Master di Primo Livello in European Master Of Science In Skin Health And Care

Didattica erogata

×
Stampa
Insegnamento
Medicinal Chemistry and pharmacology of dermatological drugs
Codice
FA0526
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
PIRALI Tracey
Docenti
Pirali Tracey, Chiazza Fausto
CFU
5.0
Ore di lezione
30.0
Ore di studio individuale
0.0
Settore Scientifico Disciplinare (SSD)
CHIM/08 - CHIMICA FARMACEUTICA, BIO/14 - FARMACOLOGIA
Tipo di insegnamento
Attività formativa integrata
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
V
Lingua insegnamento/Teaching language
English
Contenuti/Content Summary
The course provides the students with the main information about ADMET of dermatological drugs. The course also provides the students with the principles for the discovery and optimization of a bioactive compound, from hit to lead compounds to drug candidates. The design of prodrugs and soft drugs for topical use is covered. Case studies on dermatological drugs are presented from both a pharmacological and medicinal chemistry perspectives.
Testi di riferimento/Textbooks
G.L. Patrick, An introduction to medicinal chemistry, EdiSES Goodman & Gilman's pharmacological basis of therapeutic
Obiettivi formativi/Mission
1. At the end of the course the student will know and understand the basic concepts of pharmacology and medicinal chemistry, in particular the route followed by the drug in the organism, from its administration to its excretion and how it interacts with its molecular target, focusing mainly on oral and topical administration. Moreover, the path of the drug in the pharmaceutical industry, from drug discovery to drug development through drug design will be addressed. 2. The student will apply the acquired knowledge and understanding in the recognition of the chemical structures, in the discussion of the chemical and chemical-physical properties, of the mechanism of action, of the structure-activity relationship and of the metabolic fate, together with toxicological aspects. 3. The student will acquire the ability to analyze texts and papers in the pharmacology and medicinal chemistry literature. 4. The student will learn to communicate about his/her understanding, to describe, even in an original way, a topic described during lessons, to adequately answer to questions, critiques and suggestions. He/she will also learn how to present a drug to the public using the information searched in the scientific literature and in databases. 5. The student will have the learning skills to handle in a dynamic way his/her knowledge in general pharmacology and medicinal chemistry with a good degree of autonomy.
Prerequisiti/Required background knowledge
Basic knowledge of biology, biochemistry, organic chemistry, pharmacology and physiology.
Metodi didattici/Teaching methods
Lectures and case studies.
Altre informazioni/Further information
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
Written test. It covers the material delivered in lectures. Multiple choice, true/false and completion type questions are the most frequent types of questions. 1 or 2 points for the correct answer, 0 points for wrong or blank answers. Oral presentation. Students will be given a dermatological approved small molecule. Working individually, they will need to cover the main medchem aspects (metabolism, synthesis, intermolecular interactions, discovery and optimization, stereochemistry, LogP, LogD, etc.) and pharmacology aspects (mechanism of action, pharmacokinetics, therapeutic need, competitors, and place in therapy). The Case Study will be orally presented by the students with the support of slides in a 10’ presentation. The total mark is the average between the two marks.
Programma esteso/Content
Absorption. Mechanisms of absorption with a focus on skin. Phase I and phase II metabolism with a focus on skin and liver metabolism. Distribution and elimination of drugs. Principles of pharmacodynamic. Drug-target intermolecular interactions and SAR studies. Role of stereochemistry in the interaction with the binding site. Receptors and enzymes as drug targets. Drug discovery. Hit compounds and lead compounds. How to recognize drug-like molecules. LogP and logD. Lipinski rule and beyond. Strategies for lead optimization. Prodrugs and soft drugs. Case studies of dermatological drugs.
Risultati di apprendimento attesi/Intended learning objectives
At the end of the course, the student will know the principles of general pharmacology and medicinal chemistry. He/she will be able to apply these principles to a specific bioactive molecule and to evaluate its chemical, metabolic and drug-likeness properties. The student will also know the role of medicinal chemistry and pharmacology in drug discovery and in drug design and the strategies that can be used in order to improve the pharmacodynamic and pharmacokinetic properties of a dermatological drug.
Moduli
Codice Insegnamento Settore Scientifico Disciplinare (SSD) Docenti Agenda web
FA0524Medicinal chemistry of dermatological drugs CHIM/08 - CHIMICA FARMACEUTICA Pirali Tracey Non disponibile
FA0525Pharmacology of dermatological drugs BIO/14 - FARMACOLOGIA Chiazza Fausto Non disponibile
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Medicinal Chemistry and pharmacology of dermatological drugs: Medicinal chemistry of dermatological drugs
Codice
FA0524
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
PIRALI Tracey
Docenti
Pirali Tracey
CFU
3.0
Ore di lezione
18.0
Ore di studio individuale
57.0
Settore Scientifico Disciplinare (SSD)
CHIM/08 - CHIMICA FARMACEUTICA
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
G
Lingua insegnamento/Teaching language
INGLESE
English
Contenuti/Content Summary
The course provides the students with the main information about ADMET of dermatological drugs. The course also provides the students with the principles for the discovery and optimization of a bioactive compound, from hit to lead compounds to drug candidates. The design of prodrugs and soft drugs for topical use is covered. Case studies on dermatological drugs are presented from a medicinal chemistry perspectives.
Testi di riferimento/Textbooks
G.L. Patrick, An introduction to medicinal chemistry
Obiettivi formativi/Mission
1. At the end of the course the student will know and understand the basic concepts of medicinal chemistry, in particular the route followed by the drug in the organism, from its administration to its excretion and how it interacts with its molecular target, focusing mainly on oral and topical administration. Moreover, the path of the drug in the pharmaceutical industry, from drug discovery to drug development through drug design will be addressed. 2. The student will apply the acquired knowledge and understanding in the recognition of the chemical structures, in the discussion of the chemical and chemical-physical properties, of the mechanism of action, of the structure-activity relationship and of the metabolic fate. 3. The student will acquire the ability to analyze texts and papers in the medicinal chemistry literature. 4. The student will learn to communicate about his/her understanding, to describe, even in an original way, a topic described during lessons, to adequately answer to questions, critiques and suggestions. He/she will also learn how to present a drug to the public using the information searched in the scientific literature and in databases. 5. The student will have the learning skills to handle in a dynamic way his/her knowledge in medicinal chemistry with a good degree of autonomy.
Prerequisiti/Required background knowledge
Basic knowledge of biology, biochemistry, organic chemistry, pharmacology and physiology.
Metodi didattici/Teaching methods
Lectures and case studies.
Altre informazioni/Further information
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
Written test. It covers the material delivered in lectures. Multiple choice, true/false and completion type questions are the most frequent types of questions. 1 or 2 points for the correct answer, 0 points for wrong or blank answers. Oral presentation. Students will be given a dermatological approved small molecule. Working individually, they will need to cover the main medchem aspects (metabolism, synthesis, intermolecular interactions, discovery and optimization, stereochemistry, LogP, LogD, etc.) and pharmacology aspects (mechanism of action, pharmacokinetics, therapeutic need, competitors, and place in therapy). The Case Study will be orally presented by the students with the support of slides in a 10’ presentation. The total mark is the average between the two marks.
Programma esteso/Content
Absorption. Mechanisms of absorption with a focus on skin. Phase I and phase II metabolism with a focus on skin and liver metabolism. Principles of pharmacodynamic. Drug-target intermolecular interactions and SAR studies. Role of stereochemistry in the interaction with the binding site. Drug discovery. Hit compounds and lead compounds. How to recognize drug-like molecules. LogP and logD. Lipinski rule and beyond. Strategies for lead optimization. Prodrugs and soft drugs. Case studies of dermatological drugs.
Risultati di apprendimento attesi/Intended learning objectives
At the end of the course, the student will know the principles of medicinal chemistry. He/she will be able to apply these principles to a specific bioactive molecule and to evaluate its chemical, metabolic and drug-likeness properties. The student will also know the role of medicinal chemistry in drug discovery and in drug design and the strategies that can be used in order to improve the pharmacodynamic and pharmacokinetic properties of a dermatological drug.
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Medicinal Chemistry and pharmacology of dermatological drugs: Pharmacology of dermatological drugs
Codice
FA0525
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
CHIAZZA FAUSTO
Docenti
Chiazza Fausto
CFU
2.0
Ore di lezione
12.0
Ore di studio individuale
38.0
Settore Scientifico Disciplinare (SSD)
BIO/14 - FARMACOLOGIA
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
G
Lingua insegnamento/Teaching language
INGLESE
English
Contenuti/Content Summary
The course provides the students with the main information about ADME and pharmacodynamics of dermatological drugs. Case studies on dermatological drugs are presented from a pharmacological point of view.
Testi di riferimento/Textbooks
Goodman & Gilman's pharmacological basis of therapeutic
Obiettivi formativi/Mission
The course aims at providing students with adequate theoretical and practical information for dermatological general pharmacology. 1. At the end of the course the student will know and understand the basic concepts of pharmacology, in particular the route followed by the drug in the organism, from its administration to its excretion and how it interacts with its molecular target, focusing mainly on oral and topical administration. 2. The student will apply the acquired knowledge in understanding the mechanism of action and of the metabolic fate, together with toxicological aspects. 3. The student will acquire the ability to analyze texts and papers in the pharmacology literature. 4. The student will learn to communicate about her/his understanding, to describe, even in an original way, a topic described during lessons, to adequately answer to questions, critiques and suggestions. She/He will also learn how to present a drug to the public using the information searched in the scientific literature and in databases. 5. The student will have the learning skills to handle in a dynamic way her/his knowledge in general pharmacology with a good degree of autonomy.
Prerequisiti/Required background knowledge
Basic knowledge of biology, biochemistry, and physiology.
Metodi didattici/Teaching methods
Lectures and case studies.
Altre informazioni/Further information
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities. Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
Written test. It covers the material delivered in lectures. Multiple choice, true/false and completion type questions are the most frequent types of questions. 1 or 2 points for the correct answer, 0 points for wrong or blank answers. Oral presentation. Students will be given a dermatological approved small molecule. Working individually, they will need to cover the main medchem aspects (metabolism, synthesis, intermolecular interactions, discovery and optimization, stereochemistry, LogP, LogD, etc.) and pharmacology aspects (mechanism of action, pharmacokinetics, therapeutic need, competitors, and place in therapy). The Case Study will be orally presented by the students with the support of slides in a 10’ presentation. The total mark is the average between the two marks.
Programma esteso/Content
Absorption. Mechanisms of absorption with a focus on skin. Phase I and phase II metabolism with a focus on skin and liver metabolism. Distribution and elimination of drugs. Principles of pharmacodynamic. Receptors and enzymes as drug targets. Drug discovery. Case studies of dermatological drugs.
Risultati di apprendimento attesi/Intended learning objectives
At the end of the course, the student will know the principles of general pharmacology in the dermatological field. She/He will be able to apply these principles to a specific bioactive molecule and to evaluate its pharmacological, metabolic and drug-likeness properties. The student will also know the role of pharmacology in drug discovery.
×
Stampa
Insegnamento
Protein Science and molecular modelling
Codice
FA0529
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
MASSAROTTI Alberto
Docenti
Miggiano Riccardo, Massarotti Alberto
CFU
5.0
Ore di lezione
30.0
Ore di studio individuale
0.0
Settore Scientifico Disciplinare (SSD)
BIO/10 - BIOCHIMICA, CHIM/08 - CHIMICA FARMACEUTICA
Tipo di insegnamento
Attività formativa integrata
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
V
Lingua insegnamento/Teaching language
Inglese
English
Contenuti/Content Summary
Il corso coprirà diverse sezioni chiave e contenuti correlati per fornire alle studentesse e agli studenti una comprensione approfondita della scienza delle proteine e delle sue applicazioni. Inizierà con una sezione introduttiva di livellamento in cui saranno discussi i principi e le nozioni di base sulle proteine e sugli enzimi, comprese le loro proprietà e funzioni. Successivamente, il corso presenterà e discuterà i principi di base del drug design e dell'ingegneria delle proteine su base razionale. Saranno esplorati anche i metodi fisico-chimici per lo studio delle interazioni molecolari proteina-proteina e proteina-ligando. Inoltre, ci sarà un laboratorio focalizzato sui danni al DNA e la riparazione, oltre che sugli antiossidanti a base proteica. Il corso includerà seminari tenuti da esperte ed esperti di aziende impegnate nel campo della scienza delle proteine applicata alla cosmesi. Inoltre, il corso si propone di introdurre le studentesse e gli studenti ai principi principali delle simulazioni computerizzate di entità chimiche, inclusi composti e proteine. Attraverso queste sezioni integrate, le studentesse e gli studenti acquisiranno sia conoscenze teoriche sia competenze pratiche essenziali per simulare correttamente le strutture chimico-biologiche e comprendere le loro interazioni e applicazioni in vari campi.
The course will cover several key sections and related contents to provide students with a comprehensive understanding of protein science and its applications. It will begin with an introductory leveling section where the basic principles and notions of proteins and enzymes, including their properties and functions, will be discussed. Following this, the course will present and discuss the basic principles of drug design and protein engineering on a rational basis. The physical-chemical methods for the study of protein-protein and protein-ligand molecular interactions will also be explored. Additionally, there will be a workshop focusing on DNA damage and repair, as well as protein-based antioxidants. The course will include seminars led by experts from companies engaged in the field of protein science applied to cosmetics. Moreover, the course aims to introduce students to the main principles of computer simulation of chemical entities, including compounds and proteins. Through these integrated sections, students will gain both theoretical knowledge and practical skills essential for simulating chemical-biological structures and understanding their interactions and applications in various fields.
Testi di riferimento/Textbooks
Introduction to Protein Science: Architecture, Function, and Genomics by Arthur Lesk. Oxford 2015. Biochemistry 10th edition by Jeremy M. Berg, John L. Tymoczko, Lubert Stryer. Macmillan 2023 Andreas Kukol, "Molecular Modeling of Proteins", English | 2014 | ISBN: 1493914642. https://link.springer.com/book/10.1007/978-1-4939-1465-4 Nathan Brown, "In Silico Medicinal Chemistry: Computational Methods to Support Drug Design", English | 2015 | ISBN: 978-1-78262-163-8. https://pubs.rsc.org/en/content/ebook/978-1-78262-163-8
Introduction to Protein Science: Architecture, Function, and Genomics by Arthur Lesk. Oxford 2015. Biochemistry 10th edition by Jeremy M. Berg, John L. Tymoczko, Lubert Stryer. Macmillan 2023 Andreas Kukol, "Molecular Modeling of Proteins", English | 2014 | ISBN: 1493914642. https://link.springer.com/book/10.1007/978-1-4939-1465-4 Nathan Brown, "In Silico Medicinal Chemistry: Computational Methods to Support Drug Design", English | 2015 | ISBN: 978-1-78262-163-8. https://pubs.rsc.org/en/content/ebook/978-1-78262-163-8
Obiettivi formativi/Mission
1. Conoscenze: L'obiettivo del corso è quello di migliorare la conoscenza delle studentesse e degli studenti sulla scienza delle proteine, con un particolare focus sulla relazione struttura-attività nelle macromolecole biologiche e sull'approccio strutturale per la progettazione razionale di potenziali molecole ligandi proteici con potenziale terapeutico. Dopo una fase iniziale di consolidamento sui concetti fondamentali, il corso procederà a contestualizzare i principi base della scienza delle proteine nel campo cosmetico, con un percorso didattico focalizzato su alcuni temi selezionati legati alla cosmesi, inclusi gli agenti antiossidanti e la riparazione dei danni al DNA. Inoltre, al termine del corso, le studentesse e gli studenti dovranno conoscere i principali metodi attualmente utilizzati nella simulazione di sistemi di interesse chimico-biologico. In particolare, dovranno essere consapevoli delle principali tecniche computazionali utili sia per il calcolo delle energie e delle geometrie molecolari, sia per l'analisi conformazionale di piccole molecole (farmaci, ligandi endogeni) e macromolecole (proteine e acidi nucleici). 2. Capacità di applicare le conoscenze: Le studentesse e gli studenti dovranno essere in grado di identificare la procedura più appropriata per risolvere vari problemi chimico-biologici proposti durante il corso. Dovranno inoltre saper utilizzare alcuni software di modellizzazione di base per prevedere la struttura tridimensionale delle proteine e l'associazione farmaco-recettore. Questo implica non solo la comprensione degli aspetti teorici, ma anche l'applicazione delle competenze pratiche per eseguire simulazioni e analizzare i risultati in modo efficace.
1. Knowledge: The objective of the course is to enhance the students' knowledge of protein science, with a particular focus on the structure-activity relationship in biological macromolecules and the structural approach for the rational design of potential protein ligand molecules with therapeutic potential. Following an initial phase of consolidation on the fundamental concepts, the course will proceed to contextualize the basic principles of protein science in the cosmetic field, with a didactic path focused on select cosmetic-related topics, including antioxidant agents and DNA damage repair. Additionally, by the end of the course, students will have to know the main methods currently used in the simulation of systems of chemical-biological interest. They must be aware of the main computational techniques useful both for the calculation of energies and molecular geometries, and for the conformational analysis of small molecules (drugs, endogenous ligands) and macromolecules (proteins and nucleic acids). 2. Ability to apply knowledge: Students must be able to identify the most appropriate procedure to solve various chemical-biological problems proposed during the course. They should also be proficient in using basic modeling software to predict the three-dimensional structure of proteins and the drug-receptor association. This involves not only understanding the theoretical aspects but also applying practical skills to perform simulations and analyze results effectively.
Prerequisiti/Required background knowledge
Conoscenze di base in chimica generale, chimica organica, fisica e biochimica.
Basic knowledge of general chemistry, organic chemistry, physics and biochemistry.
Metodi didattici/Teaching methods
Le lezioni si svolgeranno ex-cathedra con il supporto di diapositive e materiale video, che saranno forniti alle studentesse e agli studenti all'inizio delle lezioni. L'aula sarà utilizzata per l'esecuzione di esercizi e quiz, nonché per la discussione dei dati presentati nella letteratura scientifica. Saranno introdotti argomenti generali e specifici, e saranno forniti concetti di base per facilitare la comprensione di ciascun tema. Inoltre, le studentesse e gli studenti potranno utilizzare i libri di testo consigliati per approfondire gli argomenti trattati in aula. Gli argomenti trattati in classe saranno anche oggetto di esercizi e simulazioni attraverso l'uso di programmi complessi di modellizzazione molecolare, permettendo alle studentesse e agli studenti di applicare le loro conoscenze teoriche in un contesto pratico.
Lessons will be conducted ex-cathedra with the support of slides and video material, which will be provided to students at the beginning of the lessons. The classroom setting will be utilized for the execution of problems and quizzes, as well as for discussions on the data presented in the literature. General and specific topics will be introduced, and basic concepts will be provided to facilitate the understanding of each issue. Additionally, students may utilize the recommended textbooks to further explore the topics covered in the classroom. The topics covered in class will also be the subject of exercises and simulations through the use of complex molecular modeling programs, allowing students to apply their theoretical knowledge in a practical context.
Altre informazioni/Further information
Per ulteriori informazioni, si prega di consultare la pagina del corso su D.I.R. all'indirizzo http://www.dir.uniupo.it Le studentesse e gli studenti con disabilità o con Disturbi Specifici dell’Apprendimento (DSA) o con Bisogni Educativi Speciali (BES) possono richiedere servizi e strumenti specifici a loro dedicati rivolgendosi allo Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti e consultando la pagina dedicata del sito di Ateneo: https://uniupo.it/it/servizi/servizi-studenti-disabili-e-dsa Le studentesse e gli studenti con disabilità, DSA, BES, una volta preso contatto con lo Staff di Ateneo, possono contattare la/il docente titolare dell'insegnamento in relazione alla declinazione delle modalità di esame, in merito agli aspetti didattici.
For further informations, please refer to the course page on D.I.R. at: http://www.dir.uniupo.it Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
La valutazione finale è articolata in due componenti. Per la parte di Protein Science, è previsto un test con domande a risposta multipla, che contribuisce per 3/5 al voto finale. Per la parte di Molecular Modelling, è richiesta una prova pratica consistente nella progettazione e realizzazione di un assay utilizzando i software presentati durante il corso; questa componente contribuisce per 2/5 al voto finale.
The final assessment consists of two components. For the Protein Science section, students will take a multiple-choice test, accounting for 3/5 of the final grade. For the Molecular Modelling section, students are required to complete a practical exam involving the design and implementation of an assay using the software tools introduced during the course; this component accounts for 2/5 of the final grade.
Programma esteso/Content
Principi di base della scienza delle proteine: • Amminoacidi e proteine: proprietà chimiche e strutturali • Legame peptidico e struttura delle proteine Tecniche di analisi strutturale: • Biologia strutturale: tecniche spettroscopiche e diffrattometriche per l'indagine sulla struttura delle proteine • Scienza delle proteine e drug design: principi, esempi e discussione di pubblicazioni scientifiche Metodi per l'analisi delle interazioni proteina-proteina e proteina-ligando: • Calorimetria a titolazione isoterma • Risonanza plasmonica di superficie • Termoforesi su microscala Studi di caso “proteine in azione”: • Danno al DNA e riparazione • Stress ossidativo e antiossidanti Seminario con esperta/o esterna/o: • Proteostasi Introduzione alla chemioinformatica: • Gestione delle informazioni strutturali dei composti. • Database pubblici di composti. Similarità dei composti: • Screening virtuale basato su ligandi. • Database pubblici di proteine. • Gestione delle informazioni strutturali delle proteine. • Interazioni proteina-ligando. Farmacofori: • Screening virtuale basato sulla struttura.
See the general course information sheet. Basic principles of protein science: -Amino acids and proteins: chemical and structural properties -Peptide bond and protein structure Structural analysis techniques: Structural biology: spectroscopic and diffractometric techniques for protein structure investigation - Protein science and drug design: principles, examples and discussion of scientific publications -Methods for the analysis of protein-protein and protein-ligand interactions: - Isothermal titration calorimetry - Surface plasmon resonance - Microscale thermophoresis Case studies “protein at work”: DNA damage and repair Oxidative stress and antioxidants External expert’s seminar: -Proteostasis Intro to chemoinformatics. Handling compounds structural information. Public database for compounds. Compound similarity. Ligand-based virtual screening. Public database of proteins. Handling proteins structural information. Protein-ligand interactions. Pharmacophores. Structure-based virtual screening.
Risultati di apprendimento attesi/Intended learning objectives
Si prevede che le studentesse e gli studenti saranno in grado di argomentare e partecipare a discussioni sui principi fondamentali della reattività delle macromolecole biologiche e sulla relazione struttura-funzione delle proteine. Inoltre, le studentesse e gli studenti dovranno dimostrare una comprensione approfondita del drug design basato sulla struttura. Al termine del corso, le studentesse e gli studenti avranno appreso gli aspetti fondamentali necessari per simulare correttamente le strutture chimico-biologiche. Saranno in grado di applicare questa conoscenza a problemi pratici, dimostrando la loro capacità di utilizzare efficacemente tecniche computazionali e software di modellizzazione.
It is expected that the students will be able to argue and engage in discussions on the fundamental principles of the reactivity of biological macromolecules and the structure-function relationship of proteins. Additionally, students should demonstrate a comprehensive understanding of structure-based drug design. By the end of the course, students will have learned the fundamental aspects necessary to correctly simulate chemical-biological structures. They will be able to apply this knowledge to practical problems, showcasing their ability to utilize computational techniques and modeling software effectively.
Moduli
Codice Insegnamento Settore Scientifico Disciplinare (SSD) Docenti Agenda web
FA0527Protein Science BIO/10 - BIOCHIMICA Miggiano Riccardo Non disponibile
FA0528Molecular modelling CHIM/08 - CHIMICA FARMACEUTICA Massarotti Alberto Non disponibile
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Protein Science and molecular modelling: Protein Science
Codice
FA0527
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
MIGGIANO RICCARDO
Docenti
Miggiano Riccardo
CFU
3.0
Ore di lezione
18.0
Ore di studio individuale
57.0
Settore Scientifico Disciplinare (SSD)
BIO/10 - BIOCHIMICA
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
G
Lingua insegnamento/Teaching language
Inglese
English
Contenuti/Content Summary
Il corso includerà le seguenti sezioni e i relativi contenuti: Una sezione introduttiva di livellamento in cui saranno discussi i principi e le nozioni di base sulle proteine e sugli enzimi, le loro proprietà e funzioni. Verranno presentati e discussi i principi di base del drug design e dell'ingegneria delle proteine su base razionale. Saranno inoltre discussi i metodi fisico-chimici per lo studio delle interazioni molecolari proteina-proteina e proteina-ligando. Un laboratorio sui danni al DNA e la riparazione e sugli antiossidanti a base proteica. Seminari tenuti da esperte ed esperti di aziende impegnate nel campo della scienza delle proteine applicata alla cosmesi.
The course will include the following sections and related contents: 1) introductory leveling section where basic principles and notions of proteins and enzymes, their properties and functions will be discussed. 2) basic principles of drug design and protein engineering on a rational basis will be presented and discussed 3) The physical-chemical methods for the study of protein-protein and protein-ligand molecular interactions will also be discussed. 4) Workshop of DNA damage and repair and protein-based antioxidants 5) seminars led by experts from companies engaged in the field of protein science applied to cosmetics.
Testi di riferimento/Textbooks
Introduction to Protein Science: Architecture, Function, and Genomics by Arthur Lesk. Oxford 2015. Biochemistry 10th edition by Jeremy M. Berg, John L. Tymoczko, Lubert Stryer. Macmillan 2023
Introduction to Protein Science: Architecture, Function, and Genomics by Arthur Lesk. Oxford 2015. Biochemistry 10th edition by Jeremy M. Berg, John L. Tymoczko, Lubert Stryer. Macmillan 2023
Obiettivi formativi/Mission
L'obiettivo del corso è quello di migliorare la conoscenza delle studentesse e degli studenti sulla scienza delle proteine, con un particolare focus sulla relazione struttura-attività nelle macromolecole biologiche e sull'approccio strutturale per la progettazione razionale di potenziali molecole ligandi proteici con potenziale terapeutico. Dopo una fase iniziale di consolidamento sui concetti fondamentali, il corso procederà a contestualizzare i principi base della scienza delle proteine nel campo cosmetico, con un percorso didattico focalizzato su alcuni temi selezionati legati alla cosmesi, inclusi gli agenti antiossidanti e la riparazione dei danni al DNA.
The objective of the course is to enhance the students' knowledge of protein science, with a particular focus on the structure-activity relationship in the biological macromolecules and the structural approach for the rational design of potential protein ligand molecules with therapeutic potential. Following an initial phase of consolidation on the fundamental concepts, the course will proceed to contextualize the basic principles of protein science in the cosmetic field, with a didactic path focused on select cosmetic-related topics, including antioxidant agents and DNA damage repair.
Prerequisiti/Required background knowledge
Conoscenze di base in chimica generale, chimica organica, fisica e biochimica.
Basic knowledge of general chemistry, organic chemistry, physics and biochemistry.
Metodi didattici/Teaching methods
Lezione ex-cathedra con l'uso di diapositive e materiale video. L'aula sarà utilizzata per l'esecuzione di esercizi e quiz, nonché per la discussione dei dati presentati nella letteratura scientifica. Inoltre, le studentesse e gli studenti potranno utilizzare i libri di testo consigliati per approfondire gli argomenti trattati in aula.
Lesson ex-cathedra with the slideshow and video material. The classroom setting will be utilized for the execution of problems and quizzes, as well as for discussion on the data presented in the literature. Additionally, students may utilize the recommended textbooks to further explore the topics covered in the classroom.
Altre informazioni/Further information
Per ulteriori informazioni, si prega di consultare la pagina del corso su D.I.R. all'indirizzo http://www.dir.uniupo.it Le studentesse e gli studenti con disabilità o con Disturbi Specifici dell’Apprendimento (DSA) o con Bisogni Educativi Speciali (BES) possono richiedere servizi e strumenti specifici a loro dedicati rivolgendosi allo Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti e consultando la pagina dedicata del sito di Ateneo: https://uniupo.it/it/servizi/servizi-studenti-disabili-e-dsa Le studentesse e gli studenti con disabilità, DSA, BES, una volta preso contatto con lo Staff di Ateneo, possono contattare la/il docente titolare dell'insegnamento in relazione alla declinazione delle modalità di esame, in merito agli aspetti didattici.
For further informations, please refer to the course page on D.I.R. at: http://www.dir.uniupo.it Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
Vedere la scheda dell’insegnamento generale.
See the general course information sheet.
Programma esteso/Content
Principi di base della scienza delle proteine: Amminoacidi e proteine: proprietà chimiche e strutturali Legame peptidico e struttura delle proteine Tecniche di analisi strutturale: Biologia strutturale: tecniche spettroscopiche e diffrattometriche per l'indagine sulla struttura delle proteine Scienza delle proteine e drug design: principi, esempi e discussione di pubblicazioni scientifiche Metodi per l'analisi delle interazioni proteina-proteina e proteina-ligando: Calorimetria a titolazione isoterma Risonanza plasmonica di superficie Termoforesi su microscala Studi di caso “proteine in azione”: Danno al DNA e riparazione Stress ossidativo e antiossidanti Seminario con esperta/o esterna/o: Proteostasi
Basic principles of protein science: -Amino acids and proteins: chemical and structural properties -Peptide bond and protein structure Structural analysis techniques: Structural biology: spectroscopic and diffractometric techniques for protein structure investigation - Protein science and drug design: principles, examples and discussion of scientific publications -Methods for the analysis of protein-protein and protein-ligand interactions: - Isothermal titration calorimetry - Surface plasmon resonance - Microscale thermophoresis Case studies “protein at work”: DNA damage and repair Oxidative stress and antioxidants External expert’s seminar: -Proteostasis
Risultati di apprendimento attesi/Intended learning objectives
Si prevede che le studentesse e gli studenti saranno in grado di argomentare e partecipare a discussioni sui principi fondamentali della reattività delle macromolecole biologiche e sulla relazione struttura-funzione delle proteine. Inoltre, le studentesse e gli studenti dovranno dimostrare una comprensione approfondita del drug design basato sulla struttura.
It is expected that the students will be able to argue and engage discussion on the fundamental principles of the reactivity of biological macromolecules and the structure-function relationship of proteins. Additionally, the student should demonstrate a comprehensive understanding of structure-based drug design.
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Protein Science and molecular modelling: Molecular modelling
Codice
FA0528
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
MASSAROTTI Alberto
Docenti
Massarotti Alberto
CFU
2.0
Ore di lezione
12.0
Ore di studio individuale
38.0
Settore Scientifico Disciplinare (SSD)
CHIM/08 - CHIMICA FARMACEUTICA
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
G
Lingua insegnamento/Teaching language
Inglese
English
Contenuti/Content Summary
L'obiettivo del corso è introdurre le studentesse e gli studenti ai principi principali delle simulazioni computerizzate di entità chimiche (composti, proteine).
The aim of the course is to introduce the student to the main principles about computer simulation of chemical entities (compounds, proteins).
Testi di riferimento/Textbooks
Andreas Kukol, "Molecular Modeling of Proteins", English | 2014 | ISBN: 1493914642. https://link.springer.com/book/10.1007/978-1-4939-1465-4 Nathan Brown, "In Silico Medicinal Chemistry: Computational Methods to Support Drug Design", English | 2015 | ISBN: 978-1-78262-163-8. https://pubs.rsc.org/en/content/ebook/978-1-78262-163-8
Andreas Kukol, "Molecular Modeling of Proteins", English | 2014 | ISBN: 1493914642. https://link.springer.com/book/10.1007/978-1-4939-1465-4 Nathan Brown, "In Silico Medicinal Chemistry: Computational Methods to Support Drug Design", English | 2015 | ISBN: 978-1-78262-163-8. https://pubs.rsc.org/en/content/ebook/978-1-78262-163-8
Obiettivi formativi/Mission
1. Conoscenze. Al termine del corso, le studentesse e gli studenti dovranno conoscere i principali metodi attualmente utilizzati nella simulazione di sistemi di interesse chimico-biologico. In particolare, dovranno essere consapevoli delle principali tecniche computazionali utili sia per il calcolo delle energie e delle geometrie molecolari, sia per l'analisi conformazionale di piccole molecole (farmaci, ligandi endogeni) e macromolecole (proteine e acidi nucleici). 2. Capacità di applicare le conoscenze. Le studentesse e gli studenti dovranno essere in grado di identificare la procedura più appropriata per risolvere alcuni problemi chimico-biologici che verranno proposti durante il corso. Dovranno inoltre saper utilizzare alcuni software di modellizzazione di base per prevedere la struttura tridimensionale delle proteine e l'associazione farmaco-recettore.
1. Knowledge. At the end of the course students will have to know the main methods currently used in the simulation of systems of chemical-biological interest. In particular, they must be aware of the main computational techniques useful both for the calculation of energies and molecular geometries, and for the conformational analysis of small (drugs, endogenous ligands) and macromolecules (proteins and nucleic acids). 2. Ability to apply knowledge. The student must be able to identify the most appropriate procedure to solve some chemical-biological problems that will be proposed during the course. He must also be able to use some basic modeling software to predict the three-dimensional protein structure and the drug-receptor association.
Prerequisiti/Required background knowledge
Conoscenze di base in chimica generale, chimica organica, fisica e biochimica.
Basic knowledge of general chemistry, organic chemistry, physics and biochemistry.
Metodi didattici/Teaching methods
Il corso si svolge con il supporto di diapositive, che vengono fornite alle studentesse e agli studenti all'inizio delle lezioni. Saranno introdotti argomenti generali e specifici, fornendo i concetti di base per la comprensione di ciascun tema, e saranno tenute discussioni con le studentesse e gli studenti. Gli argomenti trattati in classe saranno oggetto di esercizi/simulazioni attraverso l'uso di programmi complessi di modellizzazione molecolare.
The course is given with the support of slides, which are given to the students at the beginning of the lessons. General and specific topics will be introduced, basic concepts will be provided for the understanding of each issue, and discussions with the students will be held. The topics covered in class will be the subject of exercises/simulations through the use of complex molecular modeling programs.
Altre informazioni/Further information
Per ulteriori informazioni, si prega di consultare la pagina del corso su D.I.R. all'indirizzo http://www.dir.uniupo.it Le studentesse e gli studenti con disabilità o con Disturbi Specifici dell’Apprendimento (DSA) o con Bisogni Educativi Speciali (BES) possono richiedere servizi e strumenti specifici a loro dedicati rivolgendosi allo Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti e consultando la pagina dedicata del sito di Ateneo: https://uniupo.it/it/servizi/servizi-studenti-disabili-e-dsa Le studentesse e gli studenti con disabilità, DSA, BES, una volta preso contatto con lo Staff di Ateneo, possono contattare la/il docente titolare dell'insegnamento in relazione alla declinazione delle modalità di esame, in merito agli aspetti didattici.
For further informations, please refer to the course page on D.I.R. at: http://www.dir.uniupo.it Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
Vedere la scheda dell’insegnamento generale.
See the general course information sheet.
Programma esteso/Content
Introduzione alla chemioinformatica: Gestione delle informazioni strutturali dei composti. Database pubblici di composti. Similarità dei composti: Screening virtuale basato su ligandi. Database pubblici di proteine. Gestione delle informazioni strutturali delle proteine. Interazioni proteina-ligando. Farmacofori: Screening virtuale basato sulla struttura.
Intro to chemoinformatics. Handling compounds structural information. Public database for compounds. Compound similarity. Ligand-based virtual screening. Public database of proteins. Handling proteins structural information. Protein-ligand interactions. Pharmacophores. Structure-based virtual screening.
Risultati di apprendimento attesi/Intended learning objectives
Al termine del corso, le studentesse e gli studenti avranno appreso gli aspetti fondamentali necessari per simulare correttamente le strutture chimico-biologiche.
At the end of the course the student will have learned the fundamental aspects necessary to correctly simulate the chemical-biological structures.
×
Stampa
Insegnamento
Dermatology
Codice
FA0531
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
ZAVATTARO Elisa
Docenti
Zavattaro Elisa
CFU
5.0
Ore di lezione
30.0
Ore di studio individuale
95.0
Settore Scientifico Disciplinare (SSD)
MED/35 - MALATTIE CUTANEE E VENEREE
Tipo di insegnamento
Attività formativa monodisciplinare
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
V
Lingua insegnamento/Teaching language
INGLESE
English
Contenuti/Content Summary
Fondamenti di dermatologia con particolare attenzione a eziopatogenesi e trattamento delle malattie. Introduzione alla cosmetologia e dermatologia rigenerativa.
Principles of dermatology with a special focus on the pathogenesis and treatment of cutaneous diseases. Introduction to cosmetic and regenerative dermatology.
Testi di riferimento/Textbooks
Lezioni frontali; Video; Articoli dalla letteratura scientifica; Seminari.
Lecture notes; Videos; Scientific articles from the literature; Seminars.
Obiettivi formativi/Mission
Il corso intende promuovere la conoscenza delle basi generali delle principali patologie cutanee (a genesi infettiva, autoimmunitaria, neoplastica), con particolare attenzione al trattamento delle varie condizioni. Inoltre si intende porre l'attenzione al ruolo del microbiota cutaneo nelle varie patologie (es atopia, psoriasi, dermatiti infettive). Verranno trattate le basi del danno cutaneo UV-mediato e della fotoprotezione. Infine verrà presentata un'introduzione alla cosmetologia ed alla medicina rigenerativa in dermatologia.
The course aims to allow students to understand the general principles of the main skin diseases, thus including either infectious, immune-inflammatory, or neoplastic disorders (as listed in the program). A special attention is paid to the current dermatological treatments of the mentioned diseases. The role of cutaneous microbiome in different dermatosis (i.e. atopy, psoriasis, cutaneous infections) is also discussed. Moreover, the basis of UV-light, cutaneous actinic damage and photoprotection are presented. A brief introduction to both cosmetic dermatology and regenerative medicine in dermatology will be presented.
Prerequisiti/Required background knowledge
Concetti base di farmacologia e di immunologia.
Basic knowledge of pharmacology Basic principles of immunology.
Metodi didattici/Teaching methods
Lezioni frontali, discussioni di casi clinici, video, meeting e seminari interattivi.
Traditional lectures, discussion of case studies, recorded lectures, interactive meetings and seminars.
Altre informazioni/Further information
Le studentesse e gli studenti con disabilità o con Disturbi Specifici dell’Apprendimento (DSA) o con Bisogni Educativi Speciali (BES) possono richiedere servizi e strumenti specifici a loro dedicati rivolgendosi allo Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti e consultando la pagina dedicata del sito di Ateneo: https://uniupo.it/it/servizi/servizi-studenti-disabili-e-dsa Le studentesse e gli studenti con disabilità, DSA, BES, una volta preso contatto con lo Staff di Ateneo, possono contattare la/il docente titolare dell'insegnamento in relazione alla declinazione delle modalità di esame, in merito agli aspetti didattici.
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
Esame finale scritto con domande a scelta multipla. Non è previsto punteggio negativo in caso di risposta errata.
The exam mark will be a multiple-choice questions. There will be no negative marking.
Programma esteso/Content
- Introduzione - Lesioni cutanee primitive e secondarie - Microbioma - Dermatiti a genesi infettiva - Psoriasi - Dermatite atopica - Acne, rosacea e Idrosadenite suppurativa - Allergie e cute sensibile - Melasma e iperpigmentazione cutanea - Alopecia - Reazioni cutanee a farmaci - UV e invecchiamento cutaneo - Tumori cutanei - Melanoma - Linfomi cutanei - Malattie dermatologiche rare - Istopatologia delle malattie cutanee - Introduzione alla cosmetologia e dermatologia rigenerativa
- Introduction to the course - Primary and secondary cutaneous lesions - Microbiome overview - Cutaneous infections - Psoriasis - Atopic dermatitis - Acne, rosacea and Hidradenitis Suppurativa - Cutaneous allergies Sensitive skin - Melasma and cutaneous hyperpigmentation - Alopecia - Drug-induced skin rashes - UV light and skin photoaging - Skin cancer - Melanoma - Cutaneous lymphoma - Rare cutaneous diseases - Histopathology of skin disorders - Introduction to cosmetic dermatology and cosmeceutics - Introduction to Regenerative Dermatology
Risultati di apprendimento attesi/Intended learning objectives
Ci attendiamo che alla fine del corso l* student* abbia una discreta conoscenza delle principali malattie cutanee, con particolare riguardo alla loro patogenesi e terapia. Inoltre l* student* dovrà essere in grado di capire correttamente e discutere articoli scientifici di ambito dermatologico. In considerazione di ciò, l* student* sarà in possesso di un background scientifico sufficiente per poter proporre/sviluppare nuovi possibili terapie per le malattie cutanee.
At the end of the Course, the student is expected to thoroughly know the general principles of the main skin disorders, with special regard to their pathogenesis and current treatments. It is also expected the student to be able to understand and criticize articles from the dermatology literature. On these bases, we aim to provide the student the suitable scientific background in order to propose other possible pathway/drugs able to treat some skin diseases.
×
Stampa
Insegnamento
Pathological mechanisms of skin disorders
Codice
FA0510
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
FRACCHIA Letizia
Docenti
Porta Chiara, Fracchia Letizia
CFU
5.0
Ore di lezione
24.0
Ore di studio individuale
0.0
Settore Scientifico Disciplinare (SSD)
MED/04 - PATOLOGIA GENERALE, BIO/19 - MICROBIOLOGIA GENERALE
Tipo di insegnamento
Attività formativa integrata
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
V
Lingua insegnamento/Teaching language
English
Contenuti/Content Summary
The students will learn the basis of mucosal immunity, the pathogenesis of inflammatory skin disorders, either autoimmune disorders or allergies, and the cellular and molecular mechanisms underlying wound healing. The students will also gain knowledge on the physiological microbiota of skin and on the principal pathogens associated with skin diseases 
Testi di riferimento/Textbooks
The slides of the lectures and additional material, such as selected scientific papers and laboratory protocols will be available to students. Andreas Schwiertz - Microbiota of the Human Body: Implications in Health and Disease -Springer Verlag - 2016 (1st edition) will provide insights into the microbiota topic For background knowledge, we recommend the following text books: Michael T. Madigan, Kelly S. Bender, Daniel H. Buckley, W. Matthew Sattley, David A. Stahl - Brock Biology of Microorganisms – Pearson - 2018 (15th edition). Abul Abbas Andrew H. Lichtman Shiv Pillai. Cellular and Molecular Immunology, 10th Edition. Lauren Sompayrac. How the Immune System Works. Wiley Blackwell.
Obiettivi formativi/Mission
The course aims to: - provide students with adequate information about the skin as an ecosystem, the structure and function of the skin microbiota and factors affecting the microbial flora of the skin. - provide students with the basis for the understanding of the main microbial skin pathogens/host interaction mechanisms, microbial skin infections, microbial life in biofilms and their adverse effects on health. - provide students with the instruments for the application of some of the principal methods concerning bacterial and fungal cells cultivation and microscopic observation. - provide students with a comprehensive knowledge of skin immunity and of the pathological mechanisms underpinning the most common skin disorders. - provide students with the competences to address unmet clinical needs by suggesting experimental approaches that could be taken to identify new targets/approaches and to analyse their therapeutic potential.
Prerequisiti/Required background knowledge
Basic knowledge of microbial cell biology, genetic and metabolism that can be acquired by studying the textbook “Brock Biology of Microorganisms”. Basic knowledge of cell biology and immunology is mandatory and can be acquired by pre-course intensive tutoring. Anatomy, physiology and molecular biology are recommended.
Metodi didattici/Teaching methods
Lectures, seminars held by experts in the field, flipped classroom based on journal club discussion, lab practicals.
Altre informazioni/Further information
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
The exam will be aimed at evaluating the knowledge and notions acquired during the lectures and selected seminars. The exam will be a written test composed of 4 open questions (answers of 150-200 words maximum) and 10 multiple choices and true/false questions (with one true answer). The questions will be aimed at evaluating knowledge and understanding of the topics addressed during the lecturers and the ability to discuss the topics critically and concisely by using specific scientific and technical language. At each open question a maximum score of 5 points will be assigned. For multiple choice and true/false questions, 1 point will be obtained for the correct answer, whereas wrong or blank answers will be evaluated 0 points (maximum score will be 30 points). Teams composed of 3-4 students/each will have to prepare a journal club presentation. A list of research manuscripts that falls into the topics discussed during skin pathology lectures will be provided. However, students might discuss additional original research articles, provided that the manuscript is approved by lecturer. The scientific paper will be discussed with all classmates – who will gain valuable insights into the different topics - and lecturer, who will evaluate the students work. Each student might be awarded with a maximum score of 3 points that will be added to the score of the written test.
Programma esteso/Content
Microbial life on skin: importance for human health and implications in skin diseases. Frontal lessons (Fracchia L.) - Brief introduction about skin as an ecosystem. Definition of Microbiota and Microbiome. Sites of microbial colonisation on the skin and influence of skin components and properties on microbial life. Overview of the principal methodologies to study the human microbiota. - Structure of the healthy human skin microbiota. Functions of the healthy human skin microbiota. Skin microorganisms or communities with and adverse or sickening effect on their hosts and relations with skin microbiota. - Microbial biofilms and skin infections. Prebiotics, probiotics, postbiotics and the skin microbiota in the cosmetic industry. The good and the bad: a close sight to some microorganisms belonging to skin microbiota and to those involved in skin diseases. Laboratory (Fracchia L.) - Theory and practice of microorganism cultivation on selective media, observation of relevant skin pathogens cultivated on agar plates, Gram- staining and observation of slides by optical microscopy. - Isolation and identification of microorganisms from skin surface. - How to cultivate a biofilm in vitro Skin immunity. Overview of the immunological anatomy of the epidermis and derma biology under steady state, wound healing and skin disorders. Discussion of research articles Porta C. (frontal lessons) Infectious skin diseases. Pathogenic mechanisms underpinning the most common bacterial, fungal and viral (HPV, HSV, MCV) skin infections. Discussion of research articles. Porta C. (frontal lessons and seminars) Inflammatory skin disorders. Pathogenesis, current therapeutic options and new potential therapeutic targets of the major autoimmune and inflammatory diseases of the skin and the skin appendages, including alopecia areata, vitiligo, psoriasis, atopic dermatitis and acne vulgaris. Discussion of research articles. Porta C. (frontal lessons and seminars)
Risultati di apprendimento attesi/Intended learning objectives
At the end of the course, the student will acquire theoretical knowledge and understanding about the composition and the role of the physiological human skin microbiota as well as about the skin microorganisms or communities with adverse effect on human health and the main strategies to limit microbial invasion. The student will acquire the instruments for the application of the acquired knowledge to critically analyse and discuss clinical and experimental themes in the field of skin microbial diseases and for the application of some of the principal methods for cultivation and observation of microorganisms. The student will gain independence of judgment on the different topics addressed during the course, knowledge of their possible applications and repercussions in other scientific fields and skills regarding the verbal and written communication by the use of specific scientific and technical language. The student will acquire theoretical knowledge and understanding of cellular and molecular mechanisms underpinning cutaneous immunity, pathogenesis of inflammatory and infectious skin disorders. The student will acquire the specific scientific terminology and application of the acquired knowledge to critically analyse and discuss clinical and experimental data in the field of skin immunity and disorders. Finally, the student will gain competence to conceptually design small research projects aimed to: 1) discover new targets, 2) study the therapeutic potential of a given target 3) evaluate new approaches to target key pathogenic events.
Moduli
Codice Insegnamento Settore Scientifico Disciplinare (SSD) Docenti Agenda web
FA0508Pathology of skin disorders MED/04 - PATOLOGIA GENERALE Porta Chiara Non disponibile
FA0509Microbiology of skin disorders BIO/19 - MICROBIOLOGIA GENERALE Fracchia Letizia Non disponibile
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Pathological mechanisms of skin disorders: Pathology of skin disorders
Codice
FA0508
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
PORTA Chiara
Docenti
Porta Chiara
CFU
3.0
Ore di lezione
18.0
Ore di studio individuale
57.0
Settore Scientifico Disciplinare (SSD)
MED/04 - PATOLOGIA GENERALE
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
G
Lingua insegnamento/Teaching language
INGLESE
English
Contenuti/Content Summary
The students will learn the basis of mucosal immunity, the pathogenesis of inflammatory skin disorders, either autoimmune disorders or allergies, and the cellular and molecular mechanisms underlying wound healing.
Testi di riferimento/Textbooks
The slides of the lectures and additional material, such as selected scientific papers and laboratory protocols will be available to students. For background knowledge, we recommend the following text books: Abul Abbas Andrew H. Lichtman Shiv Pillai. Cellular and Molecular Immunology, 10th Edition. Lauren Sompayrac. How the Immune System Works. Wiley Blackwell.
Obiettivi formativi/Mission
The course aims to: - provide students with a comprehensive knowledge of skin immunity and of the pathological mechanisms underpinning the most common skin disorders. - provide students with the competences to address unmet clinical needs by suggesting experimental approaches that could be taken to identify new targets/approaches and to analyse their therapeutic potential.
Prerequisiti/Required background knowledge
Basic knowledge of cell biology and immunology is mandatory and can be acquired by pre-course intensive tutoring. Anatomy, physiology and molecular biology are recommended.
Metodi didattici/Teaching methods
Lectures, seminars held by experts in the field, flipped classroom based on journal club discussion, lab practical.
Altre informazioni/Further information
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff "Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti", consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
The exam will be aimed at evaluating the knowledge and notions acquired during the lectures and selected seminars. The exam will be a written test composed of 4 open questions (answers of 150-200 words maximum) and 10 multiple choices and true/false questions (with one true answer). The questions will be aimed at evaluating knowledge and understanding of the topics addressed during the lecturers and the ability to discuss the topics critically and concisely by using specific scientific and technical language. At each open question a maximum score of 5 points will be assigned. For multiple choice and true/false questions, 1 point will be obtained for the correct answer, whereas wrong or blank answers will be evaluated 0 points (maximum score will be 30 points). Teams composed of 3-4 students/each will have to prepare a journal club presentation. A list of research manuscripts that falls into the topics discussed during skin pathology lectures will be provided. However, students might discuss additional original research articles, provided that the manuscript is approved by lecturer. The scientific paper will be discussed with all classmates – who will gain valuable insights into the different topics - and lecturer, who will evaluate the students work. Each student might be awarded with a maximum score of 3 points that will be added to the score of the written test.
Programma esteso/Content
Skin immunity. Overview of the immunological anatomy of the epidermis and derma biology under steady state, wound healing and skin disorders. Infectious skin diseases. Pathogenic mechanisms underpinning the most common bacterial, fungal and viral (HPV, HSV, MCV) skin infections. Inflammatory skin disorders. Pathogenesis, current therapeutic options and new potential therapeutic targets of the major autoimmune and inflammatory diseases of the skin and the skin appendages, including alopecia areata, vitiligo, psoriasis, atopic dermatitis.
Risultati di apprendimento attesi/Intended learning objectives
At the end of the course, the student will acquire theoretical knowledge and understanding of cellular and molecular mechanisms underpinning cutaneous immunity, pathogenesis of inflammatory and infectious skin disorders. The student will acquire the specific scientific terminology and application of the acquired knowledge to critically analyse and discuss clinical and experimental data in the field of skin immunity and disorders. Finally, the student will gain competence to conceptually design small research projects aimed to: 1) discover new targets, 2) study the therapeutic potential of a given target 3) evaluate new approaches to target key pathogenic events.
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Pathological mechanisms of skin disorders: Microbiology of skin disorders
Codice
FA0509
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
FRACCHIA Letizia
Docenti
Fracchia Letizia
CFU
2.0
Ore di lezione
6.0
Ore di studio individuale
32.0
Settore Scientifico Disciplinare (SSD)
BIO/19 - MICROBIOLOGIA GENERALE
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
G
Lingua insegnamento/Teaching language
INGLESE
English
Contenuti/Content Summary
Frontal Lessons: Introduction to skin as an ecosystem, defining Microbiota and Microbiome, microbial colonization sites, and skin properties. Methods to study human microbiota. Structure and functions of healthy skin microbiota, adverse microorganisms, and microbial biofilms in skin infections. Role of prebiotics, probiotics, and postbiotics in cosmetics. Laboratory: Cultivation of microorganisms on selective media, observation of skin pathogens, Gram-staining, and microscopy. Isolation and identification of skin microorganisms, and in vitro biofilm cultivation methods.
Testi di riferimento/Textbooks
- The slides of the lectures and additional material, such as selected scientific papers and laboratory protocols will be available to students. - Andreas Schwiertz - Microbiota of the Human Body: Implications in Health and Disease -Springer Verlag - 2016 (1st edition) will provide insights into the microbiota topic For background knowledge, we recommend the following text books: - Michael T. Madigan, Kelly S. Bender, Daniel H. Buckley, W. Matthew Sattley, David A. Stahl - Brock Biology of Microorganisms – Pearson - 2018 (15th edition).
Obiettivi formativi/Mission
The course aims to: - provide students with adequate information about the skin as an ecosystem, the structure and function of the skin microbiota and factors affecting the microbial flora of the skin. - provide students with the basis for the understanding of the main microbial skin pathogens/host interaction mechanisms, microbial skin infections, microbial life in biofilms and their adverse effects on health. - provide students with the instruments for the application of some of the principal methods concerning bacterial and fungal cells cultivation and microscopic observation.
Prerequisiti/Required background knowledge
Basic knowledge of microbial cell biology, genetic and metabolism
Metodi didattici/Teaching methods
Lectures, seminars held by experts in the field, flipped classroom based on journal club discussion, lab practicals.
Altre informazioni/Further information
2-hour seminar with guest lecturer Dr. Andrea Maltagliati – Secretary General EFfCI – The European Federation for Cosmetic Ingredients Title: “Cosmetic Ingredients - surfing the ocean with compass indicating quality, safety and responsibility” Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
The exam will be aimed at evaluating the knowledge and notions acquired during the lectures and selected seminars. The exam will be a written test composed of 4 open questions (answers of 150-200 words maximum) and 10 multiple choices and true/false questions (with one true answer). The questions will be aimed at evaluating knowledge and understanding of the topics addressed during the lecturers and the ability to discuss the topics critically and concisely by using specific scientific and technical language. At each open question a maximum score of 5 points will be assigned. For multiple choice and true/false questions, 1 point will be obtained for the correct answer, whereas wrong or blank answers will be evaluated 0 points (maximum score will be 30 points). Teams composed of 3-4 students/each will have to prepare a journal club presentation. A list of research manuscripts that falls into the topics discussed during skin pathology lectures will be provided. However, students might discuss additional original research articles, provided that the manuscript is approved by lecturer. The scientific paper will be discussed with all classmates – who will gain valuable insights into the different topics - and lecturer, who will evaluate the students work. Each student might be awarded with a maximum score of 3 points that will be added to the score of the written test.
Programma esteso/Content
Frontal lessons: Microbial life on skin: importance for human health and implications in skin diseases. - Brief introduction about skin as an ecosystem. Definition of Microbiota and Microbiome. Sites of microbial colonisation on the skin and influence of skin components and properties on microbial life. Overview of the principal methodologies to study the human microbiota. - Structure of the healthy human skin microbiota. Functions of the healthy human skin microbiota. Skin microorganisms or communities with and adverse or sickening effect on their hosts and relations with skin microbiota. - Microbial biofilms and skin infections. Prebiotics, probiotics, postbiotics and the skin microbiota in the cosmetic industry. Laboratory: The good and the bad: a close sight to some microorganisms belonging to skin microbiota and to those involved in skin diseases. - Theory and practice of microorganism cultivation on selective media, observation of relevant skin pathogens cultivated on agar plates, Gram- staining and observation of slides by optical microscopy. - Isolation and identification of microorganisms from skin surface. - How to cultivate a biofilm in vitro
Risultati di apprendimento attesi/Intended learning objectives
At the end of the course, the student will acquire theoretical knowledge and understanding about the composition and the role of the physiological human skin microbiota as well as about the skin microorganisms or communities with adverse effect on human health and the main strategies to limit microbial invasion. The student will acquire the instruments for the application of the acquired knowledge to critically analyse and discuss clinical and experimental themes in the field of skin microbial diseases and for the application of some of the principal methods for cultivation and observation of microorganisms. The student will gain independence of judgment on the different topics addressed during the course, knowledge of their possible applications and repercussions in other scientific fields and skills regarding the verbal and written communication by the use of specific scientific and technical language.
×
Stampa
Insegnamento
Anatomy and physiology of skin and appendages
Codice
FA0507
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
BOSETTI Michela
Docenti
Lim Dmitry, Bosetti Michela
CFU
4.0
Ore di lezione
18.0
Ore di studio individuale
0.0
Settore Scientifico Disciplinare (SSD)
BIO/09 - FISIOLOGIA, BIO/16 - ANATOMIA UMANA
Tipo di insegnamento
Attività formativa integrata
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Sede
NOVARA
Frequenza obbligatoria
1
Tipo di valutazione
V
Lingua insegnamento/Teaching language
ENGLISH
Testi di riferimento/Textbooks
Gray’s Anatomy, The Anatomical Basis of Clinical Practice. Junqueira’s Basic Histology: Text and Atlas. Lever’s Histopathology of the Skin. Walter Boron and Emile Boulpaep. Medical Physiology. Elsevier. (3trd edition). Dale Purves, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, Richard D. Mooney, Michael L. Platt, and Leonard E. White. Neuroscience. Sinauer (6th edition). The slides of the lectures and additional material such as scientific publications, laboratory protocols etc. will be available to students
Obiettivi formativi/Mission
The course aims to provide students with adequate information regarding: – gross anatomy of skin and microscopic confidence in its structure; – technical skills to study in vitro skin regeneration; – search in the literature to develop an idea of skin regeneration identifying strengths and weaknesses; – multiple roles of the skin in homeostasis including protection, regulation of body temperature, sensory reception, water balance, synthesis of vitamins and hormones, and absorption of materials.
Prerequisiti/Required background knowledge
Fundamentals of mathematics, physics, chemistry, biochemistry, cellular biology, cell physiology, human anatomy and physiology
Metodi didattici/Teaching methods
Lectures, videos, seminars by experts in the field, lab practicals, upside down class
Altre informazioni/Further information
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects. Student athlete have the possibility of agreeing with the lecturer on a different exam date in the same session
Modalità di verifica dell'apprendimento/Assessment methods
The exam mark will be composed of two parts: a written test that will cover the material delivered in lectures and seminars (50% of the mark) and a project work in the form of a written essay that will cover the literature knowledge. The topic will be assigned by the lecturers and will be due on the same day of the exam. Written test: the written exam will take place in the computer room and will consist of 50 (25 for Anatomy and 25 for Physiology) closed questions. Multiple choice questions, true / false questions, completion type questions and matching type questions are the most frequent types of test questions. Written test evaluation criteria: True/ False Questions: 1 point for correct answer; -1 point for wrong answer; 0 points for not responding. Multiple choice questions: 1 point for correct answer; – 0.5 points for the wrong answer if the question allows you to choose from three options, -0.33 between four, -0.25 out of five, etc.; 0 points not responding. The penalty scores will be homogenously distributed for all tests. Rules for the written test – The test will be monitored: No Internet, No Second Screen, No outside help. You will be allowed 1 hour to complete all 2 sections (Anatomy and Physiology) of the test. Written essay evaluation criteria: Balanced fair and correct Synthesis and communicative skills Timely and pertinent Rules for the written essay – max 2 pages, single line spacing, character 12 + figures (optional) + bibliography and graphical abstract (mandatory)
Programma esteso/Content
ANATOMY. Gross structure of skin and underlying tissues, of the skin appendages and of the skin lines. Skin structure: layers of epidermis, the papillary dermis, the reticular dermis, hypodermis. Microscope-Learning 1: the skin and the hypodermis. Appendages of the skin: nails, hair and hair follicles, sebaceous glands, sweat glands. The skin throughout life. Disorders of the integumentary system. Microscope-Learning 2: appendages of the skin and examples of disorders. In vitro models to study skin tissue regeneration. PHYSIOLOGY Functions of the Integumentary System. The role of the skin in the protection from invasion by microorganisms, chemicals and other environmental factors and in preventing the body dehydration. Endocrine functions of the skin. The role of the skin in the body thermoregulation Sensory functions of the skin.
Risultati di apprendimento attesi/Intended learning objectives
The students will acquire comprehensive theoretical knowledge of the structure and role of skin in the human body physiology. They will develop a substantial set of skills, including the ability to critically analyse and discuss clinical and experimental themes related to skin structure and functions and the knowledge of their possible applications in other scientific fields. They will acquire the use of specific scientific and technical language improving their competence in the scientific communication.
Moduli
Codice Insegnamento Settore Scientifico Disciplinare (SSD) Docenti Agenda web
FA0505Physiology of skin and appendages BIO/09 - FISIOLOGIA Lim Dmitry Non disponibile
FA0506Anatomy of skin and appendages BIO/16 - ANATOMIA UMANA Bosetti Michela Non disponibile
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Anatomy and physiology of skin and appendages: Physiology of skin and appendages
Codice
FA0505
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
LIM DMITRY
Docenti
Lim Dmitry
CFU
2.0
Ore di lezione
12.0
Ore di studio individuale
38.0
Settore Scientifico Disciplinare (SSD)
BIO/09 - FISIOLOGIA
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Sede
NOVARA
Frequenza obbligatoria
1
Tipo di valutazione
G
Lingua insegnamento/Teaching language
INGLESE
English
Contenuti/Content Summary
Physiology of skin
Testi di riferimento/Textbooks
Lectures and supplementary material such as recommended articles
Obiettivi formativi/Mission
Provide knowledge about basic physiology of skin cells and skin as an organ
Prerequisiti/Required background knowledge
Anatomy of skin; cellular physiology; ion cellular signaling; electric activity of the cell
Metodi didattici/Teaching methods
Lectures in classroom.
Modalità di verifica dell'apprendimento/Assessment methods
See main course
Programma esteso/Content
Cellular physiology: electric activity of the cell; ionic signaling; elements of signal transduction. Skin as an organ, skin functions. Thermoregulation: receptors, mechanisms of signal transduction, neural paths, coordingation of central and peripheral thermoregulation. Sensation: types of sensation, receptors, mechanisms of signal transduction. Hair physiology: cellular organization, functions, integration with systemic physiological responses. Sweat physiology: types and cellular physiology of sweat glands; control of sweating; role and mechanisms in human health. The program may be subjected to modifications.
Risultati di apprendimento attesi/Intended learning objectives
Students are expected to acquire knowledge about basic physiology of skin cells and skin as an organ
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Anatomy and physiology of skin and appendages: Anatomy of skin and appendages
Codice
FA0506
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
BOSETTI Michela
Docenti
Bosetti Michela
CFU
2.0
Ore di lezione
6.0
Ore di studio individuale
32.0
Settore Scientifico Disciplinare (SSD)
BIO/16 - ANATOMIA UMANA
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Sede
NOVARA
Frequenza obbligatoria
1
Tipo di valutazione
G
Lingua insegnamento/Teaching language
INGLESE
English
Contenuti/Content Summary
Struttura macroscopica e microscopica della pelle umana normale e dei tessuti sottostanti, compresi gli annessi cutanei. Note sul danno tissutale (meccanico o indotto da ustioni), sui meccanismi coinvolti nella rigenerazione e sui modelli di studio in vitro e in vivo.
Gross and microscopic structure of normal human skin and underlying tissues together with skin appendages. Notes on tissue damage (mechanical or burn-induced), mechanisms involved in regeneration, and in vitro and in vivo study models
Testi di riferimento/Textbooks
Anatomia del Gray, le basi anatomiche della pratica clinica. Presentazioni PowerPoint, link a lezioni video, link a siti web e pubblicazioni scientifiche.
Gray’s Anatomy, The Anatomical Basis of Clinical Practice. PowerPoint presentations, links to video lessons, links to websites, and PDF scientific pubblications.
Obiettivi formativi/Mission
Il corso si propone di fornire agli studenti adeguate informazioni sull'anatomia macroscopica della pelle e una conoscenza microscopica della sua struttura. Inoltre, si propone di fornire agli studenti: - competenze tecniche per studiare la rigenerazione cutanea in vitro; - ricerca in letteratura per sviluppare un'idea di rigenerazione cutanea identificandone punti di forza e di debolezza; - esperienza di laboratorio con colture cellulari 3D per la creazione di un modello di studio della rigenerazione tissutale.
The course aims to provide students with adequate information regarding gross anatomy of skin and microscopic confidence in its structure. Moreover aims to give students: – technical skills to study in vitro skin regeneration; – search in the literature to develop an idea of skin regeneration identifying strengths and weaknesses; - laboratory experience with 3D cell cultures for the creation of a tissue regeneration study model
Prerequisiti/Required background knowledge
Fondamenti di biologia cellulare e di istologia
Fundamentals of cellular biology and histology
Metodi didattici/Teaching methods
Lezioni frontali, video, seminari, esercitazioni di laboratorio, classe capovolta
Lectures, videos, seminars, lab practicals, upside down class
Altre informazioni/Further information
Gli studenti con disabilità fisiche, DSA o Bisogni Educativi Speciali possono richiedere servizi e strumenti specifici tramite lo Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consultando la pagina web dell'Ateneo: https://www.uniupo.it/it/servizi/servizi-studenti-disabilità-fisiche-o-didattiche Gli studenti con disabilità, DSA o Bisogni Educativi Speciali, una volta contattato il Personale dell'Ateneo, possono rivolgersi al tutor responsabile del corso per definire le modalità d'esame, per quanto riguarda gli aspetti accademici. Gli studenti atleti hanno la possibilità di concordare con il docente una data d'esame diversa nella stessa sessione.
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects. Student athlete have the possibility of agreeing with the lecturer on a different exam date in the same session
Modalità di verifica dell'apprendimento/Assessment methods
Vedi il corso principale
See main course
Programma esteso/Content
Anatomia macroscopica della pelle dei suoi annessi e delle linee cutanee. Struttura microscopica a) della pelle: strati dell'epidermide, derma papillare, derma reticolare, ipoderma. Apprendimento 1 al microscopio: la pelle e l'ipoderma. b) degli annessi cutanei: unghie, peli e follicoli piliferi, ghiandole sebacee, ghiandole sudoripare. Apprendimento 2 al microscopio: annessi cutanei La pelle nel corso della vita (cenni di modificazioni strutturali e funzionali) LAB: modelli in vitro per studiare la rigenerazione dei tessuti cutanei.
Gross anatomy of skin and lines. Skin structure: layers of epidermis, the papillary dermis, the reticular dermis, hypodermis. Microscope-Learning 1: the skin and the hypodermis. Appendages of the skin: nails, hair and hair follicles, sebaceous glands, sweat glands. The skin throughout life. Disorders of the integumentary system. Microscope-Learning 2: appendages of the skin and examples of disorders. LAB: in vitro models to study skin tissue regeneration.
Risultati di apprendimento attesi/Intended learning objectives
Gli studenti acquisiranno una conoscenza teorica completa della struttura e del ruolo della pelle nella fisiologia del corpo umano oltre alla capacità di riconoscerne le strutture al microscopio. Svilupperanno un insieme sostanziale di competenze, tra cui la capacità di analizzare e discutere criticamente temi clinici e sperimentali relativi alla struttura e alle funzioni della pelle e la conoscenza delle loro possibili applicazioni in altri campi scientifici. Acquisiranno l'uso di un linguaggio scientifico e tecnico specifico, migliorando la loro competenza nella comunicazione scientifica. Saranno in grado di coltivare cellule in 3D creando un modello di di studio di pelle in vitro che analizzeranno al microscopio dopo l'inclusione in paraffina, il taglio e la colorazione.
The students will acquire comprehensive theoretical knowledge of the structure and role of skin in the human body physiology. They will develop a substantial set of skills, including the ability to critically analyse and discuss clinical and experimental themes related to skin structure and functions and the knowledge of their possible applications in other scientific fields. They will acquire the use of specific scientific and technical language improving their competence in the scientific communication. They will be able to cultivate cells in 3D by creating an in vitro skin model that they will analyze microscopically after embedding in paraffin, cutting and staining.
×
Stampa
Insegnamento
Value assessment and market access
Codice
FA0520
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
JOMMI CLAUDIO
Docenti
Jommi Claudio, Genazzani Armando
CFU
3.0
Ore di lezione
18.0
Ore di studio individuale
0.0
Settore Scientifico Disciplinare (SSD)
SECS-P/07 - ECONOMIA AZIENDALE, BIO/14 - FARMACOLOGIA
Tipo di insegnamento
Attività formativa integrata
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
V
Lingua insegnamento/Teaching language
Inglese
English
Contenuti/Content Summary
Il corso affronterà i seguenti argomenti - Introduzione alla regolamentazione ed alle dinamiche del mercato delle tecnologie sanitarie (in particolare, farmaci) - Valutazione del profilo rischiobeneficio assoluto e comparativo - Introduzione alla valutazione delle tecnologie sanitarie e alla valutazione economica - Processi di fissazione dei prezzi e di rimborso per le tecnologie sanitarie - Applicazioni in Dermatologia
The course will cover the following topics - Introduction to health technologies (in particular, medicines) market dynamics and regulation - Assessment of absolute vs comparative risk-benefit profile - Introduction to Health Technology Assessment and Economic Evaluation - Price setting and reimbursement processes for health technologies - Applications in Dermatology
Testi di riferimento/Textbooks
Il corso è organizzato in lezioni frontali, esercitazioni/simulazioni su valutazioni economiche e lavori di gruppo.
There is not a single textbook. Readings for each class will be presented during the first lesson.
Obiettivi formativi/Mission
Il corso fornisce agli studenti una comprensione delle dinamiche dei mercati delle tecnologie sanitarie dal punto di vista delle Autorità di regolamentazione, delle Agenzie di valutazione delle tecnologie sanitarie, dei pagatori e dell'industria. Dopo aver completato con successo il corso, ci si aspetta che comprendano meglio quali sono le esigenze del mercato/dei pagatori, affrontando così le traiettorie di ricerca e sviluppo guardando a quando le tecnologie verranno introdotte sul mercato.
This course provides students with an understanding of the dynamics of the health technologies markets from perspectives of Regulatory Authorities, Health Technology Assessment Agencies, Payers and the Industry. After a successful completion of the course, students are expected to better understand which are the market / payers requirements, thus addressing the research and development trajectories looking at the future launch into the market.
Prerequisiti/Required background knowledge
Nessuno
None
Metodi didattici/Teaching methods
Il corso è organizzato in lezioni frontali, esercitazioni/simulazioni su valutazioni economiche e lavori di gruppo.
The course is organized in traditional lectures, exercises / simulations on economic evaluations, and groups work.
Altre informazioni/Further information
Le studentesse e gli studenti con disabilità o con Disturbi Specifici dell’Apprendimento (DSA) o con Bisogni Educativi Speciali (BES) possono richiedere servizi e strumenti specifici a loro dedicati rivolgendosi allo Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti e consultando la pagina dedicata del sito di Ateneo: https://uniupo.it/it/servizi/servizi-studenti-disabili-e-dsa Le studentesse e gli studenti con disabilità, DSA, BES, una volta preso contatto con lo Staff di Ateneo, possono contattare la/il docente titolare dell'insegnamento in relazione alla declinazione delle modalità di esame, in merito agli aspetti Testi in inglese English The course will cover the following topics - Introduction to health technologies (in particular, medicines) market dynamics and regulation - Assessment of absolute vs comparative risk-benefit profile - Introduction to Health Technology Assessment and Economic Evaluation - Price setting and reimbursement processes for health technologies - Applications in Dermatology There is not a single textbook. Readings for each class will be presented during the first lesson. This course provides students with an understanding of the dynamics of the health technologies markets from perspectives of Regulatory Authorities, Health Technology Assessment Agencies, Payers and the Industry. After a successful completion of the course, students are expected to better understand which are the market / payers requirements, thus addressing the research and development trajectories looking at the future launch into the market. None The course is organized in traditional lectures, exercises / simulations on economic evaluations, and groups work. didattici.
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learningdisabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
La valutazione si basa su: - Esame finale (questionario aperto / discussione di un caso) (60% del voto totale) - Lavoro di gruppo (40% del voto totale)
Grading is based on: - Final exam (open questionnaire / discussion of a case-study) (60% of total grade) - Groups work (40% of total grade)
Programma esteso/Content
- Mercato delle tecnologie sanitarie: tendenze generali e regolamentazione. - Sistemi sanitari e pagatori delle tecnologie sanitarie: Governo, Assicurazioni sociali, Assicurazioni private, Pazienti (out-ofpocket). - Presentazione dei lavori di gruppo. - Beni di consumo e meccanismi di mercato. - Valutazione assoluta vs valutazione comparativa delle tecnologie sanitarie (come, chi e per cosa). - Prezzo e rimborso dei medicinali. - Valutazione delle tecnologie sanitarie. - Valutazione economica: analisi costo-efficacia e impatto sul budget. - Valutazione economica e strategie di pricing: simulazione su un farmaco dermatologico. - Presentazioni di lavori di gruppo.
- Healthcare technologies markets: general trends and regulation. - Healthcare systems and payers of healthcare technologies: Government, Social Insurance, Private Insurance, Patients (out-ofpocket). - Presentation of groups work. - Consumer goods and market mechanisms. - Absolute assessment vs comparative assessment of health technologies (how, whom and for what). - Price and reimbursement of medicines and medical devices. - Health Technology Assessment. - Economic evaluation: cost-effectiveness and budget impact analysis. - Economic evaluation and pricing strategies: simulation on a dermatological medicine. - Groups work presentations.
Risultati di apprendimento attesi/Intended learning objectives
Comprendere i mercati delle tecnologie sanitarie. Comprendere come le tendenze del mercato possono influenzare gli investimenti in ricerca e sviluppo. Avere una conoscenza introduttiva della valutazione comparativa e della valutazione economica delle tecnologie sanitarie. Applicare queste conoscenze ai prodotti rilevanti (farmaci e dispositivi dermatologici; cosmetici). Integrare le competenze scientifiche con la conoscenza degli strumenti economici e manageriali. Capire come lavorare in gruppo e discutere case-studies
Understanding healthcare technologies markets. Understanding how market trends can affect research and development investments. Having an introductory knowledge of comparative assessment and economic evaluation of healthcare technologies. Applying this knowledge to the relevant products (dermatological drugs and devices; cosmetics). Integrating scientific competences with knowledge of economics and managerial tools. Understanding how to work in a group and to discuss case studies.
Moduli
Codice Insegnamento Settore Scientifico Disciplinare (SSD) Docenti Agenda web
FA0715Value assessment and market access 1 SECS-P/07 - ECONOMIA AZIENDALE Jommi Claudio Non disponibile
FA0716Value assessment and market access 2 BIO/14 - FARMACOLOGIA Genazzani Armando Non disponibile
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Value assessment and market access 1
Codice
FA0715
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
JOMMI CLAUDIO
Docenti
Jommi Claudio
CFU
2.0
Ore di lezione
12.0
Ore di studio individuale
38.0
Settore Scientifico Disciplinare (SSD)
SECS-P/07 - ECONOMIA AZIENDALE
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
G
Lingua insegnamento/Teaching language
INGLESE
English
Contenuti/Content Summary
Il corso affronterà i seguenti argomenti - Introduzione alla regolamentazione ed alle dinamiche del mercato delle tecnologie sanitarie (in particolare, farmaci) - Valutazione del profilo rischio-beneficio assoluto e comparativo - Introduzione alla valutazione delle tecnologie sanitarie e alla valutazione economica - Processi di fissazione dei prezzi e di rimborso per le tecnologie sanitarie - Applicazioni in Dermatologia
The course will cover the following topics - Introduction to health technologies (in particular, medicines) market dynamics and regulation - Assessment of absolute vs comparative risk-benefit profile - Introduction to Health Technology Assessment and Economic Evaluation - Price setting and reimbursement processes for health technologies - Applications in Dermatology
Testi di riferimento/Textbooks
Non esiste un solo libro di testo. Verranno presentate le letture per ciascuna classe durante la prima lezione.
There is not a single textbook. Readings for each class will be presented during the first lesson.
Obiettivi formativi/Mission
Il corso fornisce agli studenti una comprensione delle dinamiche dei mercati delle tecnologie sanitarie dal punto di vista delle Autorità di regolamentazione, delle Agenzie di valutazione delle tecnologie sanitarie, dei pagatori e dell'industria. Dopo aver completato con successo il corso, ci si aspetta che comprendano meglio quali sono le esigenze del mercato/dei pagatori, affrontando così le traiettorie di ricerca e sviluppo guardando a quando le tecnologie verranno introdotte sul mercato.
This course provides students with an understanding of the dynamics of the health technologies markets from perspectives of Regulatory Authorities, Health Technology Assessment Agencies, Payers and the Industry. After a successful completion of the course, students are expected to better understand which are the market / payers requirements, thus addressing the research and development trajectories looking at the future launch into the market.
Prerequisiti/Required background knowledge
Nessuno
None
Metodi didattici/Teaching methods
Il corso è organizzato in lezioni frontali, esercitazioni/simulazioni su valutazioni economiche e lavori di gruppo.
The course is organized in traditional lectures, exercises / simulations on economic evaluations, and groups work.
Altre informazioni/Further information
Le studentesse e gli studenti con disabilità o con Disturbi Specifici dell’Apprendimento (DSA) o con Bisogni Educativi Speciali (BES) possono richiedere servizi e strumenti specifici a loro dedicati rivolgendosi allo Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti e consultando la pagina dedicata del sito di Ateneo: https://uniupo.it/it/servizi/servizi-studenti-disabili-e-dsa Le studentesse e gli studenti con disabilità, DSA, BES, una volta preso contatto con lo Staff di Ateneo, possono contattare la/il docente titolare dell'insegnamento in relazione alla declinazione delle modalità di esame, in merito agli aspetti didattici.
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
La valutazione si basa su: - Esame finale (questionario aperto / discussione di un caso) (60% del voto totale) - Lavoro di gruppo (40% del voto totale)
Grading is based on: - Final exam (open questionnaire / discussion of a case-study) (60% of total grade) - Groups work (40% of total grade)
Programma esteso/Content
- Mercato delle tecnologie sanitarie: tendenze generali e regolamentazione. - Sistemi sanitari e pagatori delle tecnologie sanitarie: Governo, Assicurazioni sociali, Assicurazioni private, Pazienti (out-of-pocket). - Presentazione dei lavori di gruppo. - Beni di consumo e meccanismi di mercato. - Valutazione assoluta vs valutazione comparativa delle tecnologie sanitarie (come, chi e per cosa). - Prezzo e rimborso dei medicinali. - Valutazione delle tecnologie sanitarie. - Valutazione economica: analisi costo-efficacia e impatto sul budget. - Valutazione economica e strategie di pricing: simulazione su un farmaco dermatologico. - Presentazioni di lavori di gruppo.
Healthcare technologies markets: general trends and regulation. - Healthcare systems and payers of healthcare technologies: Government, Social Insurance, Private Insurance, Patients (out-ofpocket). - Presentation of groups work. - Consumer goods and market mechanisms. - Absolute assessment vs comparative assessment of health technologies (how, whom and for what). - Price and reimbursement of medicines. - Health Technology Assessment. - Economic evaluation: cost-effectiveness and budget impact analysis. - Economic evaluation and pricing strategies: simulation on a dermatological medicine. - Groups work presentations.
Risultati di apprendimento attesi/Intended learning objectives
Comprendere i mercati delle tecnologie sanitarie. Comprendere come le tendenze del mercato possono influenzare gli investimenti in ricerca e sviluppo. Avere una conoscenza introduttiva della valutazione comparativa e della valutazione economica delle tecnologie sanitarie. Applicare queste conoscenze ai prodotti rilevanti (farmaci e dispositivi dermatologici; cosmetici). Integrare le competenze scientifiche con la conoscenza degli strumenti economici e manageriali. Capire come lavorare in gruppo e discutere case-studies.
Understanding healthcare technologies markets. Understanding how market trends can affect research and development investments. Having an introductory knowledge of comparative assessment and economic evaluation of healthcare technologies. Applying this knowledge to the relevant products (dermatological drugs and devices; cosmetics). Integrating scientific competences with knowledge of economics and managerial tools. Understanding how to work in a group and to discuss case studies.
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Value assessment and market access 2
Codice
FA0716
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
GENAZZANI Armando
Docenti
Genazzani Armando
CFU
1.0
Ore di lezione
6.0
Ore di studio individuale
19.0
Settore Scientifico Disciplinare (SSD)
BIO/14 - FARMACOLOGIA
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
G
×
Stampa
Insegnamento
Workshop: “An introduction to the markets of cosmetic products, dermatological drugs and medical devices”
Codice
FA0523
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
POLLASTRO Federica
Docenti
Pollastro Federica, Pirali Tracey
CFU
2.0
Ore di lezione
12.0
Ore di studio individuale
0.0
Settore Scientifico Disciplinare (SSD)
BIO/15 - BIOLOGIA FARMACEUTICA, CHIM/08 - CHIMICA FARMACEUTICA
Tipo di insegnamento
Attività formativa integrata
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
V
Lingua insegnamento/Teaching language
English
Contenuti/Content Summary
The workshop corresponds to the Induction Week in September. It will introduce students to the skin health and care industry, the main areas of investment of companies, and soft skills. The evaluation of the workshop will be based on the participation in a project focused on the communication of science.
Testi di riferimento/Textbooks
I will use slide that will not make available, so taking notes is strongly advisable.
Obiettivi formativi/Mission
The aim is to write valuable scientific articles that the general public can easily read and understand.
Prerequisiti/Required background knowledge
A good English level is mandatory as well as a strong and consistent writing style.
Metodi didattici/Teaching methods
This course is a writing laboratory where students will immediately apply what they are learning. The lab shall work as a little newsroom where teamwork and constant improvement are an effective part of the journey. Writing and producing material will be solo work, but the entire class shall help each other for better result.
Modalità di verifica dell'apprendimento/Assessment methods
I shall evaluate how the article is written, if it is suitable and understandable for a public (therefore strong jargon shall be avoided as much as possible), if complies withes the Seo rules, if it is delivered on time as well as if it is paired with the proper photos. The scientific mentor shall evaluate the scientific content considering its originality, the strong basis on which the assumptions are made, the reliability of the sources and the observations made by the students. The final mark will be expressed in 30/30 with the possibility of the laude if the product is consistent, wide and curated in all details.
Programma esteso/Content
In the first part I will explain how to write an article for the online student magazine aimed at a general public. The goal is to produce at least one product per student to be published on https://www.emotion-master.eu/emotion-student-magazine/ The product shall be an article with photos and other possible elements such as video, audio, infographics. We dive into how to choose a topic of interest, how to choose a title and how to deliver the message. Then we will focus on the SEO writing for a better positioning of the article.
Risultati di apprendimento attesi/Intended learning objectives
The student shall write at least a scientific article with photos. Photos can be taken personally, produced with AI or taken from website with free common license.
Moduli
Codice Insegnamento Settore Scientifico Disciplinare (SSD) Docenti Agenda web
FA0521Workshop: “An introduction to the markets of cosmetic products, dermatological drugs and medical devices” A BIO/15 - BIOLOGIA FARMACEUTICA Pollastro Federica Non disponibile
FA0522Workshop: “An introduction to the markets of cosmetic products, dermatological drugs and medical devices” B CHIM/08 - CHIMICA FARMACEUTICA Pirali Tracey Non disponibile
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Workshop: “An introduction to the markets of cosmetic products, dermatological drugs and medical devices” A
Codice
FA0521
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
POLLASTRO Federica
Docenti
Pollastro Federica
CFU
1.0
Ore di lezione
6.0
Ore di studio individuale
19.0
Settore Scientifico Disciplinare (SSD)
BIO/15 - BIOLOGIA FARMACEUTICA
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
G
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Workshop: “An introduction to the markets of cosmetic products, dermatological drugs and medical devices” B
Codice
FA0522
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
PIRALI Tracey
Docenti
Pirali Tracey
CFU
1.0
Ore di lezione
6.0
Ore di studio individuale
19.0
Settore Scientifico Disciplinare (SSD)
CHIM/08 - CHIMICA FARMACEUTICA
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
G
×
Stampa
Insegnamento
Understanding R&D
Codice
FA0515
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
GRILLI Mariagrazia
Docenti
Grilli Mariagrazia
CFU
2.0
Ore di lezione
12.0
Ore di studio individuale
38.0
Settore Scientifico Disciplinare (SSD)
BIO/14 - FARMACOLOGIA
Tipo di insegnamento
Attività formativa monodisciplinare
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
V
Lingua insegnamento/Teaching language
INGLESE
English
Contenuti/Content Summary
The course aims at providing a general knowledge on drug R&D process.
Testi di riferimento/Textbooks
The course topics, for their nature, are usually not appropriately covered by booktexts; for these reasons selected bibliographic references and drug documentation for discussions/group work will be provided to students.
Obiettivi formativi/Mission
People involved in the development of drugs have really diverse educational backgrounds and cooperate with their complementary knowledge and skills to the final goal of R&D. The course aims at conveying a general knowledge on the drug discovery and development process so that students from different backgrounds may be able to appreciate the meaning and importance of the different phases of R&D, become familiar with key terminology, understand complexity and identify critical factors and bottlenecks that impact the discovery of medicines. Finally students may also be able to critically understand the process that allowed a new medicine to be approved and, if given the opportunity, communicate/cooperate across the different fields of the R&D process.
Prerequisiti/Required background knowledge
No required background knowledge
Metodi didattici/Teaching methods
Teaching is given in the form of: i) classroom lectures; ii) practicals including literature and data searches; iii) discussions of case studies. Additionally, the course is enriched by 3 h seminars by the CEO of the start up company ChemiCare (Dr. Beatrice Riva) who will provide additional and personal insights into R&D process and drug development with particular reference to GXP compliance and ICH (international Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use) guidelines.
Altre informazioni/Further information
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
The students, in an individual effort, will be required to search and retrieve data on a recently developed drug for skin disorders and critically evaluate either preclinical and/or clinical aspects of the R&D process as described in a peer reviewed publication of choice .
Programma esteso/Content
The different phases of R&D and the different professional profiles involved in R&D; early and key decisions in R&D; preclinical in vitro and in vivo models in drug discovery; general principles of drug screening and assay development for drug screening; clinical trials; critical discussion of R&D process of drugs for skin disorders recently licensed; insights from being a CEO of a start up company involved in R&D (3 h seminar by Dr. Beatrice Riva): mindset, challenges, personal skills, business and market opportunity.
Risultati di apprendimento attesi/Intended learning objectives
Upon course completion, the student should be able to: i) understand the significance and relevance of the different and distinct phases of the R&D process; ii) recognize key decision points in R&D; iii) carry out searches aimed at retrieving information relevant to the development of a drug; iv) review and critically evaluate preclinical and clinical studies with a general understanding of their aim based on medical needs, of chosen procedures, of results, conclusions and relevance.
×
Stampa
Insegnamento
Principles of formulation
Codice
FA0530
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
GIOVANNELLI Lorella
Docenti
Hanno Ibrahim, Giovannelli Lorella
CFU
6.0
Ore di lezione
24.0
Ore di studio individuale
102.0
Settore Scientifico Disciplinare (SSD)
CHIM/09 - FARMACEUTICO TECNOLOGICO APPLICATIVO
Tipo di insegnamento
Attività formativa monodisciplinare
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
V
Lingua insegnamento/Teaching language
INGLESE
English
Contenuti/Content Summary
• Liquid and dispersed systems for topical intent. • Semi-solid dosage forms: dermatological and cosmetic formulations. • Preparation of dermatological formulations. • Preparation of cosmetic products.
• Liquid and dispersed systems for topical intent. • Semi-solid dosage forms: dermatological and cosmetic formulations. • Preparation of dermatological formulations. • Preparation of cosmetic products.
Testi di riferimento/Textbooks
The Design and Manufacture of Medicines; K. Aulton, Elsevier. Handbook of Cosmetic Science and Technology; A. O. Barel et al., CRC Press. Introduction to cosmetic formulation and technology; Gabriella Baki et al., Wiley, 2015. Notes and handouts distributed during seminars.
The Design and Manufacture of Medicines; K. Aulton, Elsevier. Handbook of Cosmetic Science and Technology; A. O. Barel et al., CRC Press. Introduction to cosmetic formulation and technology; Gabriella Baki et al., Wiley, 2015. Notes and handouts distributed during seminars.
Obiettivi formativi/Mission
The course aims to provide students with the basic principles of the formulation, illustrating in particular the physical-chemical characteristics of the excipients used for the preparation of dosage forms for topical application. An overview of skin care, sun care and decorative products will also be presented. Moreover, the course aims to provide the students with adequate information regarding manufacturing techniques of topical dosage forms; preparation of makeup and skincare products.
The course aims to provide students with the basic principles of the formulation, illustrating in particular the physical-chemical characteristics of the excipients used for the preparation of dosage forms for topical application. An overview of skin care, sun care and decorative products will also be presented. Moreover, the course aims to provide the students with adequate information regarding manufacturing techniques of topical dosage forms; preparation of makeup and skincare products.
Prerequisiti/Required background knowledge
Basic knowledge of chemistry, human anatomy and physiology of skin; fundamentals of medicinal chemistry and pharmacology.
Basic knowledge of chemistry, human anatomy and physiology of skin; fundamentals of medicinal chemistry and pharmacology.
Metodi didattici/Teaching methods
The course makes use of seminars, lectures and lab practicals.
The course makes use of seminars, lectures and lab practicals.
Altre informazioni/Further information
The frequency of the lessons – both frontal and preparatory to the laboratory – and the practical laboratory exercises are mandatory and certified by the teachers. It is not allowed to record, video-record and photograph the lessons – both frontal and preparatory to the laboratory. Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities. Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
The frequency of the lessons – both frontal and preparatory to the laboratory – and the practical laboratory exercises are mandatory and certified by the teachers. It is not allowed to record, video-record and photograph the lessons – both frontal and preparatory to the laboratory. Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities. Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
The exam relating to the pharmaceutical formulation will cover the topics delivered in seminars. The written test will consist of multiple choice: true/false type questions are the most frequent types of questions. 1 point for the correct answer, 0 points for wrong or blank answers. The exam relating to the cosmetic formulation will take place during the laboratory in the form of multiple choice questions (relating to the lectures) and the performance of the students during the practical part of the course. Both tests aim to verify the knowledge and ability of the students to apply in an independent way the knowledge acquired. Moreover, the communication skills of the students will be evaluated, particularly the use of specific language for the technological discipline. During the practical laboratory, the ability to apply the knowledge acquired will be evaluated, considering the accurate presentation of the topical preparation. The evaluation will consider the learning abilities of the students, in particular the ability to deal with formulative challenges in the field of topical preparations. The exam will take place during the official dates, and the grade will be expressed in thirtieths, as the average mark obtained for each part of the course.
The exam relating to the pharmaceutical formulation will cover the topics delivered in seminars. The written test will consist of multiple choice: true/false type questions are the most frequent types of questions. 1 point for the correct answer, 0 points for wrong or blank answers. The exam relating to the cosmetic formulation will take place during the laboratory in the form of multiple choice questions (relating to the lectures) and the performance of the students during the practical part of the course. Both tests aim to verify the knowledge and ability of the students to apply in an independent way the knowledge acquired. Moreover, the communication skills of the students will be evaluated, particularly the use of specific language for the technological discipline. During the practical laboratory, the ability to apply the knowledge acquired will be evaluated, considering the accurate presentation of the topical preparation. The evaluation will consider the learning abilities of the students, in particular the ability to deal with formulative challenges in the field of topical preparations. The exam will take place during the official dates, and the grade will be expressed in thirtieths, as the average mark obtained for each part of the course.
Programma esteso/Content
•Introduction: Dosage forms. Factors affecting the absorption of the drug substance from different administration routes. •Liquid and dispersed systems for topical intent: types (solutions, colloids, suspensions, emulsions), properties, stability, excipients, pharmaceutical applications, requirements. •Semisolid preparations: rational approach to drug delivery to and via the skin; physical-chemical and biological factors affecting drug penetration, percutaneous permeation and absorption. Principles of rheology, excipients. Dermatological formulations: gels, ointments, creams, pastes, patches and sunscreens. Transdermal therapeutic systems. •Cosmetic formulations: skin care, hair care and sun care formulations; decorative products. •The techniques for the formulation of cosmetic and dermatological products.
•Introduction: Dosage forms. Factors affecting the absorption of the drug substance from different administration routes. •Liquid and dispersed systems for topical intent: types (solutions, colloids, suspensions, emulsions), properties, stability, excipients, pharmaceutical applications, requirements. •Semisolid preparations: rational approach to drug delivery to and via the skin; physical-chemical and biological factors affecting drug penetration, percutaneous permeation and absorption. Principles of rheology, excipients. Dermatological formulations: gels, ointments, creams, pastes, patches and sunscreens. Transdermal therapeutic systems. •Cosmetic formulations: skin care, hair care and sun care formulations; decorative products. •The techniques for the formulation of cosmetic and dermatological products.
Risultati di apprendimento attesi/Intended learning objectives
At the end of the course, students will be required to know the main technological characteristics of the excipients used in topical forms, both dermatological and cosmetic. The student will be able to formulate topical preparations based on synthetic and natural bioactive compounds.
At the end of the course, students will be required to know the main technological characteristics of the excipients used in topical forms, both dermatological and cosmetic. The student will be able to formulate topical preparations based on synthetic and natural bioactive compounds.
×
Stampa
Insegnamento
Regulations of cosmetics, drugs and medical devices
Codice
FA0516
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
MOREL Silvia
Docenti
Morel Silvia
CFU
3.0
Ore di lezione
18.0
Ore di studio individuale
57.0
Settore Scientifico Disciplinare (SSD)
CHIM/09 - FARMACEUTICO TECNOLOGICO APPLICATIVO
Tipo di insegnamento
Attività formativa monodisciplinare
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
V
Lingua insegnamento/Teaching language
Lingua Inglese
English language
Contenuti/Content Summary
Questo corso riguarda le principali problematiche relative alla normativa e alla distinzione tra il mondo farmaceutico, quello dei dispositivi medici e quello cosmetico, in Europa
This course focuses on the main issues regarding regulations and the distinction between the pharmaceutical, the medical device and the cosmetic world, in Europe.
Testi di riferimento/Textbooks
Appunti e dispense distribuiti durante i seminari, siti web delle agenzie regolatorie o degli organi legislativi (e.g. www.ema.europa.eu; www.fda.gov; www.ich.gov).
Notes and handouts distributed during seminars, websites of the regulatory agencies or of the legislative bodies (e.g., www.ema.europa.eu; www.fda.gov; www.ich.gov).
Obiettivi formativi/Mission
L'obiettivo del corso è quello di fornire una panoramica sui requisiti dei cosmetici, dei dispositivi medici e dei medicinali per entrare nei mercati nazionali o globali, evidenziando le forti differenze che li caratterizzano.
The aim of the course is to give an overview of the requirements for cosmetics, medical devices and medicinal products to enter national or global markets and to highlight the strong differences between them.
Prerequisiti/Required background knowledge
Nessuno
None
Metodi didattici/Teaching methods
Seminari
Seminars
Altre informazioni/Further information
Le studentesse e gli studenti con disabilità o con Disturbi Specifici dell’Apprendimento (DSA) o con Bisogni Educativi Speciali (BES) possono richiedere servizi e strumenti specifici a loro dedicati rivolgendosi allo Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti e consultando la pagina dedicata del sito di Ateneo: https://uniupo.it/it/servizi/servizi-studenti-disabili-e-dsa. Le studentesse e gli studenti con disabilità, DSA, BES, una volta preso contatto con lo Staff di Ateneo, possono contattare la/il docente titolare dell'insegnamento in relazione alla declinazione delle modalità di esame, in merito agli aspetti didattici.
Students with physical disabilities, Learning Disabilities (LD) or Special Education Needs (SEN) can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities. Students with disabilities, LD or SEN, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
L'esame si compone di due parti (a) e (b), ciascuna parte concorre al voto finale per il 50%: (a) un questionario a risposta multipla di 30 domande che riguarderà le lezioni, i seminari e il materiale di lettura. Si otterrà un punto per ogni risposta corretta, mentre le risposte errate o nulle saranno valutate 0 punti; l’esame sarà cartaceo; (b) un elaborato che valuterà la capacità degli studenti di applicare le conoscenze generali fornite nei seminari ai loro domini regionali. In breve, agli studenti verrà chiesto di descrivere il quadro normativo nel proprio Paese relativo ai cosmetici, ai dispositivi medici o ai medicinali seguendo uno schema fornito dal docente. Ogni studente può adattare il contenuto dell'elaborato alla situazione specifica del proprio Paese. Gli studenti dei paesi extra-UE dovrebbero descrivere il processo che porta all'approvazione dei medicinali, le caratteristiche della loro agenzia regolatoria o le normative che regolano l'ingresso dei cosmetici o dei dispositivi medici sul mercato. Gli studenti europei dovrebbero descrivere come vengono valutati i medicinali nel proprio paese dopo l'approvazione dell'EMA, come rimborsati dai sistemi sanitari, dalle assicurazioni o dai privati. Se lo desiderano, possono anche scegliere un determinato prodotto cosmetico o un dispositivo medico e descrivere le peculiarità di quel prodotto rispetto all'intero regolamento cosmetico o dei dispositivi, ma il documento non deve riguardare il regolamento europeo generale. La valutazione verrà effettuata sulla qualità delle informazioni, sulla bibliografia, sulla capacità di rispondere allo schema fornito e sul risultato del Turnitin. È richiesto il report Turnitin. Verrà fatta la media dei due voti.
The exam is composed of two parts, each worth 50% of the final mark: (a) 30 multiple-choice questions that will cover lectures, seminars and reading material. One point will be obtained for the correct answer, whereas wrong or blank answers will be evaluated 0 points; the exam will be on paper; (b) a paper that will evaluate the students’ ability to apply the general knowledge shared at lectures and seminars in their own regional domains. Utilizing a specific format, students will briefly describe the regulatory framework in their own country related to cosmetics, medical devices or medicinal products. Each student may adapt the content of the paper to the specific situation of the country. Partner country extra-UE students should describe the process that leads to medicinal product approval, the characteristics of their regulatory agency and framework, or the regulations that govern the entrance of cosmetics or medical devices on the market. European students should describe how medicinal products are evaluated in their own country after EMA approval, as reimbursed by health systems, by insurances or by private citizens. If they wish, they may also choose a particular cosmetic product or medical device and describe the peculiarities of that product compared to the entire cosmetic or medical devices regulation, but the paper should not cover the general European cosmetic or medical devices regulation. Evaluation will be done on quality of the information, on references, on ability to answer at scheme provided, and on Turnitin report. Turnitin report is mandatory. The two scores will be averaged.
Programma esteso/Content
Legislazione cosmetica - Principi generali che regolano la normativa cosmetica e differenze sostanziali rispetto a quelle farmaceutiche e dei dispositivi medici - Breve introduzione alla legislazione dell'UE - La sicurezza del consumatore: un pilastro della legislazione cosmetica dalla Direttiva 76/768/CEE al Regolamento 1223/2009 - Definizione di prodotto cosmetico e prodotti borderline - Ruoli e responsabilità lungo la filiera - Principali meccanismi normativi per affrontare la sicurezza dei consumatori: sostanze vietate, soggette a restrizioni e autorizzate; sostanze CMR; nanomateriali; tracce di sostanze proibite; fascicolo informativo sul prodotto, valutazione della sicurezza del prodotto cosmetico, valutatore della sicurezza; etichettatura dei prodotti cosmetici; · il portale di notifica (CPNP) e la notifica dei prodotti cosmetici; · le dichiarazioni sui prodotti cosmetici e regolamento 655/2013 su criteri comuni · le strategie globali per accedere al mercato e casi studio; · L'impatto delle normative chimiche EU, REACH e CLP, sulla disciplina degli ingredienti cosmetici. Normativa sui dispositivi medici Sistema di gestione del rischio: - Qualità e conformità - UNI-EN ISO 13485:2016 - Sistema di gestione del rischio Classificazione dei dispositivi medici: - Cos'è un dispositivo medico? - Nuovo Regolamento UE - Caratteristiche dei dispositivi medici - Classificazione dei dispositivi medici - Organismi notificati Entrambe le sessioni hanno una parte teorica e una pratica. Legislazione farmaceutica · Principali pilastri su cui si basa l'approvazione dei medicinali e i principali organismi di regolamentazione · L'importanza delle questioni normative per il successo dei medicinali sul mercato, differenze tra approvazione e accesso · Panoramica dei percorsi normativi e delle differenze più importanti nei paesi ICH e non ICH · Progettare strategie di regolamentazione appropriate · Panoramica generale sulle normative GLP, GCP e GMP · Il ciclo di vita del medicinale dal punto di vista normativo · Casi studio
Cosmetic regulation · General principles that govern cosmetic regulation and substantial differences compared to pharmaceutical and medical devices regulations · Short introduction on EU legislation · The safety of consumer: a pillar of cosmetic legislation from the Directive 76/768/EEC to the Regulation 1223/2009 · Definition of cosmetic product and borderline products · Roles and responsibilities along the supply chain · Main regulatory mechanisms to address consumer safety: prohibited, restricted and authorized substances, special rules for CMR substances, nanomaterials, traces of prohibited substances, product information file, cosmetic product safety assessment, safety assessor, labelling of cosmetic products · Cosmetic Products Notification Portal (CPNP) and notification of cosmetic products · Cosmetic products claims and regulation 655/2013 on common criteria · Global strategies to access the market and case studies · The impact of EU chemical legislations, REACH and CLP, on the discipline of cosmetic ingredients Medical device regulation Risk Management System: - Quality and Compliance - UNE-EN ISO 13485:2016 - Risk Management System Classification of the medical devices: - What is a medical device? - New EU Regulation - Characteristics of the medical devices - Classification of medical devices - Notified bodies. Both sessions have a theoretical and a practical part. Pharmaceutical regulation · Main pillars on which drug approval is based and main regulatory bodies · The importance of regulatory affairs for successful medicinal products on the market, differences between approval and access · Overview of the most important regulatory pathways and differences in ICH and non-ICH countries · Designing appropriate regulatory strategies · General overview on GLP, GCP and GMP regulations · The medicinal product life cycle from a regulatory perspective · Case studies
Risultati di apprendimento attesi/Intended learning objectives
Le studentesse e gli studenti dovrebbero essere in grado di: · orientarsi attraverso linee guida, regolamenti e leggi per progettare strategie adeguate per i prodotti cosmetici, i dispositivi medici e i medicinali; · essere consapevoli della presenza di linee guida per attività particolari.
Students should be able to: · Navigate through guidelines, regulations and laws to design adequate strategies for cosmetics, medical devices and medicinal products; · Should be aware of the presence of guidelines for particular activities.
×
Stampa
Insegnamento
Organic chemistry: theory and practice
Codice
FA0519
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
PIRALI Tracey
Docenti
Minassi Alberto, Galli Ubaldina, Pirali Tracey
CFU
6.0
Ore di lezione
24.0
Ore di studio individuale
0.0
Settore Scientifico Disciplinare (SSD)
CHIM/06 - CHIMICA ORGANICA, CHIM/08 - CHIMICA FARMACEUTICA
Tipo di insegnamento
Attività formativa integrata
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
V
Lingua insegnamento/Teaching language
English
Contenuti/Content Summary
The students are introduced to the main functional groups and heterocycles, their electronic properties and reactivity. Selected examples of synthetic routes to pharmaceutical and cosmetic compounds are illustrated. The theoretical knowledge is applied in the laboratory by setting up a set of reactions and purifying the corresponding products. The synthesis leads to the preparation of a dermatological API that will be then formulated during the formulation laboratory in the second semester.
Testi di riferimento/Textbooks
Practical Organic Synthesis: A student’s guide; R. Keese, M. P. Brandle, T. P. Toube; Wiley. Advanced Practical Organic chemistry, J. Leonard, B. Lygo, G. Procter Organic Chemistry; Smith J.G.; McGraw Hill
Obiettivi formativi/Mission
The course aims at providing students with adequate theoretical and practical information for organic synthesis.
Prerequisiti/Required background knowledge
Basic knowledge of organic chemistry.
Metodi didattici/Teaching methods
The course makes use of lectures, exercises and laboratory activities.
Altre informazioni/Further information
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities. Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
The exam mark will be the average mark obtained for each module: Theory: The students will be divided in groups and each group will have to present two projects in the form of a Powerpoint presentation: one relating to an organic chemistry topic and one relating to the analysis of a synthetic strategy of a product for pharmaceutical and/or cosmetic use. Each project will be assigned a maximum score of 15 points Practice: (i) The written test covers the material delivered in lectures and seminars and is made of multiple-choice questions (20) and an exercise (6). Maximum score: 26 For multiple choice questions, 1 point will be obtained for the correct answer, whereas wrong or blank answers will be evaluated 0 points. The laboratory evaluation considers the commitment, the performance of the student in the laboratory, and the lab notebook writing. Maximum score: 6.
Programma esteso/Content
Theory: - Main functional groups and their reactivity - Methods for functional groups interconversion Practice: - The main safety principles - The main techniques used for the synthesis and purification of organic compounds (reaction setup, product isolation and purification) During the laboratory, the performed synthesis will lead to the preparation of a dermatological API that will be then formulated during the formulation laboratory in the second semester.
Risultati di apprendimento attesi/Intended learning objectives
At the end of the course, the student will be able to: - Recognize the main functional groups and predict their reactivity - Interconvert the main functional groups by using classical organic methods - Set up a reaction starting from a procedure taken from the literature, monitor it and purify the product
Moduli
Codice Insegnamento Settore Scientifico Disciplinare (SSD) Docenti Agenda web
FA0517Organic chemistry: Theory CHIM/06 - CHIMICA ORGANICA Minassi Alberto Non disponibile
FA0518Organic chemistry: Practice CHIM/08 - CHIMICA FARMACEUTICA Galli Ubaldina, Pirali Tracey Non disponibile
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Organic chemistry: theory and practice: Organic chemistry: Theory
Codice
FA0517
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
MINASSI Alberto
Docenti
Minassi Alberto
CFU
2.0
Ore di lezione
12.0
Ore di studio individuale
38.0
Settore Scientifico Disciplinare (SSD)
CHIM/06 - CHIMICA ORGANICA
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
G
Lingua insegnamento/Teaching language
INGLESE
English
Contenuti/Content Summary
The students are introduced to the main functional groups and heterocycles, their electronic properties and reactivity. Selected examples of synthetic routes to pharmaceutical and cosmetic compounds are illustrated.
Testi di riferimento/Textbooks
Organic Chemistry; Smith J.G.; McGraw Hill
Obiettivi formativi/Mission
The course aims at providing students with adequate theoretical information for organic synthesis.
Prerequisiti/Required background knowledge
Basic knowledge of organic chemistry.
Metodi didattici/Teaching methods
The course makes use of lectures, exercises and laboratory activities.
Altre informazioni/Further information
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities. Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
The exam mark will be the average mark obtained for each module: Theory: The students will be divided in groups and each group will have to present two projects in the form of a Powerpoint presentation: one relating to an organic chemistry topic and one relating to the analysis of a synthetic strategy of a product for pharmaceutical and/or cosmetic use. Each project will be assigned a maximum score of 15 points Practice: (i) The written test covers the material delivered in lectures and seminars and is made of multiple-choice questions (20) and an exercise (6). Maximum score: 26 For multiple choice questions, 1 point will be obtained for the correct answer, whereas wrong or blank answers will be evaluated 0 points. The laboratory evaluation considers the commitment, the performance of the student in the laboratory, and the lab notebook writing. Maximum score: 6.
Programma esteso/Content
- Main functional groups and their reactivity - Methods for functional groups interconversion
Risultati di apprendimento attesi/Intended learning objectives
At the end of the course, the student will be able to: - Recognize the main functional groups and predict their reactivity - Interconvert the main functional groups by using classical organic methods
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Organic chemistry: theory and practice: Organic chemistry: Practice
Codice
FA0518
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
PIRALI Tracey
Docenti
Galli Ubaldina, Pirali Tracey
CFU
4.0
Ore di lezione
12.0
Ore di studio individuale
64.0
Settore Scientifico Disciplinare (SSD)
CHIM/08 - CHIMICA FARMACEUTICA
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
G
Lingua insegnamento/Teaching language
INGLESE
English
Contenuti/Content Summary
The course addresses the main techniques to synthesize and purify organic compounds. These concepts are applied in the laboratory by setting up a set of reactions and purifying the corresponding products.
Testi di riferimento/Textbooks
Practical Organic Synthesis: A student’s guide; R. Keese, M. P. Brandle, T. P. Toube; Wiley. Advanced Practical Organic chemistry, J. Leonard, B. Lygo, G. Procter
Obiettivi formativi/Mission
The course aims at providing students with adequate practical information for organic synthesis.
Prerequisiti/Required background knowledge
Basic knowledge of organic chemistry.
Metodi didattici/Teaching methods
The course makes use of lectures, exercises and laboratory activities.
Altre informazioni/Further information
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities. Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
The exam mark will be the average mark obtained for each module: Theory: The students will be divided in groups and each group will have to present two projects in the form of a Powerpoint presentation: one relating to an organic chemistry topic and one relating to the analysis of a synthetic strategy of a product for pharmaceutical and/or cosmetic use. Each project will be assigned a maximum score of 15 points Practice: (i) The written test covers the material delivered in lectures and seminars and is made of multiple-choice questions (20) and an exercise (6). Maximum score: 26 For multiple choice questions, 1 point will be obtained for the correct answer, whereas wrong or blank answers will be evaluated 0 points. The laboratory evaluation considers the commitment, the performance of the student in the laboratory, and the lab notebook writing. Maximum score: 6.
Programma esteso/Content
- The main safety principles - The main techniques used for the synthesis and purification of organic compounds (reaction setup, product isolation and purification) During the laboratory, the performed synthesis will lead to the preparation of a dermatological API that will be then formulated during the formulation laboratory in the second semester.
Risultati di apprendimento attesi/Intended learning objectives
At the end of the course, the student will be able to set up a reaction starting from a procedure taken from the literature, monitor it and purify the product
×
Stampa
Insegnamento
Analysis for quality control
Codice
FA0532
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
APRILE SILVIO
Docenti
Del Grosso Erika, Aprile Silvio
CFU
3.0
Ore di lezione
12.0
Ore di studio individuale
51.0
Settore Scientifico Disciplinare (SSD)
CHIM/08 - CHIMICA FARMACEUTICA
Tipo di insegnamento
Attività formativa monodisciplinare
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
V
Lingua insegnamento/Teaching language
INGLESE
ENGLISH
Contenuti/Content Summary
The course will cover the key aspects of quality assurance of cosmetic and dermatological products: quality assessment during product development (Quality by Design approach); implementation of stability tests of active pharmaceutical ingredients (API) and finished products according to international regulatory guidelines (ICH); principles of qualitative and quantitative analysis for determining the identity and purity of APIs and their potency in the finished products.
Testi di riferimento/Textbooks
Students will be provided with the slides projected during lessons. Original scientific articles, useful for understanding the topics covered during the course, will also be provided.
Obiettivi formativi/Mission
Quality control (QC) of pharmaceuticals involves a series of rigorous processes and testing procedures to ensure that products meet specified standards and regulatory requirements. By attending the course, the student will be able to manage the theoretical and practical aspects of quality control in pharmaceutical products from the raw materials to the finished product and the most common analytical techniques involved.
Metodi didattici/Teaching methods
Frontal lessons and discussion of case studies. Laboratory activities.
Altre informazioni/Further information
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
Written test covering the material delivered in the lessons and seminar (true/false questions and open questions) + evaluation of the QC laboratory report.
Programma esteso/Content
• Pharmaceutical Quality System and implementation of Quality by Design: an overview; • Drug stability testing: regulatory guidance (ICH) and accepted industry practices; • Validation of analytical procedures; • Discussion of case studies: development and validation of a stability indicating HPLC method for stability testing of topical formulations; • Training to Quality Control Laboratory; • Seminar hold by an external teacher “Quality Assurance and Good Manufacturing Practices for Cosmetic industry”
Risultati di apprendimento attesi/Intended learning objectives
At the end of the course, which also includes laboratory activities, the student will have knowledge of the key aspects of quality assurance of cosmetic and dermatological products. They will also have knowledge of the analytical procedures used to determine the purity of the active pharmaceutical ingredients and their potency in the corresponding formulations. Furthermore, the student will be able to calculate, interpret and evaluate the analytical data obtained.
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Stampa
Insegnamento
Natural products and sustainability in R&D
Codice
FA0533
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
POLLASTRO Federica
Docenti
Pollastro Federica
CFU
6.0
Ore di lezione
24.0
Ore di studio individuale
102.0
Settore Scientifico Disciplinare (SSD)
BIO/15 - BIOLOGIA FARMACEUTICA
Tipo di insegnamento
Attività formativa monodisciplinare
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
V
Lingua insegnamento/Teaching language
INGLESE
English
Contenuti/Content Summary
Approach to natural active pronciples for cosmetic and dermatological use considering the advantages and disadvantages of natural compounds application as pure entities or as a phytocomplex. Classes of primary and secondary metabolites with their chemical and physiscal characteristics and different applications. From classic to modern techniques of extraction and evaporation applied to vegetable material. Classic and modern techniques applied for isolation and analysis of natural compounds.
Testi di riferimento/Textbooks
Power point slides containe all the scientific references. Book: Trease and Evans: Pharmacognosy – Elsevier; Richard J. P. Cannell: Natural Products Isolation – Springer. Book: Janes and Glavac: Modern Cosmetics - Ingredient of natural origin
Obiettivi formativi/Mission
Students will learn what a primary and secondary metabolite are and why plants produce them. They will learn and recognize classifications of natural compounds and the possibilities of interactions with our biology. They will understand important functional groups leading to precise biological effects and new biological aspects. Students will also learn different purification technologies that allow to obtain pure compounds, how to choose the best one, and how to scale up a method from the laboratory to an industrial setting. After that, students will be able to choose the best technique for the isolation of a pure active ingredient or the analysis required for the quality control and/or stability.
Prerequisiti/Required background knowledge
Organic chemistry, biology and pharmacology.
Metodi didattici/Teaching methods
Lectures with computer and video supporting: projection of powerpoint slides. Interactive lectures with discussion. Vegetable samples, extracts, different oils, essential oils and pure compounds will be shown to be touched, smelled and compared to demonstrate practically the physical, chemical and olfactory differences.
Altre informazioni/Further information
Required frequency: 75%. The attendance will be monitored in the classroom. Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
A written exam evaluating the knowledge, notions and processes acquired during the lectures. The test includes: a) 3 open questions with answers of 100-150 words maximum, 6 points each. 60% of the final grade. b) 10 multiple choice questions with one true answer, 3 points each. Correct answer gives 1.2 point. All other possibilities is 0 point. There will be no negative grades. 40% of the final grade. The overall grade will be the sum of the two parts.
Programma esteso/Content
What is a natural product? Phytocomplex and the entourage effect. Primary and secondary metabolites: definition, roles and classification. Pure natural compound and phytocomplex: advantage and disadvantage. Primary metabolites: oils, butters, waxes. Stability and characteristics. Classification and characteristics of secondary metabolites: – alkaloids: biosynthesis and isolation, a matter of basicity – isoprenoids: from essential oil composition to chemestetic properties of functional groups, how to recognize, how to apply them (TRPV3, TRPA1, TRPV1, hTAS2R) – meroterpenoids and TRPV1 – phenyl propanoids and polyketides Drying process. Solvents: differences in polarity and application. NADES. Extraction process: classic techniques as maceration, percolation, infusion and decoction, distillation, cold expression. Modern techniques: ASE, MWE, sonication, SFE, electroporation, enzymatic extraction. Rotavapor, wiped film distillation, sray drying. Isolation techniques with stationary phases: differences and how to choose the appropriate one. HPLC, FLASH chromatography and GC. Definition and application. Other processes: distillation, liquid-liquid partition, avoiding of fatty acids and waxes. Every aspect of the program is supported by examples of natural compounds and ther application in the dermatological/cosmetic field.
Risultati di apprendimento attesi/Intended learning objectives
Students should be able to recognize different classes of primary and secondary metabolites and their physical, chemical characteristics and behaviors. They should also be able to plan extraction and isolation strategies. All the principles and techniques learnt during the course will be put in practice during the laboratory included in the course.
×
Stampa
Insegnamento
Statistics, data analysis and epidemiology
Codice
FA0514
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
RINALDI Maurizio
Docenti
Rinaldi Maurizio, Barone Adesi Francesco, Scotti Lorenza
CFU
5.0
Ore di lezione
24.0
Ore di studio individuale
0.0
Settore Scientifico Disciplinare (SSD)
MAT/04 - MATEMATICHE COMPLEMENTARI, MED/42 - IGIENE GENERALE E APPLICATA, BIO/14 - FARMACOLOGIA
Tipo di insegnamento
Attività formativa integrata
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
V
Lingua insegnamento/Teaching language
Inglese
English
Contenuti/Content Summary
Statistics: basic statistical knowledge, including random variables, descriptive statistics, probability, distributions and statistical inference. Working with data: use of the R software for statistical analysis and graphics. Epidemiology: epidemiological methods in public health; epidemiological study designs (clinical trials, cohort studies, case control, transversal and descriptive studies); sources of uncertainty (role of chance, bias and confounding). Systematic reviews and meta-analysis: protocol writing, meta-analysis and risk of bias assessment.
Testi di riferimento/Textbooks
OpenIntro Statistics https://www.openintro.org/book/os/ Kenneth J. Rothman. Epidemiology: an introduction. Oxford University Press. Students will have access to lecture slides and supplementary materials, including scientific publications.
Obiettivi formativi/Mission
The course aims to provide: –        basic concepts in statistics and epidemiology; –        the know-how to perform and interpret systematic reviews and meta-analyses.
Prerequisiti/Required background knowledge
Basic mathematics
Metodi didattici/Teaching methods
Lectures, R computer labs and hands-on practicals.
Altre informazioni/Further information
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.
Modalità di verifica dell'apprendimento/Assessment methods
An online examination accounting for the 75% of the total grade to be carried out on the exam day and will be delivered through DIR. This in turn will be subdivided in: – a set of multiple-choice/answer questions (2/3 of the points) in the theoretical contents of the course. – a set of exercises involving statistical analyses/procedures (1/3 of the points). A written essay to be done at home assigned by the lecturer of the module entitled “Systematic review and meta-analysis” (25% of the final mark). Each student will be asked to write the protocol of a systematic review, followed by a meta-analysis, on a topic of his/her choice. The essay must be delivered approximately 15 days before the exam day (the exact deadline for submitting the essay will be communicated during the course).
Programma esteso/Content
Statistics: Basic elements of descriptive statistics. Single variable summary statistics (mean, and other statistical indicators) and graphics (histograms and boxplots). Double variable and regression models. Probability and discrete random variables Continuous random variables. The gaussian. Area under the normal distribution. Standardization. Confidence intervals. The Student t-distribution Statistical hypothesis testing. The t-test. 2 sample t-test.The p-value. One sided and two sided alternative hypothesis. Chi square test ANOVA Introduction to R. Import data from excel to R. Plots in base R and using the R package ggplot2. Data simulation. Statistics with R. Epidemiology: Definition of epidemiology. Measures of occurrence and association. Main Epidemiological studies: clinical trials, cohort studies, case-control studies, cross-sectional studies, descriptive studies. Sources of uncertainty in epidemiology: the role of chance, bias and confounding. Systematic review and meta-analysis: refine research question, protocol writing and registration, meta-synthesis of qualitative data, meta-analysis techniques, the risk of bias assessment. In addition to the theoretical knowledge, students will gain practical experience by designing a systematic review and meta-analysis, including writing a protocol on a pre-assigned topic.
Risultati di apprendimento attesi/Intended learning objectives
The students will be able to: –        determine the appropriate statistical procedures for specified data sets and independently perform statistical analysis of biological data; –        understand and interpret epidemiological studies; –        critically interpret and design a systematic reviews and meta-analysis.
Moduli
Codice Insegnamento Settore Scientifico Disciplinare (SSD) Docenti Agenda web
FA0511Statistics MAT/04 - MATEMATICHE COMPLEMENTARI Rinaldi Maurizio Non disponibile
FA0512Epidemiology MED/42 - IGIENE GENERALE E APPLICATA Barone Adesi Francesco Non disponibile
FA0513Data analysis BIO/14 - FARMACOLOGIA Scotti Lorenza Non disponibile
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Statistics, data analysis and epidemiology: Statistics
Codice
FA0511
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
RINALDI Maurizio
Docenti
Rinaldi Maurizio
CFU
3.0
Ore di lezione
12.0
Ore di studio individuale
51.0
Settore Scientifico Disciplinare (SSD)
MAT/04 - MATEMATICHE COMPLEMENTARI
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
G
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Statistics, data analysis and epidemiology: Epidemiology
Codice
FA0512
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
BARONE ADESI Francesco
Docenti
Barone Adesi Francesco
CFU
1.0
Ore di lezione
6.0
Ore di studio individuale
19.0
Settore Scientifico Disciplinare (SSD)
MED/42 - IGIENE GENERALE E APPLICATA
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
G
Mostra scheda insegnamento padre
×
Stampa
Insegnamento
Statistics, data analysis and epidemiology: Data analysis
Codice
FA0513
Anno Accademico
2025/2026
Anno regolamento
2025/2026
Corso di studio
European Master of Science in Skin Health and Care
Curriculum
Generico
Responsabile didattico
Scotti Lorenza
Docenti
Scotti Lorenza
CFU
1.0
Ore di lezione
6.0
Ore di studio individuale
19.0
Settore Scientifico Disciplinare (SSD)
BIO/14 - FARMACOLOGIA
Tipo di insegnamento
Modulo di sola Frequenza
Fruizione insegnamento
OBB
Anno
1
Periodo
Annuale
Frequenza obbligatoria
1
Tipo di valutazione
V
Stampa guida
Stampa
Anno Codice Insegnamento Docenti Settore Scientifico Disciplinare (SSD) Curriculum Sede CFU
1 FA0532 Analysis for quality control Del Grosso Erika, Aprile Silvio CHIM/08 Tutti 3.0
1 FA0507 Anatomy and physiology of skin and appendages Lim Dmitry, Bosetti Michela BIO/09, BIO/16 Tutti NOVARA 4.0
1 FA0531 Dermatology Zavattaro Elisa MED/35 Tutti 5.0
1 FA0526 Medicinal Chemistry and pharmacology of dermatological drugs Pirali Tracey, Chiazza Fausto CHIM/08, BIO/14 Tutti 5.0
1 FA0533 Natural products and sustainability in R&D Pollastro Federica BIO/15 Tutti 6.0
1 FA0519 Organic chemistry: theory and practice Minassi Alberto, Galli Ubaldina, Pirali Tracey CHIM/06, CHIM/08 Tutti 6.0
1 FA0510 Pathological mechanisms of skin disorders Porta Chiara, Fracchia Letizia MED/04, BIO/19 Tutti 5.0
1 FA0530 Principles of formulation Hanno Ibrahim, Giovannelli Lorella CHIM/09 Tutti 6.0
1 FA0529 Protein Science and molecular modelling Miggiano Riccardo, Massarotti Alberto BIO/10, CHIM/08 Tutti 5.0
1 FA0516 Regulations of cosmetics, drugs and medical devices Morel Silvia CHIM/09 Tutti 3.0
1 FA0514 Statistics, data analysis and epidemiology Rinaldi Maurizio, Barone Adesi Francesco, Scotti Lorenza MAT/04, MED/42, BIO/14 Tutti 5.0
1 FA0515 Understanding R&D Grilli Mariagrazia BIO/14 Tutti 2.0
1 FA0520 Value assessment and market access Jommi Claudio, Genazzani Armando SECS-P/07, BIO/14 Tutti 3.0
1 FA0523 Workshop: “An introduction to the markets of cosmetic products, dermatological drugs and medical devices” Pollastro Federica, Pirali Tracey BIO/15, CHIM/08 Tutti 2.0
Dati aggiornati al: 16/07/2026, 04:25