Ateneo - UPO

The course is divided in two parts, one devoted to radiobiology concepts and the other to radiation protection.
The program includes interactions between radiation and cells and tissues. DNA damage and repair mechanisms. Radiosensitivity. Linear-quadratic model. Early and late effects in tissues.
Graduate and stochastic effects. ICRP documents. Euratom directives. Regulatory laws in radioprotection.

RADIOBIOLOGY FOR THE RADIOLOGIST
Eric J. Hall
Lippincott Williams & Wilkins, Fifth Edition, 2000

PRINCIPLES AND PRACTICE OF RADIATION ONCOLOGY
Carlos A. Perez, Luther W. Brady, Edward C. Halperin, Rupert K Schmidt-Ullrich
Lippincott Williams & Wilkins, Fourth Edition, 2004

RADIOBIOLOGIA E RADIOPROTEZIONE
Carissimo Biagini
Piccin 1999

ELEMENTI DI RADIOBIOLOGIA CLINICA E RADIOPROTEZIONE
Roberto Orecchia, Giovanni Lucignani, Giampiero Tosi
Archimedica 2001

RADIATION PATHOLOGY
Luis Felipe Fajardo L-G, Morgan Berthrong, Robert E. Anderson
Oxford University Press, 2001

ICRP Documents (39, 41, 44, 49, 52, 53, 57, 58, 59, 60, 61, 62, 73, 75)

CE DIRECTIVES (92/69, 97/43, 59/13)

NATIONAL LAWS
(DL 26 maggio 2000, n. 187; DL 26 maggio 2000, n. 141; DL 31 luglio 2020, n. 101)

Knowledge and competences about the concepts of radiobiology with special reference to therapeutic use of ionizing radiation. General concepts of radioprotection and regulatory documents and laws.

Basic knowledge of physics, biology and radiobiology.

Teaching lessons by using powerpoint presentations and discussion in classroom. Simulation of multiple choice tests.

No specific practical training is planned for radiobiology and radioprotection but the main skills are included in the traning program in the Radiation Oncology Division.

Multiple choice test with 30 questions about the main content of the course program.

Radiobiology
General aspects of interaction between ionizing radiations and human body. Physical dose and biological parameters (LET, RBE, equivalent dose). Dose-response graphics for tumour and healthy tissues. TCP and NTCP. Dose fractionation in radiotherapy: radiosensitivity, repair of sublethal damage, cell cycle recruitment, re-oxygenation, repopulation. Conventional fractionation, hypofractionation and hyperfractionation. Cell survival curves and linear-quadratic model. Predictive tests. Physical and biological rationale of using hadrons in radiotherapy. Side effects of radiotherapy: biological aspects of early and late side effects.
Radioprotection
Main physical and biological aspects. Natural background of radiation and dose to the population. Workers classification and dose limits. Incidents related to patients and workers in radiology, nuclear medicine and radiotherapy. Radioprotection of patients in radiology, nuclear medicine and radiotherapy. Principles of justification, optimization and dose limitation. Legislative aspects of radioprotection: field of application, radioprotection of health workers, population and patients.

Knowledge and skills about radiobiology with special regard to fractionation in radiotherapy and pathogenesis of early and late side effects.
Knowledge and skills about radioprotection with special regard to situation of potential radiation exposure.
Ability to apply knowledge and skill in the professional field of interest.