Ateneo - UPO

The course offers an in-depth analysis of the molecular mechanisms underlying molecular target therapies.

Molecular Biology of the cell. Alberts B. ed. Zanichelli. Papers published on peer reviewed journals provided by the teacher. Other material provided.

The course aims to provide the student with the knowledge of the molecular mechanisms of action of targeted therapies.

Basic knowledge of cellular and molecular biology

Theoretical lectures and exercises with ppt presentation by students and searching of scientific articles in pubmed. In case of the COVID-19 emergency, the lessons will be held at a distance using e-learning technologies, according to the schedule and modality indicated by the administration.

Le studentesse e gli studenti con disabilità o con Disturbi Specifici dell’Apprendimento (DSA) o con Bisogni Educativi Speciali (BES) possono richiedere servizi e strumenti specifici a loro dedicati rivolgendosi allo Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti e consultando la pagina dedicata del sito di Ateneo: https://uniupo.it/it/servizi/servizi-studenti-disabili-e-dsa
Le studentesse e gli studenti con disabilità, DSA, BES, una volta preso contatto con lo Staff di Ateneo, possono contattare la/il docente titolare dell'insegnamento in relazione alla declinazione delle modalità di esame, in merito agli aspetti didattici.

see teaching overview shee

Receptors with intrinsic enzymatic activity, receptors coupled with cytosolic proteins, G coupled receptors, nuclear receptors, enzymes. Targeted cancer therapies: action on cell proliferation, angiogenesis, senescence and apoptosis. Mechanisms of DNA repair. Selection of patients who can benefit from molecular target therapies. Precision medicine.

By the end of the course, students must demonstrate knowledge of the signal transduction pathways generated by drug/target interactions. They should be able to analyze a scientific article effectively. These expected learning outcomes, aligned with the Dublin descriptors, are as follows: KNOWLEDGE AND COMPREHENSION: Demonstrate advanced knowledge of cellular and molecular biology. Understand the mechanisms underlying tumor development to identify molecular targets and precision therapies. APPLYING KNOWLEDGE AND COMPREHENSION: Apply theoretical principles to analyze complex molecular mechanisms. Solve problems within biomedical, molecular, and pharmacological contexts. JUDGMENT AUTONOMY: Critically evaluate experimental data. COMMUNICATION SKILLS: Clearly and coherently communicate scientific concepts, using appropriate terminology. Present and discuss course topics logically, highlighting connections between different themes. LEARNING ABILITY: Develop autonomous learning strategies for continuous knowledge expansion. Prepare for advanced studies or research activities in the field of oncology research.