Ateneo - UPO

Chemistry of the most important classes of I and II metabolites
Non-ionic reaction mechanisms (pericyclic reactions, reactions mediated by transition metals, radical reactions)
Introduction to proces development. protecting groups

Clayden, J et al.. Organic Chemistry, Piccin, 2022.
Norman, Coxon. Sintesi Organica, Piccin, 1999.
Farina, V. Dispense sul corso di chimica organometallica AA 2001-2002

Provide students with instruments to critically tackle complex molecules and reaction mechanisms.

General and inorganic chemistry
Organic chemistry II
Heterocyclic chemistry

Lessons and problem-solving sessions

Supporting material to the course will be added to the DIR platform

oral part:
critical analysis of an organic chemistry topic via powerpoint presentation. written test

1. Reactions mediated by transition metals.
1. The 18-electron rule, classification of ligands and nature of the coordinative bond
2. Reactions mediated by transition metals. General mechanisms
3. metathesis
4. Coupling reactions and Heck reactions

2. Pericyclic reactions
1.General introduction and selection rules
2. Cycloaddition reactions and structure-reactivity relationships in diene synthesis
3. 1,3-dipolar cycloadditions
4. Electrocyclic reactions
5. Sigmatropic reactions
6. Applications to industrial synthesis (vitamin D, citral)

3.Carbohydrates
1.Representation and formation of hemiacetals
2.Anomeric effect and hyperconjugation
3. Protective reactions
4. Glycosidation reactions
5. Oxidation-reduction reactions
6. Synthesis of solid-phase oilnucleotides
8. Exercises and applications

4.Amino acids and peptides
1. Acid-base properties of proteinogenic amino acids and their general synthesis
2. Asymmetric synthesis of amino acids
3. Peptide synthesis in solution
4. Solid-state peptide synthesis and basics of polymer chemistry
5. Polymerization reactions

5. Stereoelectronic effects
1. General introduction
2. Application to conformational effects
3. Application to configurational effects
4. Application to reactivity

6. Organic photochemistry
1. General aspects
2. Synthetic use
3. Photocycloadditions and their biological relevance
4. Exercises and applications

7. protective groups of the main functional groups

8. concepts of retrosynthesis and manipulation of the main functional groups

Capacity to address the chemistry and the synthesis of complex molecules applying modern reaction mechanisms