Ateneo - UPO

A.General Principles
• Pathophysiology of hematopoiesis
• Bone marrow transplantation and hematopoietic stem cells
• Pathophysiology of bone marrow failure

B.Diseases of red blood cells
• Definition, pathophysiology and classification of anemias
• Anemia by impaired synthesis of hemoglobin (iron-deficiency anemia, anemia of chronic disease, thalassemia)
• Hemoglobinopathies
• Anemia by impaired DNA synthesis (anemias deficiency of folate and vitamin B12)
• Hemolytic anemias

C.Hematologic Malignancies
• The WHO classification of Hematological Malignancies
• Acute Myeloid and Lymphoid Leukemias
• Chronic Myeloproliferative Syndromes and Myelodysplastic Syndromes
•Lymphoid Neoplasm (Hodgkin's lymphoma, non-Hodgkin's lymphomas, monoclonal gammopathy, chronic lymphocytic leukemia, hairy cell leukemia)

D. Disorders of hemostasis and coagulation
• Pathophysiology of hemostasis
• Hereditary coagulopathy (Haemophilias and vonWillebrand disease)
• CID and thrombotic microangiopathy
• Monitoring of anticoagulant therapy
• Inherited and Acquired thrombophilias
• Immunological and Non-immunological Thrombocytopenia

E. Transfusion Medicine
• Blood collection
• Test pretransfusion
• Blood products
• Complications
• Therapeutic hemapheresis

F. Giona, Ematologia smart, Idelson-Gnocchi, ISBN: 9788879477710

The objectives of the module are:
1.To learn and understand the etiology, pathophysiology, diagnosis of the main myeloid and lymphoid disorders
2.To learn and understand the main clinical manifestations, prognosis and some therapeutic outlines of the main myeloid and lymphoid disorders

The student must know the essential concepts of Anatomy, Biochemistry, Immunology, Pathology, and Semiotics.

Power point presentation and educational website

Students with physical disabilities, Learning Disabilities or Special Education Needs can request
specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse

e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities

Students with disabilities, learning disabilities or special education needs, once they have contacted
the University Staff, can refer to the tutor in charge of the course to define the examination
modalities, concerning academic aspects.

Multiple choices test

A. Parte generale
• Fisiopatologia della emolinfopoiesi
• Il trapianto di midollo osseo ed il trapianto di cellule staminali emopoietiche
• Fisiopatologia della insufficienza midollare

B. Malattie del globulo rosso
• Definizione, fisiopatologia e classificazione delle anemie
• Anemie da alterata sintesi di emoglobina (anemia sideropenica, anemia da malattia cronica, talassemie)
• Emoglobinopatie
• Anemie da alterata sintesi del DNA (anemie da carenza di folati e vitamina B12)
• Anemie emolitiche da causa intra- ed extra-eritrocitaria

C. Oncoematologia
• La classificazione WHO delle emopatie maligne
• Leucemie acute mieloidi e linfoidi
• Sindromi mieloproliferative croniche
• Sindromi mielodisplastiche
• Neoplasie delle cellule linfoidi mature (linfoma di Hodgkin, linfomi non-Hodgkin, gammopatie monoclonali, leucemia linfatica cronica, hairy cell leukemia)

D. Disordini dell'emostasi e della coagulazione
• Fisiopatologia della emostasi
• Coagulopatie ereditarie (emofilie e malattia di vonWillebrand)
• CID e microangiopatie trombotiche
• Il monitoraggio del paziente in corso di terapia anticoagulante
• Trombofilie ereditarie ed acquisite
• Piastrinopenie immunologiche e non immunologiche

E. Medicina trasfusionale
• La raccolta del sangue
• Test pretrasfusionali
• Prodotti ematici
• Complicanze
• Emaferesi terapeutica