Ateneo - UPO

Organization of the human genome.
Gene inheritance and transmission: Mendelian and non-Mendelian.
Instability of the human genome and genetic disorders.

Material provided by the professor

The students have to acquire the knowledge of principles of genetic transmission, molecular basis of heredity, genome organization, mutations and the standard techniques of DNA analysis.

Bases of cellular and molecular biology

Frontal lessons and searching research questions using PubMeb. In consideration of the COVID19 emergency, the teacher reserves to provide teaching remotely, using presentations that combine images, texts, audio and video.

Test with open-ended questions.
In consideration of the COVID19 emergency, the teacher reserves to modify the exam into an oral remote examination, using "google meet" platform.

Organization of the human genome: nuclear and mitochondrial genome - organization, distribution and function of human genes - non-coding DNA with tandem or interspersed repetitions.
Gene expression: transcriptional regulation of gene expression - post-transcriptional regulation - epigenetic mechanisms and remote control.
Hereditary transmission of a single gene: Mendelian and non-Mendelian
Instability of the human genome: chromosomal and gene mutations - somatic and germ line mutations. Effects of mutations.
Diseases due to genetic mutations: autosomal monogenic or X linked- dominant and recessive - Y - linked - dynamic mutations. Examples and methods of analysis.

Students are expected to learn the molecular bases of heredity, the main techniques for the analysis of DNA and their application.