Ateneo - UPO

PHARMACOLOGY: Preclinical and clinical development of drugs. Principles of pharmacokinetics and pharmacodynamics. Main classes of drugs. Originator drug concept, generic drug, biosimilar medication. Main classes of drugs.

PHARMACOLOGY
Beside updated publications, the following books are suggested:
1. HP Rang and MM Dale – Farmacologia, Casa Ed Ambrosiana
2. Goodman & Gilman – Le basi farmacologiche della terapia di J.G.Hardman, L.E. Limbird, A.Goodman Gilman, Curatore edizione italiana: C.Sirtori, G.Folco, G.Franceschini, S.Govoni.
3. Farmacologia generale e molecolare, a cura di F.Clementi, G.Fumagalli, Ed UTET
John Wiley & Sons Inc

PHARMACOLOGY. In the context of this Integrated Course, the module of Pharmacology will give to students the basis of pharmacokinetic and pharmacodynamic principles, the general concepts of “conventional small molecules” and biological/biotechnological drugs along with the most important pharmacological differences and their pre-clinical and clinical development. Moreover, the course will provide detailed information about selected drug classes

Students are required to have a good preparation in biochemistry, physiology, anatomy and pathology

Lectures

Students are required to have a good knowledge of English, especially in reading

Writing test multiple choice

Introduction to pharmacology
- Discovery and development of a new drug: pre-clinical and clinical phases
- The main principles of drugs, conventional small molecules, biological/biotechnological drugs, equivalent and biosimilar drugs
-Pharmacodynamic: receptors and signal transduction; meaning of agonist and antagonist; the dose-response curve;
-Pharmacokineti: absorbtion, distribution, metabolism and excretion of drugs; definition of half life, bioavailability, clearance and distribution volume
-Antiinflammatory drugs: FANS and glucocorticoids
-Immunosuppressive drugs
-Chemotherapeutci agents
-Drugs in cardiovascular system: Anti-coagulant and anti-thrombotic drugs, Anti-hypertensive drugs
-Drug for dyslipidemia
-Ttreatment for diabetes type I and II
- Drugs of nervous system: anti-depressives, anti-parkinson, anti-psycotic drugs, sedative-hypnotic, drug for neuromuscular disorders
Drug of abuse: opioids, psicostimulants, cannabinoids.
Drugs for COVID-19

At the end of the course students will have the basis to be able to face a new course of study in the field of pharmacological development