Ateneo - UPO

Laboratory Medicine

Teaching Material provided by the Professor.
Lecturer's Monographs.

To provide a thorough knowledge of Laboratory Medicine, a science that studies the alterations of the organism in the disease state, using chemical, physical, genetici and biological methods, obtaining, from patient biological samples, qualitative and quantitative data, which provide indispensable information for the clinician, not only for diagnostic purposes, but also for therapeutic, preventive, prognostic and rehabilitation purposes.

Good knowledge of Chemistry, Biochemistry, Molecular Biology and Genetics.

PowePoint presentation.
Teaching Network on DIR Website.
Frontal lessons.
Laboratory exercises.

Laboratory exercises at Clinical Chemistry Unit, "Maggiore della Carità" Hospital, Novara, during which will be deepened the topics, previously discussed during the lessons.

Multiple choice test.

The topics covered in the 25 hours of lectures are listed below.
In particular:
• Laboratory Medicine: general information.
• Bayes theory.
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Laboratory medicine in the blood diseases study and in the biological fluids evaluation (liquor, ascitic fluid, pleural fluid, synovial fluid, cardiac fluid). In particular, the following topics are analyzed:
• the blood count
• the blood count in the leukemias diagnosis
• haemostasis study
• platelet function study
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Laboratory diagnostics of hemoglobinopathies.
• Limits and potentialities of "haemoglobin profile evaluation test", carried out with high performance liquid chromatography (HPLC)
• Role of the HbA2 parameter in the diagnosis of the thalassemia trait carrier.
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• Iron metabolism.
• Laboratory test for the evaluation of the martial profile.
• Hereditary hemochromatosis.
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Laboratory medicine in the coagulation study. In particular, the following topics are covered:
• coagulation pathophysiology
• coagulation test in the evaluation of thrombotic risk and haemorrhagic risk (screening tests and specialist tests)
• pathophysiology of hereditary thrombophilias and laboratory diagnostics
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• Evolution of Laboratory Medicine in the diagnosis of myocardial infarction
• Evolution of Laboratory Medicine in the diagnosis of cardiovascular diseases
• Personalized medicine and Pharmacogenetics: its clinical applications.

Critical interpretation of laboratory data.
Prescribing appropriateness of laboratory tests.
Knowledge of diagnostic profiles, diagnostic protocols and diagnostic paths.