Ateneo - UPO

In summary, the course is structured in the following phases: - Definition of drug, pharmacology and pharmaceutical form. Prescribing tables - Pharmacokinetics: constants and therapeutic protocols - Pharmacodynamics: bases and general mechanisms, neurotransmission and modulation of primary biological systems. First of all, the definitions of active, medicament, toxic and the origin of drugs will be studied, as well as the different types of medicinal or magisterial pharmaceutical preparation. The most common pharmaceutical forms will be analyzed, with hints on the responsibility of the doctor in the pharmacological prescription. With regard to pharmacokinetics, the main routes of administration and absorption of drugs will be described, together with the general parameters, absorption kinetics and the type of tissue barriers present in the body. The main constants of the distribution will be analyzed in detail, together with the factors that influence the speed of distribution to the various compartments. Drug metabolism will be examined in detail, together with the factors that modify it. Particular attention will be paid to the analysis of the key parameters of pharmacokinetics, which will be useful in deciding the correct dosage. In the section dedicated to pharmacodynamics, the drug-receptor interactions with the constants that describe them will be analyzed. The quantitative aspects of drug responses and the analysis of dose-response curves, with the quantification of responses to agonists and antagonists will be analyzed in detail, in addition to the study of the main receptor types. Finally, the details of neurotransmission and modulation of primary biological systems will be studied, together with notions of neuropharmacology and pharmacology of complex systems. The course ends with notions on the general principles of chemotherapy and drug resistance.

Farmacologia: principi di base e applicazioni terapeutiche, a cura di F. Rossi, V. Cuomo, C. Riccardi, Edizioni Minerva MedicaLe basi farmacologiche della terapia, Goodman e Gilman, Mc Graw-HillFarmacologia, Rang H.P., Dale M.M., Ritter J.M e Moore P.K., Casa Editrice Ambrosiana

The main objective of the course is knowledge and understanding and the ability to apply the relevant knowledge that provide a solid foundation for the correct and rational use of drugs. The students will deepen their knowledge of all aspects of pharmacokinetics and pharmacodynamics that characterize the pharmacological activity of a molecule, and which are the basis of the correct dosage.The general objective is to enable the student to develop independent judgement, communication skills and learning ability for this subject.

Deep knowledge of Anatomy, Physiology and Pathophysiology is fundamental for understanding the course.

Frontal teaching in the classroom with support Power Point presentations and consultation of specific internet sites.Students will be actively involved in the learning process and in the development of a critical spirit through clinical examples and computer simulations in the classroom.Particular attention will be paid to the adoption of gender language and information for students with disabilities, with Specific Learning Disorders (DSA), with Special Educational Needs (BES).

The teacher receives on Tuesday afternoon from 2 to 6 pm. An appointment by e-mail is welcome. The teacher will answer via email to any question or doubt to the students. Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services- students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.

The oral exam consists of a part related to pharmacodynamics and a part related to pharmacokinetics, with a single final grade. Evaluation criteria: - 25- 30 points if complete answer, understanding of the principles of drug therapy: - 18-24 points partially comprehensive, partially recognizes care needs/problems and manages them not completely correctly - < 18 points if not exhaustive, does not recognize assistance needs/problems and does not know how to manage them correctly

Structural phases of the course: 1) Definition of drug and pharmacology 2) Pharmacokinetics 3) Pharmacodynamics: bases and general mechanisms 4) Pharmacodynamics: Neurotransmission and modulation of primary biological systems Detailed description of the topics INTRODUCTION: Definition of Drug, Pharmaceutical Forms. PHARMACOKINETICS: Absorption and routes of drug administration: Distribution of drugs Elimination of drugs. Drug metabolism. Pharmacokinetic parameters. Dosages and plasma concentration of drugs. Interactions between drugs (mechanisms and classification). Individual variability in drug response, pharmacogenetics and abnormal drug responses. PHARMACODYNAMICS: BASES AND GENERAL MECHANISMS Drug-receptor interaction. Quantitative aspects of drug responses. Drug-receptor interaction and quantitative response. Drugs Agonists, partial agonists / antagonists (AP), inverse agonists. Competitive, non-competitive allosteric and irreversible antagonists. Molecular basis of drug action: Specificity of receptors and signal transduction. Channel receptors, G protein-coupled receptors, Guanylate cyclase-associated receptors, Membrane receptors associated with tyrosino-kinase activity, Intracellular and nuclear receptors. Modulation of receptor responses. Pharmacological control of transport across cell membranes. The main neurotransmitters. PHARMACODYNAMICS: NEUROTRANSMISSION AND MODULATION OF PRIMARY BIOLOGICAL SYSTEMS Catecholaminergic transmission and related drugs (dopamine, noradrenaline and adrenaline): Cholinergic transmission and related drugs. Serotonergic transmission and related drugs. Glycinergic transmission GABAergic and related drugs. Peptidergic transmission and related drugs. Purinergic transmission Excitatory amino acids. Autacoids: Histaminergic neurotransmission Nitroxide Pharmacology The cascade of arachidonic acid. The course program includes addressing issues relating to the integration of the gender dimension, in particular with reference to the therapeutic management of patients and the behavior of healthcare personnel in this area.

The expected learning outcomes are non-notional knowledge of the topics covered, the critical ability to tackle the topics transversally and to place knowledge in context, and the ability to understand the correct therapeutic use of the main active ingredients. At the end of the course, the student will be able to: i) critically support the patient during drug treatments to reduce the risks, ii) appreciate the importance of pharmacology for improving health. Knowledge and Understanding: Students are expected to have demonstrated knowledge and understanding in their field of study, including some cutting-edge topics. Furthermore, they are expected to have demonstrated knowledge and understanding that extend and strengthen those typically possessed at this level of education, and that may enable them to develop and/or apply original ideas, often in a research context. Ability to Apply Knowledge and Understanding: Students are expected to be able to apply their knowledge and understanding in a manner that demonstrates a professional approach to their work and possess adequate skills to both develop and sustain arguments and solve problems in their field of study. Furthermore, they are expected to be able to apply their knowledge, understanding, and problem-solving skills to new or unfamiliar topics within broader (or interdisciplinary) contexts related to their field of study. Independent judgment: Students are expected to have the ability to collect and interpret data (usually within their field of study) deemed useful for making independent judgments, including reflection on related social, scientific, or ethical issues. They are also expected to have the ability to integrate knowledge and manage complexity, as well as formulate judgments based on limited or incomplete information, including reflection on the social and ethical responsibilities associated with the application of their knowledge and judgments. Students must be capable of critical analysis, evaluation, and synthesis of new and complex ideas. Communication skills: Students are expected to communicate information, ideas, problems, and solutions to both specialist and non-specialist audiences, and to communicate their conclusions, as well as the knowledge and rationale behind them, clearly and unambiguously. Furthermore, students must be able to communicate with their peers, the broader scholarly community, and society at large in their fields of expertise. Learning skills: Students are expected to have developed the learning skills necessary to undertake further studies with a high degree of autonomy, to have developed the learning skills that allow them to continue studying largely self-directed or autonomously, and to be capable of promoting, in academic and professional contexts, technological, social, or cultural advancement in the knowledge-based society.