Ateneo - UPO

Cells and organs of the immune system. -Antigens-Antibodies. -Complement. -Monoclonal antibodies and laboratory technique. -TCR and MHC. -Antigen presenting cells. -B and T cell maturation. -Cytokines. -Functions of T and NK cells. -Immunological memory. -Immunoelusion. -Passive and active immunization. -Hypersensibility. -Autoimmune diseases.

1) Coico, Immunologia, un corso breve. Edi Hermes- 2) Murphy, Immunobiologia di Janeway. Piccin

To acquire knowledges on the immune system function at the level of innate and adaptive immunity in order to understand also the mechanisms of immune evasion, vaccination, and the etiology and pathogenesis of allergic and autoimmune diseases.

Knowledge of basic cell biology and genetics

Frontal teaching with slides

Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects

Multiple choice quiz 5 on laboratory techniques, 15 on basic immunology and 10 on immunopathology

-Immune system. Innate and adaptive immunity. -Cells of the immune system. Receptors and mediators of innate immunity. -Organs of the immune system. -Antigens-Antibodies. Structure and function of the antibodies and antibody isotypes. Features of B cell antigens. Aptens. BCR structure and signaling. -Complement. Classic, alternative, lectinic pathway. Receptors and inhibitors. -Monoclonal antibodies and laboratory techniques. Monoclonal and polyclonal antibodies. Immunofluorescence, Western blot, RIA, ELISA, immunodiffusion. -TCR and MHC. Structure and function. The HLA system. Antigen presentation (endocytic, cytosolic, lipid pathways, cross-presentation). CD3, CD4, CD8, function and signaling. -Antigen presenting cells. Cell types, function second signal. CD28, CTLA-4 and PD-1. -B cell repertoire. Ig gene rearrangement. Antigen-independent and antigen-dependent maturation of B cells. -T cell repertoire. Thymic maturation of conventional and regulatory T cells. -Cytokines. Structure, function, receptors and signaling. -Helper and cytotoxic activities aof T cells. Th1, Th2, Th17, natural and induced Treg, CTL, NK, NKT, Tγδ. -Immune evasion. Mechanisms of immune evasion of infectious agents and tumors. -Passive and active immunization. Vaccines. -Type I, II, III, IV hypersensivity. Etiology, pathogenesis, examples. -Autoimmune diseases. Etiology, pathogenesis, examples.

Molecular basis of immunology, also in relation to applications in the field of diagnostics and therapy. Cell type and molecules responsible for alterations of the immune response and inflammation.