Ateneo - UPO

The course will deal with the etiology, pathophysiology, clinic, diagnostics, prognosis and therapeutic rationale of the main diseases of the blood and the blood and lymphatic system. The basis will also be provided for a critical interpretation of the objective findings of the haematological patient, the blood count and the main coagulation findings.

Giuliani N, Olivieri A. EMATOLOGIA. Idelson-Gnocchi, 2020
and slides and materials distributed during lessons

The general objective of the course is to enable students to know, interpret and analyze the main haematological issues relevant to the Doctor, in a critical manner, as required by the Dublin 3 descriptor. Specific objectives are: a) to know the physiopathology and clinic of haematological diseases for the purpose of correct clinical reasoning; b) to know how to critically interpret the clinical and laboratory findings of haematological diseases, in order to formulate a correct diagnostic procedure and an appropriate management choice of the patient

According to course regulation

A) Lectures with slide presentations available on the University DIR website (https://www.dir.uniupo.it/); B) Multiple choice self-assessment quiz available on the University DIR website (https://www.dir.uniupo.it/) after each lesson; C) Interpretation and presentation of clinical cases and laboratory findings

Students with physical disabilities, Learning Disabilities or Special Education Needs can request
specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse
e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/servicesstudents-physical-or-learning-disabilities
Students with disabilities, learning disabilities or special education needs, once they have contacted
the University Staff, can refer to the tutor in charge of the course to define the examination
modalities, concerning academic aspects

Written exam with 30 multiple choice questions (5 possible choices, of which only one is correct) regarding the topics of the course. Part of the questions will be of the "clinical vignette" type. Examples of are available on the UPO DIR website.
Part B: a simulated clinical case on which to produce a short written report (examples available on UPO DIR), followed by an oral discussion of the case

A. GENERAL PART A1. Pathophysiology of hemolymphopoiesis A2. Clinical and laboratory semeiotics in haematology A3. Clinical interpretation of CBC and differential A4. General strategies in the diagnosis and treatment of haematological diseases A5. Pathophysiology and clinical implications of bone marrow aplasia A6. Bone marrow aplasia B. DISEASES OF RED BLOOD CELLS B1. Definition of anemia and clinical features of the anaemic syndrome B2. Pathophysiology and classification of anemias B3. Anemias due to altered haemoglobin synthesis (sideropenic anemia, anemia of chronic disease) B4. Anemias due to altered DNA synthesis (folate deficiency and vitamin B12 deficiency) B5. Hereditary hemoglobinopathies B6. Hemolytic anemias C. HEMATONCOLOGY C1. General mechanisms of leukemogenesis and lymphomagenesis C2. Acute myeloid leukemia and acute promyelocytic leukemia C3. Acute lymphoblastic leukemia C4. Non-Hodgkin lymphomas C5. Hodgkin lymphoma C6. MBL and chronic lymphocytic leukemia C7. Hairy cell leukemia D. DISEASES OF HEMOSTASIS D1. Diagnostics of hemostasis D2. Hereditary coagulopathies (haemophilia A and B; vonWillebrand disease) D3. Acquired coagulopathies (DIC, acquired hemophilia, iatrogenic coagulopathies) D4. Immune thrombocytopenia (ITP) D5. Thrombotic microngiopathies D6. Hereditary and acquired thrombophilia E. BASICS OF TRANSFUSION MEDICINE F. CLINICAL REASONING IN HEMATOLOGY F1. Discussion of clinical cases F2. Clinical interpretation of the main laboratory findings of haematological interest G. BASICS OF HEMATOLOGIC MORPHOLOGY G1. Normal blood cells G2. Promyelocytes G3. Schistocytes

At the end of the course, students will be able to know the pathophysiology of the main non-neoplastic haematological diseases, myeloid oncology and acute lymphoblastic leukemia. In addition, students will be able to critically interpret the blood count, the main coagulation findings and the objective findings, formulating diagnostic and therapeutic hypotheses.