Laurea magistrale in Medical biotechnology

Academic program 2017/2018

Print guide
Print
Course ID Course Teachers SSD Curriculum Site CFU Year
MS0452 Fertility, reproduction and endocrine system biotechnologies MARZULLO Paolo, SURICO Daniela MED/13, MED/40 All 4 1
MS0455 Functional Genomics GIORDANO Mara, BALDANZI Gianluca, ZUCCHELLI Silvia MED/03, BIO/10, BIO/18 All 11 1
MS0459 Internal Medicine CASTELLO Luigi Mario MED/09 All 5 1
MS0465 Molecular therapy COLANGELO Donato, ELLIS Steven Robert BIO/13, BIO/14 All 11 1
MS0468 Molecular virology GARIGLIO Marisa MED/07 All 6 1
MS0469 Neoplastic and proliferative disorders ISIDORO Ciro, GAIDANO Gianluca MED/15, MED/04 All 12 1
MS0491 Regenerative Medicine FOLLENZI Antonia, PELICCI Giuliana BIO/11, BIO/17 All 10 1
MS0461 Molecular diagnostics BOLDORINI Renzo Luciano, CAPELLO Daniela, ROLLA Roberta MED/08, BIO/12, MED/05 All 11 2
MS0473 Public health and regulatory aspects FAGGIANO Fabrizio, GATTEI Valter, MAGNANI Corrado MED/42, SECS-P/07, MED/01 All 11 2
MS0480 Transplantation and Biocompatibility RIMONDINI Lia, GAIDANO Gianluca, QUAGLIA Marco, CHIOCCHETTI Annalisa, BOCCAFOSCHI Francesca, MANTOVANI Diego MED/15, MED/14, MED/04, BIO/16, MED/28, BIO/11 All 7 2
Print
CourseFertility, reproduction and endocrine system biotechnologies
Course IDMS0452
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderMARZULLO Paolo
CFU4
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year1
PeriodPrimo Semestre
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
MS0453 Endocrinology and Metabolism MED/13 - ENDOCRINOLOGIA MARZULLO Paolo
MS0454 Biotechnology of reproduction MED/40 - GINECOLOGIA E OSTETRICIA SURICO Daniela
Close course details
Show parent course details
Print
CourseEndocrinology and Metabolism
Course IDMS0453
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderMARZULLO Paolo
TeachersMARZULLO Paolo
CFU2
Teaching duration (hours)10
Individual study time 40
SSDMED/13 - ENDOCRINOLOGIA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Show parent course details
Print
CourseBiotechnology of reproduction
Course IDMS0454
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderSURICO Daniela
TeachersSURICO Daniela
CFU2
Teaching duration (hours)12
Individual study time 38
SSDMED/40 - GINECOLOGIA E OSTETRICIA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Print
CourseFunctional Genomics
Course IDMS0455
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderGIORDANO Mara
CFU11
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year1
PeriodPrimo Semestre
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
MS0456 Genomic analysis MED/03 - GENETICA MEDICA GIORDANO Mara
MS0457 Regulation of gene expression BIO/10 - BIOCHIMICA BALDANZI Gianluca
MS0458 Genetics BIO/18 - GENETICA ZUCCHELLI Silvia
Close course details
Show parent course details
Print
CourseGenomic analysis
Course IDMS0456
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderGIORDANO Mara
TeachersGIORDANO Mara
CFU5
Teaching duration (hours)30
Individual study time 95
SSDMED/03 - GENETICA MEDICA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Show parent course details
Print
CourseRegulation of gene expression
Course IDMS0457
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderBALDANZI Gianluca
TeachersBALDANZI Gianluca
CFU5
Teaching duration (hours)20
Individual study time 105
SSDBIO/10 - BIOCHIMICA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
AbstractAfter a quick review of gene structure in eukaryotes and prokaryotes, the issue of gene expression regulation will be presented. The first part of the course will deal with prokaryotes gene expression and its regulation. A series of examples will illustrate the possibility of engineering promoters and genes for biotechnological purposes. The second part of the course will deal with the eukaryotes gene expression and the multiple levels of its regulation. Issues: 1) chromatin organization and structure, 2) transcription factor function, 3) pre-initiation complex, 4) transcription termination, 5) RNA stability and 6) RNA translation. The third part of the course will deal with the mechanisms by which extracellular signals and intracellular cues regulates gene expression in eukaryotes. A particular emphasis will be placed on the alterations of gene expression in cancer and on the regulation of gene expression in function of nutrients and metabolic status of the cell.
Reference textsFor the improvement of students background Harper's Illustrated Biochemistry, 29e, Robert K. Murray, David A. Bender, Kathleen M. Botham, Peter J. Kennelly, Victor W. Rodwell, P. Anthony Weil Please note: available on Access Medicine for our students Molecular Biology of the Cell - Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter Edition:5th Please note: the 4th edition is available for free on NCBI bookshelf http://www.ncbi.nlm.nih.gov/books/NBK21054/ Suggested textbook Genomes 3 By Terence A. Brown Please note: the 2nd edition is available for free on NCBI bookshelf http://www.ncbi.nlm.nih.gov/books/NBK21128/ Cell Signalling Biology Professor Sir Michael Berridge http://www.biochemj.org/csb/ An extended series of reviews evidenced during the course.
Teaching targetsImproving background and learning problem solving in the study of gene expression.
Prerequisites• Basic Biology: Prokaryotes and Eukaryotes intracellular organization. • Basic biochemistry: DNA and RNA structure and metabolism, protein synthesis, enzyme proprieties. • Basic molecular biology: concept of gene, gene expression, promoter, transcription factor, RNA synthesis and degradation. For the students lacking a strong background in life sciences a series of readings will be proposed to improve their skills on those topics.
Didattics MethodsDuring the course, slides and webinars are extensively used. A copy of the slides and the websites used during the course will be available on the DIR site. Students will undertake teacher driven research/presentation/teamwork.
Grading rulesWritten exam on a series of topics evidenced during the course.
Full argumentsTopic 1 Gene expression regulation Recall of the organization of genes in eukaryotes (enhancers, promoters, transcription start site, introns/exons, transcription termination sites). Control of gene transcription at the level of transcription initiation rate, splicing and alternative splicing, mRNA stability, RNA interference and microRNA. Transcription factors organization: structure of DNA binding and trans-activating domains. Major DNA regulatory sequences. Assembly of RNApolII transcription initiation complex. Methods to study DNA regulatory elements, Promoter structure and transcription factor binding sites. Transcription factors and chromatin structure, chromatin remodeling and gene expression. Post transcriptional modification of histones and the histone code. DNA mutilation. Other ways to regulate gene expression: alternative promoters, alternative splicing, control of mRNA stability, control of mRNA translation, miRNA and RNA interference. Topic 2 Control of gene expression by extracellular and intracellular cues. How signal transduction pathways regulates gene expression: - The nuclear receptor family - The STAT family - ERK signaling to the serum response elements. - Myc in growth factors signaling and tumor formation - Hif in the response to hypoxia and tumorigenesis - P53 mutations, cancer and metabolism Topic 3 Tumor cell metabolism and the way to study it. Peculiarities of tumor metabolism, the Warburg effect and beyond. Methods to study metabolism, integrating gene expression, metabolomics and in vivo data. Use of mass spectrometry, PET/NMR probes, and electrodes (Oxygen Consumption Rate – ExtraCellular Acidification Rate) to study metabolism in living cells/tissues/patients. Experimental manipulation of metabolism and possible routes for cancer therapy. Topic 4 How oncogenes and altered signaling pathways regulates tumor cell metabolism. Tumor metabolomics, onco-metabolites and the peculiarities of tumor metabolism. How alterations of signal transduction machinery and gene expression integrates with a peculiar micro-environment to dictate tumor metabolism. How alterations of the metabolism (i.e. dietary habits or cell energetic status) influence chromatin status and gene expression.
Expected learning objectivesUnderstanding the mechanisms of regulation of gene expression and how such knowledge can be used in research or therapy.
Close course details
Show parent course details
Print
CourseGenetics
Course IDMS0458
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderZUCCHELLI Silvia
TeachersZUCCHELLI Silvia
CFU1
Teaching duration (hours)8
Individual study time 17
SSDBIO/18 - GENETICA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Print
CourseInternal Medicine
Course IDMS0459
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderCASTELLO Luigi Mario
TeachersCASTELLO Luigi Mario
CFU5
Teaching duration (hours)20
Individual study time 105
SSDMED/09 - MEDICINA INTERNA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Close course details
Print
CourseMolecular therapy
Course IDMS0465
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderCOLANGELO Donato
CFU11
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year1
PeriodSecondo Semestre
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
MS0466 Biotechnological applications BIO/13 - BIOLOGIA APPLICATA ELLIS Steven Robert
MS0467 Pharmacology BIO/14 - FARMACOLOGIA COLANGELO Donato
Close course details
Show parent course details
Print
CourseBiotechnological applications
Course IDMS0466
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderELLIS Steven Robert
TeachersELLIS Steven Robert
CFU6
Teaching duration (hours)36
Individual study time 114
SSDBIO/13 - BIOLOGIA APPLICATA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Show parent course details
Print
CoursePharmacology
Course IDMS0467
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderCOLANGELO Donato
TeachersCOLANGELO Donato
CFU5
Teaching duration (hours)25
Individual study time 100
SSDBIO/14 - FARMACOLOGIA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
AbstractThe course will focus on the analysis of the rational bases for the development of selected classes of target –designed drugs, also considering their pharmacokinetics and pharmacodynamic aspects for a clinical use. Furthermore, the course integrate basic pharmacology with clinic properties. Relevant drugs will be also analyzed in order to point out relevant molecular and diagnostic properties useful for the preclinical development of new biotech drugs.
Reference textsThe pharmacological bases of therapy, Goodman e Gilman, XI, Mc Graw-Hill Pharmacology, Rang H.P., Dale M.M., Ritter J.M e Moore P.K., Editor Ambrosiana
Teaching targetsThe course is intended to provide specific knowledge of pharmacologic constants that rule the therapeutic properties of selected drugs developed with biotech methodologies.
PrerequisitesBasic knowledges of Anatomy, Physiopathology and Internal Medicine
Didattics MethodsFrontal Lessons. The teaching activities will take place from the front of the classroom.
Other informationsThe teacher will meet the students on every Tuesday 2-6 p.m., best after email reservation.
Grading rulesMultiple choice tests.
Full argumentsThe course will focus on the analysis of the rational bases for the development of selected classes of target –designed drugs, also considering their pharmacokinetics and pharmacodynamic aspects for a clinical use. Furthermore, the course integrate basic pharmacology with clinic properties. Relevant drugs will be also analyzed in order to point out relevant molecular and diagnostic properties useful for the preclinical development of new biotech drugs.
Close course details
Print
CourseMolecular virology
Course IDMS0468
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderGARIGLIO Marisa
TeachersGARIGLIO Marisa
CFU6
Teaching duration (hours)28
Individual study time 122
SSDMED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Close course details
Print
CourseNeoplastic and proliferative disorders
Course IDMS0469
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderISIDORO Ciro
CFU12
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year1
PeriodPrimo Semestre
Grading typeFinal grade
Teaching languageEnglish
Abstractrefer to MS0470 and MS0471
Reference textsrefer to MS0470 and MS0471
Teaching targetsrefer to MS0470 and MS0471
Prerequisitesrefer to MS0470 and MS0471
Didattics Methodsrefer to MS0470 and MS0471
Other informationsrefer to MS0470 and MS0471
Grading rulesrefer to MS0470 and MS0471
Full argumentsrefer to MS0470 and MS0471
Expected learning objectivesrefer to MS0470 and MS0471
Modules
Course ID Course SSD Teachers
MS0470 Hematoncology MED/15 - MALATTIE DEL SANGUE GAIDANO Gianluca
MS0471 Experimental oncology MED/04 - PATOLOGIA GENERALE ISIDORO Ciro
Close course details
Show parent course details
Print
CourseHematoncology
Course IDMS0470
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderGAIDANO Gianluca
TeachersGAIDANO Gianluca
CFU5
Teaching duration (hours)20
Individual study time 105
SSDMED/15 - MALATTIE DEL SANGUE
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Show parent course details
Print
CourseExperimental oncology
Course IDMS0471
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderISIDORO Ciro
TeachersISIDORO Ciro
CFU7
Teaching duration (hours)28
Individual study time 147
SSDMED/04 - PATOLOGIA GENERALE
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
Abstract1. the epidemiologic relevance of Cancer; the influence of the environment and of the life style. 2. the main histopathologic characteristics of the tumours and their classification 3. the molecular alterations responsible for the malignant behaviour of tumour cells (loss of proliferative control; resistance to apoptosis; invasiveness; altered metabolism of glucose, aminoacids and fatty acids; altered proteome homeostasis); the role of autophagy and of cell death in cancer 4. the role of genetics and epigenetics in cancer development and progression; the genetic defects that predispose to cancer; genome (chromosomal translocation) alterations and gene mutations (oncogenes, oncosuppressors) associated with cancer 5. the origin and phenotypic characteristics of Cancer Stem Cells; the genetic and metabolic re-programming leading to cancer 6. the mechanisms of metastasis formation; the role of proteolytic enzymes 7. the inter-relationship between tumour cells and the tumour stroma, with particular regard to the role of cancer associated fibroblasts and of immune cells; 8. the molecular and patho-physiological mechanisms responsible for the cachexia syndrome. 9. the current techniques for Diagnosis (imaging, biomarkers) and the therapeutic treatments available (chemical chemotherapy, biomolecular therapy). 10. Novel therapeutic approach (epigenetics); novel paradigms for carcinogenesis (microbioma);
Reference textsThe Molecular Biology of Cancer S-Pelengaris and M. Khan (Wiley-Blackwell edition) Chapter 7 NEOPLASIA by Thomas P Stricker and V Kumar (from Robbins, The molecular Basis of Disease) USEFUL WEB SITES: http://www.insidecancer.org; http://www.nci.nih.gov/; http://www.oncolink.com/; http://www.cancer.gov; http://www.medlib.med.utah.edu/WebPath/LIVEHTML/LIVERIDX.html#5 http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.chapter.10
Teaching targets How to recognize the histopathological characteristics of major human neoplasms;  Understand what molecular and cellular alterations determine the neoplastic phenotype;  Considering the natural causes of carcinogenesis and the factors that can cause tumor recurrence, bearing in mind the role of defensive systems at the molecular, cellular and organizational levels;  Describe the distinctive (morphological, metabolic, behavioral) characteristics of neoplastic stem cells;  Know the mechanisms responsible for the infiltration and metastasis of tumors;  illustrate how the stromal microenvironment surrounding the tumor is modified and how can this promote neoplastic growth  Recognize clinical signs and know how to describe the molecular and pathophysiological mechanisms of neoplastic cachexia. KNOWLEDGE AND ABILITY EXPECTED At the end of the course, the student should be able to read and analyse scientific articles on cellular and molecular biology of the tumours (during the course each student will have to present a scientific article on a subject). Learning Outcomes: Knowledge about the cellular and molecular mechanisms underlying the cancerogenesis process. Dynamics of neoplastic populations. Natural History of Neoplasms. Risk Factors for the Development of Neoplasms.
PrerequisitesBasic Knowledge of Cell Biology and Histology, Molecular Biology and Biochemistry.
Didattics MethodsInteractive lesson involving students continuously with questions to stimulate curiosity and test understanding of concepts. Illustration of processes with practical examples. Discussion of relevant scientific articles. A copy of the slides presented during the lessons will be provided in advance
Other informationsStudents can contact the teacher and ask for explanations after appointment by email. OPTIONAL ACTIVITIES: Students are welcome to spend a period in the laboratory of Molecular Pathology to participate in the design, execution and discussion of experiments. CFU will be assigned based on the duration of the stage.
Grading rulesEXAM MODALITY (2 steps for each module) 1. Written test (30 minutes for 3 statements): answer TRUE/FALSE and give an explanation to support your answer in 5 (not less) to10 (not more) lines. (please, write in a legible writing). At least 2 out of 3 answers must be correct in order to be admitted to the next step (oral examination). (Evaluation: 6-8/30 points for each question). 2. Oral examination (approx. 10-20 min): A) discussion of the written test. B) discussion of an original articles dealing with a subject of your choice inherent the program of the course and published in a good journal (consult with your professor for an appropriate choice). (Evaluation: 4-6/30 points). C) (optional): 1 or 2 extra question(s). (Evaluation 2-4/30, Laude). Maximal score is 30 + Laude/30. 3. NOTE: 1. the final score is agreed between the two Professors as an average of the scores obtained for the two modules. 2. in case only one of the two modules (A or B) is passed (score >18/30), the vote will be considered valid for only the next session in which the other module (B or A) must be passed. In case of failure the student must repeat the exam for both (A and B) modules in a new session.
Full argumentsIntroduction to Cancer: Definition, Epidemiology, Origin of cancer (multistage carcinogenesis, genetic and epigenetic clonal expansion; mutations, risk factors). Nomenclature, Histopathology. Classification, Staging, Grading. Aetiology; Gene – environment interaction; chemical carcinogenesis; radiation and carcinogenesis; virus and carcinogenesis. Life style and Cancer (smoke, diet). Genetic and chromosome instability. DNA repair. Genetic predisposition syndromes. Cancer cell biology: Control of cell proliferation and cell differentiation: cell cycle; cell signalling. Cancer cell biology: Control of cell homeostasis; control of macromolecular turnover; Autophagy; Control of Cell death (Apoptosis, Necrosis, Autophagic cell death). Molecular Oncology 1: Oncogenes. Main Oncogenes: c-MYC, RAS, others. Oncogene addiction. Molecular Oncology 2: Tumour Suppressors. Main Tumour Suppressor genes: TP53, PTEN, BECLIN1, TSC, others. Tumour cell metabolism: Warburg effect, glutamine, glucose. Oncogenes and oncosuppressors and cancer cell metabolism. Papers’ discussion. Dormancy, Senescence, Telomerases, Cancer Stem Cells. Papers’ discussion. Epigenetics and Cancer. DNMT, HDAC, microRNAs. Oncosuppressor Imprinting (ARH-I/DIRAS3). Papers’ discussion. Tumour stroma. Cancer associated fibroblasts. Cancer inflammation. Papers’ discussion. Cell adhesion. Invasion and Metastasis. Angiogenesis. Tumour immunity. Cachexia. Cancer diagnosis, cancer therapy. Specific cancers: Colon, Breast, Lung, Prostate, Ovary, Melanomas and Skin cancers. Diet and cancer; anticancer properties of phytochemicals, vitamins, natural products. Microbioma and Cancer.
Expected learning objectivesKnowing the causes and mechanisms of carcinogenesis and tumor progression. Knowing how to interpret, discuss and present the experimental laboratory results or found in literature, specifically aimed at describing and understanding the neoplastic transformation and behavior of tumor cells.
Close course details
Print
CourseRegenerative Medicine
Course IDMS0491
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderFOLLENZI Antonia
CFU10
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year1
PeriodSecondo Semestre
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
MS0492 Molecular Biology BIO/11 - BIOLOGIA MOLECOLARE PELICCI Giuliana
MS0479 Histology, Gene and Cell Therapy BIO/17 - ISTOLOGIA FOLLENZI Antonia
Close course details
Show parent course details
Print
CourseMolecular Biology
Course IDMS0492
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderPELICCI Giuliana
TeachersPELICCI Giuliana
CFU5
Teaching duration (hours)30
Individual study time 95
SSDBIO/11 - BIOLOGIA MOLECOLARE
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodSecondo Semestre
Grading typeFinal judgment
Close course details
Show parent course details
Print
CourseHistology, Gene and Cell Therapy
Course IDMS0479
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderFOLLENZI Antonia
TeachersFOLLENZI Antonia
CFU5
Teaching duration (hours)30
Individual study time 95
SSDBIO/17 - ISTOLOGIA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodSecondo Semestre
Grading typeFinal judgment
Close course details
Print
CourseMolecular diagnostics
Course IDMS0461
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderBOLDORINI Renzo Luciano
CFU11
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year2
PeriodSecondo Semestre
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
MS0462 Pathologic basis of diseases MED/08 - ANATOMIA PATOLOGICA BOLDORINI Renzo Luciano
MS0463 Clinical applications of Molecular Biology BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA CAPELLO Daniela
MS0464 Clinical Pathology MED/05 - PATOLOGIA CLINICA ROLLA Roberta
Close course details
Show parent course details
Print
CoursePathologic basis of diseases
Course IDMS0462
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderBOLDORINI Renzo Luciano
TeachersBOLDORINI Renzo Luciano
CFU5
Teaching duration (hours)20
Individual study time 105
SSDMED/08 - ANATOMIA PATOLOGICA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
AbstractDiagnostic, prognostic and predictive factors of pathological interest of the main human malignancies: carcinoma of the lung, breast, colorectal, urinary tract, male and female genital, central nervous system, thyroid; major molecular markers of diagnostic, prognostic and predictive interest: technical principles and clinical applications.
Reference textsKumar, Abbas, Fausto. Robbins and Cotran Pathologic Basis of Disease. VII ed Elsevier, 2005-09-07; scientific articles (references given during the course).
Teaching targetsThe student must be able to understand the meaning of translational molecular diagnostic procedure in pathological context relating to the main human neoplastic diseases.
PrerequisitesNotions of Pathology, Anatomy and Histology and Molecular Biology.
Didattics MethodsPower-point presentations, CD-ROM and educational websites.
Grading rulesMultiple choice test
Close course details
Show parent course details
Print
CourseClinical applications of Molecular Biology
Course IDMS0463
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderCAPELLO Daniela
TeachersCAPELLO Daniela
CFU5
Teaching duration (hours)20
Individual study time 105
SSDBIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Show parent course details
Print
CourseClinical Pathology
Course IDMS0464
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderROLLA Roberta
TeachersROLLA Roberta
CFU1
Teaching duration (hours)4
Individual study time 21
SSDMED/05 - PATOLOGIA CLINICA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year2
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
AbstractThis course provides an overview of the current knowledge in pharmacogenetics.
Reference textsTeaching Material provided by the lecturer. Lecturer's Monograph.
Teaching targetsThe aim of the present course is to provide knowledge about the influence of genetics on drug therapy and about the validity and utility of pharmacogenomic tests in the clinical setting.
PrerequisitesThorough knowledge of Molecular Biology and Genetics (basics of genomics as well as methods to identify mutations).
Didattics MethodsPowePoint presentation. Teaching Network on DIR Website. Frontal lessons.
Grading rulesMultiple choice test
Full argumentsOne of the great challenges in drug development and therapy is maximizing therapeutic response while avoiding adverse effects. Advances in genetic knowledge, gained through sequencing, have identified heritable genetic variants that predict drug response. Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects/ toxicity. The use of these genetic informations can play a major role in clinical practice to predict the right choice and dose of medications for individuals, thus providing a scientific basic for “personalized medicine”. This is particularly important in the case of anticancer drugs whose the therapeutic index is very narrow and a large proportion of patients do not respond. Although the knowledge on an individual’s DNA sequence as an integral determinant of drug therapy has not yet become standard clinical practice, however several genetics recommendations/guidelines for physicians have been developed and are highlighted in the present course. In particular, the course explores the pharmacogenetic clinical utility in: •anticancer drugs (tamoxifen & breast cancer) •treatment of chronic pain (codeine) •antipsychotic therapy •antiplatelet therapy (clopidogrel) •oral anticoagulant therapy (warfarin)
Close course details
Print
CoursePublic health and regulatory aspects
Course IDMS0473
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderFAGGIANO Fabrizio
CFU11
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year2
PeriodPrimo Semestre
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
MS0474 Public Health MED/42 - IGIENE GENERALE E APPLICATA FAGGIANO Fabrizio
MS0475 Innovation and Patents SECS-P/07 - ECONOMIA AZIENDALE GATTEI Valter
MS0476 Biomedical statistics MED/01 - STATISTICA MEDICA MAGNANI Corrado
Close course details
Show parent course details
Print
CoursePublic Health
Course IDMS0474
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderFAGGIANO Fabrizio
TeachersFAGGIANO Fabrizio
CFU5
Teaching duration (hours)30
Individual study time 95
SSDMED/42 - IGIENE GENERALE E APPLICATA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Show parent course details
Print
CourseInnovation and Patents
Course IDMS0475
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderGATTEI Valter
TeachersGATTEI Valter
CFU1
Teaching duration (hours)8
Individual study time 17
SSDSECS-P/07 - ECONOMIA AZIENDALE
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Show parent course details
Print
CourseBiomedical statistics
Course IDMS0476
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderMAGNANI Corrado
TeachersMAGNANI Corrado
CFU5
Teaching duration (hours)20
Individual study time 105
SSDMED/01 - STATISTICA MEDICA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Print
CourseTransplantation and Biocompatibility
Course IDMS0480
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderRIMONDINI Lia
CFU7
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year2
PeriodPrimo Semestre
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
MS0481 Hematopoietic stem cell biology and transplantation MED/15 - MALATTIE DEL SANGUE GAIDANO Gianluca
MS0482 Biotechnology in kidney transplantation MED/14 - NEFROLOGIA QUAGLIA Marco
MS0483 Transplant immunology MED/04 - PATOLOGIA GENERALE CHIOCCHETTI Annalisa
MS0484 Materials Biocompatibility BIO/16 - ANATOMIA UMANA BOCCAFOSCHI Francesca
MS0485 Nanomaterials MED/28 - MALATTIE ODONTOSTOMATOLOGICHE RIMONDINI Lia
MS0493 Molecular strategies for improving materials biocompatibility BIO/11 - BIOLOGIA MOLECOLARE MANTOVANI Diego
Close course details
Show parent course details
Print
CourseHematopoietic stem cell biology and transplantation
Course IDMS0481
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderGAIDANO Gianluca
TeachersGAIDANO Gianluca
CFU1
Teaching duration (hours)6
Individual study time 19
SSDMED/15 - MALATTIE DEL SANGUE
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Show parent course details
Print
CourseBiotechnology in kidney transplantation
Course IDMS0482
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderQUAGLIA Marco
TeachersQUAGLIA Marco
CFU1
Teaching duration (hours)6
Individual study time 19
SSDMED/14 - NEFROLOGIA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Show parent course details
Print
CourseTransplant immunology
Course IDMS0483
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderCHIOCCHETTI Annalisa
TeachersCHIOCCHETTI Annalisa
CFU2
Teaching duration (hours)8
Individual study time 42
SSDMED/04 - PATOLOGIA GENERALE
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Close course details
Show parent course details
Print
CourseMaterials Biocompatibility
Course IDMS0484
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderBOCCAFOSCHI Francesca
TeachersBOCCAFOSCHI Francesca
CFU1
Teaching duration (hours)4
Individual study time 21
SSDBIO/16 - ANATOMIA UMANA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
Reference textsTeaching material furnished via DIR
Teaching targetsProvide the basis for understanding the biocompatibility of materials for biomedical use
PrerequisitesCell biology, immunology, molecular biology
Didattics MethodsLectures in class
Grading rulesWritten exam
Full arguments1.Biocompatibility: basic concepts 2. Polymers: biomechanical characteristics
Close course details
Show parent course details
Print
CourseNanomaterials
Course IDMS0485
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderRIMONDINI Lia
TeachersRIMONDINI Lia
CFU1
Teaching duration (hours)4
Individual study time 21
SSDMED/28 - MALATTIE ODONTOSTOMATOLOGICHE
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
AbstractSee Course program beloiw
Reference textsWill be provided during classes
Teaching targetsKnowledge and understanding of the main properties of the matter at the nanoscale and their characterization. Knowledge and understanding of the main properties of the nanomaterials used in Medicine and their applications. Development of skills addressed to plan R&D on nanomaterials for Medical applications.
PrerequisitesFundamentals of chimics and physics
Didattics MethodsLecture
Other informationsNone
Grading rulesWritten test: Statments assessment and comments
Full argumentsDefinition of nanomaterials; properties of the materials at the nanoscale; methods to characterized nanomaterials; methods for nanomaterials manufacturing; esample of nanomaterials used for diagnosis and treatment of various diseases (including cancer); nanocarriers for drugs, nanomaterials for tissue regeneration, toxicology of nanomaterials.
Expected learning objectivesKnowledge and understanding of the main properties of matter at nanoscale and the potential application in Medicine Knowledge of the main methods to manage and characterize matter at the nanoscale
Close course details
Show parent course details
Print
CourseMolecular strategies for improving materials biocompatibility
Course IDMS0493
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderMANTOVANI Diego
TeachersMANTOVANI Diego
CFU1
Teaching duration (hours)8
Individual study time 17
SSDBIO/11 - BIOLOGIA MOLECOLARE
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodPrimo Semestre
Grading typeFinal judgment
Close course details
Data synched: 18/01/2018, 12:00