Ateneo - UPO

Stereochemistry (part 2).
Reactivity of functional groups in aliphatic, aromatic and selected heterocyclic compounds. Introduction to the reactivity of organic natural compounds

chimica organica, bruno botta, edi-ermes

chimica organica, peter vollhardt, zanichelli

chimica organica,
Brown, Foote, Inverson
Edises

chimica organica, John McMurry, piccin

Fondamenti di chimica organica, Smith - McGraw-Hill

Knowledge of the stereochemistry of organic compounds, especially stereocenters (R/S).identification and analysis of the various stereogenic centers in the molecule
Knowledge of the reactivity and synthesis of functional groups, arenes, heterocycles and natural products.ability to analyze and recognize the various functional groups present in the molecule and to evaluate the reactivity in the various reaction conditions.

Exam preparatory General and Inorganic Chemistry and Organic Chemistry 1.

Classroom lectures. Available to students: pdf copy of lesson slides, exercises and previous exam tests.

in the case of online teaching, the lessons will be recorded for those who cannot be present

Written test with organic chemistry exercises, which will evaluate the knowledge of the reactivity of various functional groups analyzed during the course and the student's ability to apply this knowledge led to the synthesis of target molecules.
Possible oral examination to supplement the written test

CFU 1
Symmetry: elements and operations. Chirality. CIP rules and R/S descriptors. Enantiomers and diastereomers. Resolution of stereoisomers. Optical activity and enantiomeric excess. Exercises.
CFU 2-7
Chemical reactions: classification, chemical metrics, atom mapping, stoichiometry of organic reactions.
Principal reactions and syntheses of:
- Alkanes and cycloalkanes
- Alkenes, dienes and alkynes
- Alogenoalkanes and organometallic reagents (Mg, Li)
- Alcohols, ethers, thiols and thioeters
- The carbonyl group: aldehydes and ketones
- Carboxylic derivatives: carboxylic acids, esters, amides, acyl halides, anhydrides and nitriles
- Amines
- Arenes
- Heterocyclic compounds
Exercises
CFU 8
Introduction on the reactivity of natural products: lipids, aminoacids, carbohydrates. Terpenes and isoprenic rule. Exercises.

The student is able to apply the concepts learned during frontal lessons, in synthetic processes of molecules of pharmaceutical importance