Ateneo - UPO

The course will deal with the processes inherent the discovery, optimization and validation of peptides and peptidomimetics with biological activity

Peptidomimetics in organic and medicinal chemistry , Wiley Ed, Trabocchi, Guarna
Peptidi e peptidomimetici, Piccon Ed., Santagata, Caliendo

The goals of the course are to introduce students to the key topics relating to medicinal chemistry of peptides and peptidomimetics and at the same time present and discuss general strategies for their drug design. At the end of the course, the student will have gained the essential stock of knowledge with regard to the drug design and the issues relating to their development.

organic chemistry

The course consists of lectures with slides show.
If the case of a new COVID19 emergency, the lessons will be carried out by recording and uploading them on Youtube with links in the course on DIR. Upon request, question time will be organized on Google meet.

ENG: Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities
Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.

The learning assessment consists of a written examination. The questions cover all the topics which have been discussed during the lessons.

Amino acids. Amino acids chirality. Acid and basic properties of amino acids. How to react amino acids? Peptides secondary structures. Natural peptides. Peptides as drugs. Orally available peptides. Peptides thermically stable. Chemical synthesis of peptides. Protecting groups of peptides. Coupling methods. The problem of racemization. Chemical ligation. Solid phase of peptides. Combinatorial chemistry of peptides. Purification of peptides. How to improve the druglikeness of a peptide. Pseudopetides. Peptidomimetics.

The students at the end of the course will know the key topics relating to medicinal chemistry of peptides and peptidomimetics and at the same time they will be able to present and discuss the general strategies for their drug design.