Ateneo - UPO

Basic concepts of organic chemistry. Structure and nomenclature of the main organic compounds. Stereochemistry (part 1) Natural products.
(part 2).
Reactivity of functional groups in aliphatic, aromatic and selected heterocyclic compounds. Introduction to the reactivity of organic natural compounds

Brown; Chimica Organica, EdiSES McMurry; Chimica Organica, Zanichelli Clayden, Greeves, Warren, Wothers; Fondamenti di Chimica Organica, Zanichelli. Fondamenti di chimica organica, Smith - McGraw-Hill

Knowledge of the structure and nomenclature (IUPAC and trivial names) of organic molecules ad functional groups. Ability to analyse complex molecules recognising functional groups and structural residues.
Knowledge of the stereochemistry of organic compounds, especially stereocenters (R/S).identification and analysis of the various stereogenic centers in the molecule
Knowledge of the reactivity and synthesis of functional groups, arenes, heterocycles and natural products.ability to analyze and recognize the various functional groups present in the molecule and to evaluate the

Knowledge of basic concepts of general chemistry.

Classroom lectures. Available to students: pdf copy of lesson slides, exercises and previous exam tests.
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities
Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.

Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services- students physical-or-learning-disabilities
Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects

Written test with 5 exercises of organic chemistry (IUPAC nomenclature (2 exercises), natural substance, stereochemistry, functional groups)
part 2: Written test with organic chemistry exercises, which will evaluate the knowledge of the reactivity of various functional groups analyzed during the course and the student's ability to apply this knowledge led to the synthesis of target molecules.

CFU 1 Basic concepts of chemistry: atoms, molecules, chemical bonds, hybridisation, molecular structure, resonance, electronegativity. CFU 2 Radicals and functional groups: definition and structures. CFU 3 Nomenclature part 1. IUPAC Nomenclature. Basic concepts, chains, ring, bicyclic systems. CFU 4 Stereochemistry. Stereoisomerism in cyclic systems (cis-trans). Stereoisomerism of alkenes (E-Z). CFU 5 Nomenclature part 2. Arenes, heterocyclic systems, natural products.
part 2: CFU 1
Symmetry: elements and operations. Chirality. CIP rules and R/S descriptors. Enantiomers and diastereomers. Resolution of stereoisomers. Optical activity and enantiomeric excess. Exercises.
CFU 2-7
Chemical reactions: classification, chemical metrics, atom mapping, stoichiometry of organic reactions.
Principal reactions and syntheses of:
- Alkanes and cycloalkanes
- Alkenes, dienes and alkynes
- Alogenoalkanes and organometallic reagents (Mg, Li)
- Alcohols, ethers, thiols and thioeters
- The carbonyl group: aldehydes and ketones
- Carboxylic derivatives: carboxylic acids, esters, amides, acyl halides, anhydrides and nitriles
- Amines
- Arenes
- Heterocyclic compounds
Exercises
CFU 8
Introduction on the reactivity of natural products: lipids, aminoacids, carbohydrates. Terpenes and isoprenic rule. Exercises.

the preliminary knowledge to address the course of organic chemistry 2, and to deepen the chemical characteristics of the main functional groups of organic molecules
part 2: The student is able to apply the concepts learned during frontal lessons, in synthetic processes of molecules of pharmaceutical importance