Ateneo - UPO

Contenuti Structure properites (configurational, conformazional, acid-base) of
organic compounds. Functional groups and main reaction types of
organic compounds. Non-polymeric biomolecules (carbohydrates, lipids,
amino acids).

“Chimica di Base per le Scienze della Vita” Ed. Delfino, Roma. Volume II .
Autore: M. Anastasia “Chimica Organica” Ed. Edi-Ermes Autore: B. Botta
“Chimica Organica”Ed. Zanichelli Autori: K. P. C. Vollhardt – N. E. Shore
“Fondamenti di Chimica Organica” Autore: D. Klein

Provide students the essential elements of organic chemistry to critically
approach the study of complex biomolecules.

Main concepts developed in the course of General Chemistry (chemical
bond, equilibria, kinetics and thermodynamics of chemical processes)

Exercises and problems will be solved and discussed during the course.
All the material will be made available to students in the web

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The exam will be a set of multiple-choice questions aimed at developing
the attitude to critical thinking of the candidate

Credit 1: Structure and properties of organic compounds
1. General introduction to the chemical bond
2. Covalent, ionic and polar covalent chemical bonds: properties and geometry-1
3. Lewis structural formulas and formal charges and resonance formulas
4. Aromaticity
Credit 2: Functional groups, physical properties and nomenclature
5. Functional groups and their influence on physical and chemical properties (acidity and basicity)
6. Inter- and intra-molecular interactions and their effect on properties and reactivity
7. Nomenclature of organic compounds
Credit 3: Isomerism, conformation and stereochemistry analysis
8. Isomerism: definition and classification
9. Conformational analysis of acyclic and cyclic compounds. Configurational analysis: alkenes
10. Chirality and configurational analysis: diastereomerism and enantiomerism
Credit 4: Functional groups and their reactivity-1
11. Reactivity of alkanes, alkenes and alkynes: Electrophilic addition and catalytic hydrogenation
12. Alkyl halides and mono- and bimolecular nucleophilic substitution (SN) reactions
13. Mono- and bimolecular elimination reaction. Competition with SN
14. Alcohols and their reactivity
Credit 5: Functional groups and their reactivity-2
15. Ethers, epoxides, thiols and thioethers
16. Amines
17. Carbonyl derivatives and nucleophilic addition reaction
18. Tautomerism and condensation reactions
19. Carboxylic acids and nucleophilic acyl substitution reactions
20. Derivatives of carboxylic acids
Credit 6: Functional groups and their reactivity-3 / biomolecules
21. Benzene: aromaticity, nomenclature and properties
22. Reactivity of benzene and aromatic electrophilic substitution reactions
23. Phenols and aromatic amines. Aromatic nucleophilic substitution
24. Radical reactions
25. Amino acids and peptides
26. Sugars
27. Lipids

Recognize and critically evaluate the functions present in an organic molecule, knowing its properties and reactivity.