Ateneo - UPO

Introduction to epidemiology pathogenesis, physiopathology and diagnostics of blood disorders.. Basic notions on therapy with special focus on biological therapies and stem cell transplantation

Slides and web references will the critical basis for study. For consultation Williams HEMATOLOGY Mc Graw Hill is recommended

To understand the physiopathological basis of blood disorders with special interest to blood cancer; understand the principle of diagnosis and therapy of blood disorders with special respect to targeted approaches and precision medicine

notions of biochemistrym physiology, pathology and statistics

lessons and interactive discussion

Students with physical disabilities, Learning Disabilities or Special Education Needs can request
specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse

e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-
students-physical-or-learning-disabilities

Students with disabilities, learning disabilities or special education needs, once they have contacted
the University Staff, can refer to the tutor in charge of the course to define the examination
modalities, concerning academic aspects.

oral text.
Two questions will be asked each scoring 0-15 points. Laude will be given if students show additional knowledge and effective conceptual linking to other fields
Questions will be broad, but a structured answer will be requested. Both contents and ability to use an appropriate scientific language will be considered for evaluation

Blood disorders
1)Blood physiology
2) The immune system: relevant aspects to clinical haematology
3) Bone Marrow functions andHaematopoietic stem cells including stem cell plasticity
4) Anemia I
5) Hemoglobin diserders
6) Hemoglobin disorders II
7) Other inherited RBC disorders
8) Aplastic Anemia and PNH. Myeloid cancerogenesis
9)Myelodisplastic Syndromes
10) Chronic Myeloprolipherative disorders
11) chronic Myelogenous Leukemia
12) Acute Myeloid Leukemia
13a: Lymphoid cancerogenesis Lezione 14: Antigen-driven lymphomagenesi
Lezione and methods for staging and prognostication 15 Acute lymphoblastic Leukemia and NHL
16: NHL
17: HL and Chronic lymphocytic leukemia l
18: monoclonal gammopathies
19: multiple myeloma MGUS amyloidosis
20:
Targeted Therapies in hematology including MoAbs
21: CAR-T cells
and other cell therapies
22a: Stem cell transplantation
23: Clinical trials. Methodology and interpretation
24: Questions and Answers

Results:
1) to be oriented in the nosography of blood disorders
2) to understand essemtial physiopathogenetic mechanisms
3) to know the natural history of blood disorders
4) To know the laboratory tools for diagnosis
5) to know the basics of treatment