Ateneo - UPO

Cells and organs of the immune system. -Antigens-Antibodies. -Complement. -TCR and MHC. -Antigen presenting cells. -B and T cell maturation. -Cytokines. -Functions of T and NK cells. -Immunological memory.

1- Cellular and molecular immunology by Abul K. Abbas, Andrew H. Lichtman, & al. (Elsevier) 2- Kuby's immunology by Richard A. Goldsby, Thomas J. Kindt, & al. (UTET) 3- Janeway's immunobiology by Kenneth Murphy, Casey Weaver, & al.(Piccin)

To acquire knowledges on the immune system function at the level of innate and adaptive immunity in order to understand also the mechanisms of immune response and memory.

Basic knowledge of cell biology and genetics

Frontal leassons with slides

Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.

Oral examination. Questions will cover both basic immunology and immunopathology aspects. A final evaluation will be proposed and the exam will be passed if receiving 18/30 or more, till 30 cum laude

-Immune system. Innate and adaptive immunity. -Cells of the immune system. Receptors and mediators of innate immunity. -Organs of the immune system. -Antigens-Antibodies. Structure and function of the antibodies and antibody isotypes. Features of B cell antigens. Aptens. BCR structure and signaling. -Complement. Classic, alternative, lectinic pathway. Receptors and inhibitors. -Monoclonal antibodies and laboratory techniques. Monoclonal and polyclonal antibodies. Immunofluorescence, Western blot, RIA, ELISA, immunodiffusion. -TCR and MHC. Structure and function. The HLA system. Antigen presentation (endocytic, cytosolic, lipid pathways, cross-presentation). CD3, CD4, CD8, function and signaling. -Antigen presenting cells. Cell types, function second signal. CD28, CTLA-4 and PD-1. -B cell repertoire. Ig gene rearrangement. Antigen-independent and antigen-dependent maturation of B cells. -T cell repertoire. Thymic maturation of conventional and regulatory T cells. -Cytokines. Structure, function, receptors and signaling. -Helper and cytotoxic activities aof T cells. Th1, Th2, Th9, Th17, THF, natural and induced Treg, CTL, NK,

Knowledge of the immune system function and of the pathogenesis of the immune-mediated diseases