Ateneo - UPO

The course will cover the major hematologic malignancies, with a focus on their diagnostic, prognostic, and therapeutic aspects. It will also provide an overview of current research in hematology through the analysis of key clinical trials and the presentation of the latest therapeutic advances, with particular emphasis on novel biological agents and emerging treatment strategies.

Giuliani N, Olivieri A. EMATOLOGIA. Idelson-Gnocchi, 2020

The aim of the course is to render the student able to know, interpret and analyse the main hemato-oncological topics of the course that are relevant for a Physician, with a critical attitude, as requested by the Dublin descriptor 3. Specific aims are: a) know the pathophysiology and clinical picture of hemato-oncological diseases toward an appropriate clinical reasoning; b) bei able to critically interpret clinical and lab findings of hemato-oncological disorders, in order to formulate a correct diagnostic workup and an appropriate management of the patient

Knowledge of the contents of the propedeutical courses of the program

A) Taught (frontal) classes with slide presentations available on the UPO DIR website (https://www.dir.uniupo.it/); B) Interpretation and presentation of clinical cases and lab findings

Internship: discussion of clinical cases and interpretation of the main physical and lab findings of hematological interest.
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/servicesstudents-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.

The exam will be in the context of the Integrated Course of which the Hematology Oncology course is part. The exam of Hematology Oncology will be based on 10 MCQs (5 possible answers, of which only 1 is correct), on the topics taught during classes.

A. GENERAL CONCEPTS OF MYELOPROLIFERATIVE NEOPLASMS
A1. Histogenesis of myeloid neoplasms
A2. Molecular pathology of myeloid neoplasms
A3. Methodological principles for the classification of myeloid neoplasms
A4. Laboratory and instrumental diagnosis of myeloid neoplasms
A5. Clinical evaluation of myeloid neoplasms

B. MYELODYSPLASTIC SYNDROMES
B1. Definition of myelodysplastic syndromes
B2. Molecular pathogenesis of myelodysplastic syndromes
B3. Clinical presentation and diagnosis of myelodysplastic syndromes
B4. Treatment of myelodysplastic syndromes

C. CHRONIC MYELOID LEUKEMIA
C1. Pathogenesis of chronic myeloid leukemia
C2. Clinical presentation and diagnosis of chronic myeloid leukemia
C3. Treatment of chronic myeloid leukemia

D. MYELOPROLIFERATIVE NEOPLASMS
D1. Polycythemia vera
D2. Essential thrombocythemia
D3. Myelofibrosis

E. PLASMA CELL NEOPLASMS
E1. Classification and pathogenesis of plasma cell neoplasms
E2. Clinical presentation of plasma cell neoplasms
E3. Treatment of plasma cell neoplasms

F. HEMATOPOIETIC STEM CELL TRANSPLANTATION
F1. Autologous hematopoietic stem cell transplantation
F2. Allogeneic hematopoietic stem cell transplantation

G. CLINICAL RESEARCH IN HEMATOLOGY
G1. Phase 1, Phase 2, and Phase 3 clinical trials in hematologic oncology

At the end of the course, the student will be able to understand the pathophysiology, the diagnosis and the main therapeutic armamentarium of hematological malignancies. The student will also appreciate, from a precision medicine perspective, the use of molecular diagnostics for choosing the best therapeutic strategy for each patient.