Ateneo - UPO

The course will focus the main lymphoid oncohematological diseases from a diagnostic, prognostic and therapeutic point of view. The course will also focus on research in hematology. To this end, clinical trials will be analyzed, new therapeutic possibilities will be presented with new monoclonal antibodies, new biological drugs and cell therapies

Giuliani N, Olivieri A. EMATOLOGIA. Idelson-Gnocchi, 2020

The general objective of the course is to enable students to know, interpret and analyze the main oncohematological issues inherent to the course and relevant to the Doctor, in a critical way, as required by the Dublin 3 descriptor. Specific objectives are: a) know the physiopathology and clinic of oncohematological diseases for the purpose of correct clinical reasoning; b) knowing how to critically interpret the clinical and laboratory findings of oncohematological diseases, in order to formulate a correct diagnostic procedure and an appropriate management of the patient

Compliance with the prerequisites required by the most recent course regulations. Onco-hematology requires basic notions of genetics, molecular biology, immunology and general pathophysiology

A) Lectures with slide presentations available on the university's DIR website (https://www.dir.uniupo.it/); B) Multiple choice self-assessment quiz available on the University DIR website (https://www.dir.uniupo.it/) after each lesson

Students with physical disabilities, Learning Disabilities or Special Education Needs can request
specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse
e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/servicesstudents-physical-or-learning-disabilities
Students with disabilities, learning disabilities or special education needs, once they have contacted
the University Staff, can refer to the tutor in charge of the course to define the examination
modalities, concerning academic aspects.

The exam takes place as part of the Integrated Course exam of which the Oncohematology course is part. The Oncomatology exam consists of 10 multiple choice questions (5 possible answers, of which only one is correct) on the topics covered in class. Sample questions are available on UPO DIR.

A. GENERAL CONCEPTS OF LYMPHID NEOPLASIES
A1. Histogenesis of lymphoid neoplasms
A2. Molecular pathology of lymphoid neoplasms
A3. Methodological elements for the classification of lymphoid neoplasms
A4. Laboratory and instrumental diagnostics of lymphoid neoplasms
A5. Clinical semeiotics of lymphoid neoplasms

B. MAIN LYNFOID NEOPLASIES
B1. Indolent and aggressive non-Hodgkin's lymphomas
B2. Hodgkin's lymphoma
B3. Monoclonal B cell lymphocytosis and chronic lymphocytic leukemia
B4. Hairy cell leukemia
B5. Monoclonal gammopathies: MGUS, multiple myeloma and other plasma cell neoplasms

C. NEW THERAPEUTIC STRATEGIES FOR LYNFOID NEOPLASIES
C1. Immunotherapy
C2. Cellular therapies
C3. Precision medicine applied to lymphoid neoplasms

D. CLINICAL RESEARCH IN HEMATOLOGY
D1. Phase 1, phase 2 and phase 3 clinical trials in oncohematology
D2 The guidelines: use and interpretation

At the end of the course, students will be able to understand the pathophysiology, diagnosis and main therapeutic possibilities of the main oncohematological diseases of the lymphoid line. Students will also acquire, from a precision medicine perspective, knowledge of the importance of molecular diagnostics to choose the best therapeutic strategy. They will also be able to use appropriate tools to increase his knowledge and deal with relatively more complex clinical cases