Laurea magistrale ciclo unico 5 anni in Farmacia

Academic program

Print guide
Print
Course ID Course Teachers SSD Curriculum Site CFU Year
FA0003 ANALYTICAL CHEMISTRY AND METHODS IN DRUGS ANALYSIS DEL GROSSO Erika CHIM/08 All 5 1
F0491 COMPUTER SKILLS SALERNO Thomas INF/01 All 1 1
FA0004 GENERAL MICROBIOLOGY FRACCHIA Letizia BIO/19 All 7 1
FA0002 GENERL AND INORGANIC CHEMISTRY GIOVENZANA Giovanni Battista CHIM/03 All 7 1
F0489 HUMAN ANATOMY BOSETTI Michela BIO/16 All 7 1
F0042 HYGIENE BARONE ADESI Francesco MED/42 All 5 1
F0338 MATHEMATICS AND STATISTICS RINALDI Maurizio MAT/04 All 7 1
FA0005 ORGANIC CHEMISTRY I GIOVENZANA Giovanni Battista CHIM/06 All 5 1
F0339 PHYSICS ARCIDIACONO Roberta FIS/07 All 5 1
F0487 PLANT AND ANIMAL BIOLOGY MORO Laura BIO/13 All 8 1
FA0078 Statistica con R RINALDI Maurizio MAT/04 All 2 1
FA0011 ANALYSIS OF MEDICINAL I DEL GROSSO Erika CHIM/08 All 5 2
FA0007 BIOCHEMISTRY RIZZI Menico BIO/10 All 7 2
FA0050 ENGLISH L-LIN/12 All 2 2
F0485 GENERAL PHYSIOLOGY DISTASI Carla BIO/09 All 9 2
FA0012 Management issues in community and hospital pharmacies + Economic evaluation applied to pharmaceuticals and medical technologies JOMMI Claudio SECS-P/07 All 9 2
FA0006 ORGANIC CHEMISTRY II MINASSI Alberto CHIM/06 All 8 2
FA0049 PHARMACOLOGY AND PHARMACOGNOSY + MEDICINAL PLANTS LOMBARDI Grazia, FALLARINI Silvia, POLLASTRO Federica BIO/14, BIO/15 All 14 2
FA0015 Analisi dei medicinali II GALLI Ubaldina CHIM/08 All 8 3
FA0058 ESSENTIALS OF SPECTROSCOPY PANZA Luigi CHIM/06 All 1 3
FA0051 FITOCHIMICA E LABORATORIO DI PREPARAZIONI ERBORISTICHE POLLASTRO Federica CHIM/06 All 8 3
F0595 MOLECULAR BIOLOGY ROSSI Franca BIO/11 All 5 3
FA0016 Microbiologia applicata FRACCHIA Letizia BIO/19 All 5 3
F0417 PATHOLOGY (MEDICAL TERMINOLOGY) SICA Antonio, PORTA Chiara MED/04 All 12 3
F0412 PHARMACEUTICAL CHEMISTRY I SORBA Giovanni, PIRALI Tracey CHIM/08 All 10 3
FA0014 Prodotti alimentari ARLORIO Marco CHIM/10 All 5 3
FA0013 Prodotti per l'alimentazione particolare e nuovi servizi in farmacia TRAVAGLIA Fabiano CHIM/10 All 10 3
FA0020 Biochimica clinica GARAVAGLIA Silvia BIO/10 All 5 4
FA0058 ESSENTIALS OF SPECTROSCOPY PANZA Luigi CHIM/06 All 1 4
FA0018 Farmacologia, farmacoterapia e chemioterapia CANONICO Pier Luigi, CONDORELLI Fabrizio BIO/14 All 20 4
F0413 PHARMACEUTICAL CHEMISTRY II GROSA Giorgio CHIM/08 All 8 4
FA0063 PHARMACEUTICAL POLICY AND LEGISLATION DE ROSA Mauro BIO/14 All 3 4
F0488 TOXICOLOGY AND PHARMACOVIGILANCE ORSETTI Marco Riccardo Lilio BIO/14 All 10 4
FA0017 Tecnologia, legislazione e deontologia farmaceutiche I MOREL Silvia CHIM/09 All 15 4
FA0019 Tecnologia, legislazione e deontologia farmaceutiche II SEGALE Lorena CHIM/09 All 10 4
FA0100 VISUALIZZAZIONE MOLECOLARE MASSAROTTI Alberto CHIM/08 All 1 4
FA0058 ESSENTIALS OF SPECTROSCOPY PANZA Luigi CHIM/06 All 1 5
F0421 FINAL EXAM PROFIN_S All 20 5
F0068 INTERNSHIP NN All 30 5
FA0063 PHARMACEUTICAL POLICY AND LEGISLATION DE ROSA Mauro BIO/14 All 3 5
Print
CourseANALYTICAL CHEMISTRY AND METHODS IN DRUGS ANALYSIS
Course IDFA0003
Academic Year2016/2017
Year of rule2016/2017
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderDEL GROSSO Erika
TeachersDEL GROSSO Erika
CFU5
Teaching duration (hours)40
Individual study time 85
SSDCHIM/08 - CHIMICA FARMACEUTICA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractTheoretical and practical principles of gravimetric analysis (filtration and crystallization) and volumetric (chemical equilibria in solution: acid / base, redox, precipitation, complexometric).
Reference texts• D. S. Hage, J. D. Carr, “Chimica analitica e analisi quantitativa”, Casa Editrice Piccin, edizione italiana • Aràneo, “Chimica analitica Qualitativa”, Casa editrice Ambrosiana Milano; • D.C. Harris, Chimica Analitica quantitativa, Zanichelli; • D.C. Harris, Elementi di Chimica Analitica, Zanichelli; • Skoog and West, Chimica analitica, EdiSES ; • Vogel, Analisi chimica quantitativa, Casa Editrice Ambrosiana; • Tutti i testi di chimica generale
Teaching targetsThe course will give the student the first notions concerning the main techniques used in chemical laboratories and the data analyses
PrerequisitesNone
Didattics MethodsFrontal lessons
Other informationsNone
Grading rulesWritten test: trou or false test; open questions. Possible oral examination only if the teacher consider it necessary
Full argumentsPART A: Introduction to analytical chemistry The analytical process. Sample and sampling. Treatment of the sample: basic features of an analytical method. Units and concentrations. Outline of statistics for analytical chemistry. Precision and accuracy. Types of errors. PART B: Chemical equilibrium in solution. Recalls chemical equilibrium. Systematic treatment of equilibrium analyses: principles of gravimetric and volumetric analyses (tritations). Equilibria of precipitation: the solubility theory (solubility product, common-ion effect, activities). Elements of gravimetric analysis by precipitation and titration curves. Determination of the end point. Acid-base equilibria. Recalls of acid-base theory. Theory Bronsted-Lowry. Solvent role and properties of the solvents. Water proteolysis, ionic product, Kw and pKw. acid dissociation constants, Ka, Kb, pKa and pKb and relationship with Kw. Strong acids and bases. Weak acids and bases. Henderson-Hasselbalch equation. Diprotic acids and bases. Polybasic acids and bases. pH calculation. Acid-base titrations: strong acid with strong base, weak acid with strong base, weak base with strong acid. Determination of the end point. Redox equilibria. Recalls of redox theory (oxidizing and reducing agents. electrochemical series. Fundamentals of electrochemical and potentiometry. Potential standards. Equilibrium constants. The main reference electrodes and measuring). Redox titrations. Common redox reagents. titration curves. Equilibrium of complex formation. The coordination compounds and the binders characteristics. Main chelators used in analytical chemistry. Titration with EDTA. Indicators.
Close course details
Print
CourseCOMPUTER SKILLS
Course IDF0491
Academic Year2016/2017
Year of rule2016/2017
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderSALERNO Thomas
TeachersSALERNO Thomas
CFU1
Individual study time 13
SSDINF/01 - INFORMATICA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryF - Stage e altre attività formative
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageItalian
AbstractStructure of the exam. Introduction to the course. What is a computer. Hardware: Internal components of a computer motherboard , CPU , memory ( RAM and hard disk) Hardware: Interfaces and Peripherals . Capacitive screens and resistive screens . Input and output devices Software: operating systems and application programs . The PC and file management. Computer viruses: what they are and how to treat them . ( 2h ) Software : word processing ( 2h ) Software : spreadsheet, and presentation tools ( 2h ) Internet , Web , identity and reputation ( 2h ) Online transactions and security ( 2h ) Latest analysis and IT innovations ( 2h )
Reference textsAll the reference material is posted on the DIR website
Teaching targetsThe aim of the course is to provide information and methodologies to beginners for the use of PC and useful software packages to produce reports and theses .
PrerequisitesNone
Didattics MethodsLectures are given in a standard classroom , slides and videos are available for download
Grading rulesComputer test with multiple choice questions . The assessment gives rise to pass/no pass evaluation
Full argumentsStructure of the exam. Introduction to the course. What is a computer. Hardware: Internal components of a computer motherboard , CPU , memory ( RAM and hard disk) Hardware: Interfaces and Peripherals . capacitive screens and resistive screens . input and output devices Software: operating systems and application programs . The PC and file management. Computer viruses: what they are and how to treat them . ( 2h ) Software : word processing ( 2h ) Software : spreadsheet, and presentation tools ( 2h ) Internet , Web , identity and reputation ( 2h ) Online transactions and security ( 2h ) Latest analysis and IT innovations ( 2h )
Close course details
Print
CourseGENERAL MICROBIOLOGY
Course IDFA0004
Academic Year2016/2017
Year of rule2016/2017
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderFRACCHIA Letizia
TeachersFRACCHIA Letizia
CFU7
Teaching duration (hours)56
Individual study time 119
SSDBIO/19 - MICROBIOLOGIA GENERALE
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year1
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe course is composed of two parts. The first part, carried out during the first semester, is focused on the following topics: - Structure and function of the prokaryotic cell - Kinetic of microbial growth - Nutritional requirements of bacteria - Environmental effects on microbial growth - Cultivation of bacteria in the laboratory - Control of microbial growth - Duplication and expression of the prokaryotic genome - Horizontal gene transfer The second part, carried out during the second semester, addresses the following themes: - Features of microbial metabolism - Virus: structure and replication cycle of bacterial and animal viruses - Human-microorganism interaction: colonization and virulence factors - Non-specific and specific host defence mechanisms - The artificial active immunization - Antimicrobial drugs: mechanisms of action and resistance
Reference texts- Brock Biology of Microorganisms (14th Edition) Published by Benjamin Cummings, 2014 ISBN-13: 978-0321897398
Teaching targetsThe course aims to provide students with adequate information and basic knowledge on the biology of microorganisms from the point of view of cellular, metabolic and genetic organization, on the peculiarities of these aspects and on the similarities with other living beings. The course will also give students the basic knowledge about the positive and harmful interactions between microorganism and host, the pathogenic activity of microorganisms in general and of some important pathogens in particular, and about the host non-specific and specific defense mechanisms. The structure and replication mechanisms of the principal bacterial viruses (bacteriophages) and animal viruses will be also studied. Finally, the course aims to give students an adequate knowledge of the mechanisms of action of the major antibacterial drugs. The course also provides theoretical insights relating to the manipulation of microorganisms (isolation, propagation in culture, selective and differential media, conservation and sterility concept), the control of their growth (sterilization methods, treatment with disinfecting agents), their quantification and identification, including the resolution of short exercises and problems in the classroom. At the end of the course, the student will acquire theoretical knowledge and understanding about the biology of microorganisms, in particular the structure and functions of the prokaryotic cells components, their genetics and the basic understanding of the most important classes of reactions of the microbial metabolism. Knowledge will also be acquired about the interaction of organisms with the natural environment; in particular, the effects of physical, chemical and nutritional factors on microbial growth and the response to abiotic stress will be understood. An additional educational objective of the course is the understanding of the main microorganism/host interaction mechanisms, the phenomena at the origin of microbial pathogenicity and of innate and acquired host resistance to infections; basic knowledge will also be acquired about the major mechanisms of action of the most important classes of antimicrobial drugs and the resistance mechanisms implemented by pathogenic microorganisms. At the end of the course the student will acquire both the theoretical knowledge and the instruments concerning the application of some of the principal methods for cultivation, enumeration and identification of microorganisms, and will be able to solve simple problems related to microbial counting and to the preparation of culture media and solutions for microbiological use. Finally, the student must demonstrate to have acquired independence of judgment on the different topics addressed during the course, knowledge of their possible applications and repercussions in other scientific fields and skills regarding the verbal and written communication through the use of an appropriate technical and scientific language.
PrerequisitesBasic knowledge of the structure and of the principal functions of the eukaryotic and prokaryotic cell
Didattics MethodsThe course consists of lectures with slides show. Some topics will be deepened with videos in English and Italian. Topics of particular interest and relevance will be examined with the reading of scientific publications.
Other informationsThe slides of the lectures and additional material are available on the website “Didattica in Rete”: https://www.dir.uniupo.it/
Grading rulesThe exam consists of a written test with multiple choice questions (with only one true answer), true/false questions, questions with omitted words, matching words questions and open questions covering all the topics. In particular, the questions will be equally distributed on the two main parts of the course, the first concerning the structure, function, growth and cultivation of microorganisms, the second concerning metabolism, microorganism/host interaction, viruses, antimicrobial drugs. The score assigned to each question will depend on the difficulty and will be specified in the text of the examination. Unanswered or incorrect questions will be given a score of 0. For the open questions, the ability to answer using a suitable technical-scientific language will be also evaluated.
Full arguments- Structure and function of the bacterial cell Structural morphology and size of the bacterial cell The cell membrane: structure, function; transport systems The cell wall of Gram-positive and Gram-negative bacteria Gram staining - Microbial locomotion Flagella, gliding motility, chemotaxis, phototaxis and others - The surface structures and intracellular inclusions Fimbriae, pili, capsules, reserve materials, cytoplasmic inclusions, gas vesicles Endospores -The microbial metabolism: Glycolysis Respiration and electron transport chain The proton motive force The aerobic and anaerobic respiration Main types of fermentation The citric acid cycle The anabolism: the biosynthesis of key monomers Biosynthesis of peptidoglycan -The structure of DNA and DNA replication - Nutritional types of bacteria - Environmental effects on microbial growth Temperature, pH, oxygen. - Cultivation of microorganisms in the laboratory Sterilization and disinfection Complex, selective and/or differential culture media; autoclave sterilization The aseptic technique (isolation of pure culture) Identification of a bacterial strain by biochemical methods - Microbial growth The binary fission The growth cycle of a bacterial population (the growth curve) Continuous-culture: the chemostat system Direct evaluation of microbial growth: viable-cell count The indirect methods (turbidity measurement) Evaluation of the microbial biomass, chemical analysis of a cell component. - The microbial biofilms Growth and biological functions - Principles of molecular biology of microorganisms Synthesis and processing of RNA, protein synthesis - Genetic of microorganisms Transformation Generalized and specialized transduction Plasmids Conjugation Hfr conjugation and chromosomal transfer -Control of microbial growth Sterilization and disinfection: chemical and physical methods for the control of microbial growth - Principles of virology Viruses and virions General properties of viruses (viral structure and classification) Bacteriophages: virulent phages (phage T4), temperate phages (lambda phage) The animal viruses: retroviruses, DNA viruses, RNA (+) and RNA (-) viruses Growth and quantification of bacterial and animal viruses - Interactions host-microorganism Positive and egative interactions between microorganisms and human Virulence factors and bacterial toxins (exotoxins and endotoxins) - Nonspecific host defenses - Specific host defenses The immune response Antigens, T cells and cellular immunity Antibodies and immunity Humoral and cell-mediated immunity - The artificial active immunization Vaccines - Artificial passive immunization (outline) Immune sera, immunoglobulins - Antimicrobial drugs The spectrum of antimicrobial activity Mechanisms of action of antimicrobial drugs Overview of the most common antimicrobial drugs Mechanisms of resistance to antimicrobial drugs
Course borrowed toCHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - FA0022 Microbiologia generale
Close course details
Print
CourseGENERL AND INORGANIC CHEMISTRY
Course IDFA0002
Academic Year2016/2017
Year of rule2016/2017
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderGIOVENZANA Giovanni Battista
TeachersGIOVENZANA Giovanni Battista
CFU7
Teaching duration (hours)40
Individual study time 111
SSDCHIM/03 - CHIMICA GENERALE E INORGANICA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year1
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe matter: elementary particles, atoms, molecules and ions. Chemical formulas. Atomic structure and the periodic system of elements. Chemical bonds. Molecular structure. Valence, oxidation state, coordination number. Chemical reactions: classification and balancing. Thermodynamics, chemical equilibrium, equilibrium constant. Principles of kinetics. States of matter, phase transitions. Solutions: concentration, solubility. Aqueous solutions, pH, acids, bases, salts, buffers. Stoichiometry and solution equilibria. Electrochemistry. Principles of inorganic nomenclature. Chemistry of the elements. Radiochemistry and applications in medicine.
Reference textsM.S. Silberberg. Chimica La Natura molecolare della materia e delle sue trasformazioni. McGraw Hill. ISBN 9788838667459. J.C. Kotz, P.M. Treichel, G. C. Weaver. Chimica. EdiSes ISBN 9788879597777.
Teaching targetsAim of the course is the knowledge of the basic concepts of general and inorganic chemistry required to tackle the following topics of the degree course. Knowledge of the structure and properties of chemicals is required as is the ability to communicate the corresponding information using a suitable and dedicated terminology. The student should be able to predict and calculate the behavior of chemical species, retrieving the necessary data and processing it properly, paying particular attention to aspects of special biological significance.
PrerequisitesBasic concepts of mathematics and physics.
Didattics MethodsClassroom lessons (slides, movies and blackboard exercises). The course material (pdf/ppt files of slides) will be made available to the students in the online platform.
Grading rulesThe final exam of General and Inorganic Chemistry will be organized in three sections: i) general concepts; ii) prediction and calculation of thermodynamic, kinetic, equilibrium properties, iii) chemistry of the elements and their applications. Points i) and iii) will require answering to specific questions, while point ii) will require the resolution of physico-chemical problems. The student must reach at least a 6/10 grade simultaneously in each section to pass the exam. The final grade will be represented by the weighted average of the grades of the three sections.
Full argumentsThe matter: elementary particles, atoms, molecules and ions. Atomic models, quantum numbers, orbitals, electronic configuration and the periodic system of elements. Elements and compounds, chemical formulas, atomic weight, molecular weight, formula weight. Isotopes. Covalent bond, ionic bond, hydrogen bond, metallic bond, intermolecular interactions. Molecular structure: geometry, hybridization, molecular orbitals, resoncance, Lewis structures. VSEPR theory. Valence, oxidation state, coordination number. Principles of inorganic chemistry nomenclature. States of matter, definitions and properties, phase transitions. Gas laws. Chemical reactions: classification and balancing. Basics of chemical metrics. Redox reactions, definition, balancing methods, reduction potential, basics of electrochemistry, electrolysis, batteries. Principles of thermodynamics and application to chemical reactions. Enthalpy, entropy and free energy. Chemical equilibria. Equilibrium constant, influence of the temperature, Le Châtelier principle. Principles of kinetics, reaction rate, reaction order. Solutions: definition, concentration, solubility. Water self-ionisation, pH. Acids, bases, salts, buffers, coordination complexes. Stoichiometry and application to solution equilibria. Chemistry of the elements: natural abundance and sources, properties, industrial applications and biological relevance. Principles of radiochemistry and nuclear reactions, applications to medicine.
Close course details
Print
CourseHUMAN ANATOMY
Course IDF0489
Academic Year2016/2017
Year of rule2016/2017
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderBOSETTI Michela
TeachersBOSETTI Michela
CFU7
Teaching duration (hours)48
Individual study time 141
SSDBIO/16 - ANATOMIA UMANA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year1
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractGenerality: history, techniques used for the study of anatomy, microscopes, anatomical planes and anatomical terminology. Histology: epithelial, connective, muscular and nervous tissues. Most important bones muscles and joints. Blood and hemolymphopoietic organs. The heart: external and internal configuration, the main vessels of the systemic circulation. Functional anatomy of the circulatory system: the circulation in adult and in fetus. The skin. Microscopic macroscopic and functional anatomy of the central nervous system (spinal cord, brain stem, midbrain, cerebrum and cerebellum) and peripheral nervous system (generality of the large nerve plexus and the cranial nerves); the meninges and the cerebrospinal fluid; the main streets of motility and sensitivity; generality of the sympathetic nervous system. Functional anatomy and microanatomy of visceral systems: respiratory, digestive, genital and uropoietic. Functional Anatomy and microanatomy of the endocrine system.
Reference texts- Anatomia Umana di McKinley PICCIN ed. - Anatomia di Seeley SORBONA ed. - Anatomia Umana di Pasqualino-Panattoni UTET - Principi di Anatomia Umana di Tortora e Nielsen Casa Editrice Ambrosiana - Anatomia Umana di Saladin PICCIN ed. - Anatomia Umana di Castano et al. Edi-ermes
Teaching targetsKnowledge of the morphology of the human body. Macroscopic, microscopic and functional human anatomy. Topographic location of organs and microscopic recognition of tissues and organs. Ability to apply their knowledge to describe with autonomy and comunication skills organs and apparatus from a macroscopic and topographic point of view. Ability to apply the microscopic knowledge to understand and describe functional anatomy.
PrerequisitesNO
Didattics MethodsLessons in the classroom with the support of images, video and plastic (skeleton and organs). Laboratory lesson with practice activities on the preparation of biological samples for microscopic observation and slides study
Grading rulesWritten test in mid course, in February (optional) with multiple choice questions on topics: Generality; Microscopic Anatomy; Skin; Bones-Joints-Muscles; Hearth and vessels. Final oral examination. The test will be evaluated in thirty and considered as a third of the final examination. When not passing the test in progress, the arguments listed above will be asked with the rest of the program at the Oral examination. Evaluation of the acquired knowledges and of the ability to use them with comunicative skills and medical terms to describe the asked anatomical structure. The evaluation of the familiarity with microscopic structures will demonstrate functional knowledge of the anatomical structure examined. Together with the description of an anatomical structure it will be tested the ability of the student to connect various topics as a result of a depth and not only a mnemonic study.
Full arguments- GENERAL ANATOMY: General and systematic knowledge of the anatomy, topography and terminology of location and movement, full hollow organs, anatomical position. - MICROSCOPIC ANATOMY: epithelial tissues, connective tissues with particular attention to blood. Emo-limphopoietic organs. - OSTEOARTHROMIOLOGY: general anatomy of the bones, muscles and joints. - CENTRAL AND PERIPHERAL NERVOUS SYSTEM: generality of macroscopic and microscopic anatomy of the central nervous system and peripheral sympathetic nervous system, the cavities of the central nervous system, the cerebrospinal fluid, the blood-brain barrier, the meninges. Spinal cord, brainstem, cranial nerves and their nuclei, forebrain, the main motor and sensory pathways. - CARDIOVASCULAR SYSTEM: generality of systematic anatomy of the cardiovascular system, the circulation in the adult configuration inside and outside of the heart, major vessels of the trunk, cephalic end and the arts. The fetal circulation. - DIGESTIVE SYSTEM: general systematic anatomy of the digestive system, especially the stomach, liver, intestines. General information on the peritoneum. - Respiratory system: general anatomy of the respiratory system systematically, with particular reference to the upper airways and lungs, the pleura generality. - UROGENITAL SYSTEM: general anatomy of the uro-genital systematic, with particular reference to the kidney, the nephron and urinary tract stones. Bladder, uterus, fallopian tubes, sperm streets. -OTHER DEVICES AND SYSTEMS: overview of systematic anatomy of the endocrine system with particular reference to: Hypothalamus, pituitary ovary, testis, adrenal, thyroid, pancreas, digestive juxtaglomerular apparatus
Close course details
Print
CourseHYGIENE
Course IDF0042
Academic Year2016/2017
Year of rule2016/2017
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderBARONE ADESI Francesco
TeachersBARONE ADESI Francesco
CFU5
Teaching duration (hours)40
Individual study time 85
SSDMED/42 - IGIENE GENERALE E APPLICATA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractPrinciples of hygiene and public health; epidemiological methods for public health; infectious disease epidemiology; chronic disease epidemiology; proximal and distal determinants of health; effects of lifestyle on health; primary, secondary and tertiary prevention; evaluation of health interventions; the process of drug discovery and development; adverse drug reactions and pharmacovigilance; evidence-based medicine; the organization of health systems.
Reference textsFaggiano, Donato, Barbone. Manuale di Epidemiologia per la sanità pubblica. Centro Scientifico Editore. 2005 Barbuti, Fara, Giammanco. Igiene e medicina preventiva. Monduzzi Editore. 2008 Rothman. Epidemiology: An Introduction. Oxford press. Versione italiana: Rothman. Epidemiologia. Idelson – Gnocchi
Teaching targetsKNOWLEDGE AND UNDERSTANDING To know the most important sources of epidemiological data. To understand the elements in the design and conduct of the most important types of epidemiological studies. To know the most important sources of bias in epidemiological studies. to understand the criteria for characterizing the causality of associations in Medicine. to know the key features of a systematic review of the scientific literature to know the most important determinants of health in Italy and worldwide to know the differencies between primary, secondary and tertiary prevention. to know the key features of the process of drug discovery and development. to understand the key features of Evidence-Based Medicine. to know the key features of National Health Systems. APPLYING KNOWLEDGE AND UNDERSTANDING to be able to calculate measures of frequency and association to be able to calculate sensitivity, specificity, and predictive values of a clinical test to able to interpret the results of a meta-analysis
PrerequisitesNone
Didattics MethodsLectures
Other informationsNone
Grading rulesWritten exam including Single Best Answer, Open ended questions, and numerical exercises. In particular, open ended questions and numerical exercises will evaluate the ability of the student to calculate basic epidemiological measures and the ability of interpreting the results of a meta-analysis.
Full argumentsGeneral principles of Public Health Definition of Hygiene and Public Health. The concept of Health and its evolution over time. Epidemiological methods for Public Health Introduction to medical statistics (sources of data; fonti; elaboration and presentation of epidemiological data; health indicators: incidence, mortality, prevalence, survival; measures of frequency and association). Main Epidemiological studies: clinical trials, cohort studies, case-control studies, cross-sectional studies, descriptive studies. Sources of uncertainty in epidemiology: the role of chance, bias and counfounding. Effect modification. Causal inference in Epidemiology. Systematic reviews, meta-analyses, guide-lines. Infectious disease epidemiology Non-communicable disease epidemiology Introduction to pharmacoepidemiology. Determinants of health Proximal and distal determinats of health. Effects of lifestyle on health (smoking, alchol consumption, diet, overweight and obesity, physical activity) Preventive interventions Primary, secondary and tertiary prevention. Preventive strategies towards individuals and populations. Vaccinations. Screening. Evaluation of the efficacy of health interventions process of drug discovery and development Adverse Drug Events and pharmacovigilance Evidence-based medicine Disease mongering. The organization of health systems. Healthcare organization; the Italian National Health System (NHS); the corporatization of healthcare. Local Health Authorities and Hospital Health Authorities.
Close course details
Print
CourseMATHEMATICS AND STATISTICS
Course IDF0338
Academic Year2016/2017
Year of rule2016/2017
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderRINALDI Maurizio
TeachersRINALDI Maurizio
CFU7
Teaching duration (hours)48
Individual study time 115
SSDMAT/04 - MATEMATICHE COMPLEMENTARI
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year1
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractFunctions Derivatives Integrals Descriptive Statistics Probability Statistical hyphotesis testing R basics
Reference textsSergio Invernizzi, Maurizio Rinaldi, Andrea Sgarro, Moduli di Matematica e Statistica, Zanichelli Editore, Bologna 2000
Teaching targets*Knowledge and understanding The course is intended to provide students with the knowledge and the ability to manage the mathematical tools required to understand and follow the other courses of the Degree. More specifically the course aims to provide students with basic methods of differential and integral calculus plus the basic notions of probability and statistics needed to understand mathematical models and to undertake statistical analysis of experimental results. *Applying knowledge and understanding Students are expected to be able use the acquired skills even in a multidisciplinary context and they should be able to resort to mathematics and statistics even in situations external to the course. *Making judgements. At the end of the course students are expected to apply learned methods even in different situations and that they have acquired the tools needed to extend their knowledge by themselves. * Communication skills At the end of the course students are expected to be able to express the learned concepts in a clear way. * Learning skills. During the course students should learn how to study by choosing their personal path and should become able to choose the appropriate resources, possibly online.
PrerequisitesThe student should have the basic knowledge of the subject that can be acquired in a normal high school. In particular: arithmetic operations, powers, Cartesian plane, the line equations, parabola and circumference, angles, measured in degrees and radians, circular functions, fundamental formulas of plane and solid geometry. In case of failure in the test of basic knowledge the student should follow the course on basic mathematics and pass the final test.
Didattics MethodsLectures are given either in the classroom or in the computer lab.
Other informationsReference material and further details are provided on the DIR website. https://www.dir.uniupo.it/course/view.php?id=49 Enrolment key is provided during the lectures.
Grading rulesOngoing Quizzes and online Final Examination (possibly splitted in 2 parts). The ongoing quizzes are assigned periodically at the end of a given subject. The Final focuses on all the course matters. Final evaluation gives a weight of 30% to the ongoing quizzes and 70% to the Final. Ongoing quizzes could be replaced by an oral examination.
Full argumentsCredit 1 [Functions] Mathematical concept of functions. Domain and codomain (target), Image. Exponential and power functions. Function composition. Invertible function and inverse function. Inverse circular functions. Logarithms. Credit 2 [Derivatives] Meaning of Derivative Geometric meaning of the derivative. Graphic computation of the derivative through repeated zooms. Approximation of the derivative at a point via Newton quotient. Three point rule. Derivative for tabulated functions. Derivative function. Differentiation rules Derivative of the sum, of the product, of the composite function, of the reciprocal and of the quotient. Derivative of the inverse function. Application of the derivatives Increasing and decreasing functions, Minima and maxima of functions. Computation of maxima and minima with the help of the derivative, Second derivative and study of concavity-convexity of a graph. Credit 3 [Area and Integrals] Numerical Integration Definite integral for positive functions over finite intervals, Computation. Numerical integration with the rectangle methods and trapezoid method. Stochastic integration with the Montecarlo methods. Exact integration The Fundamental Theorem of Calculus. Indefinite integral and antiderivatives. Computation of antiderivatives. Area between two curves. Extensions of the Integral Integrals for non positive functions. Inversions of integration endpoints. Credit 4 [Statistical Data] Introduction Experimental data and simulated data. How to simulate a fair dice. Single Variable Statistical Units. Samples, populations, variables. Single variable statistics. Data presentations: sorting, absolute frequencies, relative frequencies. Conti- nuous and discrete variables. Bar charts, histograms and box-plot. Properties of the Summation symbol. Statistical parameter, Measures of centrality (mean, median) and measures of dispersion (extensions, quartiles, sample variance and sample standard deviation). Statistical Indices for repeated data. Credit 5 [Double variables statistics Probability.] Double variables Two variables representations. Scatter plot. Covariance, Linear regression (linear regression over X and over Y). Application of linear regression. Power and exponential laws. Variable transformations to reduce to a linear relationship. Credit 6 [Probabilities] Frequentist definition of probability. Complete systems of events. The Union and intersection of events. Bayes rule. Probability computations using Bayes rule. Random variables and probabilities densities for discrete and continuous variables. Expected values and standard deviation of a population. Computation of Expected values and variance. Normal variables. Computation of the probability P{a < X < b} for a normal variable. Standard variables. Credit 7 [Statistical Tests] Estimations of statistical parameters Reliability criterions. Confidence level and reliability. Point estimates and interval estimates. Interval estimate of the mean of a normal population. Statistical tests Student’s t-test with with one sample and two samples (paired data, equal variance data). Welch test. chi-square-test.
Close course details
Print
CourseORGANIC CHEMISTRY I
Course IDFA0005
Academic Year2016/2017
Year of rule2016/2017
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderGIOVENZANA Giovanni Battista
TeachersGIOVENZANA Giovanni Battista
CFU5
Teaching duration (hours)40
Individual study time 85
SSDCHIM/06 - CHIMICA ORGANICA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year1
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractBasic concepts of organic chemistry. Structure and nomenclature of the main organic compounds. Stereochemistry (part 1) Natural products.
Reference textsBrown; Chimica Organica, EdiSES McMurry; Chimica Organica, Zanichelli Clayden, Greeves, Warren, Wothers; Fondamenti di Chimica Organica, Zanichelli
Teaching targetsKnowledge of the structure and nomenclature (IUPAC and trivial names) of organic molecules ad functional groups. Ability to analyse complex molecules recognising functional groups and structural residues.
PrerequisitesKnowledge of basic concepts of general chemistry.
Didattics MethodsClassroom lectures. Available to students: pdf copy of lesson slides, exercises and previous exam tests.
Grading rulesWritten test with 5 exercises of organic chemistry (IUPAC nomenclature (2 exercises), natural substance, stereochemistry, functional groups) Eventual integration by oral exam.
Full argumentsCFU 1 Basic concepts of chemistry: atoms, molecules, chemical bonds, hybridisation, molecular structure, resonance, electronegativity. CFU 2 Radicals and functional groups: definition and structures. CFU 3 Nomenclature part 1. IUPAC Nomenclature. Basic concepts, chains, ring, bicyclic systems. CFU 4 Stereochemistry. Stereoisomerism in cyclic systems (cis-trans). Stereoisomerism of alkenes (E-Z). CFU 5 Nomenclature part 2. Arenes, heterocyclic systems, natural products.
Close course details
Print
CoursePHYSICS
Course IDF0339
Academic Year2016/2017
Year of rule2016/2017
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderARCIDIACONO Roberta
TeachersARCIDIACONO Roberta
CFU5
Teaching duration (hours)24
Individual study time 77
SSDFIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA)
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year1
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe course covers the following topics: Introduction on Physics observables and some reminders on Mathematics. Mechanics: Kinematics, Dynamics of the point (outline of complex systems), Statics Electricity and Magnetism Waves, Optics, Acustic Fluidostatics, Fluidodynamics Radioactivity Radiation-matter interaction.
Reference textsGiancoli, “Fisica. Principi e applicazioni” CEA Ragozzino “Principi di Fisica” EdiSES Scannicchio, “Fisica Biomedica” EdiSES J.W. Kane, M.M. Sternheim, Fisica biomedica , Edizioni Mediche Scientifiche Internazionali
Teaching targetsThe objective is to provide the students with a solid knowledge of the main concepts of General Physics, with some outline given to modern physics. These concepts are fundamental for the deep understanding of many of the phenomena in chemistry and in the involved instrumentations. The student will be able to analyze and resolve physics problems of medium/easy level. The student will have to communicate in an effective and appropriate way his knowledge.
PrerequisitesNone
Didattics MethodsThe course is offered in the traditional way, with lectures and collective exercises. Slides, and occasionally videos and multimedia applications are used to assist the lectures. Many hours are devoted to problem solving. Several homeworks are proposed to the students in order to encourage their participation.
Grading rulesMidterm written test. Final written examination, with exercizes and theory. Final oral examination optional.
Full argumentsIntroduction on Physics observables and some reminders on Mathematics. Goniometric functions. Vectors algebra. Measurement significant figures. Fundamental and derived observables. Measurements units and SI System. Units conversion. Physics laws. Mechanics Reference frames. Velocity, acceleration. Motion (linear, accelerated, circular). Freely falling object. Newton's laws. Mass, force. Friction. Work and energy.Conservative and nonconservative forces. Mechanical energy and its conservation. Power. Linear momentum and its conservation. Elastic and inelastic collisions. Center of Mass. Rotational Motion: angular acceleration, torque and rotational inertia. Angular momentum and its conservation. Rigid objects motion. Static equilibrium. Simple harmonic motion. Elasticity. Dumped and forced oscillations: resonance. Electricity and magnetism Electric charge, Coulomb law, electric field and Gauss's law. Electric potential. Definition of electronvolt. Electric dipole and its characteristics. Dipole in a uniform electric field. Conductors and insulators. Capacitor and its properties. Capacitors in series and in parallel. Electric current. Resistance and resistivity. Ohm laws. Resistors in series and in parallel. Electric power. Joule effect. DC and AC simple electric circuits. Magnetic field. Lorentz force. Mass spectrograph.. Magnetic force on a wire with current. Magnetic fields induced by currents: straight wire, spire, solenoid. Magnetic dipole and its characteristics. Magnetic field flux. Faraday-Neumann-Lenz law. Electromagnetic waves. The frequency spectrum and the visible light. Photoelectric effect. Corpuscolar nature of light. Photon. X ray generation. X-ray tube. Waves,optics, acustic Characteristics of wave motion. Wave speed in a medium. Reflection and transmission. Interference. Standing waves. Refraction and diffraction. Sound characteristics. Intensity of sound: decibel. Sources of sound. Doppler effect. Doppler flow meter. The ray model of light and its behaviour.Young's experiment. Single slit diffraction. X rays and diffraction. Fluids Pressure, density. Pascal's principle. Hydrostatic pressure. Atmospheric pressure. Stevino's law. Archimedes' principle. Fluids in motion: equation of continuity. Bernoulli's law. Viscosity. Poiseuille's equation. Hydrodinamic resistance. Stokes' law. Sedimentation velovity. Radioactivity Outline on atomic structure. Nucleus properties: dimensions, mass, binding energy. Stability curve. Alfa, beta and gamma decays. Radioactive decay law. Mean lifetime and half life; activity. Radiation-matter interaction. Outline on charged particle, photons and neutrons interaction with matter. Biologic effects. Dose.
Close course details
Print
CoursePLANT AND ANIMAL BIOLOGY
Course IDF0487
Academic Year2016/2017
Year of rule2016/2017
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderMORO Laura
TeachersMORO Laura
CFU8
Teaching duration (hours)64
Individual study time 136
SSDBIO/13 - BIOLOGIA APPLICATA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year1
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractBasic properties and components of living organisms (proteins, lipids, carbohydrates and nucleic acids) DNA organization, replication and repair Principles of transcription and translation of the genetic information Cell structure and functions Cell communication Animal and plant cell comparison
Reference textsBiologia molecolare della cellula, Alberts, Zanichelli L’essenziale di Biologia molecolare della cellula, Alberts, Zanichelli Biologia cellulare e molecolare, Karp, Edises Il mondo della cellula, Becker, Edises Biologia Vegetale, Longo, UTET Biologia vegetale, Pupillo, Zanichelli Biologia delle piante, Raven, Zanichelli
Teaching targetsTo provide students with basic knowledge of structural organization of eukaryotic cells of animals and plants, on cellular processes and intercellular relationships. Provide also basic knowledge on the mechanisms of transmission and expression of genetic information
Prerequisitesnone
Didattics MethodsClassroom lectures
Grading rulesWritten short answer-exam (exams are held in February, June / July and September with at least two calls per session).
Full arguments• Biological macromolecules: nucleic acids DNA and RNA, amino acids and proteins, lipids and carbohydrates. • DNA: the double helix structure. Levels of organization of DNA inside the cell: nuclear chromatin and chromosome structure. DNA replication. Mechanisms of control of the fidelity of copying the genetic message. Mutations: importance in the pathology and evolution. • Molecular definition of gene. • The transcription and maturation of RNAs. • The lac operon as a paradigmatic example of gene regulation in prokaryotes. • The modulation of gene expression in eukaryotes. • The genetic code and its characteristics. • The protein synthesis. • Plasma membrane: organization of the phospholipid bilayer, proteins and sugars. • The mechanisms of transport of small molecules: permeability of the bilayer, channel proteins and carrier proteins, active and passive transport. • Rough endoplasmic reticulum and Golgi apparatus: membrane and secreted protein synthesis, signal sequences, glycosylation and maturation of proteins in the Golgi. Exocytosis and endocytosis. • Smooth endoplasmic reticulum. Lysosomes and peroxisomes . • Mitochondria. • General principles of cell communication. Properties of receptors and intracellular generation of messages. The extracellular matrix: glucosamminoglycans, proteoglycans, structural proteins and adhesive proteins. • The cytoskeleton: actin and myosin microfilaments, intermediate filaments and microtubules The phases of the cell cycle and mitosis. The cell cycle control. Comparison of plant and animal organisms. • General features of plant cells: size, shape, organization, wall, plastids, vacuole. • Wall: wall formation, chemical composition of the wall, primary and secondary wall cell wall modifications. Importance of the wall in the control of osmotic pressure (see also the vacuole). • Plastids: plastids in the meristematic cell, differentiation, forms and interconversion between the plastids, hypothesis on the origin of plastids. The plastids in the adult cell: chloroplasts, leucoplasts, chromoplasts. • Vacuole: the vacuole in the meristematic cell, differentiation, the vacuole in the adult cell. Importance of the vacuole in the control of osmotic pressure. Solid and liquid includes of the vacuole. • Growth and development of plant cells. Characteristics of the meristematic cell and of adult cell. • The plant tissues. • Photosynthesis: dark phase and light phase. • Plant hormones: auxin, cytokinins, gibberellins, ethylene and abscisic acid. • Responses of plants to external stimuli, light and temperature
Close course details
Print
CourseStatistica con R
Course IDFA0078
Academic Year2016/2017
Year of rule2016/2017
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderRINALDI Maurizio
TeachersRINALDI Maurizio
CFU2
Individual study time 26
SSDMAT/04 - MATEMATICHE COMPLEMENTARI
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryD - A scelta dallo studente
Year1
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe R software and its use to represent data and for statistical data analysis.
Reference textsReference material is posted on the DIR website
Teaching targets*Knowledge and understanding The course aims to enrich the theoretical knowledge of statistics and probability with appropriate calculation data analysis. Aims of the course is also to display the results. The course in based on the free and open source software R. *Applying knowledge and understanding Students should be able to use the acquired skills even in multidisciplinary context and they should be able to analyse data and generate professional graphical representations. *Making judgements. At the end of the course students are expected to apply R even in different situations and that they have acquired the tools needed to extend their knowledge by themselves. * Communication skills At the end of the course students are expected to be able to express their results both numerically and graphically. * Learning skills. During the course students should learn how to study by choosing their personal path and should become able to choose the appropriate resources.
PrerequisitesThe student should have the basic knowledge of mathematics and statistics
Didattics MethodsPractical lectures are given in the computer lab.
Other informationsReference material and additional informations are posted on the DIR website https://www.dir.uniupo.it/enrol/index.php?id=219
Grading rulesOngoing Quizzes and online Final Examination. Both count toward the final grade in a ratio 3/7.
Full argumentsR software. Elementary operations. Functions and graphs. Import, export in R. Data Structures, packages. Matrices, lists, arrays. The data frame. Working with sata: selecting elements, logical operators. Loops and conditionals. Missing data. Additional graphics packages: ggplot2. Regression line and regression curves. Anova. Pharmacokinetic models. Clustering. Simulations.
Course borrowed toCHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - F0592 STATISTICA CON R
CHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - F0592 STATISTICA CON R
CHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - F0592 STATISTICA CON R
CHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - F0592 STATISTICA CON R
FARMACIA (1506) - FA0078 Statistica con R
FARMACIA (1506) - FA0078 Statistica con R
FARMACIA (1506) - FA0078 Statistica con R
FARMACIA (1506) - FA0078 Statistica con R
Close course details
Print
CourseANALYSIS OF MEDICINAL I
Course IDFA0011
Academic Year2016/2017
Year of rule2015/2016
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderDEL GROSSO Erika
TeachersDEL GROSSO Erika
CFU5
Teaching duration (hours)24
Individual study time 77
SSDCHIM/08 - CHIMICA FARMACEUTICA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractQuantitative analysis of the drugs through titrations + experiences titration laboratory
Reference texts* E. Abignente, D. Melisi, M.G. Rimoli, “Principi diAnalisi quantitativa dei medicinali”, Loghìa. * D. S. Hage, J. D. Carr, “Chimica analitica e analisi quantitativa”, Casa Editrice Piccin, edizione italiana * Vogel, “ Analisi chimica quantitativa”, Casa Editrice Ambrosiana * D.C. Harris, “Chimica Analitica Quantitativa”, Zanichelli. * Skoog and West, “Chimica Analitica”, EdiSES * F.Savelli-O. Bruno, “Analisi chimico farmaceutica”, Casa editrice Piccin Padova * D.L. Pavia, G.M. Lampman, G.S. Kriz, “Il laboratorio di chimica organica”, Edizioni Sorbona Milano
Teaching targetsThe course will give the student the first notions concerning the main techniques used in chemical laboratories. After the theoric part will follow some practical exercises in order to deepen the topics and to allow the student to acquire the basic handedness useful in laboratory.
PrerequisitesExam preparatory: General and Inorganic Chemistry for the frequency of the laboratory lessons. General and Inorganic chemistry and Analytical Chemistry and methodologies for analysis of medicinal products must be passed before the exam
Didattics MethodsFrontal lessons and laboratory experiences
Other informationsNone
Grading rulesA. ongoing evaluation during laboratory lessons. B. Written test (trou or fals questions, opens questions and problems) C. Possible oral examination in the case of written test at the sufficient limit
Full argumentsLABORATORY SAFETY LABORATORY GLASSWARE: use and maintenance. MEASURES OF WEIGHT: technical and analytical scales. MEASURES OF VOLUME: calibrated and graduated glasses. Expression of the concentration. QUANTITATIVE CHEMICAL ANALYSIS: VOLUMETRIC ANALYSIS -preparation of standard solutions by weighing and by dilution -concept of titration (direct and indirect titration) -standard solutions and primary standards -determination of the end of a titration: equivalence point, end-point and error tritation -concept of indicator -chemical reactions of titrations: acid-base; redox; gravimetric; complexometric.
Close course details
Print
CourseBIOCHEMISTRY
Course IDFA0007
Academic Year2016/2017
Year of rule2015/2016
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderRIZZI Menico
TeachersRIZZI Menico
CFU7
Teaching duration (hours)56
Individual study time 119
SSDBIO/10 - BIOCHIMICA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian with slide in English
Abstract- Proteins - Lipids - Carbohydrates - Enzymes - Basic thermodynamic concepts in metabolism - Carbohydrates metabolism - Biological oxidation - Lipids metabolism - Amino-acids metabolism - Nucleic acids - DNA replication - DNA transcription - Protein synthesis
Reference texts- Donald Voet, Judith G. Voet Charlotte W. Pratt FONDAMENTI DI BIOCHIMICA Terza edizione Italiana 2013, Zanichelli Editore ISBN 9788808175441 - David L. Nelson, Michael M. Cox I PRINCIPI DI BIOCHIMICA DI LEHNINGER 2006, Zanichelli Editore ISBN 978-8808-19774-0 - Thomas M: Devlin BIOCHIMICA con aspetti clinico-farmaceutici 2013, EdiSES srl ISBN: 978 8879 597 807
Teaching targetsThe Course aims at providing the necessary knwoledge to understand: (1) the structure, the function and the structure-function relationship of biological macromolecules amd (2) the metabolism. The core of the course consists on the in depth description and analysis, in different contexts, of major metabolic pathways to develop the capacity to see the metabolism as a highly integrated network with particular attention to regulatory and energetic aspects and to the description of the molecular bases of diseases. Overall, the course aims at developing in the student the capacity to see the effect of a pharmacological intervention on a specific target at the level of the whole cell/organ/organism and to analyse the effects of drug action with critical thinking. Attention is also dedicated to nomenclature and “biochemistry language” seen as a fundamental aspect to develop the essential communication skills to efficiently operates in the highly multidisciplinary field of drug development and distribution and with the general public.
PrerequisitesThe knowledge of the basic principles of general biology, phisycal-chemistry, inorganic and organic chemistry is essential. It is therefore highly recommended that the student has passed the exams of General Biology and Inorganic Chemistry and have attended the Course of Organic Chemistry , before taking the course of Biochemistry.
Didattics MethodsEx-cathedra traditional lectures. During the Course, after a specific topic has been covered by the lectures, a discussion with the students is conducted to allow both the teacher and the students to assess the extend to which the different concepts (and not specific information) have been understood and received always trying to stimulate and develop a critical thinking attitude.
Other informationsNA
Grading rulesWritten and oral exams. The written exam is based on four open questions spanning the whole program with two questions specifically addressing the central metabolism. Metabolites chemical formula, enzymatic reactions and regulation of metabolic pathways are invariably requested. Only the students that pass the written exam (i.e. that received a mark equal or higher than 18/30) can proceed to the oral part during which, starting from the questions asked in the written exam, the capacity of the student to link different topics with critical thinking in both pathological and/or physiological states, will be assessed together with the communication skills.
Full arguments- Proteins: amino-acids: structure, properties, function. The peptide bonds. Structural organization of proteins: amino-acid sequence, secondary structures; overall structure: fold type; quaternary structure. The process of protein folding. Chaperonines. Oxygen transport. Myoglobin and Hemoglobin: structure and function; allostery and allosteric factors; hemoglobin variants; the theory of co-operativity: sequential model and concerted model - Lipids: structure, properties and functions - Carbohydrates: structure, properties and functions; glycoproteins - Enzymes: classification; coenzymes; Theory of catalysis; Enzyme kinetics; mechanisms of irreversible and reversible enzyme inhibition; regulation of enzyme activity; examples of enzyme catalysis (serine proteinases). -Basic thermodynamic concept in metabolism: phospho-compounds; ATP and the reaction of phosphorylation. Redox equilibrium in the biological systems: NAD(P) and FAD - Carbohydrates metabolism: Glycolysis. Fermentation. Glycogen degradation. Gluconeogenesis. Pyruvate oxidation and the citric cycle. - Biological oxidation: the respiratory chain: electron transport and oxidative phosphorylation. FoF1 ATP synthase. - Lipids metabolism: lipids transport and activation; fatty acids transport into mitochondria; the process of beta-oxidation: odd chain, saturated and unsaturated fatty acids. Ketone bodies. Fatty acids biosynthesis. - Amino-acids metabolism. Oxidation of amino-acids and the urea cycle. - DNA replication: the DNA replication machinery in prokaryotes and eukaryotes and major differences - DNA transcription: synthesis of mRNA; RNA polymerase: structure and enzyme mechanism; post-trancriptional modifications; regulation of transcription - Protein synthesis: the genetic code; the process of translation: tRNA; aminoacyl-tRNA synthetases; ribosome structure and catalysis; initiation-elongation-termination processes in protein synthesis; ribosome inhibition; post-translational modifications.
Close course details
Print
CourseENGLISH
Course IDFA0050
Academic Year2016/2017
Year of rule2015/2016
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
CFU2
Individual study time 50
SSDL-LIN/12 - LINGUA E TRADUZIONE - LINGUA INGLESE
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryE - Prova finale e lingua straniera
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Print
CourseGENERAL PHYSIOLOGY
Course IDF0485
Academic Year2016/2017
Year of rule2015/2016
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderDISTASI Carla
TeachersDISTASI Carla
CFU9
Teaching duration (hours)72
Individual study time 153
SSDBIO/09 - FISIOLOGIA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year2
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThis course deals with the functioning of the human body at all levels and introduces the fundamental principles of cell physiology, homeostasis, and control mechanisms in mammals. Covers the basics of human physiology including the cellular functions involved with membrane transport and cell signaling, electrical activity of the cells, muscle contraction as well as the basic functions of human nervous, endocrine, digestive, cardiovascular, respiratory and urinary system
Reference texts1) SILVERTHORN DU, Human Physiology: An Integrated Approach, Pearson 2) STANFIELD C.L. Principles of Human Physiology, Pearson 3) PURVES D et al. Neuroscience, Sinauer 4) D'ANGELO, PERES. Fisiologia. 2011. Edi-ermes
Teaching targetsThe course aims to provide the basics of cell physiology and the physiology of organs and systems. Students will acquire the knowledge and understanding of the mechanisms associated with the functioning of cells, tissues, organs and apparatus in the human body. They will be able to expose the contents of the course in a logical and comprehensive way, with good mastery of the scientific language, by linking the various topics. They will be able to apply knowledge to pharmacological and technological disciplines in order to understand the action of the drugs and biomolecules
PrerequisitesHuman Anatomy
Didattics MethodsConventional lectures
Grading rulesThe exam consists of a written test that will take place in the computer classroom of the Department. The written test consists of 30 questions, mostly multiple choice questions, with some requiring True or False responses and an essay question. The written test is aimed at assessing the acquired knowledge and understanding. The essay question is also aimed verifying student's communicative and expressive skills.
Full argumentsCell physiology: cellular membranes and transmembrane transports. Carriers, pumps and channels. Endocytosis, exocytosis. Membrane potentials and action potentials. Contraction of skeletal muscle. Excitation of skeletal muscle: neuromuscular transmission and excitation-contraction coupling. Contraction and excitation of smooth muscle. The nervous system. General principles and sensory physiology. Organization of the nervous system, functions of synapses. Sensory receptors, neuronal circuits for processing information. Somatic sensations: the tactile and position senses. Pain and thermal sensations. Motor and integrative neurophysiology. The cord reflexes Cortical and brain stem control of motor function. Contributions of the cerebellum and basal ganglia to overall motor control. Cerebral cortex, intellectual functions of the brain, learning and memory. The limbic system and the hypothalamus. The autonomic nervous system and the adrenal medulla. Cardiac muscle: the heart as a pump and function of the heart muscles. Rhythmical excitatory and conductive system of the heart. The normal electrocardiogram. Cardiac output, venous return, and their regulation. The circulation: pressure, flow, and resistance. Vascular distensibility and functions of the arterial and venous systems. The microcirculation and lymphatic system: capillary fluid exchange, interstitial fluid, and lymph flow Nervous regulation of the circulation, and rapid control of arterial pressure. Blood cells and blood coagulation. Kidneys: glomerular filtration, renal blood flow, and their control. Tubular reabsorption and secretion. Urine concentration and dilution; regulation of extracellular fluid osmolarity and sodium concentration. Renal regulation of potassium, calcium, phosphate, and magnesium; integration of renal mechanisms for control of blood volume and extracellular fluid volume. Acid-base regulation. Respiration. Pulmonary ventilation. Pulmonary circulation, pleural fluid. Physical principles of gas exchange; diffusion of oxygen and carbon dioxide through the respiratory membrane. Transport of oxygen and carbon dioxide in blood and tissue fluids. Regulation of respiration. Gastrointestinal physiology motility, nervous control, and blood circulation. Propulsion and mixing of food in the alimentary canal. Secretory functions of the alimentary tract. Digestion and absoprtion. Body temperature regulation. Endocrinology. Pituitary hormones and their control by the hypopthalamus. Thyroid metabolic hormones. Adenocortical hormones. Insulin, glucagon, and diabetes mellitus. Parathyroid hormone, calcitonin, calcium and phosphate metabolism, vitamin D.
Close course details
Print
CourseManagement issues in community and hospital pharmacies + Economic evaluation applied to pharmaceuticals and medical technologies
Course IDFA0012
Academic Year2016/2017
Year of rule2015/2016
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderJOMMI Claudio
TeachersJOMMI Claudio
CFU9
Teaching duration (hours)72
Individual study time 153
SSDSECS-P/07 - ECONOMIA AZIENDALE
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year2
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractFirst part The Italian health care system and the regulation of the pharmaceutical market. Second Part The organisations where pharmacists work: community pharmacies, industry and health care organisations. Management issues. Case-studies on marketing and logistics applied to community pharmacies. Third part Economic evaluation of drugs. Theory and applications to case-studies. Fourth part Indicators of drugs consumption and expenditure.
Reference textsPart 1: Gianfrate F, Il mercato dei farmaci tra salute e business, Franco Angeli Editore, 2014 ed altre letture. Part 2: Maggi D (a cura di) (2013), Economia dell'azienda farmacia e del settore farmaceutico, Egea, Milano Part 3: Mennini FS, Cicchetti A, Fattore G, Russo P. La Valutazione Economica dei Programmi Sanitari. Il Pensiero Scientifico ed. 2011. Terza Edizione. Part 4: Readings list The instructor will load slides on the dedicated e-learning space. Students attending the course will be provided access to the slides presented
Teaching targetsThe course aims at (i) making students aware of the regulatory context of the community pharmacies and the pharmaceutical companies and of innovation processes in the pharmaceutical industry, (ii) facing management issues in the community pharmacies, (iii) and carrying out drugs comparative analysis from an economic perspective. The students are also expected to apply knowledge and competences to exercises on economic evaluation of drugs and case-studies on marketing and drugs logistics. Finally students are expected to develop sutonomy and comminucation skills through a groups project.
PrerequisitesNone
Didattics MethodsThe course is organised in traditional lectures, class discussion of exercises and case-studies. Students are also required to work on a groups project. Topics and organisation of groups project are presented during the first classes. Students are required to participate fully in class and pull their weight in group work. Group projects will be graded.
Other informationsNone
Grading rulesGrading is based on: • two partial written exams (one - during the course or in February 2017- on the topics discussed during the first part of the course; one – June, July and September 2017 - on the topics discussed during the second part of the course) (80% of the final grade; 40% each); • groups project results (20% of the grade). Students are required to prepare a written document (.doc, max 10 pages) and a PowerPoint presentation (max 15 Slides) by the last class, when findings of the projects will be discussed. Both the documents should include a first page with the First Name, Surname and Matricola Number of the group’s members. If the group does not present its work, its members will be not graded (null grading). The organisation of groups project and minimum requirements for its members will be discussed in class; • if a student does not participate in any group, he/she required to carry out an individual work on the same topic of the groups project and provide the instructor his/her work (written document, .doc, max 10 pages) by the second partial written exam. Students are invited to consider that: • the first partial written exam can be carried out only during the course or in February 2017. Since June 2017, students who have not carried out the first partial written exam can sustain only a general written exam on the whole programme (80% of grades); • the second partial written exam can be carried out only in June, July and September 2017. Afterwards students are required to sustain only the general written exam and all partial grades will be lost; • groups / individual projects grades (20% of total grade) are for ever valid; • students are not required to pass a partial written exams to get a final grade. However also a grade below 18 will be considered to calculate the weighted final grade; • before starting the exam, the student should inform the instructor if he / she is willing to carry out the second partial exam or the general written exam; • students are allowed to repeat the exam in any scheduled date after the date the exam has been sustained.
Full argumentsFirst part The Italian health care system and regulation of the pharmaceutical market. The Italian health care systems. Pharmaceutical market. The economics of drugs Research and Development. Patent protection. Pharmaceutical market regulation: Marketing Authorisation, Price and Reimbursement, Distribution, Regional and Local Policies. Second Part The organisations where pharmacists work: community pharmacies, industry and health care organisations. Management issues. - The organisations and the their functions - Marketing: theory and case-studies - Accounting - Costs analysis - Logistics and supply chain: theory and case-studies Third part Economic evaluation of drugs Health Technology Assessment. Costs and efficacy/effectiveness: definition and assessment. Economic evaluations and their use in decision-making. Budget impact analysis; exercises on the economic evaluation of drugs Fourth part Indicators of drugs consumption and expenditure.
Close course details
Print
CourseORGANIC CHEMISTRY II
Course IDFA0006
Academic Year2016/2017
Year of rule2015/2016
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderMINASSI Alberto
TeachersMINASSI Alberto
CFU8
Teaching duration (hours)64
Individual study time 136
SSDCHIM/06 - CHIMICA ORGANICA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year2
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractStereochemistry (part 2). Reactivity of functional groups in aliphatic, aromatic and selected heterocyclic compounds. Introduction to the reactivity of organic natural compounds
Reference textschimica organica, bruno botta, edi-ermes chimica organica, peter vollhardt, zanichelli
Teaching targetsKnowledge of the stereochemistry of organic compounds, especially stereocenters (R/S).identification and analysis of the various stereogenic centers in the molecule Knowledge of the reactivity and synthesis of functional groups, arenes, heterocycles and natural products.ability to analyze and recognize the various functional groups present in the molecule and to evaluate the reactivity in the various reaction conditions.
PrerequisitesExam preparatory General and Inorganic Chemistry and Organic Chemistry 1.
Didattics MethodsClassroom lectures. Available to students: pdf copy of lesson slides, exercises and previous exam tests.
Grading rulesWritten test with organic chemistry exercises, which will evaluate the knowledge of the reactivity of various functional groups analyzed during the course and the student's ability to apply this knowledge led to the synthesis of target molecules. Possible oral examination to supplement the written test
Full argumentsCFU 1 Symmetry: elements and operations. Chirality. CIP rules and R/S descriptors. Enantiomers and diastereomers. Resolution of stereoisomers. Optical activity and enantiomeric excess. Exercises. CFU 2-7 Chemical reactions: classification, chemical metrics, atom mapping, stoichiometry of organic reactions. Principal reactions and syntheses of: - Alkanes and cycloalkanes - Alkenes, dienes and alkynes - Alogenoalkanes and organometallic reagents (Mg, Li) - Alcohols, ethers, thiols and thioeters - The carbonyl group: aldehydes and ketones - Carboxylic derivatives: carboxylic acids, esters, amides, acyl halides, anhydrides and nitriles - Amines - Arenes - Heterocyclic compounds Exercises CFU 8 Introduction on the reactivity of natural products: lipids, aminoacids, carbohydrates. Terpenes and isoprenic rule. Exercises.
Close course details
Print
CoursePHARMACOLOGY AND PHARMACOGNOSY + MEDICINAL PLANTS
Course IDFA0049
Academic Year2016/2017
Year of rule2015/2016
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderLOMBARDI Grazia
CFU14
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year2
PeriodAnnuale
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
FA0044 PHARMACOLOGY AND PHARMACOGNOSY BIO/14 - FARMACOLOGIA LOMBARDI Grazia
FA0045 MEDICINAL PLANTS BIO/15 - BIOLOGIA FARMACEUTICA FALLARINI Silvia, POLLASTRO Federica
Close course details
Show parent course details
Print
CoursePHARMACOLOGY AND PHARMACOGNOSY
Course IDFA0044
Academic Year2016/2017
Year of rule2015/2016
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderLOMBARDI Grazia
TeachersLOMBARDI Grazia
CFU9
Teaching duration (hours)72
Individual study time 153
SSDBIO/14 - FARMACOLOGIA
Course typeModulo di sola Frequenza
Course categoryB - Caratterizzante
Year2
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageItalian
AbstractThe Course is organized in a section (4 CFU) of General Pharmacology and one (5 CFU) of Pharmacognosy. During the Course, the student will acquire specific skills on the application of pharmacological knowledge and develop independent judgment, communication skills, and ability to learn. In the first part of the Course the basis of drug activities will be treated (principles of Pharmacodynamics and Pharmacokinetics). The factors that determine the variability in drug responses, the drug to drug interactions, the adverse drug reactions, the abnormal reactions to drug delivery, as well as some principles of Pharmacogenetics and Pharmacovigilance will be also considered. The second part of the Course will be inherent in the systematic treatment of several natural compounds used in therapy.
Reference textsH.P. Rang, M.M. Dale, J.M. Ritter, Farmacologia, Ed. Casa Editrice Elsevier-Masson B.G. Katzung, Farmacologia Generale e Clinica, Ed. Piccin Michelle A. Clark, Richard Finkel, Jose A. Rey, Karen Whalen, Basi della Farmacologia, Ed. Zanichelli Goodman & Gilman Le basi farmacologiche della Terapia. Il Manuale, Ed. Zanichelli A. Bruni, Farmacognosia generale e applicata, Ed. Piccin Trease, W.C. Evans, Pharmacognosy, Ed. Elsevier Dewick P.M., Chimica, Biosintesi e bioattività delle sostanze naturali, Ed. Piccin E. Ragazzi, Farmacognosia minerale, Ed. CEDAM
Teaching targetsThe Course aims to give to the students the principles of Pharmacology and Pharmacognosy. To achieve this goal a section (4 CFU) of General Pharmacology, dealing with the basis of drug action, and a section (5 CFU) of Pharmacognosy, dealing with the general principles as well as the specific study of natural bioactive compounds, will be considered.
PrerequisitesWe strongly suggest to pass the Biology, Biochemistry, Physiology, and Pathology exams before studying this Course
Didattics MethodsLectures will be given throughout the October-January and March-June. The students will be constantly stimulated to participate to the lesson with questions and comments in order to ensure the achievement of the goals. Seminars on specific scientific topics will be always organized.
Other informationsThe Professor will receive the students for specific questions every day by appointment.
Grading rulesWritten exams with open questions with multiple choices will be proposed. There will be the possibility of supplementary oral examinations. The questions will be organized to allow students the achievement of goals.
Full arguments• Introduction to this discipline, general principles • Pharmacodynamics: 6. Drug-receptor interactions; 7. Receptor theories; concentration-response curves, agonists, antagonists, partial agonists, inverse agonists; 8. Drug specificity, potency, efficacy, and affinity; the median effective dose; the therapeutic index; 9. G protein-coupled receptors, ion channel-linked receptors, intracellular receptors, enzyme-linked receptors; 10. The intracellular effector systems. • Pharmacokinetics: 10. Chemical-physical properties of drugs; translocation of drugs across cell barriers; 11. Routes of drug administration; biodisponibility; 12. Drug absorption; 13. Drug-protein binding; 14. Drug distribution in the body; 15. The apparent volume of distribution; 16. Biotransformation and bioactivation; 17. Removal of drugs from the body; renal excretion, the clearance concept; 18. Kinetics of drug elimination, plasma half life. • Individual variations in drug responses • Drug interactions • Harmful effects of drugs: the median lethal dose • Abnormal drug responses • Principles of Pharmacogenetics and Pharmcovigilance PHARMACOGNOSY (5 CFU) • General principles: drugs in Pharmacognosy. Biogenesis of the main pharmacologically active compounds: synthetic pathways • Genetic and environmental factors affecting the contents of biologically active compounds • Cell cultures as methods for studying the main biosynthetic pathways and the sources of biologically active compounds • Preparation, preservation, recognition, quality determination, purity, and activity of drugs • Vegetable drugs used in the pathology of: f. The central and peripheral nervous systems: psycostimulants and tonics (cocaine, methylxanthine), hypnotics and sedatives (chrysin, valerianic acid), antidepressives (hypericin), analgesics (morphine); g. The cardiovascular system: cardiotonic (digoxin), vasoconstrictor (ergot alkaloids), antihypertensive (reserpine) agents; h. The respiratory system: cough suppression (codeine), antiasthma (ephedrine) agents; i. The gastrointestinal system: stomatics (azulenes), eupeptics (capsaicin), antispastics (atropine); j. The urogenital system: anti-androgens (Serenoa Repens), antiseptics (arbutin). • Drugs from plants, animals, and minerals: hormones, vitamins, antibiotics, halogens, metals, alkaline metals, metalloids, non-metals
Close course details
Show parent course details
Print
CourseMEDICINAL PLANTS
Course IDFA0045
Academic Year2016/2017
Year of rule2015/2016
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderFALLARINI Silvia
TeachersFALLARINI Silvia, POLLASTRO Federica
CFU5
Teaching duration (hours)40
Individual study time 85
SSDBIO/15 - BIOLOGIA FARMACEUTICA
Course typeModulo di sola Frequenza
Course categoryB - Caratterizzante
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageItalian
AbstractModulo A Subjects of Medicinal Plant’s A module are anatomy, biology, physiology and characterization of superior plants and definition of their secondary metabolites. Systematic characterization of fungi, lichens and ferns. Module B Subjects of Medicinal Plant’s B module are: - botanical description and characterization of main pharmacological relevant angiosperm plants, - the knowledge of their use in traditional medicine, - the knowledge of their drugs, - their drug’s active principles, - therapeutic and toxicological effects of drug’s active principles and their phamaceutical applications
Reference textsBiologia e Botanica Farmaceutica - Senatore (Piccin) Chimica e Farmacologia delle Piante Medicinali - Perdetti (Studio Edizioni) Manuale di botanica farmaceutica –Maugini (Piccin
Teaching targetsModule A The students attending this course learn the fundamentals of general botany and the nomenclature needed for medicinal plants morphological description and classification. Moreover, students will learn the secondary metabolites produced by plants and their tissue/organ accumulation sites, the preparation procedures and the therapeutic properties of drugs. Module B At the end of the academic course, students must possess knowledge of principal medicinal plants. They have to demonstrate to have knowledge of their botanical description, classification, use in traditional medicine, drugs, active principles of explained plants, of their biological targets, their pharmacological/toxicological effects and pharmacological applications. Moreover, students must demonstrate to have developed a correct language ability and to use appropriate terminology.
PrerequisitesIt is recommended to have passed the examination of Plant Biology
Didattics MethodsLectures with practical demonstration of botanical samples and computer support: projection of powerpoint slides. Slides will be at students disposition.
Other informationsLectures
Grading rulesWritten exam with open questions, multiple choice questions or questions with syntetic answers. Questions will be focused on all contents explained and concerned during lecturers. To pass exam, students must demonstrate to have knowledge of plant botanical descriptions, their use in traditional medicine, their drugs, their active principles, their pharmacological/toxycological targets and their pharmacological applications. Language and terminology must be appropriate.
Full argumentsModule A Historical overview Biological and Physiological part: - Plant cell - Plant tissues - plant organs - Modified epidermal cells - Secretory structures - Reproductive organs Anatomical part - Root - Stem - Leafs - Flowers - Fruits and seeds Factors that influences the production of plant secondary metabolites Plant active principles Alkaloids, phenolic compounds, flavonoids, tannins, glycosides, terpenoids, steroids, volatile oils, mucilages, bitter compounds, and iridoids Drugs - Harvesting of drugs - Preparation of herbal medicines Systemic botany - Fungi - Algae - Lichens Module B The following list of plant will be explained in: - botanical description and characterization, - their use in traditional medicine, - their drugs, - their drug’s active principles, - therapeutic and toxicological effects of drug’s active principles and their phamaceutical applications Angiosperm: Fagaceae: Castanea sativa Juglandaceae: Juglans regia Salicaceae: Salix alba, Populus alba Cannabaceae: Cannabis sativa, Humulus lupulus Ranuncolacee: Aconitum napellus Lauraceae: Laurus nobilis, Cinnamomum camphora, Cinnamomum zeylanycum Euphorbiaceae: Ricino communis, Euphorbia pulcherrima, Euphorbia resinifera Brassicaceae or Crucifereae: Brassica nigra, Brassica oleracea Rosaceae and sub-family: Fragaria vesca, Crataegus monogyna Leguminosae: Tamarindus indica, Carrube, Glycine max, Glycyrrhiza glabra Umbelliferae: Daucus carota, Petroselinum sativum, Pimpinella anisum, Centella asiatica, Cicuta virosa, Conium maculatum, Oenanthe crocata, Angelica archangelica Ericaceae: Vaccinium myrtillus Rubiaceae: Coffea arabica, Ilex paraguariensis Teaceae: Camellia sinensis Apocinaceae: Nerium oleander, Catharanthus roseus (Pervinca), Strofanto, Rauwolfia Oleaceae: Olea europea Linaceae: Linum usitatissimum Labiateae: Mentha piperita, Salvia officinalis, Salvia sclarea, Lavandula angustifolia, Melissa officinalis Araliaceae: Panax giseng, Hedera helix, Elaeis guineensis, Serenoa repens Gentianaceae: Genziana lutea Solanaceae: Solanum tuberosum, Solanum lycopersicum, Solanum melongena, Atropa belladonna, Datura stramonium, Hyoscyamus niger, Mandragora autumnalis, Capsicum Compositae: Matricaria chamomilla, Tanacetum parthenium, Taraxacum officinalis, Artemisia absinthium, Artemisia umbelliformis, Artemisia annua, Cynara scolymus, Lactuga sativa, Helichrysum italicum, Silybum marianum, Arnica montana, Echinacea purpurea Hypericaceae: Hypericum perforatum Myrtaceae: Myrto communis, Melaleuca alternifolia (tea tree) Scrophularaiaceae: Digitalis purpurea, Digitalis lanata Papaveraceae: Papaver somniferum Crassulaceae: Rhodiola rosea Valerainaceae: Valeriana officinalis Cucurbitaceae: Cucurbita maxima Vitaceae: Vitis vinifera Malvaceae: Malva sylvestris Pedaliaceae: Harpagophytum procumbens Burseraceae: Boswellia sacra, Boswellia serrata Liliaceae: Allium cepa, Allium sativum, Colchicum autumnale, Convallaria majalis, Aloe vera Graminaceae: Triticum aestivum, Oryza sativa, Avena sativa, Zea mays, Triticum spelta Zingiberaceae: Zingiber officinalis, Curcuma longa
Close course details
Print
CourseAnalisi dei medicinali II
Course IDFA0015
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderGALLI Ubaldina
CFU8
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year3
PeriodAnnuale
Grading typeFinal grade
Teaching languageItalian
AbstractQualitative chemical analysis of inorganic drugs: identification of cations and anions Qualitative chemical analysis of organic and metallorganic drugs: elemental analysis, determination of solubility, chemical tests for the characterization of functional groups. Determination of chemical-physical constants. Thin layer chromatography. Extraction and purification with solvent: Infrared spectrometry. UV/Visible spectrometry.
Reference texts“European Pharmacopoeia” “Analisi Chimico Farmaceutica” F. Savelli – O. Bruno, Piccin Editore “Analisi Farmaceutica” David G. Watson, EdiSES Editore “Analisi Farmaceutica Qualitativa” A. Carta Edises Editore
Teaching targetsProvide guide line in the identification process of known and unknown compounds of pharmaceutical interest according to “European Pharmacopoeia”.
PrerequisitesMedicinal Analysis 1 and Organic Chemistry 1
Didattics MethodsTraditional theoretical lessons and practical lessons in the laboratory, compulsory attendance.
Grading rulesThere aren’t traditional sessions but, for the admission to the laboratory, one mandatory written test about security and theoretical knowledge (30 questions: open questions and multiple choice answers) is required. The written admission tests are planned in February at the end of the theoretical lessons. If students don’t stand the first test (minimum required score 18/30), a second and third chances (written test) are possible in the same month. The final evaluation score holds in due consideration the written test score and the lab score.
Full argumentsQUALITATIVE CHEMICAL ANALYSIS: sampling and homogenization of compounds; preliminary examination: physical state, color, odor; determination of inorganic, organic and metallorganic nature of the compounds by ignition test; dry test (flame test ) Qualitative chemical analysis of inorganic compounds: - solubility, determination of pH, - wet test: identification of cations (NH4+, Al+++, Ag+, Bi+++, Ca++, Li+, Mg++, K+, Na+, Zn++) and anions (CO3- -, HCO3 -, Cl -, PO4- - -, I -, NO3 -, SO4- - , BO3- - -, F -, S2O3- -) contained in inorganic drugs, adopting methods of identification described in the European Pharmacopoeia. Qualitative chemical analysis of organic and metallorganic compounds: - elemental analysis: Lassaigne test (fusion with sodium) for the determination of the presence of nitrogen, sulfur, chlorine, bromine, iodine, fluorine and phosphorus. - dry test (flame test for metallorganic compounds) - Theory of solubility, determination of solubility in water, organic solvent (ether), 5% hydrochloric acid solution, 5% sodium hydroxide solution, 5% sodium bicarbonate solution and cold concentrated sulfuric acid. - Chemical tests for the characterization of functional groups: alkenes, alkynes, aromatic hydrocarbons, halides, alcohols, phenols, ethers, aldehydes, ketones, carboxylic acids, acyl halides, acid anhydrides, esters, amides, nitriles, amines, nitro-compounds, sulfonamides, amino acids, carbohydrates -use of the European Pharmacopoeia - determination of chemical-physical constants: melting point, (mixed melting point method, corrected melting point); polarimetry: specific rotation. THIN LAYER CHROMATOGRAPHY (TLC): technique, application, determination of Rf value and Rstd value, detection methods, bidimensional TLC, preparative TLC. INFRARED SPECTROMETRY: theory, schematic diagram of spectrometers, application, study of the IR spectra of several organic compounds. UV/VISIBLE SPECTROMETRY: theory, schematic diagram of spectrometers, applications. EXTRACTION AND PURIFICATION WITH SOLVENT: purpose, solvent choice, extraction technique with separation funnel, methods of extraction: solvent/water, solvent/acid aqueous solution, solvent/basic aqueous solution. PRACTICAL LESSONS: Ignition test of compounds, Lassaigne test to get elemental analysis. Determination of the identity of unknown inorganic drugs. Determination of the identity of ten known organic and metallorganic drugs. Purification of a drug from a mixture by extraction with solvents. Qualitative analysis of drugs by UV/VIS. Spectrometry.
Modules
Course ID Course SSD Teachers
FA0079 Analisi dei medicinali II mod. a CHIM/08 - CHIMICA FARMACEUTICA GALLI Ubaldina
FA0080 Analisi dei medicinali II mod. b CHIM/08 - CHIMICA FARMACEUTICA GALLI Ubaldina
Close course details
Show parent course details
Print
CourseAnalisi dei medicinali II mod. a
Course IDFA0079
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderGALLI Ubaldina
TeachersGALLI Ubaldina
CFU5
Teaching duration (hours)40
Individual study time 85
SSDCHIM/08 - CHIMICA FARMACEUTICA
Course typeModulo di sola Frequenza
Course categoryB - Caratterizzante
Year3
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Close course details
Show parent course details
Print
CourseAnalisi dei medicinali II mod. b
Course IDFA0080
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderGALLI Ubaldina
TeachersGALLI Ubaldina
CFU3
Individual study time 39
SSDCHIM/08 - CHIMICA FARMACEUTICA
Course typeModulo di sola Frequenza
Course categoryB - Caratterizzante
Year3
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Sites and/or partitions
Cognomi A-D
Cognomi E-N
Cognomi O-Z
Close course details
Show parent course details
Print
CourseAnalisi dei medicinali II mod. b
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderGALLI Ubaldina
TeachersGALLI Ubaldina
Course typePartizione alfabetica AD-EN-OZ
Year3
PartitionCognomi A-D
Frequenza obbligatoriaYes
Close course details
Show parent course details
Print
CourseAnalisi dei medicinali II mod. b
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderGALLI Ubaldina
TeachersGALLI Ubaldina
Course typePartizione alfabetica AD-EN-OZ
Year3
PartitionCognomi E-N
Frequenza obbligatoriaYes
Close course details
Show parent course details
Print
CourseAnalisi dei medicinali II mod. b
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderGALLI Ubaldina
TeachersGALLI Ubaldina
Course typePartizione alfabetica AD-EN-OZ
Year3
PartitionCognomi O-Z
Frequenza obbligatoriaYes
Close course details
Print
CourseESSENTIALS OF SPECTROSCOPY
Course IDFA0058
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderPANZA Luigi
TeachersPANZA Luigi
CFU1
Teaching duration (hours)8
Individual study time 17
SSDCHIM/06 - CHIMICA ORGANICA
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryD - A scelta dallo studente
Year3
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractIntroduction to instrumental spectroscopic analytical methods Introduction to Infrared spectroscopy (IR) Nuclear magnetic resonance spectroscopy (NMR)
Reference textsSlides provided by the teacher M. Hesse, H. Meier, B. Zeeh, Metodi spetroscopici in chimica organica, Edises
Teaching targetsProvide students with the basic knowledge of IR and NMR spectroscopy and the essential elements for the identification of organic substances.
PrerequisitesKnowledge of the structure of the main classes of organic compounds
Didattics MethodsLectures with multimedia support and exercises
Grading rulesOral exam in which, from a series of IR and NMR spectra, the student should identify the structure of a simple organic compound.
Full argumentsIntroduction to spectroscopic analysis methods. Outline of infrared spectroscopy (IR) - Characteristics of a traditional IR spectrophotometer and Fourier transform (FT-IR). The harmonic oscillator. Anharmonicity and quantization. Types of vibration. Instrumentation and sample preparation. The infrared spectrum and typical vibration frequencies of main functional groups. Nuclear magnetic resonance spectroscopy (NMR) - The nuclear spin. Theory of NMR spectroscopy, with particular regard to the technical pulse Fourier transform. Spectral parameters: chemical shift, fine structure, integration of signals. 1H NMR proton. Spectra of the first order. Outline of spin systems. Relationship between structure and chemical shift. Symmetry, chirality and NMR spectrum. 13C NMR: characteristics of the 13C nucleus. Decoupled spectra, off-resonance, DEPT and APT. Relationship between structure and chemical shift.
Course borrowed toFARMACIA (1506) - FA0058 Elementi di spettroscopia NMR
FARMACIA (1506) - FA0058 Elementi di spettroscopia NMR
Close course details
Print
CourseFITOCHIMICA E LABORATORIO DI PREPARAZIONI ERBORISTICHE
Course IDFA0051
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderPOLLASTRO Federica
CFU8
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year3
PeriodPrimo Semestre
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
FA0081 FITOCHIMICA E LABORATORIO DI PREPARAZIONI ERBORISTICHE mod. a CHIM/06 - CHIMICA ORGANICA POLLASTRO Federica
FA0082 FITOCHIMICA E LABORATORIO DI PREPARAZIONI ERBORISTICHE mod. b CHIM/06 - CHIMICA ORGANICA MINASSI Alberto, POLLASTRO Federica
Close course details
Show parent course details
Print
CourseFITOCHIMICA E LABORATORIO DI PREPARAZIONI ERBORISTICHE mod. a
Course IDFA0081
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderPOLLASTRO Federica
TeachersPOLLASTRO Federica
CFU7
Teaching duration (hours)56
Individual study time 119
SSDCHIM/06 - CHIMICA ORGANICA
Course typeModulo di sola Frequenza
Course categoryA - Base
Year3
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Teaching languageItalian
AbstractDefinition and characterization of medicinal and officinal plants. Controls required on substances. Secondary metabolites and their biosynthesis. Extraction and purification strategies for natural compounds: strategies, methodologies, choice criterions and application. Phytochemical instrumentation and criterion of choice. Pharmaceutical preparation based on medicinal and officinal plants.
Reference textsCHIMICA, BIOSINTESI E BIOATTIVITA’ DELLE SOSTANZE NATURALI DEWICK, P.M.; PICCIN MANUALE DELL’ERBORISTA BIOSINTESI, ESTRAZIONE ED IDENTIFICAZIONE DELLE SOSTANZE DI ORIGINE VEGETALE MORELLI, I.; FLAMINI, G.; PISTELLI, L.; TECNICHE NUOVE
Teaching targetsSudents must be able to characterize medicinal and officinal plants Knowledge of material validation controls is required. Knowledge of second metabolite classes and biosynthesis. Knowledge of extraction and purification strategies and methods of natural compounds from medicinal plants. Moreover, stundents must be able to theoretically and manage indipendently choose the most appropriate technique. Knowledge of main phytochemical analytical instruments. Knowlende of main pharmaceutical preparation based on medicinal and officinal plants. Use correct terminology and appropriate language.
PrerequisitesMedicinal Analysis exam passed
Didattics MethodsLectures with computer and video supporting: projection of powerpoint slides. The slides are present on the site in advance of the start of the courses. Presentation of the practical part in order to introduce students to what will be the experiences that they will be addressed in the laboratory and what are the main instruments that they will use.
Grading rulesWritten exam with open questions, multiple choice questions or questions with syntetic answers. Questions will be focused on all contents explained and concerned during lecturers. To pass exam, students must demonstrate to have knowledge definition and characterization of medicinal and officinal plants, of required material validation controls, of second metabolite classes and biosynthesis. Knowledge of extraction and purification strategies and methods of natural compounds from medicinal plants. Moreover, stundents must be able to theoretically and manage indipendently choose the most appropriate technique. Knowledge of main phytochemical analytical instruments amd their application. Knowlende of main pharmaceutical preparation based on medicinal and officinal plants. Use correct terminology and appropriate language.
Full argumentsMedicinal and officinal plants: definition and characterization • Controls required on botanical source • Second metabolites: alcaloids, terpenoids, phenolic compounds and their biosynthesis • Purification techniques • Extractive technique • Analytical instruments and their functions • Preparations based on medicinal and officinal plants
Close course details
Show parent course details
Print
CourseFITOCHIMICA E LABORATORIO DI PREPARAZIONI ERBORISTICHE mod. b
Course IDFA0082
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderMINASSI Alberto
TeachersPOLLASTRO Federica
CFU1
Individual study time 13
SSDCHIM/06 - CHIMICA ORGANICA
Course typeModulo di sola Frequenza
Course categoryA - Base
Year3
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Sites and/or partitions
Cognomi A-G
Cognomi H-Z
Close course details
Show parent course details
Print
CourseFITOCHIMICA E LABORATORIO DI PREPARAZIONI ERBORISTICHE mod. b
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderPOLLASTRO Federica
TeachersPOLLASTRO Federica
Year3
PartitionCognomi A-G
Frequenza obbligatoriaYes
Teaching languageItaliano
AbstractAmyrin esters extraction from Ilex paraguariensis and their hydrolysis to amyrins. Steam distillation of Zingiber zerumbeth roots to obtain zerumbone and purification of zerumbone by gravimetric coloumn chromatography. Isolation od ricinoleic acid from ricin oil and liquid-liquid partition. Evapotation by rotavapor and compound TLC analysis.
Reference textsCHIMICA, BIOSINTESI E BIOATTIVITA’ DELLE SOSTANZE NATURALI DEWICK, P.M.; PICCIN MANUALE DELL’ERBORISTA BIOSINTESI, ESTRAZIONE ED IDENTIFICAZIONE DELLE SOSTANZE DI ORIGINE VEGETALE MORELLI, I.; FLAMINI, G.; PISTELLI, L.; TECNICHE NUOVE
Teaching targetsStudents must be able to purify the indicated compounds, to describe on his laboratory book, techniques used and to understand methods and criticalities as explained in A-module.
Didattics MethodsPractical activities in laboratory with instruments. In the didactic laboratories the students will do experiments to test their ability of the application of the concepts acquired during the first part of the course. Every experience has a dedicated tutor who will follow and support the students in the performance of their work
Grading rulesWritten activities description on laboratory book. Explanation of methods and criticalities observed.
Full argumentsAmyrin esters extraction from Ilex paraguariensis and their hydrolysis to amyrins. Steam distillation of Zingiber zerumbeth roots to obtain zerumbone and purification of zerumbone by gravimetric coloumn chromatography. Isolation od ricinoleic acid from ricin oil and liquid-liquid partition. Evapotation by rotavapor and compound TLC analysis.
Close course details
Show parent course details
Print
CourseFITOCHIMICA E LABORATORIO DI PREPARAZIONI ERBORISTICHE mod. b
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderPOLLASTRO Federica
TeachersPOLLASTRO Federica
Year3
PartitionCognomi H-Z
Frequenza obbligatoriaYes
Teaching languageItalian
AbstractAmyrin esters extraction from Ilex paraguariensis and their hydrolysis to amyrins. Steam distillation of Zingiber zerumbeth roots to obtain zerumbone and purification of zerumbone by gravimetric coloumn chromatography. Isolation od ricinoleic acid from ricin oil and liquid-liquid partition. Evapotation by rotavapor and compound TLC analysis.
Reference textsCHIMICA, BIOSINTESI E BIOATTIVITA’ DELLE SOSTANZE NATURALI DEWICK, P.M.; PICCIN MANUALE DELL’ERBORISTA BIOSINTESI, ESTRAZIONE ED IDENTIFICAZIONE DELLE SOSTANZE DI ORIGINE VEGETALE MORELLI, I.; FLAMINI, G.; PISTELLI, L.; TECNICHE NUOVE
Teaching targetsStudents must be able to purify the indicated compounds, to describe on his laboratory book, techniques used and to understand methods and criticalities as explained in A-module.
PrerequisitesA-module of same exam
Didattics MethodsPractical activities in laboratory with instruments and under tutor supervision.
Grading rulesWritten activities description on laboratory book. Explanation of methods and criticalities observed.
Full argumentsAmyrin esters extraction from Ilex paraguariensis and their hydrolysis to amyrins. Steam distillation of Zingiber zerumbeth roots to obtain zerumbone and purification of zerumbone by gravimetric coloumn chromatography. Isolation od ricinoleic acid from ricin oil and liquid-liquid partition. Evapotation by rotavapor and compound TLC analysis.
Close course details
Print
CourseMOLECULAR BIOLOGY
Course IDF0595
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderROSSI Franca
TeachersROSSI Franca
CFU5
Teaching duration (hours)40
Individual study time 85
SSDBIO/11 - BIOLOGIA MOLECOLARE
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year3
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe timeline of the discoveries and advancements in Molecular Biology Organization, structure and evolution of genes, chromosomes and genomes Replication and maintenance of the genome Transcription and its regulation RNA processing and maturation Translation and its regulation Genomic alterations, epigenetic and post-translational modifications Approaches, techniques and models in Molecular Biology
Reference textsAmaldi, et al. Biologia molecolare, 2nd ed. Casa Editrice Ambrosiana. Distribuzione Zanichelli ISBN: 9788808185679 Watson, et al. DNA ricombinante, 2nd ed. (3rd US ed.) Zanichelli ISBN 978-88-08-06623-7
Teaching targetsThe “Molecular Biology” course describes, at the molecular level, the main biological phenomena taking place inside the cell, through the in depth study of DNA, RNA, proteins, and other macromolecules involved in genetic information transmission, expression and integration. A special emphasis will be given to the description of molecular techniques currently used in the molecular biology field, as well as of selected well established model systems. Overall, the course aims at boosting the Student’s capability of carry out an integrated analysis of multiple aspects of the biology of the cell, in physiologic and pathologic conditions
PrerequisitesAn adequate knowledge of the eukaryotic cell biology and protein biochemistry is required.
Didattics MethodsLectures/seminars and “virtual-lab”
Grading rulesWritten test. An average test consists of: multiple choice questions, each containing 4 "True / False" statements; an exercise that asks the student to depict a specific molecular phenomenon/mechanism concerning the nucleic acid/protein biology/biochemistry/enzymology (e.g., "Illustrate the reaction catalysed by the DNA ligase"); a free-text, to in depth describe a selected topic in Molecular Biology (e.g., "The Evolution of the Human Genome Project"). Programma esteso -Introduzione al corso -La tecnologia di base per la realizzazione di molecole di DNA ricombinante: endonucleasi di restrizione, enzimi di modificazione e vettori. La reazione di polimerizzazione a catena (PCR). Costruzione di genoteche. Sequenziamento del DNA: metodo di Sanger e sua automazione. -Struttura degli acidi nucleici ed organizzazione dei genomi eucariotici. -Elementi trasponibili. -Replicazione del DNA e controllo della replicazione nel ciclo cellulare -Mutazioni del DNA e meccanismi di riparazione del DNA (DSBR, HR e NHEJ). -Ricombinazione del DNA. -Trascrizione del DNA/sintesi dell'RNA. L'unità di trascrizione. Le RNA polimerasi eucariotiche. I promotori ed i fattori di trascrizione. Modificatori e rimodellatori della cromatina ed effetti sul tasso di trascrizione dei geni. -Processamento dell'RNA: capping, poliadenilazione e splicing; la biogenesi del rRNA; il rimodellamento dei tRNA; editing dell'RNA -Il traffico nucleo-citoplasmatico: i segnali di localizzazione nucleare e di esporto; attività di importine ed esportine; il ciclo di RAN; l'esporto dell'mRNA. -Il processo della traduzione/sintesi proteica: aspetti comuni e differenze nella sintesi di proteine con petide segnale. -Regolazione della traduzione: elementi di risposta nell'RNA non tradotto; modulazione dei fattori di inizio; degradazione del'RNA codificante e di quello non-senso. -Modificazioni post-traduzionali: proteolisi sequenza specifica; fosforilazione; acetilazione; glicosilazione; lipidazione; ubiquitinazione e sumoilazione. -Topogenesi, indirizzamento e smistamento delle proteine -Comunicazione intercellulare e trasduzione del segnale: modalità della comunicazione; caratteristiche e proprietà della trasduzione; classi di ligandi e di recettori; secondi messaggeri, mediatori/selettori ed effettori. Caratteristiche delle reti di trasduzione del segnale. Esempi di vie di trasduzione del segnale. - Metodi di rivelazione usati in biologia molecolare: colorimetria, chemiluminescenza, fluorescenza. Sonde di DNA marcato per l'identificazione di sequenze specifiche di DNA (Southern blot e FISH). - Strategia per il sequenziamento dei genomi: frammentazione e clonaggio in vettori ad alta capacità (Cosmidi, YAC e BAC). - Cenni sull’analisi delle proteine. Studio della localizzazione sub-cellulare delle proteine.
Full arguments-Introduction -The recombinant DNA: restriction endonucleases and modification enzymes; sub-cloning vectors. The polymerase chain reaction (PCR). Construction of gene libraries. DNA Sequencing: the Sanger method and its automation. -The structure of nucleic acids and organization of eukaryotic genomes. -Transposable elements. -DNA replication and its control. -Mutations and DNA repair mechanisms (DR, DSBR, HR and NHEJ). -DNA recombination. -The transcription units. Eukaryotic RNA polymerases. Promoters and transcription factors. Chromatin remodeling and effects on gene transcription rates. -RNA processing: capping, polyadenylation and splicing; biogenesis of rRNA; remodeling of tRNA; RNA editing. -The nucleus-cytoplasm traffic: nuclear localization and export signals; importins and exportins; the RAN cycle. -Protein synthesis: similarities and differences in the synthesis of proteins with petide signal. -Translation control: response elements in untranslated RNA; modulation of initiation factors; RNA degradation. -Post-translational modifications: site-specific proteolysis; phosphorylation; acetylation; glycosylation; lipidation; ubiquitination and sumoylation. -Protein topogenesis, addressing and sorting. -Cell communication and intercellular signal transduction: characteristics and properties; classes of ligands and receptors; second messengers, mediators/effectors. Examples of signal transduction pathways. - Detection methods used in Molecular Biology: radioactive isotopes, colorimetry, chemiluminescence, fluorescence. Labeled DNA probes for the identification of specific sequences of DNA (Southern blot and FISH). - Strategies for the genome sequencing: cloning in high-capacity vectors (cosmids, YAC and BAC). - Generation of monoclonal antibodies: obtaining hybridoma. Antibody Phage Display. - Basic techniques in protein analysis. Study of the sub-cellular localization of proteins. - Flow cytometry: principles and applications. -The model organisms. -Genesis of knock-out mice: positive/negative selection. Analysis of the phenotype. - Artificial cultures of animal cells: basic concepts.
Course borrowed fromCHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - FA0087 Biologia molecolare con laboratorio mod. a
Close course details
Print
CourseMicrobiologia applicata
Course IDFA0016
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderFRACCHIA Letizia
TeachersFRACCHIA Letizia
CFU5
Teaching duration (hours)40
Individual study time 85
SSDBIO/19 - MICROBIOLOGIA GENERALE
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year3
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe course is composed of two parts. The first part is focused on the microbiological control of pharmaceutical products. In particular: • Sterilization and sterility assurance of pharmaceutical products • Assays and methods for the microbiological evaluation of pharmaceutical products • Sampling and analysis of pharmaceutical environments to minimize microbial survival. • Microbiological and physical/chemical characteristics of drinking water and of water for pharmaceutical purposes • Pyrogens and endotoxin testing in injectable products The second part is dedicated to the industrial microbiology. In particular, the following topics will be addressed: • The fermentation processes: measures and regulation, culture media and raw materials • Isolation and selection of industrially relevant microorganisms • Methods for the production of microbial metabolites • Kinetic of microbiological processes and evaluation of microbial growth • Recovery of fermentation products (downstream) • Microbial biomass
Reference textsHandbook of microbiological quality control: pharmaceuticals and medical devices Edited by Rosamund M. Baird, Norman A. Hodges, Stephen P. Denyer. - New York: CRC Press, c2000.-XVI, 254 p. Industrial Microbiology: An Introduction Edited by Michael J. Waites, Neil L. Morgan, John S. Rockey, Gary Higton; John Wiley & Sons, 01 apr 2009-304 p.
Teaching targetsThe course aims to provide students with a theoretical overview of the main methods currently used in the microbiological quality control of pharmaceutical products. Moreover, the knowledge of the fundamental aspects of applied microbiology related to the microbial fermentation systems and recovery of the end-products will be acquired. In general, the student will acquire knowledge and understanding about the applications of the methods outlined in the areas of pharmaceutical and industrial microbiology. In particular, the student will achieve the theoretical knowledge to evaluate the microbiological characteristics of non-sterile pharmaceutical preparations, to detect and quantify the presence of pathogenic microorganisms in such products, to ensure the sterility and quantify the presence of bacterial endotoxins in sterile preparations, to evaluate the hygienic requirements of pharmaceutical environments. In addition, the student will be aware of the main technologies used for microbial fermentation in bioreactors. In particular, the main types of bioreactors will be described, as well as the control systems of the fermentation process, the different techniques of immobilization of microbial cells, the isolation of the fermentation products and the main types of biomasses. Particular attention will be paid to deepening the biological aspects of fermentation processes. In this regard, the student will acquire knowledge about the methods of isolation and selection of microorganisms of industrial interest, the use of renewable growth substrates, the kinetics and quantification of microbial growth in the industrial field. The ultimate goal of the course is to provide students with a theoretical framework and with the tools for the application of the main microbiological methods and processes currently used in the pharmaceutical and industrial sectors, to achieve the ability to critically select the technologies and the methods described in the two areas and to further develop and deepen skills in the microbiological field. After completing the course, students must demonstrate independent judgment and skills related to verbal and written communication through the use of an appropriate technical-scientific language.
PrerequisitesSkills about the structure and function of the prokaryotic cell, the microbial metabolism, the methods of cultivation and quantification of microbial cultures. This knowledge is provided by the General Microbiology teaching that takes place during the first year.
Didattics MethodsThe course consists of lectures with slides show. Some topics will be deepened with videos in English and Italian. Topics of particular interest and relevance will be examined with the reading of scientific publications.
Other informationsThe slides of the lectures and supplementary material are available on the website “Didattica in Rete”: https://www.dir.uniupo.it/
Grading rulesWritten exam with open questions. In particular, the questions will be equally distributed on the two main themes of the course: the microbiological control of pharmaceutical products and the industrial microbiology. The students will also be evaluated for their ability to respond to the questions using a suitable technical and scientific language.
Full argumentsMicrobiological control of pharmaceutical products • Sterilization methods for pharmaceutical products • Biological indicators for sterilization • Sterility testing for bacteria and fungi • Validation of sterility tests • Microbial evaluation of non-sterile pharmaceutical preparations • Microbial limits testing • Quantitative determination (total microbial counts, pour-plate method, filtration, Most Probable Number) • Validation of qualitative methods: culture media and microbial strains used for the validation • Methods for the detection of specific microorganisms (E. coli, Salmonella spp., S. aureus, P. aeruginosa, Clostridia) • Automated rapid methods (impedometry and bioluminescence) • Analysis and control of pharmaceutical environments to minimize microbial survival. • Sampling and Assays for environment and operational structures • Microbiological monitoring of drinking water and water for pharmaceutical purposes • Limulus Amebocyte Lysate test (LAL) for the determination of pyrogens in injectable products Industrial Microbiology • The fermentation processes • Industrially relevant metabolic accumulations • Isolation and selection of industrially relevant microorganisms (primary and secondary screening) • Procedures for obtaining microbial metabolites • Culture media and raw materials • Monitoring and control of fermentation processes • Immobilization of microbial cells • Fermentation process kinetics • Evaluation of microbial growth • Recovery of fermentation products (downstream) • Microbial biomass
Close course details
Print
CoursePATHOLOGY (MEDICAL TERMINOLOGY)
Course IDF0417
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderSICA Antonio
TeachersSICA Antonio, PORTA Chiara
CFU12
Teaching duration (hours)96
Individual study time 204
SSDMED/04 - PATOLOGIA GENERALE
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryA - Base
Year3
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractBasic knowledge of the pathogenic mechanisms; cellular pathology, basic knowledge of the innate and adaptive immune system, basic knowledge of oncology, basic knowledge of immunopathology, physiology of the vessels and clotting; mechanisms promoting the metabolic syndrome
Reference textsLe basi patologiche delle malattie, Robbins, Cotran, Piccin editore Patologia Generale; Pontieri-Russo-Frati, Piccin editore Fondamenti di Immunologia ABBAS ABUL K.-LICHTMAN ANDREW H. Piccin editore
Teaching targetsUnderstand the etiologic basis and pathological mechanisms that guide the development of diseases. Acquire full knowledge and understanding of the topics discussed and application skills. Acquire critical guidance on the topics discussed and communicative skills
PrerequisitesExam preparatory Biology animal and plant It is advisable to have already followed the physiology course
Didattics MethodsTraditional: lectures and seminars
Other informationsThe first two modules will be provided by Dr. Chiara Porta
Grading rulesWritten (test with multiple choice questions) and oral (open-ended questions) exam
Full arguments1: Adaptive cell response. Cellular damage and death. Cell and tissue responses to stress conditions. Cell death: necrosis and apoptosis Degenerative processes by macromolecules accumulation 2: Inflammation and innate immunity Biological and physical barriers of innate immunity Innate immune cells: origin and functions Endothelium and leukocyte recruitment Pathogen recognition: structure and signaling of TLR receptors family Mechanisms of pathogens killing: phagocytosis and reactive oxygen species. Soluble mediators of innate immunity: vasoactive ammines and inflammatory cytokines Transcriptional programs of innate immunity and inflammation. The complement system Chronic and polarized inflammation. Granuloma. Tissue repair: Granulation tissues Fibrosis and sclerosis Dendritic cells: link between innate and adaptive immunity. 3: Specific immunity Specific Immunity: Specificity, memory and tolearnce Lymphocyte functions Primary and secondary lymphoid tissues B lymphocytes: differentiation, activation and maturation Antibodies: structure, classes, functions. Immunoglobulin genes: mechanisms of rearrangement, variability, Primary and secondary response T lymphocytes: differentiation, activation and maturation The TCR: structure, signaling transduction, mechanisms of rearrangement and variability The major complex of hystocompatibility: class I and class II (structures and functions) HLA genes: poligenia and polimorphism; MHC restriction and graft rejection Cytiotoxic T lymphocytes Helper T lymphocytes Thymic selection Peripheral and central tolerance 4: Principles of Oncology Definition and classification Biology of tumor growth Tumor angiogenesis and metastasis Neoplastic transformation: chemical and phisical transformation Oncogenic viruses Cancerogenesis as a multistep process Oncogenes: definition and classification; Role in neoplastic transformation Onco-suppressor genes: Role in neoplastic transformation and in tumor growth Apoptotic genes and DNA repair genes: Genetic instability. Gene Methylation Tumor immunology Dendritic cell-based vaccines 5: Immunopatology congenital and acquired immunodeficiency Hypersensibility reactions types I, II; III and IV Autoimmune reactions: antibody- and cell-mediated Tolerance and graft rejection Mucosal immunity and inflammatory bowel diseases (IBD) 6: Phisiology of vessels and coagulation Atherosclerosis: pathogenesis and risk factors atherosclerotic plaques: generation and stabilization Clinical manifestation of atherosclerosis Haemorrhagic diseases Thrombosis: pathogenesis and clinical manifestation Metabolic syndrome
Close course details
Print
CoursePHARMACEUTICAL CHEMISTRY I
Course IDF0412
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderSORBA Giovanni
TeachersSORBA Giovanni, PIRALI Tracey
CFU10
Teaching duration (hours)80
Individual study time 170
SSDCHIM/08 - CHIMICA FARMACEUTICA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year3
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractModule A Medicinal Chemistry definition. Pharmaceutical Phase Routes of administration. Pharmacokinetic Phase Absorption. Distribution. Elimination. Metabolism. Excretion. Pharmacodynamic Phase Intermolecular interactions. Role of steoreochemistry in the interaction with the binding site. Receptors as drug targets. Enzymes as drug targets. Miscellaneous drug targets. Hit compound and lead compound. Finding a lead. How to recognize drug-like molecules. Drug design The optimization of target interactions. The optimization of the access to the target. Drug development Preclinical and clinical trials. Exercises. Module B Chemotherapeutic Agents: 1) Antiparasitic A. 2) Antimicrobial A. 3) Antibiotics 4) Antiviral A. 5) Antineoplastic A. 6) Antifungal and Anthelmintic A.
Reference textsA. Gasco, F. Gualtieri, C. Melchiorre Chimica Farmaceutica (I Eds.) Casa Editrice Ambrosiana; W. Foye, Principi di Chimica Farmaceutica, Piccin; (VI Eds.); Wilson and Gisvold, Chimica Farmaceutica (I Eds.) Casa Editrice Ambrosiana; G.L. Patrick Introduzione alla Chimica Farmaceutica (edizione integrata) EdiSES; Medicinal Chemistry: The Modern Drug Discovery Process, E. Stevens
Teaching targetsThe aim of module A is to introduce the student to the main principles of medicinal chemistry, while module B aims at describing the main drugs used in chemotherapy and integrates with the next course in Medicinal Chemistry 2 for the discussion of the other classes of drugs. The specific objectives of the course, according to the Dublino descriptors, are the following: 1. Knowledge and understanding. At the end of the course the student will know and understand the basic concepts of medicinal chemistry, in particular the route followed by the drug in the organism, from its administration to its excretion (pharmaceutical, pharmacokinetic, pharmacodynamic phases). Moreover, the itinerary of the drug in the pharmaceutical industry, from drug discovery to drug development through drug design, will be addressed. The student will also know and understand the main drugs used in chemotherapy. 2. The student will apply the acquired knowledge and understanding in the recognition of the chemical structures, in the discussion of the chemical and chemico-physical properties, of the mechanism of action, of the structure-activity relationship, of the metabolic fate and of the plausible routes for the synthesis of drugs. 3. The student will acquire the ability to identify and use data to formulate responses to well-defined concrete and abstract problems regarding the structure-activity relationship, the metabolism, the related toxicity, the synthesis, the drug-drug interaction for specific cases of drugs. Moreover, the student will be provided with all the tools necessary for the critical analysis of texts and papers in the medicinal chemistry literature. 4. The student will learn to communicate about his/her understanding, to describe, even in an original way, a topic described during lessons, to adequately answer to questions, critiques and suggestions. 5. The student will have the learning skills to handle in a dinamic way his/her knowledge in medicinal chemistry with some autonomy.
PrerequisitesIn order to give the exam in Medicinal Chemistry I it is necessary that the student has passed the exam in Organic Chemistry II. Good knowledge in general biology, biochemistry, general pharmacology and human physiology is strongly recomended.
Didattics MethodsThe course is given with the support of slides, which are given to the students at the beginning of the lessons. General and specific topics will be introduced, basic concepts will be provided for the understanding of each issue, and discussions with the students will be held. It will be explained how to acquire the competences needed to predict the chemical and physico-chemical properties of drugs starting from their structures, to identify the structural elements necessary for their mechanism of action and to recognize alert groups that can lead to toxicological problems.
Grading rulesModule A The exam consists in a written test displaying 15 questions. 10 questions are general and cover the program of the course. 5 questions are exercises regarding a drug molecule whose structure is given by the professor. These exercises consist in the identification of acid and basic centers, stereogenic centers, intermolecular interactions, possible metabolism reactions, etc. Module B The exam consists in a written test displaying 3 questions and in an oral discussion. The exam aims at verifying both the knowledge on the contents of the course and the ability to apply this knowledge to specific cases of drugs used in chemotherapy. The student has to demonstrate to be able to recognize a chemotherapy drug from its structure, to identify the functional groups, the acid, basic and stereogenic centers, the plausible reactions of metabolism, the routes for its preparation, etc. Through these tests, it will be verified that the student has achieved the objectives of knowledge and understanding of the contents of the course, the ability to communicate these concepts in a clear and correct manner and the competence to apply the acquired knowledge and skills to specific concerns regarding the medicinal chemistry of the different classes of drugs.
Full argumentsModule A Medicinal Chemistry definition. Pharmaceutical Phase Routes of administration. Pharmacokinetic Phase Absorption. Mechanisms of absorption. Passive diffusion. Partition coefficient. Fick law. Henderson-Hasselbach equation. Ion-pair absorption. Carrier mediated transport. Vescicolar transport. Convective trasport. The absorption in the oral administration: first-pass metabolism. Distribution. Plasma protein binding. Accumulation. Blood-brain barrier. Placental barrier. Elimination. Renal excretion. Phase I and phase II metabolism. Soft e hard drugs. Pharmacokinetic concepts. Plasma concentration-time curve. Clearance. Half-life. Bioavailability. Apparent volume of distribution. Factors that influence pharmacokinetics. Pharmacodynamic Phase Intermolecular interactions. Covalent bond. Ionic bond. Dipole-dipole interaction. Ion-dipole interaction. Hydrogen bond. Halogen bond. Charge transfer. Van der Waals interactions. Hydrophobic interactions. Pi greco-pi greco interactions. Role of steoreochemistry in the interaction with the binding site. Three point contact model. Pfeiffer rule. Eutomer, distomer, eudismic ratio. Chiral switch. Methods for the chiral switch. Receptors as drug targets: theories, strategies to design agonists, antagonists, allosteric modulators, inverse agonists. Enzymes as drug targets: competitive reversible, non competitive reversible, irreversible inhibitors, transition-state analogues, suicide substrates. Miscellaneous drug targets: transport proteins as drug targets, structural proteins as drug targets, protein-protein interactions, lipids as drug targets. Hit compound and lead compound. Choosing a disease, a drug target, a bioassay. High-throughput screening, NMR screening, virtual screening. Parallel and combinatorial synthesis. Finding a lead: natural products, serendipity, natural ligand modifications, me-too drugs, SOSA approach, screening, de novo drug design, fragment-based drug design. How to recognize drug-like molecules. Lipinski and Veber rules. Drug design The optimization of target interactions: structure-activity relationships, isosteres and bioisosteres, classic and non classic bioisosteres, pharmacophore identification, drug design strategies (extension, chain extension/contraction, homology, vinilogy, benzology, ring expansion/contraction, ring variations, ring fusion, structure simplification, structure rigidification, conformational blockers, twin drugs and hybrids). The optimization of the access to the target: how to optimize the hydrophobic and hydrophilic properties, how to improve the chemical and the metabolic stability, prodrugs, mutue prodrugs. Drug development Preclinical and clinical trials. Exercises on specific molecules of drugs. Module B Drugs for the treatment of trypanosomiasis, antimalarials, amebiasis, giardiasis, trichomoniasis, leishmaniasis. Synthetic antibacterial agents: sulfonamides, dihydrofolate reductase inhibitor, quinolones, oxazolidinones antimycobacterial, nitroderivatives. Antibacterial antibiotics: Background and current status, mechanism of action, chemical classification, microbial resistance, spectrum of activity. β-Lactam antibiotics: penicillins, cephalosporins, monobactams, carbapenemes. Aminoglycosides; tetracyclines; macrolides; lincomycines; polypeptides; unclassified antibiotics. The classification and biochemistry of viruses, classification of viruses. Nucleoside antimetabolites, agent for the treatment of HIV infection. Anticancer drug: classification, alkylating agents, antimetabolites, antibiotic and natural product, protein kinase inhibitors, hormones, miscellaneous compound. Antifungal and anthelmintics, most important agents.
Close course details
Print
CourseProdotti alimentari
Course IDFA0014
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderARLORIO Marco
TeachersARLORIO Marco
CFU5
Teaching duration (hours)40
Individual study time 85
SSDCHIM/10 - CHIMICA DEGLI ALIMENTI
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year3
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageThe teaching will be delivered in Italian; part of the material used by the teacher will be in English.
Abstract- Definitions: food product, ingredient, processed food, regulatory framework - Food products in Pharma area - Chemical composition of foods: (principal and minor compounds) - Bioactive compounds in foods and nutraceutics: examples from plant, animal and fungal foods - Definition of NOAEL and DGA, toxicological studies and Risk Assessment - Improvement agents (food additives, enzymes, flavouring compounds): classification and case studies - Food contaminants: classification and case studies - Residues in foods: plant protection products, pesticides and veterinary drugs - The food significance in modern nutrition - Detoxification mechanisms (overview)
Reference textsSlides used in the course, provided by the Teacher Food Composition: *INTRODUZIONE ALLA CHIMICA DEGLI ALIMENTI. Martelli, M. Arlorio:. Edizioni CLU, 1996, Torino *CHIMICA DEGLI ALIMENTI, a cura di A. Martelli, P. Cabras. Piccin Editore, 2003 *P. Cappelli, V. Vannucchi: Chimica degli alimenti, Ed. Zanichelli Toxicology and Food Toxicology: *TOSSICOLOGIA, a cura di C.G. Galli, E. Corsini, M. Marinovich. Piccin Editore, 2003 Regulatory framework: Gazzette Ufficiali Italiana ed Europea (e supplementi) For insight into the topic of food chemistry: *Belitz, Grosch, Schieberle “Food Chemistry”, Ed. Springer (IV Edition) For insight into the topic of Toxicology: Food Toxicology. W. Helferich, C. Winter Editor. CRC Press, Boca Raton Florida, 2001 Food Biotechnology: *C.Gigliotti, R.Verga: Biotecnologie Alimentari, Ed. Piccin Padova.
Teaching targetsThe course aims to provide basic knowledge concerning) i) the chemical composition and nutritional value of the food and ii) knowledge on chemistry and usefulness of the main food additives, processing aids and flavorings. Moreover, the course will take into account iii) the main contaminants (natural and induced by technology) and residues (veterinary drugs/pesticides) in foods also describing their chemical structures, toxicological aspects and the "food risk" correlated to their presence in diet. Another aim will be to transfer a general basic knowledge on the regulatory framework in food and nutrition area. Particular emphasis will be given to the description of the main bioactive compounds in "functional foods” and ingredients used also for the formulation of dietary supplements and "nutraceuticals", in order to provide the student a broad knowledge in the field. The knowledge gained from the course will be useful to the student in Pharmacy to manage the foods, food supplements and the "diet products" in Pharmacy, and to suggest correct nutritional information to the customer who uses them, showing autonomy in judgement and capacity to disseminate the key information.
PrerequisitesAlthough no official prerequisites are required, we recommend the acquisition of knowledge about the courses of Organic Chemistry and Biochemistry, fundamental for the understanding of Food Products lessons.
Didattics MethodsThe teaching method used provides ex-cathedra lectures given by the teacher, complemented by class discussion of cases study. The discussion of selected case studies is finalized to improve the capacity to critically understand the arguments correlated to the course, permitting to the student to acquire in autonomy the knowledge, object of the course. Specific seminars could be organized in cooperation with external Teachers and experts in the field.
Other informationsConsidering the complexity of the theme (that require preliminary knowledge about organic chemistry, biochemistry, microbiology) and considering the key impact of this knowledge in Pharmacy area, in order to improve the learning level quality the teacher will try to recall the principal concepts useful to understand the course, hoping to establish an interactive approach with the class. The course takes time to study in addition to the lessons, in order to improve the capacity to manage this field deepening the topics.
Grading rulesThe assessment of the learning is based on the elaboration of a written Test that includes: 1. writing of structural formulas of the compounds considered during the course (the list of the structure to be known can be downloaded from the Department's website) 2. open questions, that relate to topics covered and 3. some multiple choice questions. The first part (structural formulas) will permit the evaluation of the degree of knowledge about the “chemistry” of the foods considered in this course, moreover the drafting of the “open questions” will permit the evaluation of the general knowledge about the field. Finally, the reply to the last two questions (multiple choice) will permit the evaluation of the deepening of the study performed by the student. The overcoming of the first part of the written Test (4 out of 6 formulas must to be exact) will be considered to gain access to parts 2 and 3 of the Test and, therefore, to reach the evaluation of the same. The Test schedule is posted on the Department's website.
Full argumentsFood Chemistry Definition (food, ingredients, processed foods) regulatory framework. Foods meaning in Pharma area. Plant and animal proteins. Soy and derived foods. Fruits, vegetables, pulses. Preservation, Ethylene’s role, modified atmospheres. Non alcoholic beverages, fruit juices, nectars, marmalade and jams. Cereals, proteins and celiac disease. Minor cereals and pseudo-cereals. Flours, semolina, bread and pasta. Bakery products. Starch, HGCS, HMCS, HFCS, Honey. Sucrose. Bioactive compounds from foods: case studies. Wine, chemical composition, alcoholic grade. Special wines. Beer, malt production, minor compound of beer. Nervine foods. Food lipids: classification, rectification, hardening. Oxidation and thermo-oxidation. lipids deterioration. Margarine, olive oil and other oils. Milk: composition and classification. HD milk, concentrated and powdered milk. Butter, Yogurt and fermented milks. Cheese, composition and classification. Meat: classification and composition, minor bioactive compounds. Homogenised and lyophilised meats. Fish and Fish products. Eggs and derived products. Water. Novel ingredients e novel foods; Food supplements (definitions and regulatory facts). Food Additives, contaminants and residues Quality and safety of foods, toxicity, Risk assessment (NOAEL; DGA). EU’s regulatory framework. Food colours; sweeteners (bulk or intensive): classification, properties, examples. Other Additives (classification and case studies). Flavourings and Enzymes. Classification of undesired contaminants in foods. Adverse reactions. Antinutritive compounds. Natural toxins (from plant, bacteria, fungi, algae and microalgae, fish). Toxic compounds from essential oils. Microbiological diseases. Food allergens. SO2. Pseudo-allergic reactions, biogenic amines in foods. Food parasites (Anisakis). Technological contaminants: examples. Heavy metals. Residues (pesticides, products for plant protection, veterinary drugs). Environmental contaminants; contaminant from packages. Endocrine disruptors. Detoxifications mechanisms. Web resources.
Close course details
Print
CourseProdotti per l'alimentazione particolare e nuovi servizi in farmacia
Course IDFA0013
Academic Year2016/2017
Year of rule2014/2015
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderTRAVAGLIA Fabiano
TeachersTRAVAGLIA Fabiano
CFU10
Teaching duration (hours)80
Individual study time 170
SSDCHIM/10 - CHIMICA DEGLI ALIMENTI
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year3
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractFoods for particular nutritional uses e new service in pharmacy The course will be divided into three main parts: - General knowledge of nutrition (first part) - Foods for particular nutritional uses, dietary foods for special medical purposes and infant formula (second part) - Law n° 69/2009: indication of new services in Pharmacy. Seminars and practical tests (third part)
Reference texts- F. Evangelisti, P. Restani: Prodotti Dietetici, Ed. Piccin Padova - A. Zangara, E. Bianchi: Dietologia, Ed. Piccin Padova - G. Arienti: Le basi molecolari della nutrizione, Ed. Piccin Padova - P. Cabras, A. Martelli: Chimica degli alimenti, Ed. Piccin Padova - A. Raimondi, C. Lucas: Manuale di Scienza dell’alimentazione e Dietetica, Ed. Piccin Padova - F. Fidanza: Alimentazione e nutrizione umana, Ed. Gnocchi Napoli - Lecture slides
Teaching targetsThe course intends to train, in the future pharmacist, the ability to respond in a clear manner and scientifically valid to the new services in pharmacy (e.g blood tests, blood pressure check, etc.). Students will acquire the knowledge regarding health and nutrition, foods and nutrients. In addition is expected the knowledge regarding Foods for particular nutritional uses (dietetic product, dietary supplements, baby foods, herbal supplements, probiotic and nutraceutical products and novel foods).
PrerequisitesPropaedeutic exam: analysis of medicines 1 Basic concepts of physiology, organic chemistry and biochemistry are highly recommended.
Didattics MethodsFrontal teaching and, if possible, seminars in accordance with the major companies in the sector "point of care testing" will be organized.
Grading rulesThe final examination consists in a written test divided into two sections (90 minutes to complete all sections): 1) Nutrition and foods for particular nutritional uses: 27 questions (7 multiple choice questions and 20 essay questions) 2) New services in pharmacies: 3 essay questions. This type of examination confirms the knowledge in particular of the new services in pharmacies. The scores will also be indicated for each question. Points are not deducted for incorrect answers. To pass the written test, students must obtain at least 18/30.
Full argumentsI part: presentation of the course. Basic concepts of nutrition. Carbohydrates: physical and chemical proprieties. Monosaccharides: pentoses and hexoses. Fermentation of monosaccharides. Polyalcohols, uronic acids and glycosides. disaccharides, oligosaccharides, simple and complex carbohydrates. Maillard reactions. Dietary lipids: composition and classification. Essential fatty acids (EFA). Triglycerides, phospholipids, emulsifying properties, unsaponifiable fraction. Amino acids: stereochemistry and classification. Peptide bond and proteins: classification. Essential and limiting amino acids. Complementary action of proteins. Essential amino acid index, biological value and nutritional index Alcohol intake, dietary and toxicological aspects. Vitamins: fat soluble and water soluble. Minerals: macro and microminerals. Energy, plastic and bioregulator value of foods. Energy units: kJ and kCal, energy balance, caloric equivalents. Basal metabolic rate (BMR). Body mass index (BMI), Energy needs, calculation of basal metabolic rate. Measuring energy expenditure. Dietary Guidelines. Healthy Diet Guidelines (LARN). Food composition tables. Basic Food Groups. The food characteristics and nutritional significance of major food groups. Recommended daily calorie intake. Metabolizable energy, energy partition of proteins, lipids and carbohydrates. Protein need according to the LARN. Protein Quality Evaluation. Parameters for assessing the nutritional value of protein. Digestion, absorption and metabolism of protein. Proper Protein Intake: protein excess and protein deficiency. The Kwashiorkor syndrome. Cow's milk protein intolerance (CMPI), gluten intolerance (celiac disease). Gluten Free Foods. Gluten free statement. Amino acid disorders: phenylketonuria, leucinosis. Dietary interventions. Glucid intake, glycemic index. Digestion, absorption and metabolism of glucids. Prebiotic oligosaccharides. Carbohydrate intolerance (mono and disaccharide intolerance), acetone breath in children, sugar and physical activity. The definition and classification of dietary fiber. Burkitt's theory. Bran, fiber content of foods, the positive effects of fiber. Dietary fiber: effect on carbohydrate and lipid metabolism. Guidelines on fiber intake. Adverse effects of the dietary fiber. Dietary lipids: form and function. Fatty acid distribution: saturated, monounsaturated and polyunsaturated. Deficiency/excess lipid. Short/medium/long chain fatty acids. Monounsaturated and polyunsaturated fatty acids. Essential fatty acids (ω-6 e ω-3). Elongation and desaturation of fatty acids, various pathways for the formation of eicosanoids. Fish oils: DHA and EPA. Trans fatty acid. Digestion, absorption and metabolism of lipids. Lipoproteins: chylomicrons, VLDL, LDL and HDL, lipemic levels in the blood. Diet and atherosclerosis. The main dietary lipids. Mediterranean diet and American "pyramid". Vitamins: technological aspects, losses due to processing of foods. Vitamins intake and vitamin deficiencies. Role of water in nutrition. The water balance. Dietary minerals and oligoelements: biological function. Macroelements and microelements. Salt and hypertension, iodized salt. Comparison of dietary patterns. Effects of storage and processing treatments on the nutritive composition. Nutritional needs of the elderly. Nutritional needs during pregnancy and lactation. The ideal weight, body mass index. Overweight and obesity. Main causes of weight gain, difference between android and gynoid obesity. Consequences of obesity. Overview of pharmacological treatment of obesity. Galenicals and masterful. Dietary treatment of obesity: starvation and modified fast. Balanced and unbalanced low-calorie diets. Artificial Nutrition: enteral and parenteral feeding. Products for enteral and parenteral nutrition. Nutritional needs of infant. Breast milk: characteristics and composition. Comparison between breast milk and cow's milk. Methods of drying cow’s milk: roller and spray dried. Baby milk: European and national legislation. Starting formula milk, acidified milk, anti regurgitation milk, formulas for premature babies. Hypoallergenic milks, soy milk. Baby weaning products: legislation, cereal products and non-cereal products. Baby foods: Homogenized and freeze-dried. Tutorials calculation. Bioactive components: polyphenols and antioxidants. II part: foods for particular nutritional uses: dietetic product, dietary supplements, herbal supplements, probiotic and nutraceutical products. National and European Legislation. III part: Law n° 69/2009: indication of new services in Pharmacy. Minimum and maximum blood pressures (diastolic and systolic), the main blood pressure monitors, with tutorials, recording parameters and statistical evaluation. Main self-test: theoretical principles, blood glucose test, cholesterol, triglycerides, uric acid, hemoglobin, and celiac disease self-test. Ethanol: absorption, metabolism, breathalyzer test (chemical and electronic devices).
Close course details
Print
CourseBiochimica clinica
Course IDFA0020
Academic Year2016/2017
Year of rule2013/2014
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderGARAVAGLIA Silvia
TeachersGARAVAGLIA Silvia
CFU5
Teaching duration (hours)40
Individual study time 85
SSDBIO/10 - BIOCHIMICA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year4
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe course of CLINICAL BIOCHEMISTRY for students of the 4th year PHARMACY aims to address the principles and characteristics of the basic methodologies used in a laboratory of clinical biochemistry. More in detail: • Introduction to Clinical Biochemistry. • Principles and characteristics of the principal methods used for analysis in a clinical biochemistry laboratory. • Electrophoretic techniques • Immunological techniques and radioimmunoassay and enzyme immunoassays tests. With an approach to clinical cases analysis, the following topics will be discussed: • Adjusting the metabolism of energy substrates. • Glycogen metabolism and glucose homeostasis in the blood. • Digestion and transport of lipids assumed in the diet. • Intestinal absorption, synthesis, metabolism and fate of cholesterol. • Metabolism of carbohydrate and lipids in physiological and pathological conditions. • Action of hormones that regulate energy metabolism. • Plasma proteins • Serum cardiac enzymes in atherosclerotic cardiovascular disease • Liver function test and high liver enzymes. • Renal function. • Hemoglobinopathies. • Porphyria. • Tumour Markers. • Monothematic courses: tuberculosis, malaria, virus.
Reference texts- Gaw A. et al. “Clinical Biochemistry, 5th Edition” CHURCHILL LIVINGSTONE ISBN: 9780702051791. - Nessar Ahmed “Clinical Biochemistry” OXFORD UNIVERSITY PRESS. ISBN-13: 9780199533930
Teaching targetsThe course aims to deepen the knowledge of basic biochemistry topics framing them in a medical-health perspective. In addition, for the main clinical biochemistry analysis, the application and interpretation of the results will be deeply described. Also it will be encouraged the research of most recent data published in scientific journals of international importance to deepen all the studied arguments using the scientific web-search "PubMed".
PrerequisitesNone. However, it will be required a good preparation in biochemistry
Didattics Methodsex-cathedra traditional lectures
Grading rulesDuring the oral exam will be assessed the student's ability to link different topics, including the overall logic of the metabolism with a point of view medical health. In addition, it will be assessed the ability to describe the principles, applications and interpretation of the main clinical biochemistry analysis results.
Full argumentsIntroduction to Clinical Biochemistry Definition, the laboratory data and expression of biochemical results. Principles and characteristics of the principal methods used for analysis in a clinical biochemistry laboratory Predictive value, pre-analytical, analytical, and post-analytical variability, classification of measurement errors, interpretation of a clinical biochemistry outcome. Electrophoretic techniques Electrophoresis in agarose matrices for the analysis of nucleic acids; SDS-PAGE and isoelectric focusing of proteins; immunoblotting by western blot Immunological techniques and radioimmunoassay and enzyme immunoassays tests. ELISA and RIA, enzyme kinetics, KM and Vmax. Glycogen metabolism and glucose homeostasis in the body. Glycolysis, Glycogen degradation and synthesis, and Gluconeogenesis in different compart of the body. Action of hormones that regulate energy metabolism Insulin, glucagon and other hormones involved in the regulation of blood glucose concentration. Metabolism of carbohydrate in pathological conditions. Hyperglycemia, diabete type I and type II, hypoglycemia and anorexia. Glycogen storage disease Digestion and transport of lipids assumed in the diet. Chylomicrons, VLDL, LDL and HDL Intestinal absorption, synthesis, metabolism and fate of cholesterol. HMCoA-reduttasi. Metabolism of lipids in pathological conditions. Dyslipidemies, and atherosclerotic cardiovascular disease. Plasma proteins, coagulation and fibrinolysis. Albumin and Prealbumin. Proteins involved in the homeostasis of the iron -Transferrin Ferritin Ceruloplasmine-. The C-reactive protein. Serum cardiac enzymes in Myocardial infarction and in Liver function test. AST, ALT, GGT, ALP and CHE in hepatitis, poisoning, liver cirrhosis and biliary stasis. CK, myoglobin, cardiac Troponins, hFABP and GPBB in Myocardial Infarction. Renal function. Urine Analysis, Urea cycle, purine and pyrimidine metabolism. Haemoglobinopathies. Thalassemia and haemoglobin variants Porphyria. Deficit ALA synthetase, ADP, AIP, CEP, PCT, HCP, PV and EPP. Tumour Markers. Tumour marker, Cancer Stem Cells, Negative false, Positive false, Sensitivity, Specificity and Predictive value, ROC curve. PSA, CA-153, MCA, TPA, Cytokeratin 19, NSE and thyroglobulin. Marker detectable in the urine. Primary secondary, and tertiary prevention. Monothematic courses. Tuberculosis, malaria, virus
Close course details
Print
CourseESSENTIALS OF SPECTROSCOPY
Course IDFA0058
Academic Year2016/2017
Year of rule2013/2014
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderPANZA Luigi
TeachersPANZA Luigi
CFU1
Teaching duration (hours)8
Individual study time 17
SSDCHIM/06 - CHIMICA ORGANICA
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryD - A scelta dallo studente
Year4
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractIntroduction to instrumental spectroscopic analytical methods Introduction to Infrared spectroscopy (IR) Nuclear magnetic resonance spectroscopy (NMR)
Reference textsSlides provided by the teacher M. Hesse, H. Meier, B. Zeeh, Metodi spetroscopici in chimica organica, Edises
Teaching targetsProvide students with the basic knowledge of IR and NMR spectroscopy and the essential elements for the identification of organic substances.
PrerequisitesKnowledge of the structure of the main classes of organic compounds
Didattics MethodsLectures with multimedia support and exercises
Grading rulesOral exam in which, from a series of IR and NMR spectra, the student should identify the structure of a simple organic compound.
Full argumentsIntroduction to spectroscopic analysis methods. Outline of infrared spectroscopy (IR) - Characteristics of a traditional IR spectrophotometer and Fourier transform (FT-IR). The harmonic oscillator. Anharmonicity and quantization. Types of vibration. Instrumentation and sample preparation. The infrared spectrum and typical vibration frequencies of main functional groups. Nuclear magnetic resonance spectroscopy (NMR) - The nuclear spin. Theory of NMR spectroscopy, with particular regard to the technical pulse Fourier transform. Spectral parameters: chemical shift, fine structure, integration of signals. 1H NMR proton. Spectra of the first order. Outline of spin systems. Relationship between structure and chemical shift. Symmetry, chirality and NMR spectrum. 13C NMR: characteristics of the 13C nucleus. Decoupled spectra, off-resonance, DEPT and APT. Relationship between structure and chemical shift.
Course borrowed fromFARMACIA (1506) - FA0058 Elementi di spettroscopia NMR
Close course details
Print
CourseFarmacologia, farmacoterapia e chemioterapia
Course IDFA0018
Academic Year2016/2017
Year of rule2013/2014
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderCANONICO Pier Luigi
TeachersCANONICO Pier Luigi, CONDORELLI Fabrizio
CFU20
Teaching duration (hours)160
Individual study time 340
SSDBIO/14 - FARMACOLOGIA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year4
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractPharmacology and pharmacotherapy Principles of general pharmacology. The concept of neurotransmission, and compounds acting at synaptic and junctional level. Neuropsychopharmacology. Anesthetics and analgesics. Autacoids and therapy of inflammation. Cardiovascular and renal pharmacology. Drugs for the gastroenteric and respiratory systems. Endocrine pharmacology; pharmacology of metabolic diseases. Hematological drugs. Chemotherapy The course focuses on the description of the major therapeutic class used in the treatment of cancer and infectious diseases .
Reference textsF. Rossi, V. Cuomo, C. Riccardi – Farmacologia, Edizioni Minerva Medica, last edition B.G. Katzung, S.B. Master, A.J. Trevor – Farmacologia Generale e Clinica, Piccin, last edition Goodman & Gilman – Le Basi Farmacologiche della Terapia. Il manuale, Zanichelli, last edition H.P. Rang, M.M. Dale, J.M. Ritter, Farmacologia, Casa Editrice Ambrosiana, last edition
Teaching targetsPharmacology and pharmacotherapy The aim of this course is to help the student to understand the general mechanisms involved in the relationships between the drug and the organism, and the action of the drugs in different pathologies. Ideally, at the end of the course the student has to know the pharmaco-therapeutical approach to the different pathologies, and has be able to give advices to patients and to develop control capabilities. Finally, he/she should have enough skills to follow the continuous evolution of pharmacology and pharmacotherapy. Chemotherapy The goal of the course is to provide basic knowledge on the pharmacokinetics, pharmacodynamic and clinical aspects of molecules used to treat oncological and infectious diseases, providing also the critical tools for understanding the therapeutic decisions.
PrerequisitesNone. It is strongly suggested that the student has already positively performed the following courses: Biochemistry, Physiology, Pathology, Biology, Anatomy
Didattics MethodsPharmacology and pharmacotherapy Frontal classes. It will be stimulated the active participation of the student through the recall of concepts already addressed in other courses, which relate to various aspects of the drug and the disease. Chemioterapy The course contents will be transmitted through oral presentations supported by explanatory multimedia about the different topics included in the program. It will be stimulated the active participation of the student through the recall of concepts already addressed in other courses, which relate to various aspects of the drug and the disease.
Other informationsnone
Grading rulesOral examination. Oral examination is performed by asking to the student some questions related to topics indicated in the course programme and given during the specific classes. To obtain positive results, the student must show a sufficient level of knowledge and of associative capabilities related to the different arguments; he/she must show that he understood and knows the critical concepts of the various topics. Greater levels of knowledge together with a demontrated capability of application of this background to the practice leads to an evalutation superior to that required for the minimal score. To obtain a high level of evaluation the student has to be able to utilize his/her knowledge to debate deeply some of the critical aspects of the different topics.
Full argumentsPharmacology and pharmacotherapy General pharmacology. General principles of neurotransmission and compounds acting at synaptic and junctional level – Introduction to neurotransmission and to pharmacology of autonomic nervous system. Serotonin and histamine agonists and antagonists. Drugs of the neuromuscular junction. Neuropsychopharmacology – Antiparkinson drugs, antiepileptics, headache therapy, general concepts on anti-dementia therapy, anxiolytics, antidepressants, antipsychotics. Anesthesia and analgesia – Hypnotics, general and local anesthetics, opiates, analgesics and pain therapy. Autacoids and therapy of inflammation – Histamine, kynins, prostaglandins. Non steroidal antiinflammatory drugs, pharmacotherapy of autoimmune diseases. Cardiovascular drugs and diuretics – Cardiotonics, antiarrhythmics, pharmacological treatment of coronary syndromes, antihypertensive drugs, therapy of shock. Diuretics. Drugs for the gastroenteric and respiratory systems – Pharmacotherapy of peptic ulcer. Drugs for gastrointestinal motility alterations, emetics and antiemetics. Mucolytics. Therapy of asthma and of COPD. Endocrine pharmacology and pharmacology of metabolic diseases – Hypothalanic and hypophyseal hormones; pharmacology of hypophyseal diseases. Adrenal hormones: corticosteroids, sexual hormones, contraceptive procedures, ecbolics; antiandrogens and antiestrogens. Anti-osteoporotic drugs. Thyoid hormones and anti-thyroid drugs. Antidiabetic and anti-dyslipidemic drugs. Pharmacological treatment of gout. Hematological drugs. Chemioterapy Cell cycle regulation and principles of Pharmacotherapy Mechanisms of cell death (apoptosis vs. necrosis) and principles of Pharmacotherapy Classes of antineoplastic chemotherapy: -Anti-metabolites -Alkylating agents -Inhibitors of the mitotic spindle (and Next Generation inhibitors) -Inhibitors Topoisomerases -Inhibitors of protein kinases -Monoclonal antibodies -Immunological approaches in the treatment of cancer -Cellular therapies Anti-microbial chemotherapy -General principles Classes of antibacterial drugs: • Drugs acting on the bacterial cell wall (including anti-TB) • Anti-bacterial Sulphonamides, trimethoprim - sulfamethoxazole • Quinolones • Rifamycins • Bacterial protein synthesis inhibitors Antiviral chemotherapies
Close course details
Print
CoursePHARMACEUTICAL CHEMISTRY II
Course IDF0413
Academic Year2016/2017
Year of rule2013/2014
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderGROSA Giorgio
TeachersGROSA Giorgio
CFU8
Teaching duration (hours)64
Individual study time 136
SSDCHIM/08 - CHIMICA FARMACEUTICA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year4
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
Abstract• Drugs acting on the eicosanoids system: nimesulide, coxibs; salycilic and anthranylic acid derivatives; acetic and propionic acid derivatives; pyrazolidindiones; benzothiazines. • Drugs acting on the steroid hormones system: estrogens; androgens; progestins; glucocorticoids; mineralocorticoids. • Drugs acting on the cardiovascular and renal systems: cardiac glycosides, anti-arhythmics, anticoagulants, fibrinolytic, antiplatelet, antianginal and diuretic drugs; ACE-inhibitors. • Drugs acting on the metabolic diseases: lipid lowering and antidiabetic drugs. • Drugs acting on the istaminergic system. H1and H2-Antihistamines • Drugs acting on the CNS: general anesthetics, sedative-hypnotics, antepileptic drugs. opioid analgesics. neuroleptics. antidepressants. Antiemetics: structures and mechanism of action. Anti Parkinson drugs:. • Drugs acting on the adrenergic system: alfa-agonists and antagonists. beta-agonists and beta antagonists. • Drugs acting on the cholinergic system: muscarinic and nicotinic agonists and antagonist Acetylcholinesterase inhibitors. muscarinic antagonists
Reference texts1) Foye-Lemke-Williams: Principi di Chimica Farmaceutica; Casa Editrice Piccin. 2) Merck Index 3) Gasco, F. Gualtieri, F. C. Melchiorre: Chimica Farmaceutica; Casa Editrice Ambrosiana
Teaching targetsBy the end of the course, the student should have a good understanding of the aspects dealing with the mode of action of drugs. During the course will be dealed the principal drug families: their structure-activity relationships, therapeutical utilization, and their related metabolic and chemical-toxicological aspects should be known by the students.
PrerequisitesExam preparatory Pharmaceutical Chemistry 1 Course teaching is based on the assumption that students have previous knowledge from basal courses in organic chemistry and biochemistry.
Didattics MethodsDuring the lessons will be treated all the different drugs classes with the structures and the relative mechanism of action; moreover the main aspects of the metabolic fate of the drugs were treated highlighting in particular the formation of reactive and toxic species.
Grading rulesThe learning assessment consists of a written test (1.5 hour) and oral examination. The written test consists of 17 questions (1.6 points each) plus an open question for which the maximum possible score is 4 points. In the questions, the structural formula, the mechanism of action and the therapeutic use of the drugs are generally required. Where applicable, the metabolic pathways of the drugs, in particular those involved in the appearance of adverse effects, may also be required. In the open question, referring to a class of drugs, or part of it, the student is required to deal comprehensively the topic, highlighting all aspects of the drugs including the structural formulas, the mechanisms of action, the therapeutic use, SAR and the metabolism. The oral part can be accessed only if the score of the written test is greater than 17. The oral part, which relates to the whole program, aims to highlight the student's ability to present the required topic in a concise and appropriate manner while using the correct terminology.
Full argumentsArachidonic acid cascade: prostaglandins, thromboxanes and leukotrienes. Non steroidal antinflammatory drugs: mode of action, SAR, pharmacological profile, (COX 1 and COX 2 selectivity) and main aspects of their metabolism. Anti-arthritic drugs and antigout: structures and mechanism of action. Antiasthmatic drugs: structures and mechanism of action. Biosynthetic pathways of sex hormones; estrogen agonists and antagonists; aromatase inhibitors. Progesterone agonist/antagonist. Androgens and antiandrogens. Anti-inflammatory corticosteroids. Cardiovascular drugs: cardiac glycosides: general structure and mechanism of action. Anti-arhythmics: structures and mechanisms of action. Anticoagulants, fibrinolytic and antiplatelet agents: structure and mechanism of action. Antianginal drugs: structure and mechanism of action and SAR. ACE-inhibitors. Diuretics: classification of drugs, structures and mechanism of action. Lipid lowering drugs: blood lipoproteins and cholesterol biosynthesis. Statins: mechanism of action, SAR; fibrates. Antidiabetic drugs: structures and mechanism of action. Antihistamines: histamine; H1 antagonists. H2 antagonists: proton pump inhibitors, structures and activation mechanism . Drugs acting on the CNS. General anesthetics: gaseous, volatiles and endovenous (modes of action). Sedative-hypnotics: structures and mechanism of action and SAR: barbiturates, chloral hydrate; benzodiazepines. Antepileptic drugs. Opioid analgesics: peptidergic transmission. Morphine: mode of action, therapeutic use, SAR; partial agonists and antagonists. Neuroleptics: dopamine and its receptors; phenothiazines, thioxanthenes, butyrophenones. Antidepressants: MAO irreversible and reversible inhibitors: mechanism of inhibition. Serotonin cycle. Reuptake inhibitors (serotonin and other neurostransmitter): tricyclic antidepressants endowed with 6,6,6 and 6,7,6 cycle (structure, mode of action). Antiemetics: structures and mechanism of action. Anti Parkinson drugs: levodopa and DOPA-decarboxylase inhibitors, COMT inhibitors, MAO inhibitors; dopamine receptor agonists. Epinephrine and norepinephrine biosynthesis and metabolism. -agonists and antagonists. Non selective -agonists and 2- selective agonist. - non selective antagonists and selective 1-antagonists. Cholinergic drugs: muscarinic and nicotinic agonists. Acetylcholinesterase inhibitors. Non-selective ans selective muscarinic antagonists. Nicotinic antagonists: ganglioplegics and neuromuscular blocking agents. Local anesthetics: structures and mechanism of action.
Close course details
Print
CoursePHARMACEUTICAL POLICY AND LEGISLATION
Course IDFA0063
Academic Year2016/2017
Year of rule2013/2014
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderDE ROSA Mauro
TeachersDE ROSA Mauro
CFU3
Teaching duration (hours)24
Individual study time 51
SSDBIO/14 - FARMACOLOGIA
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryD - A scelta dallo studente
Year4
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Course borrowed toCHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - FA0063 Politiche farmaceutiche
CHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - FA0063 Politiche farmaceutiche
FARMACIA (1506) - FA0063 Politiche farmaceutiche
Close course details
Print
CourseTOXICOLOGY AND PHARMACOVIGILANCE
Course IDF0488
Academic Year2016/2017
Year of rule2013/2014
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderORSETTI Marco Riccardo Lilio
TeachersORSETTI Marco Riccardo Lilio
CFU10
Teaching duration (hours)80
Individual study time 170
SSDBIO/14 - FARMACOLOGIA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year4
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Close course details
Print
CourseTecnologia, legislazione e deontologia farmaceutiche I
Course IDFA0017
Academic Year2016/2017
Year of rule2013/2014
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderMOREL Silvia
TeachersMOREL Silvia
CFU15
Teaching duration (hours)120
Individual study time 255
SSDCHIM/09 - FARMACEUTICO TECNOLOGICO APPLICATIVO
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year4
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe course provide the basis about the design, the formulation and the control of pharmaceutical dosage forms in accordance with current regulation. The fundamentals of legislation in the field of medicine, in the distribution to the public of medicinal products for human use, veterinary and "parafarmaco", are given. Regulatory aspects relating to the responsibility of the pharmacist in the pharmacy as well as the social function of the pharmacy on the territory are provided. Some aspects of professional ethic are given.
Reference texts- A.T. Florence, D. Attwood – Physicochemical Principles of Pharmacy – Macmillan, LTD - M.Aulton, K. Taylor – Aulton’s Pharmaceutics – IV ed. 2013, Churchill Livingstone - Ph.Eur. 9th Edition - EDQM - F.U. XII Edition - IPZS - L.Lachman, H.A. Liebermann, J.L. Kanig – The Theory and Practice of Industrial Pharmacy Lea Febiger. Philadelphia - A.N. Martin, J Swarbrick, A.Cammarata, Physical Pharmacy- Lea & Febiger – Philadelphia
Teaching targetsThe course aims to provide students the knowledge and theunderstanding of the basics regarding the design, formulation and control of pharmaceutical dosage forms in accordance with local regulations. In addition, the fundamentals of the legislation in the field of medicine, the public distribution of medicinal products for human and veterinary use and some professional ethic concepts are provided.
PrerequisitesWe recommend a good knowledge of previous year courses.
Didattics MethodsThe course is throughout the year with lectures.
Other informationsExternal specialists can supplement lessons with seminars.
Grading rulesWritten with open questions and oral throughout the program, according to the schedule established annually.
Full argumentsBasic definitions: Dlvo 219/06 and glossary F.U. Italian Pharmacopoeia. European Pharmacopoeia. International Pharmacopoeia. American Pharmacopoeia. LADME. Main pharmaceutical dosage forms and controls F.U. Excipients, vehicles, additives used in the preparation of pharmaceutical dosage forms. Metrology. Drug stability. Gas for medicinal use. Foams. Sprays. Pressurized pharmaceutical preparations. Inhalation dosage forms. Liquid solutions. Colloidal dispersions. Emulsions. Suspensions. Microemulsions. LCD. Syrups and use of sweeteners. Drops. Preparations obtained from herbal drugs. Parenteral preparations. Semi-solid preparations for cutaneous application. Nasal, ear, eye preparations. Rectal and vaginal preparations. Oromucosal preparations. Powders. Preparation of homeopathic medicines. Veterinary medicines. Main pharmaceutical operations. Glass and plastic material containers. Basic legislative notions. Notices about Italian, international and European legislation. Pharmacist ethics code. Good galenic preparation law (NBP e DM 18/11/2003, successively modified). Italian health organization. L.833/78. Health professions. Professional associations. Licensed to practice. Responsibility of the pharmacist. Pharmaceutical services. Administrative classification of pharmacies. L. 248/2006. Distribution of pharmacies on the territory. Supervision of pharmaceutical services. Inspections at the pharmacy. Texts, registers and documents required. Medicinal products for human use (Dlgs 219/2006, successively modified). Purchase, storage and sell out of narcotic drugs (DPR309/90 and successively modified). Pain therapy (L.12/2001 and successively modified). Storage and sell out of toxic substances. Veterinary medicinal products (Dlgs 193/2006, successively modified). Medicinal products delivery: medical prescription. SOP, OTC. Generics. Biosimilars. Anti-doping law. Homeopathic medicines. Herbal products. Orphan drugs. Drugs off-label. Medical devices. Biocide. L. 69/2009. Cosmetic products (regulation 1223/2009/EU). Food in pharmacy: HACCP. Oxygen. Expired medicines, failures, imperfect. Supervision of all products.
Close course details
Print
CourseTecnologia, legislazione e deontologia farmaceutiche II
Course IDFA0019
Academic Year2016/2017
Year of rule2013/2014
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderSEGALE Lorena
TeachersSEGALE Lorena
CFU10
Teaching duration (hours)56
Individual study time 158
SSDCHIM/09 - FARMACEUTICO TECNOLOGICO APPLICATIVO
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year4
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractIntroduction Pharmaceutical powders Granules Tablets Capsules Multi-unit systems Modified release drug delivery systems Pediatric formulations Galenic preparations Practical exercises in laboratory
Reference textsColombo, P et al.: Principi di tecnologie farmaceutiche. Ed. Ambrosiana. Aulton, ME and Taylor, KMG: Tecnologie farmaceutiche. Progettazione e allestimento dei medicinali, Ed. Edra. Minghetti, P; Marchetti, M.: Legislazione farmaceutica, Ed. Ambrosiana. Farmacopea Ufficiale Italiana edizione vigente; Farmacopea Europea edizione vigente.
Teaching targetsThe couse is divided in two parts: theoretical lessons and practical exercises. The aim of the course is to provide the theoretical notions about the main conventional and unconventional solid dosage forms and about their specific characteristics, manufacturing methods and the technological tests used to assess their quality according to Pharmacopoeia requirements. Moreover, the course provides theoretical and practical information about methods of preparation, price determination, labelling and quality control of galenic products. The student uses the knowledge acquired to face problems about drug formulation and dosage forms (excipients, fabrication methods, quality control tests) using the specific language for this specialistic discipline. Moreover, the course gives to the student skills to manage an advance conversation on dosage forms and galenic products and supplies basic expertise to carry out the professional activity in Pharmacy. The course gives tools to apply the knowledge acquired in the conduction of the work as pharmaceutical technologist or pharmacist and to face the professional responsabilities.
PrerequisitesExam preparatory General and Inorganic Chemistry A good knowledge of the course of the previous years is recommended
Didattics MethodsPharmaceutical technology: frontal lectures. Galenicals: frontal lectures and practical exercises in laboratory.
Grading rulesWritten and/or oral examination; ongoing evaluation during laboratory training. Written test: dispensation of a galenic prescription and questions about topics reported in the program of the course. Oral examination: verification of the capability to hold a conversation (using the appropriate technical language) about pharmaceutical dosage forms and related problems. Ongoing evaluation: composition of the price and labelling of galenic product. The access to the oral examination is allowed only if the student passes the written test.
Full argumentsIntroduction: Principles of biopharmaceutics. Conventional and unconventional drug delivery systems. Concept of preformulation. Pharmaceutical powders: Powders as dosage form. Granules: Introduction to granulation, granulation methods and mechanisms; formulation of granules; specific technological assays. Tablets: Definition; classification; tablet excipients and formulations; tablet production; specific technological tests; coating of tablets. Capsules: Definition; hard and soft capsules: preparation, formulation and specific technological tests. Multi-unit systems: Microparticles and pellets; preparation, formulation and specific technological tests. Modified release drug delivery systems: Unconventional oral dosage forms: characteristics and drug release mechanisms. Reservoir systems, matrix systems, osmotic pump systems; site-specific drug delivery systems and time-specific drug delivery systems; fast release systems. Transdermal drug delivery systems. Intravaginal and intrauterine drug delivery systems. Intraocular drug delivery systems. Pediatric formulations. Galenic preparations: Magistral and officinal galenic products: preparation; composition of price according to National Price List for galenic preparations (statute articles and enclosures A and B - D.M. 18 agosto 1993); composition of label of galenic preparations. Laboratory practical exercises: Galenic preparations: preparation of galenic formulations (suppositories, ovules, syrups, solutions, emulsions, creams, ointments, gels, pastes). Composition of the price and labelling of the galenic preparations. Quality assurance: preparation of solid dosage forms (capsules and tablets) and quality assurance tests according to the Pharmacopoeia specifications. Use of software for the management of the professional activity in Pharmacy.
Close course details
Print
CourseVISUALIZZAZIONE MOLECOLARE
Course IDFA0100
Academic Year2016/2017
Year of rule2013/2014
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderMASSAROTTI Alberto
TeachersMASSAROTTI Alberto
CFU1
Teaching duration (hours)8
Individual study time 17
SSDCHIM/08 - CHIMICA FARMACEUTICA
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryD - A scelta dallo studente
Year4
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractThe aim of the course is to introduce the student to the main principles of molecular visualization of chemical entities (compounds, proteins).
Reference textsThe course is given with the support of slides.
Teaching targets1. Knowledge and understanding. At the end of the course the student will know and understand the basic concepts of molecular visualization, in particular the student will be instructed on the techniques used to support drug design. 2. Ability to apply knowledge and understanding. The student will be able to apply the knowledge and understanding gained the recognition of chemical structures in 3D space, the discussion of their interactions, and their graphic representation. 3. Management of the knowledge acquired at the end of the expression of judgments relating to the 3D structures of molecules and proteins. In addition, the student will be provided with the necessary tools to apply these skills to the critical evaluation to the figures of scientific articles. 4. Skill in communication, in the know explain, even in an original way, a molecule or protein using the lessons dealt software. 5. Ability to learn and learn how to handle dynamically, and as independent as possible, their own body of knowledge on the structure of molecules and proteins.
PrerequisitesGood knowledge in general biology, biochemistry, general pharmacology, and medicinal chemistry is strongly recommended.
Didattics MethodsThe course is given with the support of slides, which are given to the students at the beginning of the lessons. General and specific topics will be introduced, basic concepts will be provided for the understanding of each issue, and discussions with the students will be held. A forum section on the course page on D.I.R. (http://www.dir.uniupo.it) will help the discussions.
Other informationsFor further informations, please refer to the course page on D.I.R. at: http://www.dir.uniupo.it
Grading rulesThe final exam will be focused on a practical exercise with oral discussion. The exam aims at verifying the ability to create a figure of molecules using the knowledge learned in this course.
Full argumentsThe topics will be: • History of the representation of the molecules • Database for structures of organic compounds and proteins • Most popular programs for molecular visualization • Download, upload and basic display of a model • Interaction with the molecular models in a virtual space • Measurement of molecular characteristics • Surface properties • Analysis of the protein-inhibitor interactions • Alignment of 3D structures • Create high-definition images • Managing multiple representations (or scenes) • Creating animations • Molecular Editing • Scripting
Course borrowed toCHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - FA0100 VISUALIZZAZIONE MOLECOLARE
CHIMICA E TECNOLOGIA FARMACEUTICHE (1505) - FA0100 VISUALIZZAZIONE MOLECOLARE
FARMACIA (1506) - FA0100 VISUALIZZAZIONE MOLECOLARE
Close course details
Print
CourseESSENTIALS OF SPECTROSCOPY
Course IDFA0058
Academic Year2016/2017
Year of rule2012/2013
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderPANZA Luigi
TeachersPANZA Luigi
CFU1
Teaching duration (hours)8
Individual study time 17
SSDCHIM/06 - CHIMICA ORGANICA
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryD - A scelta dallo studente
Year5
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageItalian
AbstractIntroduction to instrumental spectroscopic analytical methods Introduction to Infrared spectroscopy (IR) Nuclear magnetic resonance spectroscopy (NMR)
Reference textsSlides provided by the teacher M. Hesse, H. Meier, B. Zeeh, Metodi spetroscopici in chimica organica, Edises
Teaching targetsProvide students with the basic knowledge of IR and NMR spectroscopy and the essential elements for the identification of organic substances.
PrerequisitesKnowledge of the structure of the main classes of organic compounds
Didattics MethodsLectures with multimedia support and exercises
Grading rulesOral exam in which, from a series of IR and NMR spectra, the student should identify the structure of a simple organic compound.
Full argumentsIntroduction to spectroscopic analysis methods. Outline of infrared spectroscopy (IR) - Characteristics of a traditional IR spectrophotometer and Fourier transform (FT-IR). The harmonic oscillator. Anharmonicity and quantization. Types of vibration. Instrumentation and sample preparation. The infrared spectrum and typical vibration frequencies of main functional groups. Nuclear magnetic resonance spectroscopy (NMR) - The nuclear spin. Theory of NMR spectroscopy, with particular regard to the technical pulse Fourier transform. Spectral parameters: chemical shift, fine structure, integration of signals. 1H NMR proton. Spectra of the first order. Outline of spin systems. Relationship between structure and chemical shift. Symmetry, chirality and NMR spectrum. 13C NMR: characteristics of the 13C nucleus. Decoupled spectra, off-resonance, DEPT and APT. Relationship between structure and chemical shift.
Course borrowed fromFARMACIA (1506) - FA0058 Elementi di spettroscopia NMR
Close course details
Print
CourseFINAL EXAM
Course IDF0421
Academic Year2016/2017
Year of rule2012/2013
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
CFU20
Individual study time 500
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryE - Prova finale e lingua straniera
Year5
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal grade
Close course details
Print
CourseINTERNSHIP
Course IDF0068
Academic Year2016/2017
Year of rule2012/2013
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
CFU30
Individual study time 900
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryS - Insegnamento di sede
Year5
PeriodAnnuale
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Print
CoursePHARMACEUTICAL POLICY AND LEGISLATION
Course IDFA0063
Academic Year2016/2017
Year of rule2012/2013
Degree1506 - FARMACIA
CurriculumCORSO GENERICO
Teaching leaderDE ROSA Mauro
TeachersDE ROSA Mauro
CFU3
Teaching duration (hours)24
Individual study time 51
SSDBIO/14 - FARMACOLOGIA
Course typeAttività formativa monodisciplinare
Course mandatorietyOpzional course
Course categoryD - A scelta dallo studente
Year5
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Course borrowed fromFARMACIA (1506) - FA0063 Politiche farmaceutiche
Close course details
Data synched: 19/12/2017, 19:13