Ateneo - UPO

Principles of pharmacology and toxicology: kynetic and dynamic.
Toxic effects and mechanism, molecular targets.
Carbon monoxide and methaemoglobin.
Mushroom poisoning
Toxicity of nervous system.
Drug abuse
Prion diseases
Doping

Suggested books:
• Farmacologia generale e molecolare. Clementi & Fumagalli, IV Ed, UTET
• Elementi di tossicologia, Lu Frank C. - Kacew Sam, Ed EMSI

Students should acquire a good background of parmacology and toxicology to understand the mechanisms of toxicological effects induced by different
drugs and environmental xenobiotics

Students are required to have a good preparation in biochemistry, physiology, anatomy and pathology

Lectures with power point presentation

The student is required a good level of knowledge of English, especially in reading.
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities
Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.

Oral test

-Introduction to pharmacology and toxicology
Pharmacodynamic: receptors and signal transduction; meaning of agonist and antagonist; the dose-response curve;
-Pharmacokinetic: absorbtion, distribution, metabolism and excretion of xenobiotics; meaning of half life, bioavailability, clearance and distribution volume
- Toxicity of monoxide carbon, methemoglobin
Toxicity of NSAID
Toxicity of nervous system: glutammatergic system, GABAergic system and colinergic system.
Drug abuse: opioids, barbiturates and benzodiazepines,psicostimulants, cannabinoids, ethanol.
Prion diseases
Doping.
Integration of the gender dimension: where of interest, attention will be paid to gender pharmacology

It is expected that the student will know the basic principles of pharmacology and toxicology. In addition, the student must know the drug-toxicology characteristics of some classes of drugs and toxic substances of greater use.