Ateneo - UPO

Organization of the human genome.

Hereditary transmission of a single gene: Mendelian and non-Mendelian inheritance.

Instability of the human genome and diseases caused by gene mutations.

Material provided by the professor.

The students have to acquire the knowledge of principles of genetic

transmission, molecular basis of heredity, genome organization,

mutations and the standard techniques of DNA analysis.

Bases of cellular and molecular biology.

Lectures and group work.

Students with physical disabilities, Learning Disabilities or Special

Education Needs can request specific services and tools via the Staff

Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli

Studenti, consulting the University webpage:

https://www.uniupo.it/en/services/services-students-physical-or-learningdisabilities

Students with disabilities, learning disabilities or special

education needs, once they have contacted the University Staff, can refer

to the tutor in charge of the course to define the examination modalities,

concerning academic aspects.

Test with open-ended questions and assessment of the work carried out

in groups.

Organization of the human genome: nuclear and mitochondrial genome -

organization, distribution and function of human genes - non-coding DNA

with tandem or interspersed repetitions.

Gene expression: transcriptional regulation of gene expression - posttranscriptional

regulation - epigenetic mechanisms and remote control.

Hereditary transmission of a single gene: Mendelian and non-Mendelian

Instability of the human genome: chromosomal and gene mutations -

somatic and germ line mutations. Effects of mutations.

Diseases due to genetic mutations: autosomal monogenic or X linkeddominant

and recessive - Y - linked - dynamic mutations. Examples and

methods of analysis.

Students are expected to learn the molecular basis of heredity, the

principal tecniques for the analysis of DNA and their application