Ateneo - UPO

Organization of the human genome.
Gene inheritance and transmission: Mendelian and non-Mendelian.
Instability of the human genome and genetic disorders.

Material provided by the teacher

The students have to acquire the knowledge of principles of genetic transmission, molecular basis of heredity, genome organization, mutations and the standard techniques of DNA analysis.

None

Lectures and group work.

Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.

Test with open-ended questions and assessment of the work carried out in groups.

Organization of the human genome: nuclear and mitochondrial genome - organization, distribution and function of human genes - non-coding DNA with tandem or interspersed repetitions.
Gene expression: transcriptional regulation of gene expression - post-transcriptional regulation - epigenetic mechanisms and remote control.
Hereditary transmission of a single gene: Mendelian and non-Mendelian
Instability of the human genome: chromosomal and gene mutations - somatic and germ line mutations. Effects of mutations.
Diseases due to genetic mutations: autosomal monogenic or X linked- dominant and recessive - Y - linked - dynamic mutations. Examples and methods of analysis.

Students are expected to learn the molecular basis of heredity, the principal tecniques for the analysis of DNA and their application.