Ateneo - UPO

Main histology methods: fixation and staining. Description of the tissues of the human body in their morphological, localization and functional aspect. Description of the main cell types found in the human tissues

ISTOLOGIA E ANATOMIA MICROSCOPICA - Wheather - Edra (Edizione 2025) ISTOLOGIA UMANA. Testo atlante di istologia e anatomia microscopica - Stevens e Lowe - CEA (Edizione 2008) JUNQUEIRA ISTOLOGIA. Testo e atlante - A. Mescher - Piccin (Edizione 2020) ISTOLOGIA - Monesi - Piccin (Edizione 2026) ISTOLOGIA. Testo e atlante con elementi di biologia cellulare e molecolare - Pawlina - CEA (Edizione 2026) ISTOLOGIA UMANA - Belmonte, Angelucci, Follenzi, Tamagnone - Idelson Gnocchi (Edizione 2025)

By the end of the course, students should have acquired a thorough understanding of the various tissues of the human body and the relationship between their structure and function; as well as the main cells that compose tissues. They should also be able to recognize human histological specimens.

Cell Biology of eukaryote cells

Classroom lessons and Power Point presentations (uploaded to DIR) Observation in class of online histological slides

Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.

The exam consists of a written test (35-40 multiple-choice questions, of which only one is correct) to be taken on a computer (PC or tablet). Use of the Safe Exam Browser is mandatory. Registration for the exam is mandatory through the dedicated UPO website. Only correct answers are counted for grading purposes.

- Introduction to histological preparations: dehydration, fixation, cutting and staining - Epithelial tissues. Cellular polarization. Cytoplasmic and surface specializations, related to protective, mechanical, barrier and transport functions. - Classification, structure. Cytoskeleton, cell junctions, basement membrane. - Tegumentary system - Exocrine glandular epithelia. Structure and classification. Specializations of secretory functions. Histology of salivary glands, Brunner’s glands, exocrine pancreas - Endocrine glandular epithelia. Hormonal signals and tissue homeostasis. Hypothalamo-hypophyseal axis. Histology of thyroid, adrenal gland, pancreatic islets, Leydig’s cells - Connective tissues: components and functions of the extracellular matrix. Cells and their relationships with the matrix. Classification of connective tissues. - Blood: plasma, serum, cells. Cell structure, life span, and function, leukocyte formula. - Hemopoiesis. Multipotent stem cells and precursors. Hemocateresis. Histology of bone marrow - Lymphatic tissues: structure and organization of the lymphatic system. Classification of lymphocytes, membrane markers. Lymphopoiesis and lymphocyte maturation. Histology of thymus, spleen and lymph nodes - Cartilage and bone tissue. Mechanical functions and metabolic homeostasis. Ossification, growth, remodeling. - White and brown adipose tissue - Muscular tissue: skeletal, smooth, cardiac. Membrane, cytoskeletal and metabolic structure and specializations. Mechanism and regulation of muscle contraction. - Blood vessels: structure. Capillaries and sinusoids. - Nervous tissue. Ultrastructural specializations of neurons. Axonal transport. Electrical properties of the membrane. Synapses and neuro-muscular junction. Myelination. Gray matter and white matter. Description of glial cells - Tissue homeostasis: General information on differentiation, maintenance and renewal of tissues: adult stem cells. Oogenesis and spermatogenesis with histology of ovary and testis

Ability to recognize and describe human tissue by observing a histological preparation, with a description of the morphology of the cells and their function.