Ateneo - UPO

Quantitative analysis of the drugs through titrations + experiences titration laboratory

* E. Abignente, D. Melisi, M.G. Rimoli, “Principi diAnalisi quantitativa dei medicinali”, Loghìa.
* D. S. Hage, J. D. Carr, “Chimica analitica e analisi quantitativa”, Casa Editrice Piccin, edizione italiana
* Vogel, “ Analisi chimica quantitativa”, Casa Editrice Ambrosiana
* D.C. Harris, “Chimica Analitica Quantitativa”, Zanichelli.
* Skoog and West, “Chimica Analitica”, EdiSES
* F.Savelli-O. Bruno, “Analisi chimico farmaceutica”, Casa editrice Piccin Padova
* D.L. Pavia, G.M. Lampman, G.S. Kriz, “Il laboratorio di chimica organica”, Edizioni Sorbona Milano

The course will give the student the first notions concerning the main techniques used in chemical laboratories. After the theoric part will follow some practical exercises in order to deepen the topics and to allow the student to acquire the basic handedness useful in laboratory.

There are no specific prerequisites although the knowledge of the basic notions of the main chemical reactions and general chemistry are very important. It is however necessary to follow the entire course and then to take the exam to be in compliance with the prerequisites provided for in the study plan.

Frontal lessons and laboratory experiences (related to COVID pandemic situation)

None

Knowledge assessment
Ongoing test 1: Entrance test for laboratory exercises: theory (multiple choice-true false) + 2 problems on concentration calculation; to enter the laboratory the evaluation must be > 18/30. Maximum duration 30 min.
Ongoing test 2: Evaluation of quantitative determinations for a maximum of 2 points
Ongoing test 3: 2 Problems to solve last day of laboratory on laboratory experiences. Maximum duration 30 min. Rating in /30
Ongoing test 4: 2 dosing problems + dosing theory (open questions). Maximum duration 1h. Rating in /30

The final grade will be calculated as
(A+C+D)/3+B

LABORATORY SAFETY
LABORATORY GLASSWARE: use and maintenance.
MEASURES OF WEIGHT: technical and analytical scales.
MEASURES OF VOLUME: calibrated and graduated glasses. Expression of the concentration.
QUANTITATIVE CHEMICAL ANALYSIS: VOLUMETRIC ANALYSIS
-preparation of standard solutions by weighing and by dilution
-concept of titration (direct and indirect titration)
-standard solutions and primary standards
-determination of the end of a titration: equivalence point, end-point and error tritation
-concept of indicator
-chemical reactions of titrations: acid-base; redox; gravimetric; complexometric.

At the end of the course the student must have acquired the manual to carry out a titration (technique still evaluated in the test for the qualification to practice the profession) and will solve problems of quantitative analysis