Ateneo - UPO

This course is aimed at generating and interpreting laboratory medicine data and understanding the basic principles of the microbiological diagnostics to approach properly the diagnosis of infectious diseases.

La Posata, Medicina di Laboratorio
Patrick R. Murray, Ken S. Rosenthal. “Microbiologia Medica” 7a edizione
-Kenneth J. Ryan, C. George Ray. “Sherris. Medical Microbiology” 6th edition
- Guido Antonelli Principi di Microbiologia Medica (II Edizione) Casa Editrice Ambrosiana

To provide a thorough knowledge of Laboratory Medicine, a science that
studies the alterations of the organism in the disease state, using
chemical, physical, genetici and biological methods, obtaining, from
patient biological samples, qualitative and quantitative data, which
provide indispensable information for the clinician, not only for diagnostic
purposes, but also for therapeutic, preventive, prognostic and
rehabilitation purposes.

Good knowledge of Chemistry, Biochemistry, Immunology, Molecular Biology,
Genetics and Medical Microbiology.

The teaching activity is supported by slide presentation. All the teaching material will be available through the DIR website.

The exam consists of a written test. The level of difficulty of the questions corresponds to the program carried out (slides of the lessons published on DIR) and to the reference texts indicated on the Syllabus.
The written test consists of 12 open questions which require a concise answer. Each question is awarded 2.7 points; the written test is considered passed if the overall evaluation is not less than 18 points. The judging criteria adopted will be numerical and will progressively go from a minimum of 18 to a maximum of 30 cum laude (32.4 points), based on the level of preparation of the student. During the written test it is not allowed to consult any microbiology textbook and any multimedia means.

CLINICAL PATHOLOGY
1. Reductionistic and holistic approach to laboratory medicine
2. Bayesian apprach and predictive powers (negative and positive)
3. Margin of error
4. Pre-analytic, analytic and post-analytic phases, localization of laboratory errors
5. Blood analysis
6. Haemostasis
7. Flow cytometry
8. Necrosis biomarkers
9. Inflammation biomarkers
10. Neoplastic biomarkers
11. Genetic diagnosis
12. Omic diagnosis

CLINICAL MICROBIOLOGY
Basic concepts of the microbiological diagnostics and techniques.
Diagnosis of the viral infections in the respiratory and gastrointestinal tract.
Diagnosis of the viral infections in the blood circulation system
Diagnosis of the infections in the urogenital tract and during pregnancy
Diagnosis of bacterial infections in the blood circulation system and the central nervous system.
Assessing and monitoring of antimicrobial resistance

The students must demonstrate: i) they have acquired the basic concepts of the diagnosis of infectious diseases, ii) an appropriate scientific language, and iii) they are able to use the supplied material for a critical and reasoned study.