxhlet and Van Gulik); titrimetric acidity and lactic acids (enzymatic). Fat fraction: acidity, peroxide number, oxidation index, FAME composition by GC. Proteins electrophoresis: extraction, SDS-PAGE and urea-PAGE, image analysis. Quantification of biogenic amines by HPLC. DNA analysis: extraction, clean-up and amplification
Close course details
Print
CourseChimica farmaceutica e progettazione del farmaco II
Course IDFA0035
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderSORBA Giovanni
TeachersSORBA Giovanni, TRON Gian Cesare
CFU11
Teaching duration (hours)88
Individual study time 187
SSDCHIM/08 - Pharmaceutical chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year4
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractModule A The course deals with the in-depth study of different classes of drugs, considering the rationale behind their discovery, the mechanism of action, the structure-activity relationships, and the therapeutic use. In particular we will consider the following classes of drugs: Cardiovascular agents; Drug actin on the renal system; Prostaglandins, leukotrienes, and essential fatty acids; Histamine and antihistaminic agent; Antiulcer agents; Steroid hormones and therapeutically related compounds. Module B The course deals with the in-depth study of different classes of drugs, considering the rationale behind their discovery, the mechanism of action, the structure-activity relationships, and the therapeutic use. In particular we will consider the following classes of drugs: anti-cancer, anti-bacterial, anti-viral.
Reference textsA. Gasco, F. Gualtieri, C. Melchiorre Chimica Farmaceutica (I Eds.) Casa Editrice Ambrosiana; W. Foye, Principi di Chimica Farmaceutica, Piccin; (VI Eds.); Wilson and Gisvold, Chimica Farmaceutica (I Eds.) Casa Editrice Ambrosiana; G.L. Patrick Introduzione alla Chimica Farmaceutica (edizione integrata) EdiSES. T.L. Lemke, D.A. Williams. Foye’s, Principi di Chimica Farmaceutica, V Eds. Piccin.
Teaching targetsModule A The student should be able to recognize and to write the structures of the main drugs of the classes highlighted in the content. He should be able to discuss their chemical and physical properties, their mode of action and the relationships between the structure and biological activity, understand how they were designed and synthesized. Module B The goals of the course of Medicinal Chemistry and Drug Design II are: To provide students with the fundamental knowledge on antibacterial, anticancer and antiviral drugs, and at the same time the general strategies for their design, the study of their mechanisms of action at the molecular level, their chemical- toxicological aspects and their relationships between chemical structure and biological activity. At the end of the course, the student will have gain a deep knowledge concerning these classes of drugs, in particular with regard to their mechanism of action at the chemical level. At the end of the course, the student will be able to read, in a critical manner, books and scientific articles regarding these classes of drugs.
PrerequisitesRegarding preparatory Pharmaceutical Chemistry and Drug design I Preliminary matters Knowledge in the field of Organic Chemistry, General Pathology, Biochemistry, Physiology, Pharmacology.
Didattics MethodsFrontal Seminar
Grading rulesModule A Oral discussion on a scientific paper previously provided to the student. Module B Written exam with five essay questions.
Full argumentsModule A Cardiovascular agents. positive inotropic, antianginal, antiarrhythmic agents, diuretics, ACE inhibitors, calcium channel modulators, central and peripheral sympatholytic agents, vasodilators, inhibitors of cholesterol biosynthesis and antilipoproteinemici; design and synthesis of agents of the cardiovascular system, the search for new agents for the cardiovascular system Agents that interfere with the hormone system (corticosteroids, glucocorticoids, male and female sex hormones). Nomenclature, structure, mechanisms of action, biosynthesis and metabolism. Drugs that act on receptors SAR steroids. Antagonists of steroids, mechanism of action, design and synthesis. Nonsteroidal anti-inflammatory drugs, antihistamines and anti-allergy drugs. Design and synthesis of NSAIDs and H1 antihistamines, the search for new NSAIDs and antihistamines H1. Histamine receptor H1, H2, H3 and H4 ligands. Antisecretory agents: H2 antihistamines, proton pump inhibitors. Design and synthesis of H2 antagonists and proton pump inhibitors. Module B Antibacterial agents. The giants of the past: Leeuwenhoek, Spallanzani, Pasteur, Lister, Kock. The bacterial cell. Gram + and Gram -. The bacterial cell wall. Proflavine. Sulfonamides. The problem of the resistance. Sulphones. Diidrofolate reductase inhibitors. Penicillins. Cephalosporins. Carbapenenms. Monobactams. Beta-lactamase inhibitors. Other antibiotics which act on bacterial cell wall. Antibacterial agents which act on the plasma membrane. Antibacterial agents which impair protein synthesis. Antibacterial agents which act on nucleic acids. Antitubercular drugs. Antiprotozoal drugs. Antimalarian drugs. Antifungal drugs. Anthelmintic drugs. Anticancer drugs. Cancer: an introduction. Causes of cancer. Antimetabolites. Drugs acting on nucleic acids. Drugs acting on tubulin. Hormone-based terapies. Kinases inhibitors.Miscellaneous enzyme inhibitors. Antiviral agents. Virus. Structure of virus. Life cycle of virus. Antiviral drugs against DNA virus. Antiviral drugs against RNA virus. Hiv virus and drugs.Antiviral drugs against flu virus. Antiviral drug against cold virus. Antiviral drugs against hepatite virus.
Close course details
Print
CourseFarmacologia sperimentale e farmacoterapia
Course IDFA0037
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderGRILLI Mariagrazia
TeachersGRILLI Mariagrazia
CFU15
Teaching duration (hours)120
Individual study time 255
SSDBIO/14 - Pharmacology
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year4
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractPharmacotherapy- the treatment of disease through the administration of medications- is a course that introduces students to the main drug classes currently available for the treatment of major human diseases. A basic understanding of treatment options available for such disease states is also developed during this course through the discussion, for each drug, of mechanism of actions, side effects, contraindications and limitations in their use in specific patient subpopulations. Anatomy, physiology, pathophysiology, genetics, cellular and molecular biology, clinical biochemistry aspects related to the presentation and management of such diseases will also be discussed during the course since they are essential to understand the rational basis of therapeutic interventions. Physicochemical and biological principles of dosage forms and drug delivery strategies used to treat specific human disorders will also be reviewed. The course will extensively evaluate and discuss, in an integrated manner, all the variables (genetic and non genetic) that regulate interaction between drugs and human body and that ultimately affect, in an individual manner, therapeutic actions as well as side effects and toxicity of clinically relevant drugs. Altogether, the student will be able to understand the rationale upon which drug therapy decisions are based. Moreover the course includes a module which covers modern aspects of preclinical pharmacology which are critical for new drug discovery
Reference textsAny pharmacotherapy textbook covering the topics of the course can be used, provided it is an updated edition. For example: Goodman and Gilman, The pharmacological basis of therapeutics. Ed. MacGraw-Hill; B.G. Katzung, Farmacologia generale e clinica, Piccin; Howland and Mycek, Le basi della farmacologia, Zanichelli; Rang, Dale, Ritter, Farmacologia, Casa Editrice Ambrosiana. For topics which may not be covered by booktexts (i.e. preclinical pharmacology and biotechnological drugs), bibliographic references will be provided.
Teaching targetsThis course provides students with an integrated approach to understanding principles of and solve problems related to pharmacological treatment of human diseases. Pharmacotherapy enables students to discover connections across multiple disciplines (among others, anatomy, physiology, pathology, biochemistry), see them applied in clinical therapy and to integrate skills and knowledge gained in previous years of their curriculum studiorum for understanding therapy. Students, at the end of this course are formed and can inform people about the correct use and choice of drugs, and should be capable of understanding drug interactions and adverse reactions. In addition, students will be able to critically evaluate the experimental approaches for screening, mechanisms of action definition and pharmacological characterization of new drugs.
PrerequisitesThe following exams: physiology, pathology, cellular and molecular pharmacology are prerequisites for the course of preclinical pharmacology and pharmacotherapy.
Didattics MethodsTeaching is given in the form of lectures and group discussions of case studies which will allow the students to critically contribute in the topic understanding. Additionally, every year seminars or workshop on specific topics will be organized with national and international experts. Student attendance is mandatory. Students will be actively involved in the discussion with experts.
Grading rulesThe final exam consists in a 30-40 min discussion on selected course topics and will be mainly aimed at evaluating the ability of the students to prove not only their knowledge but also their ability to logically connect concepts, their problem solving ability and their communication skills. Students who have failed the first examination can re-try only after skipping one examination session. Examinations are available, on average, once a month.
Full argumentsPreclinical Pharmacology: in search for new drugs. Target identification and validation in drug discovery. Hit identification and lead optimization. Modern approaches to assay development with a specific focus on functional cell-based assays. Main technological platforms for high throughput screening in drug discovery. Orphan receptors: discussion of successful case studies of GPCR deorphanization. Pharmacogenetics/genomics applied to drug discovery. Animal models in research and drug discovery. Pharmacotherapy. Variability in the individual response to drugs: genetic and non genetic factors. Pharmacogenetics and Pharmacogenomics: applications in therapy. Adverse drug reactions (ADR). Interaction between drugs, between drug and natural products, drugs and food. Drugs of Peripheral nervous system and neuromuscolar junction. Cholinergic agonists and antagonists and cholinesterase inhibitory drugs; adrenergic agonists and antagonists; pharmacology of neuromuscolar transmission.
Pharmacotherapy of major psychiatric disorders. Anxiolytics, Antidepressants, Mood stabilizers, Antipsychotics. Pharmacotherapy of major neurological disorders. Parkinson’s disease. Anticonvulsant drugs. Benzodiazepines and other sedative-hypnotic drugs. Pain as a symptom or as a disease. NSAID, paracetamol, opiates (SAO, LAO, ROO), treatment of neuropathic pain. Headache and migraine therapy. Immune system and inflammation. Glucocorticoids, Immunosuppressive agents and immunostimulants. Antiistaminic drugs. Anesthesia: local and general anesthetics. Cardiovascular system and kidney. Drugs for the treatment of cardiac insufficiency and myocardial ischemia. Antiarrhythmic drugs. Drugs acting on the renin-angiotensin-aldosterone system. Antihypertensive agents. Diuretics. Drugs acting on the blood. Anticoagulant and antiplatelet drugs. Fibrinolitics. Endocrine system and metabolism. Therapy of osteoporosis and diabetes. Antidislipidemic drugs. Respiratory System. Bronchodilatators and agents used in the treatment of asthma. Antitussive agents and mucolitics. Gastrointestinal System. Agents used for the control of gastric acidity and treatment of peptic ulcers. Agents used for diarrhea and constipation. Antiemetics and proemetics. Prokinetic agents.
Biotech drugs: Peculiarities of biotech drugs vs small molecules. Adverse reactions to biotech drugs. Immunogenicity of biotech drugs. Therapeutic proteins: insulins and insulin analogs, GH and GH antagonist, CSFs, interferons, erithropoietins, tPAs. Evolution and innovation of therapeutic proteins, biobetters. Glicoingegnerization and pegylation. Aptamers. Advanced therapies: gene therapy and cellular therapy. The use of stem cells in human therapy.
Close course details
Print
CourseMetodologie avanzate in analisi chimica-tossicologica
Course IDFA0036
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderALLEGRONE Gianna
TeachersALLEGRONE Gianna
CFU5
Teaching duration (hours)40
Individual study time 85
SSDCHIM/08 - Pharmaceutical chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryB - Caratterizzante
Year4
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractGas Chromatography Mass Spectrometry. Gas-chromatography-mass spectrometry (GC-MS). Liquid chromatography-mass spectrometry (LC-MS) Interfacing problems Pollutants and related methods of analysis Pesticides. Dibenzodioxins and dibenzofurans. Polychlorinated biphenyls (PCB). POP list
Reference textsD.C.Harris “Quantitative chemical analysis” ed.Zanichelli Watson, “Pharmaceutical analysis”, 3th ed. Elsevier C. Baird “ Enviromental chemistry” Freeman and Company New York Watson and Sparkma “Introduction to Mass Spectrometry” ed.Wiley
Teaching targetsKnowledge of advanced analytical techniques applicable to the determination of drugs, pollutants and bioactive substances present in complex matrices
PrerequisitesBasic knowledge of organic chemistry and pharmaceutical analysis
Didattics MethodsLessons
Grading rulesThe exam includes a written test followed by an oral interview. The written test, which lasts 90 minutes consists of 5 open questions. The interview initially involves the review of the written exam and then a question on a topic of the program.
Full argumentsPrinciples of gas chromatography. Gas Chromatography: injectors, columns, detectors. Selectivity, efficiency, resolution. Van Deemter equation. Retention indices: Kovats indices Headspace methods: static, dynamic, SPME Principles of mass spectrometry. Sources: IE, CI, ESI, APCI, Maldi. Analyzers: magnetic, double focusing, quadrupole, ion trap, TOF Resolving power and resolution. Tandem mass spectrometry. High resolution mass spectrometry. Mass spectrum. Molecular ion and pseudomolecolar ion, isotopic abundance, fragmentations. Gas-chromatography-mass spectrometry (GC-MS). Definition of the gas chromatographic method. Definition of the spectrometric method. Full scan, SIM, MS / MS. Qualitative analysis. Use of database. Quantitative analysis. Calibration curve. Internal standard method. Isootopic dilution Liquid chromatography-mass spectrometry (LC-MS) Interfacing problems Qualitative and quantitative analysis. Definition of the chromatographic method. Definition of the spectrometric method Pollutants and related methods of analysis Pesticides. Chlorinated, organophosphorus, carbamates insecticides. Pyrethrins and pyrethroids insecticides. Erbicides: a) interfering with the growth factors of the plant: auxinic herbicides; b) interfering with the photosynthesis process: triazine, cloroacetamidi, urea derivatives, dipiridilici derivatives; c) interfering the synthesis of aromatic amino acids: glyphosate; d) interfering the cell division: sulfonylureas. Inorganic and metal organic fungicides, organic fungicides: dithiocarbamates, benzimidazoles, and diphenyl. Repellents. Dibenzodioxins and dibenzofurans: structures, sources of pollution, toxicity. Polychlorinated biphenyls (PCB): structures, sources of pollution, toxicity, methods of disposal POP list
Close course details
Print
CoursePHARMACEUTICAL POLICY AND LEGISLATION
Course IDFA0063
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderDE ROSA Mauro
TeachersDE ROSA Mauro
CFU3
Teaching duration (hours)24
Individual study time 51
SSDBIO/14 - Pharmacology
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryD - A scelta dallo studente
Year4
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Course borrowed fromFARMACIA (1506) - FA0063 Politiche farmaceutiche
Close course details
Print
CourseRilascio e direzionamento di sostanze bioattive
Course IDFA0038
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderPATTARINO Franco
TeachersPATTARINO Franco
CFU5
Teaching duration (hours)40
Individual study time 85
SSDCHIM/09 - Pharmaceutical and technological applications of chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year4
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractIt is an advanced teaching of pharmaceutical technology, aimed to describe the concepts, the strategies and the technologies employed in the production of therapeutic systems, pharmaceutical forms that are able to control the release of a drug, to modify its absorption and to target it to the site of action.
Reference textsColombo P et al. Principi di tecnologie farmaceutiche. 2° Ed, 2015, Ed. Ambrosiana. Aulton ME, Taylor K.M.G. Tecnologie farmaceutiche, 2015 EDRA LSWR. R. Notari - Biofarmaceutica e Farmacocinetica - Piccin Ed. L. Shargel and A.B.C. Yu - Biofarmaceutica e Farmacocinetica - Masson A.T. Florence, D.T. Attwood - Physicochemical Principles of Pharmacy - MacMillan Press, Hong Kong L. Lachman, H.A. Liebermann, J.L. Kanig - The Theory and Practice of Industrial Pharmacy - Lea & Febiger, Philadelphia M. Chasin and R. Langer - Biodegradable Polymers as Drug Delivery Systems - Marcel Dekker Inc. S. Vomero - Chimica Farmaceutica Applicata - La Gogliardica, Eur Roma Alexander Steinbüchel and Robert H. Marchessault - Biopolymers for medical and pharmaceutical applications - Wiley-VCH, vol. 1 e 2.
Teaching targetsThe course objectives are: - Provide students with knowledge about the characteristics and functions of therapeutic systems and the ability to understand which tools and methodologies to use for design, develop and manufacture the modified-release drug forms - Develop the students' ability to apply their knowledge for the identification and description of the technological and biopharmaceutical properties of advanced pharmaceutical forms - Develop the students' ability to use the specific language of this very specialized discipline - Developing the students' critical skills to evaluate the influence of the properties of the pharmaceutical vehicle on the drug activity - Direct the students to use tools that allow them to update the knowledges in the field of pharmaceutical technology
PrerequisitesThere are no prerequisites, but it is strongly recommended to attend the training only after having attended and/or passed the examinations of the courses of the first three years and in particular those of Medicinal Chemistry, Pharmacology and Pharmaceutical Technology.
Didattics MethodsThe course will be provided in form of lectures. Occasionally, the students will be asked to answer questions about the treated subjects and to recover supplementary material from AIFA, EMA and FDA websites.
Grading rulesThe examination will be carried out in oral form. To achieve the final vote, the student must demonstrate that he has understood, and he is able to use the fundamental concepts of each topic. The evaluation will be based on the following criteria: 1. knowledge and theoretical understanding and application of the studied subjects; 2. independence of judgment and ability to link the studied arguments; 3. communication skills and appropriateness in the use of technical language; 4. learning ability.
Full arguments• Pharmacokinetics models: physiologically-based and compartmental-based PK models, kinetics parameters. Dosing and dosing adaptation in children, elderly and uremic patients. Bioavailability and bioequivalence: definitions, “in vitro” and “in vivo” studies. • Macromolecules as components of pharmaceutical formulations. Generalities and polymers’ classification, polymerization mechanisms and techniques. Natural and synthetic polymers in the pharmaceutical field, modified natural polymers. Polymeric pro-drugs • Drug delivery systems. Production. Drug release kinetics. Description of the different DDS: injectable systems, subcutaneous implants, intravaginal, intrauterine and intraocular devices, gastro-intestinal delivery systems, transdermal systems. • Biotechnological therapeutic products: formulation strategies, manufacturing technologies, quality controls
Close course details
Print
CourseSPECTROSCOPIC METHODS IN ORGANIC CHEMISTRY AND LABORATORY OF SYNTHETIC MEDICINAL CHEMISTRY
Course IDF0504
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderPANZA Luigi
TeachersPANZA Luigi, MINASSI Alberto, PIRALI Tracey
CFU15
Course typeAttività formativa integrata
Course mandatorietyOpzional course
Year4
PeriodAnnuale
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
F0480 SPECTROSCOPIC METHODS IN ORGANIC CHEMISTRY CHIM/06 - Organic chemistry PANZA Luigi, MINASSI Alberto
F0481 LABORATORY OF SYNTHETIC MEDICINAL CHEMISTRY CHIM/08 - Pharmaceutical chemistry PIRALI Tracey
Close course details
Show parent course details
Print
CourseSPECTROSCOPIC METHODS IN ORGANIC CHEMISTRY
Course IDF0480
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderPANZA Luigi
TeachersPANZA Luigi, MINASSI Alberto
CFU7
Teaching duration (hours)56
Individual study time 119
SSDCHIM/06 - Organic chemistry
Course typeModulo di sola Frequenza
Course categoryC - Affine o integrativo
Year4
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageItalian
AbstractUltraviolet spectroscopy (UV) Infrared spectroscopy (IR) Nuclear magnetic resonance spectroscopy (NMR) Mass spectrometry (MS)
Reference textsR.M. Silverstein, F.X. Webster, Identificazione spettroscopica di composti organici, Casa Editrice Ambrosiana Additional textbook M. Hesse, H. Meier, B. Zeeh, Metodi spetroscopici in chimica organica, Edises G.F. Pedulli, Metodi fisici in chimica organica, Ed. Piccin H. Günther, NMR spectroscopy, Wiley Ed.
Teaching targetsProvide students with the knowledge of the physical principles underlying the different spectroscopic techniques and instrumentation used for the acquisition of spectra. The course is largely devoted to the interpretation of the spectra obtained with different techniques in order to allow the student to master the different spectroscopies especially from the practical point of view, allowing the student to identify unknown organic compounds. The course is complemented by demonstration visits to the various instruments available in the Department.
PrerequisitesKnowledge of the structures of the main classes of organic compounds
Didattics MethodsLectures with multimedia support and several exercises of structure elucidation.
Grading rulesWritten test usually containing a theoretical question and the identification of an unknown compound by analysis of IR, NMR and mass spectra, followed by a short oral exam. It will be possible, and highly recommended, to pass the exam through in-course tests.
Full argumentsIntroduction to spectroscopic methods. Properties of electromagnetic radiation. Electromagnetic spectrum. Absorption and emission spectroscopy. UV spectroscopy – Molecular energetic levels. Instrumentation. Typical parameters of an absorption spectrum. Electronic transitions and molecular orbitals. Main cromophores. Woodward rules. Law of Lambert-Beer. Uses of electronic spectroscopy. Mention to emission spectroscopy. Infrared spectroscopy (IR) – Traditional and Fourier transformation (FT-IR) spectrometers. The harmonic oscillator. Non-harmonicity and quantization. Type of vibrations. Instrumentation and sample preparation. The IR spectrum and characteristic absorptions of functional groups. Fingerprints region. Nuclear magnetic resonance spectroscopy (NMR) – The nuclear spin. Theory of NMR spectroscopy, pulse tecnique and Fourier transformation. Relaxation. Spectral paraneters: chemical shift, spin-spin coupling, integration. 1H NMR: first order spectra. Analysis of main spin systems. Relationship between structure and chemical shift. Symmetry, chirality, dynamic phenomena and NMR spectrum. Spin decoupling and Nuclear Overhauser effect (nOe). 13C NMR: features of 13C nucleus. Decoupled, off-resonance, DEPT e APT spectra. Relationship between structure and chemical shift. Introduction to main 2D omo- and etheronuclear techniques. Mass spectrometry – Instrumentation. Ion sources: EI, CI, FD, DCI, FAB, APCI, IS, TS, ESI. Mass analyzers: electromagnetic, quadrupole, ion trap, TOF. MS-MS spectra. detectors. Chemical and isotopic mass. Mass and electronic parity. Molecular mass and molecular formula determination. Exact mass and resolution. Choice of ionization method for different class of compounds. Fragmentation and rearrangement reactions of the main classes of organic compounds. Spectra analysis and identification of organic compounds from mass spectra.
Close course details
Show parent course details
Print
CourseLABORATORY OF SYNTHETIC MEDICINAL CHEMISTRY
Course IDF0481
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderPIRALI Tracey
TeachersPIRALI Tracey
CFU8
Teaching duration (hours)32
Individual study time 120
SSDCHIM/08 - Pharmaceutical chemistry
Course typeModulo di sola Frequenza
Course categoryC - Affine o integrativo
Year4
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageItalian
AbstractThe significance of organic synthesis. Safe working in a chemical laboratory. Equipments. Solvents. The reagents. Inert atmosphere techniques. Conducting the reaction itself. Following the reaction. Working up reactions. Purification processes. Product characterization. The research notebook. Searching the literature. Non-conventional techniques. Process chemistry.
Reference textsLa chimica organica in laboratorio - Tomo I - M. d’Ischia - Piccin Chimica organica sperimentale - R.M. Roberts - Zanichelli Vogel’s textbook of practical organic chemistry - A. I. Vogel – Longman Practical process research and development - N. G. Anderson – Academic Press
Teaching targetsThe aim of this course is to introduce the student to the practical organic synthesis. It consists of a series of lessons focused on the safety in laboratory and the main techniques used for the set up and control of the reaction, together with the purification of the product. All these methods are carried out in a series of practical experiments during the laboratory. Moreover, some aspects regarding the scientific literature search and process chemistry will be addressed. At the end of the course, the student will know how to work in a safe manner and will know the main techniques used in an organic synthesis laboratory; he/she will apply the acquired knowledge and understanding in the laboratory, reproducing a procedure for the set up of a reaction taken from the scientific literature in the laboratory; last, the student will be able to communicate his/her knowledge and understanding in the laboratory with the colleagues and the professor. The course will allow the student to gain the necessary judicial autonomy to work in a safe manner, to conduct an organic synthesis in the laboratory, and to search information in the scientific literature.
PrerequisitesOrganic Chemistry 1, Drug Analysis 2
Didattics MethodsThe course in divided in three parts. The first part consists in frontal lessons that regard the safe working in a chemical laboratory and the main techniques used in an organic chemistry laboratory. At the end of this section, procedures of reactions taken from scientific papers are given to the students, translated and analysed at the blackboard. The second section is the laboratory, where the students practice with a series of reactions, using the techniques learned in the first part of the course. In the third part of the course aspects such as searching the literature, non-conventional techniques and process chemistry are handled. One of these lessons is given in the computer room, where the students have the opportunity to search information in the scientific literature using data bases, search engines and Sci-Finder. The frontal lessons are given with the support of power point slides, which are furnished to the students at the beginning of the course.
Grading rulesThe student will give a written test with 30 questions before attending the laboratory. 25 questions concern the topics handled in the frontal lessons and the student has to demonstrate that he/she knows all the safety rules and the main techniques that he/she will apply in the laboratory. 5 questions consist in answering questions and solving exercises that regard a procedure in english taken from a scientific paper. During the laboraotry the student will be evaluated taking into account his/her commitment and the results gained. A second written test of 5 questions at the end of the course will regard the last topics of the course, such as searching the literature, non-conventional techniques and process chemistry. The final mark will take into account the results of the two written tests and of the laboratory activities.
Full argumentsThe significance of organic synthesis. Safe working in a chemical laboratory. Contact with chemical reagents for ingestion, inhalation, direct absorption. Toxic, cancerogenic, teratogenic, flammable, explosive reagents. Equipments. Solvents. The effect of the solvent on chemical reactions. Selection, purification and drying of solvents. The reagents. Purification. Measurement. Inert atmosphere techniques. Conducting the reaction itself. Temperature control. How to heat and cool reactions. Reactions with gas reagents. Special reaction techniques. Catalytic hydrogenation. Reactions with liquid ammonia. Following the reaction. Thin layer cromatography (TLC). Working up reactions. Quenching. Extraction. Drying organic solutions. Filtration. Evaporation of the solvent. Purification processes. Column cromatography. Distillation. Crystallization. Sublimation. Product characterization. The research notebook. Examples of reaction procedures: how to make calculations and choose the right apparatus. Searching the literature. Non-conventional techniques. Green chemistry. Phase transfer catalysis. Ionic liquids. Microwaves. Ultrasonication. Biocatalysis. Industrial organic synthesis. Properties of an industrial synthesis. Process chemistry: laboratory synthesis, scale up, pilot plant, production. Conducting the reaction, work up and purification at industrial level.
Close course details
Print
CourseSTATISTIC WITH R
Course IDF0592
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderRINALDI Maurizio
TeachersRINALDI Maurizio
CFU2
Individual study time 26
SSDMAT/04 - Mathematics education and history of mathematics
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryD - A scelta dallo studente
Year4
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe R software and its use to represent data and for statistical data analysis.
Reference textsReference material is posted on the DIR website
Teaching targets*Knowledge and understanding The course aims to enrich the theoretical knowledge of statistics and probability with appropriate calculation data analysis. Aims of the course is also to display the results. The course in based on the free and open source software R. *Applying knowledge and understanding Students should be able to use the acquired skills even in multidisciplinary context and they should be able to analyse data and generate professional graphical representations. *Making judgements. At the end of the course students are expected to apply R even in different situations and that they have acquired the tools needed to extend their knowledge by themselves. * Communication skills At the end of the course students are expected to be able to express their results both numerically and graphically. * Learning skills. During the course students should learn how to study by choosing their personal path and should become able to choose the appropriate resources.
PrerequisitesThe student should have the basic knowledge of mathematics and statistics
Didattics MethodsPractical lectures are given in the computer lab.
Other informationsReference material and additional informations are posted on the DIR website https://www.dir.uniupo.it/enrol/index.php?id=219
Grading rulesOngoing Quizzes and online Final Examination. Both count toward the final grade in a ratio 3/7.
Full argumentsR software. Elementary operations. Functions and graphs. Import, export in R. Data Structures, packages. Matrices, lists, arrays. The data frame. Working with sata: selecting elements, logical operators. Loops and conditionals. Missing data. Additional graphics packages: ggplot2. Regression line and regression curves. Anova. Pharmacokinetic models. Clustering. Simulations.
Course borrowed fromFARMACIA (1506) - FA0078 Statistica con R
Close course details
Print
CourseTecnologia e Legislazione Farmaceutiche II
Course IDFA0033
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderGIOVANNELLI Lorella
TeachersGIOVANNELLI Lorella
CFU10
Teaching duration (hours)56
Individual study time 158
SSDCHIM/09 - Pharmaceutical and technological applications of chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year4
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
Abstract• Dispersed systems: colloidal systems, emulsions and suspensions. • Semisolid preparations: dermatological formulations. • Nasal and pulmonary dosage forms. • Suppositories. • Production of semi-solid preparations. • Sterilization. • Medical devices. • Pharmaceutical legislation: Italian and supranational laws. Classification of pharmacies and medicines. Dispensation of medicinal products in local pharmacies. General characteristics of cosmetic and homeopathic products. Authorization for marketing of medicinal products. Protection of the intellectual activity. • Propaedeutic lectures and practical exercises in laboratory: preparation, composition of the price, labelling and quality control of magistral and officinal galenic formulations. Use of software for the management of the professional activity.
Reference textsColombo P et al. Principi di tecnologie farmaceutiche. Ed. Ambrosiana. Minghetti P, Marchetti M. Legislazione farmaceutica. Ed. Ambrosiana. Farmacopea Ufficiale Italiana, current edition. European Pharmacopoeia, current edition. Bettiol F. Manuale delle preparazioni galeniche. Ed. Tecniche nuove. Lachman L, Lieberman H, Kanig J. The theory and practice of industrial pharmacy. Ed. Lea & Febiger, USA. Fabris L, Rigamonti S. La fabbricazione industriale dei medicinali. Ed. Esculapio, Bologna. Manuali Tecnici A.F.I., Ed. OEMF, Milano.
Teaching targetsThe objective of the first part of the course is to give to the student the theoretical notions on pharmaceuticals dosage forms explained during the course of Tecnologia e Legislazione farmaceutiche I: semisolid preparations, nasal and pulmonary dosage forms and suppositories. In particular, physico-chemical characteristics of excipients used for the preparation of these dosage forms are explained, together with the technological and biopharmaceutical properties of final forms, the preparation methods in pharmacy and the production in industrial laboratories, and the correlated quality controls. Moreover, the course has the object to provide basic notions of pharmaceutical legislation, national and supranational, regulating industrial activities and the production and marketing of various types of medicinal products, their classification and related dispensing discipline in local pharmacies. The second part of the course aims to provide to the students theoretical and practical information about methods of preparation, price determination, labelling and quality control of magistral and officinal galenic preparations, according to the pharmacopoeia requirements. Particular attention is dedicated to the description of the technological characteristics of the immediate release dosage forms usually prepared in pharmacy and in pharmaceutical industry.
PrerequisitesFundamentals of pharmaceutical chemistry, pharmacology and pharmaceutical technology.
Didattics MethodsThe frontal lessons (7CFU), and the exercises concerning the expedition of a medical recipe, are supported by the aid of multimedia tools for the exposition of the didactic materials. The mandatory practical exercises are carried out individually in the laboratory. Some information about the use of specific informatics media are provided for the management of the professional activity of the pharmacist, and the correlated individual exercises are carried out in the informatics laboratory. 3 CFU are dedicated to all laboratory exercises.
Other informationsAttendance to the lessons: obligatory
Grading rulesThe written exam concerns the theoretical and practical basis about the formulation, preparation and control of the immediate release pharmaceutical dosage forms and about the basic concepts of pharmaceutical legislation. Students may perform the oral exam only if the written one is sufficient; oral exam it can consist of questions intended to test the knowledge and ability to apply in an independent way the knowledge acquired. Moreover, the communication skills of the student are evaluated, in particular the use of specific language for the pharmaceutical and technological discipline. The evaluation of both tests consider the student’s learning skills, in particular the capability to face the professional responsibilities of a pharmacist and of a pharmaceutical technologist. Capability of upgrade, through the scientific publications in the field of pharmaceutical technology. The exams, either written and oral, take place during the official dates and the grade is expressed in thirtieths. During the practical laboratory, the ability to apply the knowledge acquired are evaluated, considering in particular the accurate presentation of the pharmaceutical preparation, the correct expedition of a medical recipe and the composition of the technical report about the quality control of the officinal products that student prepares. Interim evaluations are considered valid for the exam if the grade, expressed in thirtieths, is greater than/equal to eighteen. The overall grade, expressed in thirtieths, is calculated from the average, weighed on the number of CFU, of the grades obtained in the written and oral tests and during the practical exercises.
Full arguments• Dispersed systems: colloidal systems: classification, properties, pharmaceutical applications. Suspensions: definition and properties: wettability (contact angle), sedimentation (Stokes’ Law), zeta potential, stability: flocculation, de-flocculation, caking; pharmaceutical suspensions, routes of administration, requirements, quality assurance tests. Emulsions: definition; tests for identification of emulsion type, emulsifying agents, stability: sedimentation, creaming, coalescence, phase inversion; manufacture methods; quality assurance tests. • Semisolid preparations: principles of rheology; classification of semisolid preparations: definitions, excipients, manufacture methods; dermatological formulations: trans-epidermal penetration; physicochemical and biological factors affecting penetration, percutaneous permeation and absorption. Transdermal therapeutic systems. Liquid crystals. • Nasal and pulmonary dosage forms: classification, characteristics, devices. • Suppositories: definitions and classification; suppository specific excipients; manufacture procedure (melting and compression methods); substitution factor; examples of suppository formulations; specific technological tests; rectal drug delivery systems. • Equipment for the production of semi-solid preparations. • Sterilization: definition, physical and chemical methods; sterility assurance level. • Secondary packaging. • Medical devices: definitions, requirements, classification, examples, CE mark. • Pharmaceutical legislation: Italian government; sources of law; penal and civil code. Supranational laws. Italian health organization. Italian Pharmacopoeia, European Pharmacopoeia and United States Pharmacopoeia. Management of health waste. Type of pharmacy, organic plan, health professions, ethical code. Classification of medicines. Medical prescription: type of prescription, formalisms, validity. Toxic substances: definition, supplying, storage, prescription, dispensation. Narcotic and mood-altering substances: Table 7 of Italian Pharmacopoeia, supplying, storage, documentation, dispensation. Cosmetic products: definition and general characteristics. Homeopathic products: definition and general characteristics. Authorization for marketing of medicinal products. Protection of the intellectual activity • Propaedeutic lectures and practical exercises in laboratory. Galenic preparations: preparation of magistral galenic formulations (suppositories, ovules, syrups, solutions, emulsions, suspensions, creams, ointments, gels, pastes). Composition of the price according to the National Price List of drugs, labelling and control of the preparation. Production of officinal galenic preparations: semisolid preparations for cutaneous application. Perfusion solutions of the pharmaceutical factories and of Hospital Pharmacy. Preparation of isosmotic and isotonic solutions. Quality control tests: control of the dosage forms (in particular solid dosage forms such as capsules and tablets and semisolid preparations) according to Pharmacopoeia requirements. Composition of the certificate of analysis. Use of software for the management of the professional activity.
Close course details
Print
CourseTossicologia e laboratorio di farmacologia
Course IDFA0039
Academic Year2016/2017
Year of rule2013/2014
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderTERRAZZINO Salvatore
TeachersTERRAZZINO Salvatore
CFU6
Teaching duration (hours)24
Individual study time 90
SSDBIO/14 - Pharmacology
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year4
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractTOXICOLOGY MODULE 1. General principles of toxicology 2. Disposition of toxicants 3. Non organ-directed toxicity 4. Target organ toxicity 5. Toxic agents PHARMACOLOGY LABORATORY MODULE Pharmacodynamics Determination of ligand affinity and of maximum number of binding sites. Binding Type 1 - (Progressive increase of the radioactive ligand). The Scatchard plot. Binding Type 2 -(Fixed concentration of radioactive ligand and increasing concentrations of non-radioactive ligand). IC50 calculation. Pharmacokinetics Single intravenous or oral administration: determining of terminal plasma half-life, plasma clearance, renal clearance and volume of distribution. Continuous infusion: calculation of plasma concentration at steady state Repeated administrations: determining maximum and minimum steady-state plasma levels.
Reference textsCassarett and Doull: Elementi di tossicologia, Casa Editrice Ambrosiana Piera Ghi: Tossicologia, Edizioni Minerva Medica. Handouts provided at class.
Teaching targetsKnowledge of toxicodynamic and toxicokinetic mechanisms that regulate the toxic effects produced by synthetic and natural xenobiotics, especially with regard to drugs, and knowledge of methodologies used for evaluation of the toxicological risk derived from exposure to toxic agents. At the end of the course: KNOWLEDGE AND UNDERSTANDING ABILITY the student knows concepts related to -molecular and toxicokinetic mechanisms underlying the development of xenobiotic toxic effects; -the general principles governing the estimation of the risk resulting from exposure to chemical agents. In addition, the student has knowledge of preclinical experimentation required to characterize the toxicological profile of a xenobiotic, in particular to novel drug marketing. APPLYING KNOWLEDGE AND UNDERSTANDING the student is able to: -understand and evaluate the risk/benefit of drugs; -use the toxicological knowledge in the process of research and drug development; -understand and solve questions on pharmacokinetics and pharmacodynamics by experimental data processing. LEARNING SKILLS, JUDGEMENT AND COMMUNICATION SKILLS the student is able to critically discuss on the course topics, avoiding a mnemonic knowledge.
PrerequisitesThere are no formal requirements although to gain the most from the course a knowledge of pharmacology is required.
Didattics MethodsTraditional teaching method through frontal lectures and classroom excercises. The educational material consists of the recommended text books and of material (handouts and slides) made available to students in the dedicated website (https://dir.uniupo.it). The frontal lectures provide close interaction between the teacher and students; during the lesson the teacher asks questions to students to stimulate critical thinking and ability to connect the diverse topics.
Grading rulesTOXICOLOGY MODULE The exam consists of an oral test on the course contents. PHARMACOLOGY LABORATORY MODULE The exam consists of a written test comprising one question on pharmacodynamics and one on pharmacokinetics. The final mark is the average of written and oral tests, expressed in thirties.
Full argumentsTOXICOLOGY MODULE 1. General principles of toxicology: History and scope of toxicology- Principles of toxicology -Mechanisms of toxicity - Risk assessment - Pharmacovigilance - A-F classification of adverse drug reactions. 2. Disposition of toxicants: Absorption, distribution, and escretion of toxicants - Biotransformation of xenobiotics -Toxicokinetics. 3. Non organ-directed toxicity: Chemical carcinogenesis - Genetic Toxicology -Development toxicology. 4. Target Organ toxicity: Toxic responses of the blood - Toxic responses of the immune system - Toxic responses of the liver - Toxic responses of the kidney - Toxic responses of the respiratory system - Toxic responses of the nervous system - Toxic responses of the cardiovascular system - Toxic responses of the endocrine system - Toxic responses of the reproductive system. 5. Toxic agents: Toxic effects of pesticides - Toxic effects of metals. PHARMACOLOGY LABORATORY MODULE Single intravenous or oral administration: determining of terminal plasma half-life, plasma clearance, renal clearance and volume of distribution. Continuous infusion: calculation of plasma concentration at steady state Repeated administrations: determining maximum and minimum steady-state plasma levels.
Close course details
Print
CourseADVANCED SYNTHETIC METHODS
Course IDFA0056
Academic Year2016/2017
Year of rule2012/2013
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderPANZA Luigi
TeachersPANZA Luigi
CFU2
Teaching duration (hours)16
Individual study time 34
SSDCHIM/06 - Organic chemistry
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryD - A scelta dallo studente
Year5
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractProtecting groups Organoboron compounds Organosilicon compounds Organotin compounds Modern synthetic strategies
Reference textsSlides provided by the teacher with references to chemical literature and to advanced books.
Teaching targetsProvide students with the knowledge of modern synthesis techniques to supplement the curricular preparation. Introduce students to the principles of modern organic synthesis and to their use
PrerequisitesKnowledge of the structure and of the reactivity of the main classes of organic compounds
Didattics MethodsLectures with multimedia support. Discussion of examples of total synthesis and exercises.
Grading rulesOral exam based on the critical analysis of a literature article on the synthesis of complex molecules.
Full argumentsProtecting Groups: Introduction to the use of protecting groups in organic synthesis. Protecting groups for the main functional groups: introduction and removal. Orthogonality of protecting groups. Organoboron compounds: Introduction to the element. Boranes and their use in synthesis: alkyl, alchenyl- and alkinylborani. Preparation and reactivity. Outline of boronic acids and their use in cross coupling reactions. Outline of boron cluster. Organosilicon compounds: Introduction to the element. Silicones. Silyl enol ethers, vinylsilanes, epoxysilanes, allylsilanes and their use in organic synthesis. -Silyl carbanions. Trimethylsilyl cyanide. Trimethylsilyl triflate. Trimethylsilyl iodide. Organotin compounds. Introduction to the element. Stannilethers and acetals. Vinyl and allyl stannanes and their use in organic synthesis. Hydrides of tin. Alkynyl stannanes. Modern synthetic strategies. A brief history of organic synthesis. Retrosynthesis: definitions of concepts of synthons, retrons, disconnections, transformations. Retrosynthetic analysis. Guidelines for the application of the different strategies used in the retrosynthetic analysis: strategies based on structure, functional groups or processes. Examples of total synthesis.
Course borrowed fromCHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - FA0056 Metodologie sintentiche avanzate
Close course details
Print
CourseFINAL EXAM
Course IDF0421
Academic Year2016/2017
Year of rule2012/2013
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
CFU30
Individual study time 750
Course typeAttività formativa monodisciplinare
Course categoryE - Prova finale e lingua straniera
Year5
Frequenza obbligatoriaYes
Grading typeFinal grade
Close course details
Print
CourseINTERNSHIP
Course IDF0068
Academic Year2016/2017
Year of rule2012/2013
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
CFU30
Individual study time 900
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryS - Insegnamento di sede
Year5
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Close course details
Print
CoursePHARMACEUTICAL POLICY AND LEGISLATION
Course IDFA0063
Academic Year2016/2017
Year of rule2012/2013
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderDE ROSA Mauro
TeachersDE ROSA Mauro
CFU3
Teaching duration (hours)24
Individual study time 51
SSDBIO/14 - Pharmacology
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryD - A scelta dallo studente
Year5
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Course borrowed fromFARMACIA (1506) - FA0063 Politiche farmaceutiche
Close course details
Print
CourseSTATISTIC WITH R
Course IDF0592
Academic Year2016/2017
Year of rule2012/2013
Degree1505 - CHIMICA E TECNOLOGIA FARMACEUTICHE
CurriculumCORSO GENERICO
Teaching leaderRINALDI Maurizio
TeachersRINALDI Maurizio
CFU2
Individual study time 26
SSDMAT/04 - Mathematics education and history of mathematics
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryD - A scelta dallo studente
Year5
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe R software and its use to represent data and for statistical data analysis.
Reference textsReference material is posted on the DIR website
Teaching targets*Knowledge and understanding The course aims to enrich the theoretical knowledge of statistics and probability with appropriate calculation data analysis. Aims of the course is also to display the results. The course in based on the free and open source software R. *Applying knowledge and understanding Students should be able to use the acquired skills even in multidisciplinary context and they should be able to analyse data and generate professional graphical representations. *Making judgements. At the end of the course students are expected to apply R even in different situations and that they have acquired the tools needed to extend their knowledge by themselves. * Communication skills At the end of the course students are expected to be able to express their results both numerically and graphically. * Learning skills. During the course students should learn how to study by choosing their personal path and should become able to choose the appropriate resources.
PrerequisitesThe student should have the basic knowledge of mathematics and statistics
Didattics MethodsPractical lectures are given in the computer lab.
Other informationsReference material and additional informations are posted on the DIR website https://www.dir.uniupo.it/enrol/index.php?id=219
Grading rulesOngoing Quizzes and online Final Examination. Both count toward the final grade in a ratio 3/7.
Full argumentsR software. Elementary operations. Functions and graphs. Import, export in R. Data Structures, packages. Matrices, lists, arrays. The data frame. Working with sata: selecting elements, logical operators. Loops and conditionals. Missing data. Additional graphics packages: ggplot2. Regression line and regression curves. Anova. Pharmacokinetic models. Clustering. Simulations.
Course borrowed fromFARMACIA (1506) - FA0078 Statistica con R
Close course details
Data synched: 19/12/2017, 19:12