Ateneo - UPO

Topics in carbohydrate chemistry, including chemical synthesis of complex oligosaccharides, complex glycoconjugates (glycolipids, glycopeptides, and glycoproteins) and biological significance in vaccine design and development of immunotherapeutics.

• Handbook of Chemical Glycosylation: Advances in Stereoselectivity and Therapeutic Relevance, edited by Alexei V. Demchenko (2008). published by Wiley-VCH. ISBN: 978-3-527-31780-6.
• Carbohydrates in Chemistry and Biology Author(s):Prof. Dr. Beat Ernst, Prof. Dr. Gerald W. Hart, Prof. Dr. Pierre Sinaý Print: ISBN:9783527295111 |Online: ISBN:9783527618255 |DOI:10.1002/9783527618255 Copyright © 2000 WILEY‐VCH Verlag GmbH

Give the basics of carbohydrate chemistry and their biological functions.

Basic knowledge of Organic Chemistry

Chalk talk/White board and PowerPoint presentation will be the main approach for teaching this course.

Students are encouraged to actively participate in the learning process by asking questions and discussing topics during lecture and/or outside classroom, e.g., during office hours.

Problem sets, quizzes, and exams will used to assess students’ learning effectiveness. 1 Problem Set, 2 quizzes and a comprehensive exam.

This course covers various chemistry topics in carbohydrate molecules, e.g., oligosaccharides and glycoconjugates (glycolipids, glycopeptides, and glycoproteins). These topics include nomenclature of carbohydrates, structure determination of carbohydrates, chemical synthesis of oligosaccharides and glycoconjugates, and synthesis and biological studies of carbohydrate-based vaccines.
Chalk talk and PowerPoint presentation will be the main approach for teaching this course. Students are encouraged to actively participate in the learning process by asking questions and discussing topics during lecture and/or outside classroom, e.g., during office hours. Problem sets, quizzes, and exams will used to assess students’ learning effectiveness.
In addition, students will be assigned course materials involving comprehensive review of certain literature topics in carbohydrate chemistry for development of their critical thinking skills.

Students who successfully complete this course will be able to:
• Name various types of carbohydrate molecules and draw their structures;
• Understand chemical and enzymatic synthesis of complex oligosaccharides;
• Understand chemical and enzymatic synthesis of complex glycoconjugates including glycolipids and glycoproteins;
• Develop feasible strategies for the synthesis of complex oligosaccharides and glycoconjugates;
Understand the basics of synthesis and biological studies of carbohydrate-based vaccines.