Ateneo - UPO

Basic concept of radiobiology: interactions between radiation and cells and tissues; DNA damage and repair mechanisms; radiosensitivity; early and late effects in tissues.

Radioprotection: graduate and stochastic effects; radioprotection measures in healthcare environment; ICRP documents; Euratom directives; regulatory laws in radioprotection.

DL 31 luglio 2020, n. 101

A SYLLABUS FOR THE EDUCATION AND TRAINING OF RADIATION ONCOLOGY NURSES IAEA (International Atomic Energy Agency)
Vienna, 2008

PRINCIPLES AND PRACTICE OF RADIATION ONCOLOGY
Edward C. Halperin, David E. Wazer, Carlos A. Perez, Luther W. Brady
Lippincott Williams & Wilkins, 7th Edition, 2018

The module aims at the acquisition of knowledge about the basic radiobiology and radioprotection and the competences about radioprotection in healthcare environment.

Basic knowledge of physics of radiation, biology and general pathology.

Teaching lessons by using powerpoint presentations and discussion in classroom. Simulation of multiple-choice tests.

Under request, visit in of a radiotherapy unit.

Multiple choice test about the main content of the course program. Question will focus on the topics of the course. Students have to demonstrate to know the basic knowledge of radiobiology and radioprotection.

Radiobiology
General aspects of ionizing radiations. Natural radioactivity. Historical notes. Physical, chemical and biological phases of interactions between radiation and human tissues. Direct and indirect effects. Damage to DNA and repair mechanisms. International Units. LET, RBE. Cell survival curves. Dose fractionation. Radiosensitivity. Repair of subletal damage. Recruitment in cell cycle. Re-oxygenation. Cell repopulation.

Radioprotection
Radioprotection. General aspects. Stochastic and non-stochastic effects. Natural and artificial sources of radiation. Graduate and non-graduate effects. Early and late effects. Oncogenesis. Measures for radioprotection: DPI and dosimetry. International and National laws on Radioprotection.

Knowledge of physical and radiobiological basis of the ionizing radiation.
Knowledge of principles of radioprotection and skills to apply such knowledge.