Ateneo - UPO

The course offers an in-depth analysis of the molecular mechanisms underlying molecular target therapies.

Molecular Biology of the cell. Alberts B. ed. Zanichelli. Papers published on peer reviewed journals provided by the teacher. Other material provided.

The course aims to provide the student with the deep knowledge of the molecular mechanisms of action of targeted therapies.

Basic knowledge of cellular and molecular biology

Theoretical lectures and exercises with ppt presentation by students and searching of scientific articles in pubmed.

Students with disabilities, Specific Learning Disorders (SLD), or Special Educational Needs (SEN) may request dedicated services and support by contacting the Student Careers Development and Coordination Office and consulting the dedicated page on the University's website: https://uniupo.it/it/servizi/servizi-studenti-disabili-e-dsa

After contacting the University Office, students with disabilities, SLD, or SEN may also contact the course instructor to discuss any teaching-related aspects concerning the adaptation of examination arrangements

See teaching overview shee.

Receptors with intrinsic enzymatic activity, receptors coupled with cytosolic proteins, G coupled receptors, nuclear receptors, enzymes as molecular targets. Targeted cancer therapies: action on cell proliferation, angiogenesis, senescence and apoptosis. Mechanisms of DNA repair. Selection of patients who can benefit from molecular target therapies. Precision medicine.

By the end of the course, students must demonstrate deep knowledge of the signal transduction pathways generated by drug/target interactions. They should be able to analyze a scientific article effectively. These expected learning outcomes, aligned with the Dublin descriptors, are as follows: KNOWLEDGE AND COMPREHENSION: Demonstrate advanced knowledge of cellular and molecular biology. Understand the mechanisms underlying tumor development to identify molecular targets and precision therapies. APPLYING KNOWLEDGE AND COMPREHENSION: Apply theoretical principles to analyze complex molecular mechanisms. Solve problems within biomedical, molecular, and pharmacological contexts. JUDGMENT AUTONOMY: Critically evaluate experimental data. COMMUNICATION SKILLS: Clearly and coherently communicate scientific concepts, using appropriate terminology. Present and discuss course topics logically, highlighting connections between different themes. LEARNING ABILITY: Develop autonomous learning strategies for continuous knowledge expansion. Prepare for advanced studies or research activities in the field of oncology research.