Ateneo - UPO

-Cells and organs of the immune system.
-Antigens-Antibodies.
-Complement.
-Monoclonal antibodies and laboratory technique.
-TCR and MHC.
-Antigen presenting cells.
-B and T cell maturation.
-Cytokines.
-Functions of T and NK cells.
-Immunological memory.
-Immunoelusion.
-Passive and active immunization.
-Hypersensibility.
-Autoimmune diseases.

1) Dianzani-Pucillo, Immunologia e Immunopatologia. Edi Hermes, 2022
2) Coico, Immunologia in percorso breve, Edi.Ermes, 2018
3) Murphy, Immunobiologia di Janeway. Piccin, 2017

To acquire knowledges on the immune system function at the level of innate and adaptive immunity in order to understand also the mechanisms of immune evasion, vaccination, and the etiology and pathogenesis of allergic and autoimmune diseases.

Knowledge of basic cell biology and genetic

Frontal teaching with slides.
The slides are available, including slides with vocal comment. Interactivity is promoted by discussion of scientific articles and optional attendance at the Immunology laboratory

none

written text: four open questions

-Immune system. Innate and adaptive immunity.
-Cells of the immune system. Receptors and mediators of innate immunity.
-Organs of the immune system.
-Antigens-Antibodies. Structure and function of the antibodies and antibody isotypes. Features of B cell antigens. Aptens. BCR structure and signaling.
-Complement. Classic, alternative, lectinic pathway. Receptors and inhibitors.
-Monoclonal antibodies and laboratory techniques. Monoclonal and polyclonal antibodies. Immunofluorescence, Western blot, RIA, ELISA, immunodiffusion.
-TCR and MHC. Structure and function. The HLA system. Antigen presentation (endocytic, cytosolic, lipid pathways, cross-presentation). CD3, CD4, CD8, function and signaling.
-Antigen presenting cells. Cell types, function second signal. CD28, CTLA-4 and PD-1.
-B cell repertoire. Ig gene rearrangement. Antigen-independent and antigen-dependent maturation of B cells.
-T cell repertoire. Thymic maturation of conventional and regulatory T cells.
-Cytokines. Structure, function, receptors and signaling.
-Helper and cytotoxic activities aof T cells. Th1, Th2, Th17, natural and induced Treg, CTL, NK, NKT, Tγδ.
-Immune evasion. Mechanisms of immune evasion of infectious agents and tumors.
-Passive and active immunization. Vaccines.
-Type I, II, III, IV hypersensivity. Etiology, pathogenesis, examples.
-Autoimmune diseases. Etiology, pathogenesis, examples.

Molecular and cellular basis of the immune response, and lymphocyte development. Students must acquire autonomous judgement, ability to communicate using adequate terminology, and capacity of continuous updating