Ateneo - UPO

The course addresses the main techniques to synthesize and purify organic compounds. These concepts are applied in the laboratory by setting up a set of reactions and purifying the corresponding products.

Practical Organic Synthesis: A student’s guide; R. Keese, M. P. Brandle, T. P. Toube; Wiley. Advanced Practical Organic chemistry, J. Leonard, B. Lygo, G. Procter

The course aims at providing students with adequate practical information for organic synthesis.

Basic knowledge of organic chemistry.

The course makes use of lectures, exercises and laboratory activities.

Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities. Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.

The exam mark will be the average mark obtained for each module: Theory: The students will be divided in groups and each group will have to present two projects in the form of a Powerpoint presentation: one relating to an organic chemistry topic and one relating to the analysis of a synthetic strategy of a product for pharmaceutical and/or cosmetic use. Each project will be assigned a maximum score of 15 points Practice: (i) The written test covers the material delivered in lectures and seminars and is made of multiple-choice questions (20) and an exercise (6). Maximum score: 26 For multiple choice questions, 1 point will be obtained for the correct answer, whereas wrong or blank answers will be evaluated 0 points. The laboratory evaluation considers the commitment, the performance of the student in the laboratory, and the lab notebook writing. Maximum score: 6.

- The main safety principles - The main techniques used for the synthesis and purification of organic compounds (reaction setup, product isolation and purification) During the laboratory, the performed synthesis will lead to the preparation of a dermatological API that will be then formulated during the formulation laboratory in the second semester.

At the end of the course, the student will be able to set up a reaction starting from a procedure taken from the literature, monitor it and purify the product