Ateneo - UPO

Organization of the human genome.Hereditary transmission of a single gene: Mendelian and non-Mendelian inheritance.Instability of the human genome and diseases caused by gene mutations.

Material provided by the professor.

The students have to acquire the knowledge of principles of genetictransmission, molecular basis of heredity, genome organization,mutations and the standard techniques of DNA analysis.

Bases of cellular and molecular biology.

Lectures and group work.

Students with physical disabilities, Learning Disabilities or SpecialEducation Needs can request specific services and tools via the StaffSviluppo e Coordinamento Carriere e Servizi alle Studentesse e agliStudenti, consulting the University webpage:https://www.uniupo.it/en/services/services-students-physical-or-learningdisabilitiesStudents with disabilities, learning disabilities or specialeducation needs, once they have contacted the University Staff, can referto the tutor in charge of the course to define the examination modalities,concerning academic aspects.

Test with open-ended questions and assessment of the work carried outin groups.

Organization of the human genome: nuclear and mitochondrial genome -organization, distribution and function of human genes - non-coding DNAwith tandem or interspersed repetitions.Gene expression: transcriptional regulation of gene expression - posttranscriptionalregulation - epigenetic mechanisms and remote control.Hereditary transmission of a single gene: Mendelian and non-MendelianInstability of the human genome: chromosomal and gene mutations -somatic and germ line mutations. Effects of mutations.Diseases due to genetic mutations: autosomal monogenic or X linkeddominantand recessive - Y - linked - dynamic mutations. Examples andmethods of analysis.

Students are expected to learn the molecular basis of heredity, theprincipal tecniques for the analysis of DNA and their application