Ateneo - UPO

PHARMACOLOGY: Preclinical and clinical development of drugs. Principles of pharmacokinetics and pharmacodynamics. Main classes of drugs. Originator drug concept, generic drug, biosimilar medication. Main classes of drugs.

PHARMACOLOGY
Beside updated publications, the following books are suggested:
1. HP Rang and MM Dale – Farmacologia, Casa Ed Ambrosiana
2. Goodman & Gilman – Le basi farmacologiche della terapia di J.G.Hardman, L.E. Limbird, A.Goodman Gilman, Curatore edizione italiana: C.Sirtori, G.Folco, G.Franceschini, S.Govoni.
3. Farmacologia generale e molecolare, a cura di F.Clementi, G.Fumagalli, Ed UTET
John Wiley & Sons Inc

PHARMACOLOGY. In the context of this Integrated Course, the module of Pharmacology will give to students the basis of pharmacokinetic and pharmacodynamic principles, the general concepts of “conventional small molecules” and biological/biotechnological drugs along with the most important pharmacological differences and their pre-clinical and clinical development. Moreover, the course will provide detailed information about selected drug classes

Students are required to have a good preparation in biochemistry, physiology, anatomy and pathology

Lectures

Students are required to have a good knowledge of English, especially in reading.
Students with physical disabilities, Learning Disabilities or Special Education Needs can request specific services and tools via the Staff Sviluppo e Coordinamento Carriere e Servizi alle Studentesse e agli Studenti, consulting the University webpage: https://www.uniupo.it/en/services/services-students-physical-or-learning-disabilities
Students with disabilities, learning disabilities or special education needs, once they have contacted the University Staff, can refer to the tutor in charge of the course to define the examination modalities, concerning academic aspects.

Written exam with 35 multiple choice questions.
The exam is considered passed if half plus one question is answered.

Introduction to pharmacology
- Discovery and development of a new drug: pre-clinical and clinical phases
- The main principles of drugs, conventional small molecules, biological/biotechnological drugs, equivalent and biosimilar drugs
-Pharmacodynamic: receptors and signal transduction; meaning of agonist and antagonist; the dose-response curve;
-Pharmacokineti: absorbtion, distribution, metabolism and excretion of drugs; definition of half life, bioavailability, clearance and distribution volume
-Antiinflammatory drugs: FANS and glucocorticoids
-Immunosuppressive drugs
-Chemotherapeutci agents
-Drugs in cardiovascular system: Anti-coagulant and anti-thrombotic drugs, Anti-hypertensive drugs
-Drug for dyslipidemia
-Ttreatment for diabetes type I and II
- Drugs of nervous system: anti-depressives, anti-parkinson, anti-psycotic drugs, sedative-hypnotic, drug for neuromuscular disorders
Drug of abuse: opioids, psicostimulants, cannabinoids.
Drugs for COVID-19.
Integration of the gender dimension: where of interest, attention will be paid to gender pharmacology.

According to the Dublin descriptors D1- KNOWLEDGE AND UNDERSTANDING: The student will know and understand the basic notions of general pharmacology and the pharmacological characteristics of different classes of a. D2- ABILITY TO APPLY KNOWLEDGE AND UNDERSTANDING: The student will acquire the ability to use the theoretical knowledge imparted in class to reason critically, demonstrating that they are able to make connections between the different topics and to apply the knowledge acquired in the context of the synthesis of new drugs. D3- JUDGMENT ABILITY: The student will acquire the ability to critically examine the theoretical notions acquired and to be able to independently argue the problems arising from the practical application of the same. D4- COMMUNICATION SKILLS: The student will acquire the ability to disseminate the knowledge assimilated using a specific and appropriate vocabulary in order to be able to compare themselves in a professional and competent manner in the academic and subsequently working environment. D5-LEARNING ABILITY: The student will acquire a learning ability useful for continuous and constant updating on the new possibilities of discovering new pharmacological targets.