Laurea magistrale in Medical biotechnology

Academic program

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Year Course ID Course Teachers SSD Curriculum Site CFU
1 MS0452 Fertility, reproduction and endocrine system biotechnologies MARZULLO Paolo, SURICO Daniela MED/13, MED/40 All 4
1 MS0455 Functional Genomics GIORDANO Mara, BALDANZI Gianluca, ZUCCHELLI Silvia MED/03, BIO/10, BIO/18 All 11
1 MS0459 Internal Medicine CASTELLO Luigi Mario MED/09 All 5
1 MS0465 Molecular therapy COLANGELO Donato, ELLIS Steven Robert BIO/13, BIO/14 All 11
1 MS0468 Molecular virology GARIGLIO Marisa MED/07 All 6
1 MS0469 Neoplastic and proliferative disorders ISIDORO Ciro, GAIDANO Gianluca MED/15, MED/04 All 12
1 MS0491 Regenerative Medicine FOLLENZI Antonia, PELICCI Giuliana BIO/11, BIO/17 All 10
2 MS0461 Molecular diagnostics BOLDORINI Renzo Luciano, CAPELLO Daniela, ROLLA Roberta MED/08, BIO/12, MED/05 All 11
2 MS0473 Public health and regulatory aspects FAGGIANO Fabrizio, GATTEI Valter, MAGNANI Corrado MED/42, SECS-P/07, MED/01 All 11
2 MS0480 Transplantation and Biocompatibility RIMONDINI Lia, GAIDANO Gianluca, QUAGLIA Marco, CHIOCCHETTI Annalisa, BOCCAFOSCHI Francesca, MANTOVANI Diego MED/15, MED/14, MED/04, BIO/16, MED/28, BIO/11 All 7
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CourseFertility, reproduction and endocrine system biotechnologies
Course IDMS0452
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderMARZULLO Paolo
TeachersMARZULLO Paolo, SURICO Daniela
CFU4
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year1
PeriodPrimo Semestre
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
MS0453 Endocrinology and Metabolism MED/13 - ENDOCRINOLOGIA MARZULLO Paolo
MS0454 Biotechnology of reproduction MED/40 - GINECOLOGIA E OSTETRICIA SURICO Daniela
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CourseEndocrinology and Metabolism
Course IDMS0453
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderMARZULLO Paolo
TeachersMARZULLO Paolo
CFU2
Teaching duration (hours)10
Individual study time 40
SSDMED/13 - ENDOCRINOLOGIA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
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CourseBiotechnology of reproduction
Course IDMS0454
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderSURICO Daniela
TeachersSURICO Daniela
CFU2
Teaching duration (hours)12
Individual study time 38
SSDMED/40 - GINECOLOGIA E OSTETRICIA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageenglish
Didattics Methodspower point slides
Grading rulesThe exam consists of a written test containing n° 3 statements. The student must answer true/false and provide a brief explanation
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CourseFunctional Genomics
Course IDMS0455
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderGIORDANO Mara
TeachersGIORDANO Mara, BALDANZI Gianluca, ZUCCHELLI Silvia
CFU11
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year1
PeriodPrimo Semestre
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
MS0456 Genomic analysis MED/03 - GENETICA MEDICA GIORDANO Mara
MS0457 Regulation of gene expression BIO/10 - BIOCHIMICA BALDANZI Gianluca
MS0458 Genetics BIO/18 - GENETICA ZUCCHELLI Silvia
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CourseGenomic analysis
Course IDMS0456
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderGIORDANO Mara
TeachersGIORDANO Mara
CFU5
Teaching duration (hours)30
Individual study time 95
SSDMED/03 - GENETICA MEDICA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
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CourseRegulation of gene expression
Course IDMS0457
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderBALDANZI Gianluca
TeachersBALDANZI Gianluca
CFU5
Teaching duration (hours)20
Individual study time 105
SSDBIO/10 - BIOCHIMICA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
AbstractAfter a quick review of gene structure in eukaryotes and prokaryotes, the issue of gene expression regulation will be presented. The first part of the course will deal with prokaryotes gene expression and its regulation. A series of examples will illustrate the possibility of engineering promoters and genes for biotechnological purposes. The second part of the course will deal with the eukaryotes gene expression and the multiple levels of its regulation. Issues: 1) chromatin organization and structure, 2) transcription factor function, 3) pre-initiation complex, 4) transcription termination, 5) RNA stability and 6) RNA translation. The third part of the course will deal with the mechanisms by which extracellular signals and intracellular cues regulates gene expression in eukaryotes. A particular emphasis will be placed on the alterations of gene expression in cancer and on the regulation of gene expression in function of nutrients and metabolic status of the cell.
Reference textsFor the improvement of students background Harper's Illustrated Biochemistry, 29e, Robert K. Murray, David A. Bender, Kathleen M. Botham, Peter J. Kennelly, Victor W. Rodwell, P. Anthony Weil Please note: available on Access Medicine for our students Molecular Biology of the Cell - Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter Edition:5th Please note: the 4th edition is available for free on NCBI bookshelf http://www.ncbi.nlm.nih.gov/books/NBK21054/ Suggested textbook Genomes 3 By Terence A. Brown Please note: the 2nd edition is available for free on NCBI bookshelf http://www.ncbi.nlm.nih.gov/books/NBK21128/ Cell Signalling Biology Professor Sir Michael Berridge http://www.biochemj.org/csb/ An extended series of reviews evidenced during the course.
Teaching targetsImproving background and learning problem solving in the study of gene expression.
Prerequisites• Basic Biology: Prokaryotes and Eukaryotes intracellular organization. • Basic biochemistry: DNA and RNA structure and metabolism, protein synthesis, enzyme proprieties. • Basic molecular biology: concept of gene, gene expression, promoter, transcription factor, RNA synthesis and degradation. For the students lacking a strong background in life sciences a series of readings will be proposed to improve their skills on those topics.
Didattics MethodsDuring the course, slides and webinars are extensively used. A copy of the slides and the websites used during the course will be available on the DIR site. Students will undertake teacher driven research/presentation/teamwork.
Grading rulesWritten exam on a series of topics evidenced during the course.
Full argumentsTopic 1 Gene expression regulation Recall of the organization of genes in eukaryotes (enhancers, promoters, transcription start site, introns/exons, transcription termination sites). Control of gene transcription at the level of transcription initiation rate, splicing and alternative splicing, mRNA stability, RNA interference and microRNA. Transcription factors organization: structure of DNA binding and trans-activating domains. Major DNA regulatory sequences. Assembly of RNApolII transcription initiation complex. Methods to study DNA regulatory elements, Promoter structure and transcription factor binding sites. Transcription factors and chromatin structure, chromatin remodeling and gene expression. Post transcriptional modification of histones and the histone code. DNA mutilation. Other ways to regulate gene expression: alternative promoters, alternative splicing, control of mRNA stability, control of mRNA translation, miRNA and RNA interference. Topic 2 Control of gene expression by extracellular and intracellular cues. How signal transduction pathways regulates gene expression: - The nuclear receptor family - The STAT family - ERK signaling to the serum response elements. Topic 3 Transcription factors mutated in tumors. - Myc amplification in growth factors signaling and tumor formation - Hif in the response to hypoxia and tumorigenesis - P53 mutations, Case study: How oncogenes and altered signaling pathways regulates tumor cell metabolism. Peculiarities of tumor metabolism, the Warburg effect and beyond. Methods to study metabolism, integrating gene expression, metabolomics and in vivo data. Use of mass spectrometry, PET/NMR probes, and electrodes (Oxygen Consumption Rate – ExtraCellular Acidification Rate) to study metabolism in living cells/tissues/patients. Experimental manipulation of metabolism and possible routes for cancer therapy. Tumor metabolomics, onco-metabolites and the peculiarities of tumor metabolism. How alterations of signal transduction machinery and gene expression integrates with a peculiar micro-environment to dictate tumor metabolism. How alterations of the metabolism (i.e. dietary habits or cell energetic status) influence chromatin status and gene expression.
Expected learning objectivesUnderstanding the mechanisms of regulation of gene expression and how such knowledge can be used in research or therapy.
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CourseGenetics
Course IDMS0458
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderZUCCHELLI Silvia
TeachersZUCCHELLI Silvia
CFU1
Teaching duration (hours)8
Individual study time 17
SSDBIO/18 - GENETICA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
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CourseInternal Medicine
Course IDMS0459
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderCASTELLO Luigi Mario
TeachersCASTELLO Luigi Mario
CFU5
Teaching duration (hours)20
Individual study time 105
SSDMED/09 - MEDICINA INTERNA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageEnglish
AbstractThe course will transmit skills on the growing role of biotechnology applications both in the diagnostic and in the therapeutic approach to different acute and chronic diseases. The topics that will be object of the lessons have been selected to give examples of diseases characterized by educational relevance in the description of the diagnostic approach strategies (genetic diseases on one hand but also the development of diagnostic strategies in the fight against doping in sport) in the study of pathophysiology (diabetes mellitus, hypercalcemia) and in the therapeutic approach (evolution of the treatment of diabetes mellitus, viral hepatitis and autoimmune diseases such as rheumatoid arthritis). The course will also show some examples of the development of drugs obtained by recombinant DNA techniques and the development of innovative therapeutic strategies such as stem cell transplantation and gene therapy in different conditions.
Reference textsScientific articles provided by the teacher during the course. The recommended text for consultation is: Harrison's Principles of Internal Medicine, McGraw-Hill Editions, in the latest edition available online for UPO students through Access Medicine.
Teaching targetsThe aim of the course is to give notions of methodology relating to the main biotechnological applications in Internal Medicine. In particular, the course will transmit skills on the growing role of biotechnology applications both in the diagnostic and in the therapeutic approach to different acute and chronic diseases. The topics that will be object of the lessons have been selected to give examples of diseases characterized by educational relevance in the description of the diagnostic approach strategies (genetic diseases on one hand but also the development of diagnostic strategies in the fight against doping in sport) in the study of pathophysiology (diabetes mellitus, hypercalcemia) and in the therapeutic approach (evolution of the treatment of diabetes mellitus, viral hepatitis and autoimmune diseases such as rheumatoid arthritis). The course will also show some examples of the development of drugs obtained by recombinant DNA techniques and the development of innovative therapeutic strategies such as stem cell transplantation and gene therapy in different conditions.
PrerequisitesThe student should possess basic knowledge about the Human Anatomy, Biochemistry, Physiology, Pharmacology and General Pathology.
Didattics MethodsEx-cathedra lectures with supporting slides.
Other informationsAll the teaching material concerning the course will be available for registered students, on the DIR platform.
Grading rulesThe examination consists in 20 statements to which the students attribute a true or false judgment. Few lines of comment, motivating the answer, are needed. This kind of examination will be performed on the computer, using the DIR platform. If the number of registered students is very low, the teacher can opt for an oral examination.
Full arguments• Criteria for the definition of sepsis and its study models • Cystic fibrosis: clinical manifestations, diagnosis and principles of gene therapy • Lung tumors: classification and principles of targeted-therapy • The biological basis of autoimmune disease therapy • The biological basis of diabetes mellitus therapy • Physiopathological aspects of paraneoplastic hypercalcemias • Biotechnological strategies in the fight against the use of doping substances in sport • Acute thromboembolic events and platelet activation • Hypertension
Expected learning objectivesThe student should demonstrate competence regarding the topics scheduled in the course. Speculative and pragmatic skills will be also tested during the examination in order to assess the application of knowledge in a practical context.
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CourseMolecular therapy
Course IDMS0465
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderCOLANGELO Donato
TeachersELLIS Steven Robert, COLANGELO Donato
CFU11
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year1
PeriodSecondo Semestre
Grading typeFinal grade
Teaching languageEnglish
Modules
Course ID Course SSD Teachers
MS0466 Biotechnological applications BIO/13 - BIOLOGIA APPLICATA ELLIS Steven Robert
MS0467 Pharmacology BIO/14 - FARMACOLOGIA COLANGELO Donato
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CourseBiotechnological applications
Course IDMS0466
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderELLIS Steven Robert
TeachersELLIS Steven Robert
CFU6
Teaching duration (hours)36
Individual study time 114
SSDBIO/13 - BIOLOGIA APPLICATA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
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CoursePharmacology
Course IDMS0467
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderCOLANGELO Donato
TeachersCOLANGELO Donato
CFU5
Teaching duration (hours)25
Individual study time 100
SSDBIO/14 - FARMACOLOGIA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
AbstractThe course will focus on the analysis of the rational bases for the development of selected classes of target –designed drugs, also considering their pharmacokinetics and pharmacodynamic aspects for a clinical use. Furthermore, the course integrate basic pharmacology with clinic properties. Relevant drugs will be also analyzed in order to point out relevant molecular and diagnostic properties useful for the preclinical development of new biotech drugs.
Reference textsThe pharmacological bases of therapy, Goodman e Gilman, XI, Mc Graw-Hill Pharmacology, Rang H.P., Dale M.M., Ritter J.M e Moore P.K., Editor Ambrosiana
Teaching targetsThe course is intended to provide specific knowledge of pharmacologic constants that rule the therapeutic properties of selected drugs developed with biotech methodologies.
PrerequisitesBasic knowledges of Anatomy, Physiopathology and Internal Medicine
Didattics MethodsFrontal Lessons. The teaching activities will take place from the front of the classroom.
Other informationsThe teacher will meet the students on every Tuesday 2-6 p.m., best after email reservation.
Grading rulesMultiple choice tests.
Full argumentsThe course will focus on the analysis of the rational bases for the development of selected classes of target –designed drugs, also considering their pharmacokinetics and pharmacodynamic aspects for a clinical use. Furthermore, the course integrate basic pharmacology with clinic properties. Relevant drugs will be also analyzed in order to point out relevant molecular and diagnostic properties useful for the preclinical development of new biotech drugs.
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CourseMolecular virology
Course IDMS0468
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderGARIGLIO Marisa
TeachersGARIGLIO Marisa
CFU6
Teaching duration (hours)28
Individual study time 122
SSDMED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
Course typeAttività formativa monodisciplinare
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal grade
Teaching languageEnglish
Reference textsBrooks “Jawetz, Melnick, & Adelberg's Medical Microbiology” - Levinson “Review of Medical Microbiology and Immunology” - Ryan “Sherris Medical Microbiology” - David M Knipe, Peter Howley “Fields Virology” 6th edition
Teaching targetsUnderstanding the interplay between viruses and their host organisms giving to students a view of innate defenses and viral pathogenesis focusing on medically important viruses.
PrerequisitesThe students are expected to know basic virology and fundamentals of molecular and cellular biology.
Didattics MethodsThe course consist of 28h of frontal lessons. All the slides of each lesson will be available to the students (DIR).
Grading rulesThe exam will be divided in two part: written (6 open questions) and oral.
Full argumentsThe course deals with basic virology and virological terminology. The effect of virus infection at organism level is addressed. The focus of the course is on molecular virology, especially on virus replication in the infected cell and the molecular mechanisms of this. A selected set of relevant human viruses, differing in their genome structure (RNA versus DNA, circular versus linear) and in their virion architecture will be discussed, the content of the course being specialised with respect to molecular biology, molecular genetics, recombinational events, virus-host interactions and innate immunity. The focus is on medically important viruses, such as tumour viruses, hepatitis viruses, HIV and herpesviruses.
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CourseNeoplastic and proliferative disorders
Course IDMS0469
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderISIDORO Ciro
TeachersGAIDANO Gianluca, ISIDORO Ciro
CFU12
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year1
PeriodPrimo Semestre
Grading typeFinal grade
Teaching languageEnglish
Abstractrefer to MS0470 and MS0471
Reference textsrefer to MS0470 and MS0471
Teaching targetsrefer to MS0470 and MS0471
Prerequisitesrefer to MS0470 and MS0471
Didattics Methodsrefer to MS0470 and MS0471
Other informationsrefer to MS0470 and MS0471
Grading rulesrefer to MS0470 and MS0471
Full argumentsrefer to MS0470 and MS0471
Expected learning objectivesrefer to MS0470 and MS0471
Modules
Course ID Course SSD Teachers
MS0470 Hematoncology MED/15 - MALATTIE DEL SANGUE GAIDANO Gianluca
MS0471 Experimental oncology MED/04 - PATOLOGIA GENERALE ISIDORO Ciro
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CourseHematoncology
Course IDMS0470
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderGAIDANO Gianluca
TeachersGAIDANO Gianluca
CFU5
Teaching duration (hours)20
Individual study time 105
SSDMED/15 - MALATTIE DEL SANGUE
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageThe course is given in English
AbstractThe course will deal with the molecular pathology of the main haematological malignancies, especially by analysing the topics relevant for the profession of Medical Biotechnologist. During the course, self-evaluation exercises will also be proposed, as well as additional material for in-depth study and group presentations on topics of particular interest.
Reference textsReference textbook: Williams Hematology, 9e Author(s): Kenneth Kaushansky, Marshall A. Lichtman, Josef T. Prchal, Marcel M. Levi, Oliver W. Press, Linda J. Burns and Michael Caligiuri (available on UPO off campus library via AccessMedicine)
Teaching targetsThe aim of the course is to render the student able to know, interpret and analyse the main hematological topics of the course, that are are relevant for a Medical Biotechnologist, with a critical attitude, as requested by the Dublin descriptor 3.
PrerequisitesBasic knowledge of cell and molecular biology
Didattics MethodsA) Taught (frontal) classes with slide presentations available on the UPO DIR website (https://www.dir.uniupo.it/); B) Self-assessment tests after each class; C) Group presentations by the students on topics agreed upon with the professor
Other informationsParticipation in the self-assessment activitities after each class is strongly recommended
Grading rulesThe exam will be in the context of the exam of the integrated course. The exam of Hematoncology will be based on 4 statements, for which the candidate has to: i) assign true/false; ii) write 5-10 lines of comment to justify the choice. Examples of these tests are provided as self-assessment tests after each class.
Full argumentsA. Hematopoiesis and hematopoietic stem cell B. General concepts of myeloid neoplasia and chronic myeloid leukemia: general concepts, molecular pathology, molecular diagnostics and target treatment C. BCR/ABL negative myeloproliferative neoplasia (MPN): general concepts, molecular pathology, molecular diagnostics and target treatment D. General concepts on lymphoid neoplasia, Analysis of B-cell clonality, and Mantle cell lymphoma: general concepts, molecular pathology, molecular diagnostics and target treatment E. Follicular lymphoma: general concepts, molecular pathology, molecular diagnostics and target treatment F. Hairy cell leukemia and Burkitt lymphoma: general concepts, molecular pathology, molecular diagnostics and target treatment G. Lymphoplasmacytic lymphoma and Splenic marginal zone lymphoma: general concepts, molecular pathology, molecular diagnostics and target treatment H. Chronic lymphocytic leukemia: general concepts, molecular pathology, molecular diagnostics and target treatment I. Acute lymphoblastic leukemia and CAR T-cells: general concepts, molecular pathology, molecular diagnostics and target treatment J. Minimal residual disease (MRD); Precision Medicine, Clinical Trials and Benefit Sharing in Hematoncology
Expected learning objectivesAt the end of the course, the student will be able to: i) critically analyse the molecular pathology of several models of hematologic malignancies; ii) appreciate the importance of molecular pathology for improving precision medicine, molecular diagnosis and target treatment in hematologic neoplasia
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CourseExperimental oncology
Course IDMS0471
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderISIDORO Ciro
TeachersISIDORO Ciro
CFU7
Teaching duration (hours)28
Individual study time 147
SSDMED/04 - PATOLOGIA GENERALE
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
Abstract1. the epidemiologic relevance of Cancer; the influence of the environment and of the life style. 2. the main histopathologic characteristics of the tumours and their classification 3. the molecular alterations responsible for the malignant behaviour of tumour cells (loss of proliferative control; resistance to apoptosis; invasiveness; altered metabolism of glucose, aminoacids and fatty acids; altered proteome homeostasis); the role of autophagy and of cell death in cancer 4. the role of genetics and epigenetics in cancer development and progression; the genetic defects that predispose to cancer; genome (chromosomal translocation) alterations and gene mutations (oncogenes, oncosuppressors) associated with cancer 5. the origin and phenotypic characteristics of Cancer Stem Cells; the genetic and metabolic re-programming leading to cancer 6. the mechanisms of metastasis formation; the role of proteolytic enzymes 7. the inter-relationship between tumour cells and the tumour stroma, with particular regard to the role of cancer associated fibroblasts and of immune cells; 8. the molecular and patho-physiological mechanisms responsible for the cachexia syndrome. 9. the current techniques for Diagnosis (imaging, biomarkers) and the therapeutic treatments available (chemical chemotherapy, biomolecular therapy). 10. Novel therapeutic approach (epigenetics); novel paradigms for carcinogenesis (microbioma);
Reference textsThe Molecular Biology of Cancer S-Pelengaris and M. Khan (Wiley-Blackwell edition) Chapter 7 NEOPLASIA by Thomas P Stricker and V Kumar (from Robbins, The molecular Basis of Disease) USEFUL WEB SITES: http://www.insidecancer.org; http://www.nci.nih.gov/; http://www.oncolink.com/; http://www.cancer.gov; http://www.medlib.med.utah.edu/WebPath/LIVEHTML/LIVERIDX.html#5 http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.chapter.10
Teaching targets How to recognize the histopathological characteristics of major human neoplasms;  Understand what molecular and cellular alterations determine the neoplastic phenotype;  Considering the natural causes of carcinogenesis and the factors that can cause tumor recurrence, bearing in mind the role of defensive systems at the molecular, cellular and organizational levels;  Describe the distinctive (morphological, metabolic, behavioral) characteristics of neoplastic stem cells;  Know the mechanisms responsible for the infiltration and metastasis of tumors;  illustrate how the stromal microenvironment surrounding the tumor is modified and how can this promote neoplastic growth  Recognize clinical signs and know how to describe the molecular and pathophysiological mechanisms of neoplastic cachexia. KNOWLEDGE AND ABILITY EXPECTED At the end of the course, the student should be able to read and analyse scientific articles on cellular and molecular biology of the tumours (during the course each student will have to present a scientific article on a subject). Learning Outcomes: Knowledge about the cellular and molecular mechanisms underlying the cancerogenesis process. Dynamics of neoplastic populations. Natural History of Neoplasms. Risk Factors for the Development of Neoplasms.
PrerequisitesBasic Knowledge of Cell Biology and Histology, Molecular Biology and Biochemistry.
Didattics MethodsInteractive lesson involving students continuously with questions to stimulate curiosity and test understanding of concepts. Illustration of processes with practical examples. Discussion of relevant scientific articles. A copy of the slides presented during the lessons will be provided in advance
Other informationsStudents can contact the teacher and ask for explanations after appointment by email. OPTIONAL ACTIVITIES: Students are welcome to spend a period in the laboratory of Molecular Pathology to participate in the design, execution and discussion of experiments. CFU will be assigned based on the duration of the stage.
Grading rulesEXAM MODALITY (2 steps for each module) 1. Written test (30 minutes for 3 statements): answer TRUE/FALSE and give an explanation to support your answer in 5 (not less) to10 (not more) lines. (please, write in a legible writing). At least 2 out of 3 answers must be correct in order to be admitted to the next step (oral examination). (Evaluation: 6-8/30 points for each question). 2. Oral examination (approx. 10-20 min): A) discussion of the written test. B) discussion of an original articles dealing with a subject of your choice inherent the program of the course and published in a good journal (consult with your professor for an appropriate choice). (Evaluation: 4-6/30 points). C) (optional): 1 or 2 extra question(s). (Evaluation 2-4/30, Laude). Maximal score is 30 + Laude/30. 3. NOTE: 1. the final score is agreed between the two Professors as an average of the scores obtained for the two modules. 2. in case only one of the two modules (A or B) is passed (score >18/30), the vote will be considered valid for only the next session in which the other module (B or A) must be passed. In case of failure the student must repeat the exam for both (A and B) modules in a new session.
Full argumentsIntroduction to Cancer: Definition, Epidemiology, Origin of cancer (multistage carcinogenesis, genetic and epigenetic clonal expansion; mutations, risk factors). Nomenclature, Histopathology. Classification, Staging, Grading. Aetiology; Gene – environment interaction; chemical carcinogenesis; radiation and carcinogenesis; virus and carcinogenesis. Life style and Cancer (smoke, diet). Genetic and chromosome instability. DNA repair. Genetic predisposition syndromes. Cancer cell biology: Control of cell proliferation and cell differentiation: cell cycle; cell signalling. Cancer cell biology: Control of cell homeostasis; control of macromolecular turnover; Autophagy; Control of Cell death (Apoptosis, Necrosis, Autophagic cell death). Molecular Oncology 1: Oncogenes. Main Oncogenes: c-MYC, RAS, others. Oncogene addiction. Molecular Oncology 2: Tumour Suppressors. Main Tumour Suppressor genes: TP53, PTEN, BECLIN1, TSC, others. Tumour cell metabolism: Warburg effect, glutamine, glucose. Oncogenes and oncosuppressors and cancer cell metabolism. Papers’ discussion. Dormancy, Senescence, Telomerases, Cancer Stem Cells. Papers’ discussion. Epigenetics and Cancer. DNMT, HDAC, microRNAs. Oncosuppressor Imprinting (ARH-I/DIRAS3). Papers’ discussion. Tumour stroma. Cancer associated fibroblasts. Cancer inflammation. Papers’ discussion. Cell adhesion. Invasion and Metastasis. Angiogenesis. Tumour immunity. Cachexia. Cancer diagnosis, cancer therapy. Specific cancers: Colon, Breast, Lung, Prostate, Ovary, Melanomas and Skin cancers. Diet and cancer; anticancer properties of phytochemicals, vitamins, natural products. Microbioma and Cancer.
Expected learning objectivesKnowing the causes and mechanisms of carcinogenesis and tumor progression. Knowing how to interpret, discuss and present the experimental laboratory results or found in literature, specifically aimed at describing and understanding the neoplastic transformation and behavior of tumor cells.
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CourseRegenerative Medicine
Course IDMS0491
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderFOLLENZI Antonia
TeachersPELICCI Giuliana, FOLLENZI Antonia
CFU10
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year1
PeriodSecondo Semestre
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
MS0492 Molecular Biology BIO/11 - BIOLOGIA MOLECOLARE PELICCI Giuliana
MS0479 Histology, Gene and Cell Therapy BIO/17 - ISTOLOGIA FOLLENZI Antonia
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CourseMolecular Biology
Course IDMS0492
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderPELICCI Giuliana
TeachersPELICCI Giuliana
CFU5
Teaching duration (hours)30
Individual study time 95
SSDBIO/11 - BIOLOGIA MOLECOLARE
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodSecondo Semestre
Grading typeFinal judgment
Teaching languageEnglish
AbstractReview of general topics of Molecular Biology relevant to the understanding of the course. Chromatin Remodeling: Histone Modifications, DNA methylation Structural classes of transcription factors (Myc, Fos) Epigenetic definition: epigenetic diseases and epigenetic therapies. Oncogenes and tumor suppressor genes. P53 function in normal and tumoral cells. MDM2 as an oncogene. pRb function. Heterogeneity of tumors, stochastic and hierarchical theories, properties of cancer stem cells, their isolation, asymmetric and symmetric divisions. Signaling Pathways activated in cancer stem cells, therapeutic implications of cancer stem cells. Reprogramming of somatic cells to pluripotency by somatic cell nuclear transfer (SCNT) into oocytes. Fusion between somatic and pluripotent cells and ectopic expression of defined transcription factors. Sheep cloned by nuclear transfer (Dolly sheep). Induced pluripotent stem cells (iPS cells); Yamanaka papers; reprogramming by transcription factors; causes of low reprogramming efficiency. Parallelisms between epigenetic reprogramming and cancer. Therapeutic use of iPS Cells and embryonic stem cells.
Reference textsMolecular Biology of the Cell Alberts Scientific Papers
Teaching targetsProvide basic knowledge of stem cell biology, reprogramming and pluripotency with particular reference to bio-medical applications, their research perspectives and the understanding of the major cellular processes.
PrerequisitesA basic understanding of cell biology and molecular biology.
Didattics MethodsPowerPoint presentations of lessons and articles provided by the lecturer
Grading rulesWritten Examination and oral presentation of a scientific journal article.
Full argumentsReview of general topics of Molecular Biology relevant to the understanding of the course. Chromatin Remodeling: Histone Modifications, DNA methylation Structural classes of transcription factors (Myc, Fos) Epigenetic definition: epigenetic diseases and epigenetic therapies. Oncogenes and tumor suppressor genes. P53 function in normal and tumoral cells. MDM2 as an oncogene. pRb function. Heterogeneity of tumors, stochastic and hierarchical theories, properties of cancer stem cells, their isolation, asymmetric and symmetric divisions. Signaling Pathways activated in cancer stem cells, therapeutic implications of cancer stem cells. Reprogramming of somatic cells to pluripotency by somatic cell nuclear transfer (SCNT) into oocytes. Fusion between somatic and pluripotent cells and ectopic expression of defined transcription factors. Sheep cloned by nuclear transfer (Dolly sheep). Induced pluripotent stem cells (iPS cells); Yamanaka papers; reprogramming by transcription factors; causes of low reprogramming efficiency. Parallelisms between epigenetic reprogramming and cancer. Therapeutic use of iPS Cells and embryonic stem cells.
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CourseHistology, Gene and Cell Therapy
Course IDMS0479
Academic Year2017/2018
Year of rule2017/2018
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderFOLLENZI Antonia
TeachersFOLLENZI Antonia
CFU5
Teaching duration (hours)30
Individual study time 95
SSDBIO/17 - ISTOLOGIA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year1
PeriodSecondo Semestre
Grading typeFinal judgment
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CourseMolecular diagnostics
Course IDMS0461
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderBOLDORINI Renzo Luciano
TeachersBOLDORINI Renzo Luciano, CAPELLO Daniela, ROLLA Roberta
CFU11
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year2
PeriodSecondo Semestre
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
MS0462 Pathologic basis of diseases MED/08 - ANATOMIA PATOLOGICA BOLDORINI Renzo Luciano
MS0463 Clinical applications of Molecular Biology BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA CAPELLO Daniela
MS0464 Clinical Pathology MED/05 - PATOLOGIA CLINICA ROLLA Roberta
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CoursePathologic basis of diseases
Course IDMS0462
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderBOLDORINI Renzo Luciano
TeachersBOLDORINI Renzo Luciano
CFU5
Teaching duration (hours)20
Individual study time 105
SSDMED/08 - ANATOMIA PATOLOGICA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
AbstractDiagnostic, prognostic and predictive factors of pathological interest of the main human malignancies: carcinoma of the lung, breast, colorectal, urinary tract, male and female genital, central nervous system, thyroid; major molecular markers of diagnostic, prognostic and predictive interest: technical principles and clinical applications.
Reference textsKumar, Abbas, Fausto. Robbins and Cotran Pathologic Basis of Disease. VII ed Elsevier, 2005-09-07; scientific articles (references given during the course).
Teaching targetsThe student must be able to understand the meaning of translational molecular diagnostic procedure in pathological context relating to the main human neoplastic diseases.
PrerequisitesNotions of Pathology, Anatomy and Histology and Molecular Biology.
Didattics MethodsPower-point presentations, CD-ROM and educational websites.
Grading rulesMultiple choice test
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CourseClinical applications of Molecular Biology
Course IDMS0463
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderCAPELLO Daniela
TeachersCAPELLO Daniela
CFU5
Teaching duration (hours)20
Individual study time 105
SSDBIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
AbstractOMICS strategies are driving clinical oncology to take a molecular approach to diagnosis, prognostication, and treatment selection. The main objective of the course is providing the basic knowledge for the use of biomarkers in molecular diagnostic and target therapy of cancer
Reference textsSlides; scientific papers discussed during the classes; online public database resources
Teaching targetsAt the end of the course students will have a general knowledge of 1) the main molecular strategies utilized for the identification and the analysis of biomarkers in oncology: from the genome-wide approaches to the “marker specific”-based methods; 2) the most relevant actionable mutations and biochemical pathways in cancer:
PrerequisitesThe student are expected to have a general knowledge of molecular biology and genetics and of the main technologies for genomic investigations
Didattics MethodsSlides presented during the course, interactive journal clubs; PDF copy of scientific papers
Other informationsAll the teaching material and information regarding the course will be available on DIR (https://www.dir.uniupo.it/)
Grading rulesEvaluation will consist in a written short report on a topic discussed during the course and an oral presentation of a scientific paper with critical discussion. A short, written multiple choice test will allow to evaluate learning concerning the main molecular biology techniques applied to cancer diagnostic.
Full arguments1. Molecular strategies utilized for the identification and the analysis of biomarkers in oncology: from the genome-wide approaches to the “marker specific”-based methods2. Mutational landscape of cancer. Definition of drivers and passenger mutations. Classification of tumor driver genes. Strategies for identifying new candidate cancer genes among low frequently mutated genes. The problem of saturation. Mutational heterogeneity in cancer: mutations originated prior tumor initiation and mutations originating during tumor progression. Mutation timer and tumor evolution. Interpatient, intrapatient and intraclonal tumor heterogeneity. Clonal evolution theories. The prospective use of deep sequencing in diagnostic and therapy of cancer.3. Genetic lesions in cancer. Analysis of the most relevant actionable mutations and biochemical pathways in cancer: i) growth factors/tyrosine kinase receptors; ii) PI3K/Akt/mTOR pathway; iii) MAP kinases pathways; iv) cancer stem cells as possible targets in tumor therapy; v) metabolic reprogramming in tumors, hypoxia and neo-angiogenesis; vi) Mechanisms of cancer metastasis: the role of the microenvironment and the role of mutations
Expected learning objectivesAt the end of the course students are expected to have acquired a general knowledge about the main molecular strategies utilized for the identification and the analysis of biomarkers in oncology and about the most important molecular targets currently used for cancer diagnosis and therapy
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CourseClinical Pathology
Course IDMS0464
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderROLLA Roberta
TeachersROLLA Roberta
CFU1
Teaching duration (hours)4
Individual study time 21
SSDMED/05 - PATOLOGIA CLINICA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year2
PeriodSecondo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
AbstractThis course provides an overview of the current knowledge in pharmacogenetics.
Reference textsTeaching Material provided by the lecturer. Lecturer's Monograph.
Teaching targetsThe aim of the present course is to provide knowledge about the influence of genetics on drug therapy and about the validity and utility of pharmacogenomic tests in the clinical setting.
PrerequisitesThorough knowledge of Molecular Biology and Genetics (basics of genomics as well as methods to identify mutations).
Didattics MethodsPowePoint presentation. Teaching Network on DIR Website. Frontal lessons.
Grading rulesMultiple choice test
Full argumentsOne of the great challenges in drug development and therapy is maximizing therapeutic response while avoiding adverse effects. Advances in genetic knowledge, gained through sequencing, have identified heritable genetic variants that predict drug response. Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects/ toxicity. The use of these genetic informations can play a major role in clinical practice to predict the right choice and dose of medications for individuals, thus providing a scientific basic for “personalized medicine”. This is particularly important in the case of anticancer drugs whose the therapeutic index is very narrow and a large proportion of patients do not respond. Although the knowledge on an individual’s DNA sequence as an integral determinant of drug therapy has not yet become standard clinical practice, however several genetics recommendations/guidelines for physicians have been developed and are highlighted in the present course. In particular, the course explores the pharmacogenetic clinical utility in: •anticancer drugs (tamoxifen & breast cancer) •treatment of chronic pain (codeine) •antipsychotic therapy •antiplatelet therapy (clopidogrel) •oral anticoagulant therapy (warfarin)
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CoursePublic health and regulatory aspects
Course IDMS0473
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderFAGGIANO Fabrizio
TeachersFAGGIANO Fabrizio, GATTEI Valter, MAGNANI Corrado
CFU11
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year2
PeriodPrimo Semestre
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
MS0474 Public Health MED/42 - IGIENE GENERALE E APPLICATA FAGGIANO Fabrizio
MS0475 Innovation and Patents SECS-P/07 - ECONOMIA AZIENDALE GATTEI Valter
MS0476 Biomedical statistics MED/01 - STATISTICA MEDICA MAGNANI Corrado
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CoursePublic Health
Course IDMS0474
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderFAGGIANO Fabrizio
TeachersFAGGIANO Fabrizio
CFU5
Teaching duration (hours)30
Individual study time 95
SSDMED/42 - IGIENE GENERALE E APPLICATA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
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CourseInnovation and Patents
Course IDMS0475
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderGATTEI Valter
TeachersGATTEI Valter
CFU1
Teaching duration (hours)8
Individual study time 17
SSDSECS-P/07 - ECONOMIA AZIENDALE
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
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CourseBiomedical statistics
Course IDMS0476
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderMAGNANI Corrado
TeachersMAGNANI Corrado
CFU5
Teaching duration (hours)20
Individual study time 105
SSDMED/01 - STATISTICA MEDICA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
AbstractStatistical inference, design of experimental study, methods of statistical analysis
Reference textsOnline Statistics Education: An Interactive Multimedia Course of Study (available at: onlinestatbook.com)In English-Triola & Triola. Biostatistics. Pearson International Ed-Rosner Fundamentals of Biostatistics. Thomson Books In Italian:- Pagano e Gauvreau Biostatistica, II ed. Idelson - Daniel WW Biostatistica Edises 2000Further redings:•Armitage & Berry Metodi statistici nella ricerca medica, 3a edizione McGraw-Hill (In English Statistical Methods in Medical Research, 4th Edition. Peter Armitage, Geoffrey Berry, J. N. S. Matthews. Wiley ed). •Siegel & Castellan Statistica non parametrica. McGraw-Hill. (In English Nonparametric Statistics for the Behavioral Sciences, II ed. Mc Graw Hill)•Altman, Machin, Bryant & Gardner Statistica medica - Intervalli di confidenza nella ricerca biomedica. Minerva Medica 2004 (In English Statistics with confidence, Ed BMJ Books)•Bossi, Cortinovis, Duca, Marubini Introduzione alla Statistica medica Nuova Italia Scientifica.Further teaching material will be given or indicated during the course.
Teaching targetsIt is an upper level course, for students who already undertook a first level statistics course.At the end students are expected to plan an experimental study and to conduct basic analyses of numerical and categorical data.
PrerequisitesBasic knowledge in mathematics and statistics, corresponding to the programns in high school (mathematics) and in three years degree in biotechnology (statistics).
Didattics MethodsLectures and exercises
Grading rulesWritten test, including solution of numerical problems and interpretation of results.
Full argumentsSampling, inference, statistical testing of hypothesis (test of hypothesis) and confidence intervalIntroduction to the experimental designStatistical powerANOVA (Analysis of variance ) one level of classificationLinear regression analysis Analysis of cross-classified data
Expected learning objectivesAt the end students are expected to plan an experimental study and to conduct basic analyses of numerical and categorical data.
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CourseTransplantation and Biocompatibility
Course IDMS0480
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderRIMONDINI Lia
TeachersGAIDANO Gianluca, QUAGLIA Marco, CHIOCCHETTI Annalisa, BOCCAFOSCHI Francesca, RIMONDINI Lia, MANTOVANI Diego
CFU7
Course typeAttività formativa integrata
Course mandatorietyMandatory course
Year2
PeriodPrimo Semestre
Grading typeFinal grade
Modules
Course ID Course SSD Teachers
MS0481 Hematopoietic stem cell biology and transplantation MED/15 - MALATTIE DEL SANGUE GAIDANO Gianluca
MS0482 Biotechnology in kidney transplantation MED/14 - NEFROLOGIA QUAGLIA Marco
MS0483 Transplant immunology MED/04 - PATOLOGIA GENERALE CHIOCCHETTI Annalisa
MS0484 Materials Biocompatibility BIO/16 - ANATOMIA UMANA BOCCAFOSCHI Francesca
MS0485 Nanomaterials MED/28 - MALATTIE ODONTOSTOMATOLOGICHE RIMONDINI Lia
MS0493 Molecular strategies for improving materials biocompatibility BIO/11 - BIOLOGIA MOLECOLARE MANTOVANI Diego
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CourseHematopoietic stem cell biology and transplantation
Course IDMS0481
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderGAIDANO Gianluca
TeachersGAIDANO Gianluca
CFU1
Teaching duration (hours)6
Individual study time 19
SSDMED/15 - MALATTIE DEL SANGUE
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageThe course will be given in English
AbstractThe course will deal with hematopoietic stem cell transplantation, both autologous and allogeneic, with a particular focus on the aspects that are relevant for Medical Biotechnologists.
Reference textsTesto per la consultazione: Williams Hematology, 9e Author(s): Kenneth Kaushansky, Marshall A. Lichtman, Josef T. Prchal, Marcel M. Levi, Oliver W. Press, Linda J. Burns and Michael Caligiuri (available on UPO off campus library via AccessMedicine)
Teaching targetsThe aim of the course is to render the student able to know, interpret and analyse the main hematological topics of the course, that are are relevant for a Medical Biotechnologist, with a critical attitude, as requested by the Dublin descriptor 3.
PrerequisitesKnowledge of main blood disorders and of immunology
Didattics MethodsA) Taught (frontal) classes with slide presentations available on the UPO DIR website (https://www.dir.uniupo.it/); B) Self-assessment tests after each class
Other informationsParticipation in the self-assessment activitities after each class is strongly recommended
Grading rulesThe exam will be in the context of the exam of the integrated course. The exam of Hematopoietic Stem Cell Biology and Transplantation will be based on 3 statements, for which the candidate has to: i) assign true/false; ii) write 5-10 lines of comment to justify the choice. Examples of these tests are provided as self-assessment tests after each class.
Full argumentsA. The hematopoietic stem cell B. Hematopoiesis C. General concepts of hematopoietic stem cell transplant D. Autologous stem cell transplant E. Allogeneic and syngeic stem cell transplant F. Graft versus host disease and graft verus tumor effect
Expected learning objectivesAt the end of the course, the student will be able to critically analyse the strategies of transplant procedures of hematopoietic stem cells and their application in hematology
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CourseBiotechnology in kidney transplantation
Course IDMS0482
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderQUAGLIA Marco
TeachersQUAGLIA Marco
CFU1
Teaching duration (hours)6
Individual study time 19
SSDMED/14 - NEFROLOGIA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
AbstractThe course aims at providing general knowledge about management of nephropathic patient, including patient with chronic kidney disease (CKD), on dialysis and with renal transplant, with a focus on modern therapies and diagnostic tools of renal disease and on attendant biotechnological aspects. The following topics will be covered in detail: Assessment of renal function and urinalysis Diagnostic tools in Nephrology including renal biopsy Nephrological syndromes and main renal disorders Chronic kidney disease (CKD) and acute kidney injury (AKI) Artificial renal replacement therapy (RRT): hemodialysis and peritoneal dialysis. Biotechnological applications in dialysis. Naturall renal replacement therapy (RRT): renal transplant. Principles of immunosuppressive therapy. Biotechnological applications in renal transplant.
Reference textsThe slides presented during formal lessons represent the reference material for final exam. For further study, main textbooks of Nephrology and selected review articles are available for consultation at the Nephrology and Renal Transplant Unit.
Teaching targets1) knowledge and understanding of main pathophysiological mechanisms of renal disease; 2) knowledge and understanding of main renal disorders and attendant clinical and laboratory manifestations; 3) knowledge and understanding of principles of therapy of renal disorders, with a focus on artificial and natural renal replacement therapy (RRT) and relative biotechnological applications 4) knowledge and understanding of clinical problems of nephropathic patient, including patient with advanced chronic kidney disease (CKD), patient on dialysis and with renal transplant and relative biotechnological applications 5) development of autonomous judging skills and of adequate communicative skills, (correct medical language) 6) development of autonomous learning skills towards main topics of Nephrology.
PrerequisitesStudent must be familiar with basicl principles of anatomy and renal physiology
Didattics MethodsThe course is based on 3 lessonswhich deal with topics described in the program. Within each lesson attendant biotechnological aspects are highlighted. Students are offered the possibility to explore biotechnological aspects of their interest through direct involvement in laboratory activities. Teaching tools are Videoprojector and PCs with Internet connection, which can be found in the Nephrology and Transplant Unit, where a Nephrological library and main texts and nephrological reviews are also available for further study.
Other informationsProf Marco Quaglia is always available for any further information or request at the Nephrology and Transplant Unit of "Maggiore della Carità" Hospital in Novara (0321-3733786).
Grading rulesFinal exam is based on a written proof which contains "statements". The student is required to judge them (true/false) and to comment on them motivating his judgement. "Statements"are about general topics of Nephrology, Dialysis and Transplantation with biotechnological implications.
Full argumentsPrinciples of anatomy and renal physiology. Basis of renal semeiotics. Urinalysis and urinary sediment. Study of renal function. Renal ultrasound and other instrumental exams to study renal disorders. Renal biopsy. The nephrological syndromes: isolated urinary abnormalities, nephrotic syndrome, acute nephritic syndrome, rapidly progressive syndrome; acute kidney injury (AKI) and chronic kidney disease (CKD). Primary and secondary glomerulonephritis. Acute and chronic interstitial nephritis. Acuta pyelonephritis. Vascular nephropathies. Acute kidney injury (AKI). Chronic kidney disease (CKD). Progression of chronic renal failure. Uremic syndrome. Preparation for dialysis. Hemodialysis: general principles and indications. Arterial-venous fistula for hemodialysis. Management of hemodialysis patient. Peritoneal dialysis: general principles and indications. Management of hemodialysis patient. Renal transplant. General principles and indications. Management of renal transplant patient. The immunosuppressive therapy. Complications of renal transplant. The role of C4d in the diagnosis of antibody-mediated rejection.
Expected learning objectivesGeneral knowledge of main topics of Nephrology, Dialysis and Transplantation with a focus on biotechnological applications.
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CourseTransplant immunology
Course IDMS0483
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderCHIOCCHETTI Annalisa
TeachersCHIOCCHETTI Annalisa
CFU2
Teaching duration (hours)8
Individual study time 42
SSDMED/04 - PATOLOGIA GENERALE
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
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CourseMaterials Biocompatibility
Course IDMS0484
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderBOCCAFOSCHI Francesca
TeachersBOCCAFOSCHI Francesca
CFU1
Teaching duration (hours)4
Individual study time 21
SSDBIO/16 - ANATOMIA UMANA
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
Reference textsTeaching material furnished via DIR
Teaching targetsProvide the basis for understanding the biocompatibility of materials for biomedical use
PrerequisitesCell biology, immunology, molecular biology
Didattics MethodsLectures in class
Grading rulesWritten exam
Full arguments1.Biocompatibility: basic concepts 2. Polymers: biomechanical characteristics
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CourseNanomaterials
Course IDMS0485
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderRIMONDINI Lia
TeachersRIMONDINI Lia
CFU1
Teaching duration (hours)4
Individual study time 21
SSDMED/28 - MALATTIE ODONTOSTOMATOLOGICHE
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryC - Affine o integrativo
Year2
PeriodPrimo Semestre
Frequenza obbligatoriaYes
Grading typeFinal judgment
Teaching languageEnglish
AbstractSee Course program beloiw
Reference textsWill be provided during classes
Teaching targetsKnowledge and understanding of the main properties of the matter at the nanoscale and their characterization. Knowledge and understanding of the main properties of the nanomaterials used in Medicine and their applications. Development of skills addressed to plan R&D on nanomaterials for Medical applications.
PrerequisitesFundamentals of chimics and physics
Didattics MethodsLecture
Other informationsNone
Grading rulesWritten test: Statments assessment and comments
Full argumentsDefinition of nanomaterials; properties of the materials at the nanoscale; methods to characterized nanomaterials; methods for nanomaterials manufacturing; esample of nanomaterials used for diagnosis and treatment of various diseases (including cancer); nanocarriers for drugs, nanomaterials for tissue regeneration, toxicology of nanomaterials.
Expected learning objectivesKnowledge and understanding of the main properties of matter at nanoscale and the potential application in Medicine Knowledge of the main methods to manage and characterize matter at the nanoscale
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CourseMolecular strategies for improving materials biocompatibility
Course IDMS0493
Academic Year2017/2018
Year of rule2016/2017
DegreeA004 - MEDICAL BIOTECHNOLOGY
CurriculumCORSO GENERICO
Teaching leaderMANTOVANI Diego
TeachersMANTOVANI Diego
CFU1
Teaching duration (hours)8
Individual study time 17
SSDBIO/11 - BIOLOGIA MOLECOLARE
Course typeModulo di sola Frequenza
Course mandatorietyMandatory course
Course categoryB - Caratterizzante
Year2
PeriodPrimo Semestre
Grading typeFinal judgment
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Data synched: 24/09/2018, 20:28