Ateneo - UPO

-Cells and organs of the immune system.
-Antigens-Antibodies.
-Complement.
-Monoclonal antibodies and laboratory technique.
-TCR and MHC.
-Antigen presenting cells.
-B and T cell maturation.
-B and T cell functions
-B and T cell activation
-B and T cell memory
-Tolerance
-NK cells

1) Dianzani-Pucillo, Immunologia e Immunopatologia. Edi Hermes, 2022
2) Coico, Immunologia in percorso breve, Edi.Ermes, 2018
3) Murphy, Immunobiologia di Janeway. Piccin, 2017

To acquire knowledges on the immune system function at the level of innate and adaptive immunity. Students will acquire autonomous judgement, ability to communicate using adequate terminology, and capacity of continuous updating

Knowledge of basic cell biology and genetics

Frontal teaching with slides.
The slides are available, including slides with vocal comment. Interactivity is promoted by discussion of scientific articles and optional attendance at the Immunology laboratory

Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services- students-physical-or-learning-disabilitiesStudents with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.

Oral examination assessing knowledge of the main principles and technical terminology of immunology

-Immune system. Innate and adaptive immunity.
-Cells of the immune system. Receptors and mediators of innate immunity.
-Organs of the immune system.
-Antigens-Antibodies. Structure and function of the antibodies and antibody isotypes. Features of B cell antigens. Aptens. BCR structure and signaling.
-Complement. Classic, alternative, lectinic pathway. Receptors and inhibitors.
-Monoclonal antibodies and laboratory techniques. Monoclonal and polyclonal antibodies. Immunofluorescence, Western blot, RIA, ELISA, immunodiffusion.
-TCR and MHC. Structure and function. The HLA system. Antigen presentation (endocytic, cytosolic, lipid pathways, cross-presentation). CD3, CD4, CD8, function and signaling.
-Antigen presenting cells. Cell types, function second signal. CD28, CTLA-4 and PD-1.
-B cell repertoire. Ig gene rearrangement. Antigen-independent and antigen-dependent maturation of B cells.
-T cell repertoire. Thymic maturation of conventional and regulatory T cells.
-Function of T helper, T cytotoxic and T regulatory cells
-Meccanismi di tolleranza immunitaria centrale e periferica
-Cellule NK: attivazione e funzione. Innate lymphoid cells

Molecular and cellular basis of the immune response, and lymphocyte development. Students must acquire autonomous judgement, ability to communicate using adequate terminology, and capacity of continuous updating