Ateneo - UPO

The course will provide the tools to understand the management of the complexities related to hematopoietic stem cell transplantation, CAR-T cell therapies, to the new biological drugs precision medicine and to clinical trials. Some issues related to bioethical implications of clinical research will be discussed

Teaching materials used during lessons (slides, etc) will be pivotal for exam preparation

As an additional learning tool (consultation only)

Giuliani N, Olivieri A. EMATOLOGIA. Idelson-Gnocchi, 2020. The textbook does not surrogate for slides and materials used during the lesson

L'obiettivo formativo del corso e' di rendere lo studente capace di conoscere, interpretare ed analizzare le principali tematiche ematologiche inerenti al corso in maniera critica, come richiesto dal descrittore di Dublino 3.

Basic knowledge of blood disorders

taught (frontal) classes with slide presentations

None

The exam of Blood Diseases will be based on 12 MCQs (4 possible answers, of which only 1 is correct), on the topics taught during classes

A. Transplant of hematopoietuc stem cells and CAR-T therapies: autologous transplant; allogeneic transplant; transplant and CAR-T complications complications; Graft versus host diseases (GVHD); CRS and neurotoxicity complexity of transplant procedures

B. Precision Medicine and new drugs in hematoncology: monoclonal antibodies; "small molecules" for target therapies

C. Clinical trials in hematocology: phase I, phase II, phase III; the concept of "benefit sharing" in hematological scientific research; other bioethical issues in clinical research

At the end of the course, the student will be able to critically analyse: i) the strategy of transplant procedures of hematopoietic stem cells and CAR-T therapies; ii) the complexity of new drugs in hematoncology; iii) the methodology and problematics of clinical trials in hematoncology