Ateneo - UPO

Safety in the chemical laboratory. Standard laboratory instrumentation. Nature and Purpose of Analytical Chemistry. Data evaluation. Acidic and basic properties.The solubility. Lipophilicity. Sample purification. Tritations. Introduction to chromatographic separation techniques and to analytical detection systems. Classroom exercises.

D.C. Harris, Chimica analitica quantitativa, Zanichelli, ed. 3, 2017, ISBN 8808821056.

The course objectives are to provide students with: the basic knowledge about safety in chemical laboratories; the most common equipment in use in laboratories; the notions concerning the obtaining and the critical manipulation of analytical data. The knowledge of the basic techniques used in chemical analytic laboratories. The classroom exercises, allow the student to gain familiarity with the calculations necessary for the preparation of solutions and the determination of physicochemical constants.

Basic knowledge of general and inorganic chemistry. Mathematical and statistical concepts.

The course consists of lectures with slides show. Some topics will be deepened with videos in English and Italian. Tutorials will be held in class. If the COVID19 emergency continues, the lessons will be carried out by recording and uploading them on DIR.

Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: __https://www.uniupo.it/en/services/servicesstudents-physical-or-learning-disabilities. _Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects._ For further informations, please refer to the course page on D.I.R. at: http://www.dir.uniupo.it

The assessment and the achievement of targets is through the final exam , written with oral discussion of the results , which ensures the acquisition of knowledge and understanding expectations . The written test consists of carrying out simple numerical exercises in situations involving well known drug. The examination is intended to assess on the achievement of the following learning objectives : knowledge of processing procedures and evaluation of experimental data ; knowledge of the main chemical equilibria in solution and the ability to solve problems in which they are involved ; knowledge of the basic principles underlying the main analytical techniques.

Risks arising from handling chemicals; Common instruments in analytical lab and rules of conduct. Balances; containers; measurement and transfer of volumes; laboratory book. Nature and purpose of analytical chemistry, function and its applications. Analytical procedures and related issues. Techniques and methods of analysis. Sampling and sample processing. Calibration and standards. The quality assurance in analytical laboratories. Errors in analytical measurements; Accuracy and precision; significant figures; tests of significance; calibration and linear regression. Quality control and chemometrics. Activity and activity coefficient, ionic strength; acid and base strength; Calculation of pH of aqueous solution of dilute acids and bases; Calculation of the salts solution pH, hydrolysis of salts; Ionization of weak acids and bases, equation of Henderson-Hasselbach. Buffer solutions; relations between the structure and character of acid-base; Determination of the pKa and P (log P). The dissolution process; solvents; relations between solubility and structure; solubility essays; solubility of poorly soluble products; solubility product. TITRATIONS Acid-base titrations: strong acid with strong base, weak acid with strong base, weak base with strong acid. Determination of the end point. Other types of tritrations. Introduction to chromatographic separation techniques and to analytical detection systems.

At the end of the course, the student will acquire theoretical knowledge and understanding about the analytical chemistry. Knowledge will also be acquired about the analytical procedures and carrying out simple numerical exercises in situations involving well known drug.