Ateneo - UPO

Principles of pharmacology and toxicology: kynetic and dynamic.
Toxic effects and mechanism, molecular targets.
Carbon monoxide and methaemoglobin.
Mushroom poisoning
Toxicity of nervous system.
Drug abuse
Prion diseases
Doping

Suggested books:
• Farmacologia generale e molecolare. Clementi & Fumagalli, IV Ed, UTET
• Elementi di tossicologia, Lu Frank C. - Kacew Sam, Ed EMSI

Students should acquire a good background of parmacology and toxicology to understand the mechanisms of toxicological effects induced by different
drugs and environmental xenobiotics

Students are required to have a good preparation in biochemistry, physiology, anatomy and pathology

Lectures with power point presentation

The student is required a good level of knowledge of English, especially in reading.
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities
Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.

Oral test

-Introduction to pharmacology and toxicology
Pharmacodynamic: receptors and signal transduction; meaning of agonist and antagonist; the dose-response curve;
-Pharmacokinetic: absorbtion, distribution, metabolism and excretion of xenobiotics; meaning of half life, bioavailability, clearance and distribution volume
- Toxicity of monoxide carbon, methemoglobin
Toxicity of NSAID
Toxicity of nervous system: glutammatergic system, GABAergic system and colinergic system.
Drug abuse: opioids, barbiturates and benzodiazepines,psicostimulants, cannabinoids, ethanol.
Prion diseases
Doping.
Integration of the gender dimension: where of interest, attention will be paid to gender pharmacology

According to the Dublin descriptors D1- KNOWLEDGE AND UNDERSTANDING: The student will know and understand the basic notions of general pharmacology and the pharmaco-toxicological characteristics of substances of abuse and of different classes of drugs. D2- ABILITY TO APPLY KNOWLEDGE AND UNDERSTANDING: The student will acquire the ability to use the theoretical knowledge imparted in class to reason critically, demonstrating that they are able to make connections between the different topics and to apply the knowledge acquired in the context of clinical analyses of different drugs or toxic substances. D3- JUDGMENT ABILITY: The student will acquire the ability to critically examine the theoretical notions acquired and to be able to independently argue the problems arising from their practical application. D4-COMMUNICATION SKILLS: The student will acquire the ability to disseminate the knowledge assimilated using a specific and appropriate vocabulary in order to be able to compare themselves in a professional and competent manner in the academic and subsequently working environment. D5-LEARNING SKILLS: The student will acquire a learning ability useful for continuous and constant updating regarding the procedures to be performed in the context of a clinical analysis laboratory