Ateneo - UPO

The aims of the course are as follows:
1. To know the biology of hematopoietic stem cell and of hemopoiesis
2. To know the sources of hematopoietic stem cells, the biology of stem cell mobilization, and the procedures of processing hematopoietic stem cells
3. To know the physiology of autologous, allogeneic and cord blood stem cell transplantation
4. To know the pathogenesis of graft versus host disease
5. To know the biotechnological procedures applied to hematopoietic stem cell transplantation (HLA typing, monitoring of engraftment and hematopoietic reconstitution, terapeutic manipulation and engineering of the graft)

Slides presented during the course; materials deposited on the DIR website; scientific papers presented in class and/or at journal clubs.

Suggested textbook: HEMATOLOGY For Medical Students and General Practitioners, ISBN: 9788879477727

Expand the knowledge on stem cell biology and its application in clinics

The student is expected to have a good knowledge of basic biology principles of cellular cross-talking between cells and basic notions of histology.

Lectures and interaction in class. A periodic self assessment of the knowledge will be planned during the classes.

Additional materials
Williams Hematology, 9e
Author(s): Kenneth Kaushansky, Marshall A. Lichtman, Josef T. Prchal, Marcel M. Levi, Oliver W. Press, Linda J. Burns and Michael Caligiuri (available on su UPO off campus library through AccessMedicine)
Suggested textbook: HEMATOLOGY For Medical Students and General Practitioners, ISBN: 9788879477727

The exams is part of an integrated course. The final test will be written and it consists of 3 different statement which must be addressed as true or false by the applicant. A brief comment explaining the choice is needed. Examples of the written exam will be presented at the end of every class.

Course program:
Hematopoietic stem cell and hemopoiesis
- Hematopoietic stem cell biology
- Bone marrow microenvironment

Hematopoietic stem cells sources
- Bone marrow stem cells
- Peripheral blood stem cells
- Cord blood stem cells
- Stem cell mobilization and collection
- Stem cell processing and cryopreservation

Hematoietic stem cell transplantation
- Autologous hematopoietic stem cell transplantation
- Allogeneic hematopoietic stem cell transplantation
- Cord clod hematopoietic stem cell transplantation

Hematopoietic stem cell transplantation conditioning regimens
- Condistioning regimens for autologous hematopoietic stem cell transplantation
- Myeloablative conditioning regimens for allogeneic hematopoietic stem cell transplantation
- Non-myeloablative conditioning regimens for allogeneic hematopoietic stem cell transplantation

Cell Therapy
- Graft versus tumor reaction
- Therapeutic manipulations of the graft
- Therapeutic utilization of cellular populations

The aims of the course are as follows:
1. To know the biology of hematopoietic stem cell and of hemopoiesis
2. To know the sources of hematopoietic stem cells, the biology of stem cell mobilization, and the procedures of processing hematopoietic stem cells
3. To know the physiology of autologous, allogeneic and cord blood stem cell transplantation
4. To know the pathogenesis of graft versus host disease
5. To know the biotechnological procedures applied to hematopoietic stem cell transplantation (HLA typing, monitoring of engraftment and hematopoietic reconstitution, terapeutic manipulation and engineering of the graft)